New insights on the dense molecular gas in NGC253 as traced by HCN and HCO+

We have imaged the central ~1kpc of the circumnuclear starburst disk in the galaxy NGC253 in the HCN(1-0), HCO+(1-0), and CO(1-0) transitions at 60pc resolution using the Owens Valley Radio Observatory Millimeter-Wavelength Array (OVRO). We have also obtained Atacama Pathfinder Experiment (APEX) observations of the HCN(4-3) and the HCO+(4-3) lines of the starburst disk. We find that the emission from the HCN(1-0) and HCO+(1-0) transitions, both indicators of dense molecular gas, trace regions which are non-distinguishable within the uncertainties of our observations. Even though the continuum flux varies by more than a factor 10 across the starburst disk, the HCN/HCO+ ratio is constant throughout the disk, and we derive an average ratio of 1.1+/-0.2. From an excitation analysis we find that all lines from both molecules are subthermally excited and that they are optically thick. This subthermal excitation implies that the observed HCN/HCO+ line ratio is sensitive to the underlying chemistry. The constant line ratio thus implies that there are no strong abundance gradients across the starburst disk of NGC253. This finding may also explain the variations in L'(HCN)/L'(HCO+) between different star forming galaxies both nearby and at high redshifts.Comment: 9 pages, 12 figures, ApJ in press (volume 666 September

A direct D-bar reconstruction algorithm for recovering a complex conductivity in 2-D

A direct reconstruction algorithm for complex conductivities in $W^{2,\infty}(\Omega)$, where $\Omega$ is a bounded, simply connected Lipschitz domain in $\mathbb{R}^2$, is presented. The framework is based on the uniqueness proof by Francini [Inverse Problems 20 2000], but equations relating the Dirichlet-to-Neumann to the scattering transform and the exponentially growing solutions are not present in that work, and are derived here. The algorithm constitutes the first D-bar method for the reconstruction of conductivities and permittivities in two dimensions. Reconstructions of numerically simulated chest phantoms with discontinuities at the organ boundaries are included.Comment: This is an author-created, un-copyedited version of an article accepted for publication in [insert name of journal]. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at 10.1088/0266-5611/28/9/09500

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer

Triple negative breast cancer (TNBC) is characterized by multiple genetic events occurring in concert to drive pathogenic features of the disease. Here we interrogated the coordinate impact of p53, RB, and MYC in a genetic model of TNBC, in parallel with the analysis of clinical specimens. Primary mouse mammary epithelial cells (mMEC) with defined genetic features were used to delineate the combined action of RB and/or p53 in the genesis of TNBC. In this context, the deletion of either RB or p53 alone and in combination increased the proliferation of mMEC; however, the cells did not have the capacity to invade in matrigel. Gene expression profiling revealed that loss of each tumor suppressor has effects related to proliferation, but RB loss in particular leads to alterations in gene expression associated with the epithelial-to-mesenchymal transition. The overexpression of MYC in combination with p53 loss or combined RB/p53 loss drove rapid cell growth. While the effects of MYC overexpression had a dominant impact on gene expression, loss of RB further enhanced the deregulation of a gene expression signature associated with invasion. Specific RB loss lead to enhanced invasion in boyden chambers assays and gave rise to tumors with minimal epithelial characteristics relative to RB-proficient models. Therapeutic screening revealed that RB-deficient cells were particularly resistant to agents targeting PI3K and MEK pathway. Consistent with the aggressive behavior of the preclinical models of MYC overexpression and RB loss, human TNBC tumors that express high levels of MYC and are devoid of RB have a particularly poor outcome. Together these results underscore the potency of tumor suppressor pathways in specifying the biology of breast cancer. Further, they demonstrate that MYC overexpression in concert with RB can promote a particularly aggressive form of TNB

Extended modular operad

This paper is a sequel to [LoMa] where moduli spaces of painted stable curves were introduced and studied. We define the extended modular operad of genus zero, algebras over this operad, and study the formal differential geometric structures related to these algebras: pencils of flat connections and Frobenius manifolds without metric. We focus here on the combinatorial aspects of the picture. Algebraic geometric aspects are treated in [Ma2].Comment: 38 pp., amstex file, no figures. This version contains additional references and minor change

Diamagnetic Susceptibility and Current Distributions in Granular Superconductors at Percolation

Comments: 4 pages RevTeX, 4 Postscript figures. References added. We study a two-dimensional granular superconducting network at the percolation threshold under the influence of an external perpendicular magnetic field. By numerical simulations on the full nonlinear problem, we determine the scaling exponent for the magnetic susceptibility. Further, we report on the scaling properties of the current distribution. The scaling of the current is found to be independent of the value of the magnetic field. Our results are in contradiction with previous numerical results based on linearized equations. We find a value for the susceptibility exponent which does not agree with existing theoretical suggestions, but agrees perfectly with renormalization group calculations

Experimental investigation of the Landau-Pomeranchuk-Migdal effect in low-Z targets

In the CERN NA63 collaboration we have addressed the question of the potential inadequacy of the commonly used Migdal formulation of the Landau-Pomeranchuk-Migdal (LPM) effect by measuring the photon emission by 20 and 178 GeV electrons in the range 100 MeV - 4 GeV, in targets of LowDensityPolyEthylene (LDPE), C, Al, Ti, Fe, Cu, Mo and, as a reference target, Ta. For each target and energy, a comparison between simulated values based on the LPM suppression of incoherent bremsstrahlung is shown, taking multi-photon effects into account. For these targets and energies, we find that Migdal's theoretical formulation is adequate to a precision of better than about 5%, irrespective of the target substance.Comment: 8 pages, 13 figure

