Negotiating Gender: Female Combat Soldiers in Denmark

Based on interviews with female combat soldiers, we explore what role conceptions of femininity and masculinity play for female Danish combat soldiers’ experiences and behaviour in the military community. We find that female combat soldiers’ status and ability to fulfil their potential as soldiers are determined by their capability to navigate expectations linked to their gender and their position as soldiers, respectively. Female combat soldiers must break down negative expectations linked to their gender while simultaneously and continuously navigating the limitations of forms of femininity accepted in the Danish Military

Choice of metrics matters—Future scenarios on milk and beef production in Norway using an LCA approach

The consumption of dairy and beef products is expected to increase globally in the future, and at the same time, food must be produced in a more sustainable way, including reduced greenhouse gas (GHG) emissions, avoided feed-food competition, and reduced biodiversity loss. The purpose of the study was to a) provide an overall life cycle assessment (LCA) of these impacts for various future milk and beef production systems in