Experimental investigations of synchrotron radiation at the onset of the quantum regime

The classical description of synchrotron radiation fails at large Lorentz factors, $\gamma$, for relativistic electrons crossing strong transverse magnetic fields $B$. In the rest frame of the electron this field is comparable to the so-called critical field $B_0 = 4.414\cdot10^9$ T. For $\chi = \gamma B/B_0 \simeq 1$ quantum corrections are essential for the description of synchrotron radiation to conserve energy. With electrons of energies 10-150 GeV penetrating a germanium single crystal along the $$ axis, we have experimentally investigated the transition from the regime where classical synchrotron radiation is an adequate description, to the regime where the emission drastically changes character; not only in magnitude, but also in spectral shape. The spectrum can only be described by quantum synchrotron radiation formulas. Apart from being a test of strong-field quantum electrodynamics, the experimental results are also relevant for the design of future linear colliders where beamstrahlung - a closely related process - may limit the achievable luminosity.Comment: 11 pages, 18 figures, submitted to PR

First Detection of HCO+ Emission at High Redshift

We report the detection of HCO+(1-0) emission towards the Cloverleaf quasar (z=2.56) through observations with the Very Large Array. This is the first detection of ionized molecular gas emission at high redshift (z>2). HCO+ emission is a star formation indicator similar to HCN, tracing dense molecular hydrogen gas (n(H_2) ~= 10^5 cm^{-3}) within star-forming molecular clouds. We derive a lensing-corrected HCO+ line luminosity of L'(HCO+) = 3.5 x 10^9 K km/s pc^2. Combining our new results with CO and HCN measurements from the literature, we find a HCO+/CO luminosity ratio of 0.08 and a HCO+/HCN luminosity ratio of 0.8. These ratios fall within the scatter of the same relationships found for low-z star-forming galaxies. However, a HCO+/HCN luminosity ratio close to unity would not be expected for the Cloverleaf if the recently suggested relation between this ratio and the far-infrared luminosity were to hold. We conclude that a ratio between HCO+ and HCN luminosity close to 1 is likely due to the fact that the emission from both lines is optically thick and thermalized and emerges from dense regions of similar volumes. The CO, HCN and HCO+ luminosities suggest that the Cloverleaf is a composite AGN--starburst system, in agreement with the previous finding that about 20% of the total infrared luminosity in this system results from dust heated by star formation rather than heating by the AGN. We conclude that HCO+ is potentially a good tracer for dense molecular gas at high redshift.Comment: 5 pages, 3 figures, ApJL, in press (accepted May 17, 2006

From clear lakes to murky waters - tracing the functional response of high-latitude lake communities to concurrent 'greening' and 'browning'

Climate change and the intensification of land use practices are causing widespread eutrophication of subarctic lakes. The implications of this rapid change for lake ecosystem function remain poorly understood. To assess how freshwater communities respond to such profound changes in their habitat and resource availability, we conducted a space-for-time analysis of food-web structure in 30 lakes situated across a temperature-productivity gradient equivalent to the predicted future climate of subarctic Europe (temperature +3 degrees C, precipitation +30% and nutrient +45 mu g L-1 total phosphorus). Along this gradient, we observed an increase in the assimilation of pelagic-derived carbon from 25 to 75% throughout primary, secondary and tertiary consumers. This shift was overwhelmingly driven by the consumption of pelagic detritus by benthic primary consumers and was not accompanied by increased pelagic foraging by higher trophic level consumers. Our data also revealed a convergence of the carbon isotope ratios of pelagic and benthic food web endmembers in the warmest, most productive lakes indicating that the incorporation of terrestrial derived carbon into aquatic food webs increases as land use intensifies. These results, reflecting changes along a gradient characteristic of the predicted future environment throughout the subarctic, indicate that climate and land use driven eutrophication and browning are radically altering the function and fuelling of aquatic food webs in this biome.Peer reviewe

Investigation of the importance of rock chemistry for saxicolous lichen communities of the New Idria serpentinite mass, San Benito County, California, USA

Although several lichen inventories exist for European ultramafic sites, only four surveys of serpentine lichens for North America have been published to date. Of those, only one has been conducted in California. We conducted a survey of saxicolous lichens from ultramafic rocks (including nephrite, partially serpentinized peridotite, and serpentinite) and non-ultramafic rocks (including silica-carbonate, shale, and sandstone) at the New Idria serpentinite mass, San Benito County, California. X-ray Fluorescence Analysis of the rocks from which the lichens were collected revealed significant elemental differences between the ultramafic and non-ultramafic rocks for 26 of the 32 major and trace elements analyzed. We identified a total of 119 species of lichenized and lichenicolous fungi; 60 species were restricted to ultramafic substrata, 19 to silica-carbonate, and 15 to shale and sandstone. Only 4 species were shared in common. A permutational multivariate analysis of variance (perMANOVA) test revealed significant differences in lichen assemblages between ultramafic and non-ultramafic rocks at the species level but not at the generic level, with species richness (alpha-diversity) significantly greater at the ultramafic sites. We suggest that, although differences in geochemistry clearly influence the lichen community composition, other factors, especially substratum age and the physical characteristics of the rock, are of equal, if not greater, importance. Of all the species collected, six, Buellia aethalea, B. ocellata, Caloplaca oblongula, Rhizocarpon saurinum, Thelocarpon laureri, and Trapelia obtegens, are reported new to California, along with an apparently previously undescribed Solenopsora sp. The rest of the species encountered are relatively frequent in the lichen flora of southern and central California, except Aspicilia praecrenata, a rare California endemic that we collected on both ultramafic and non-ultramafic rocks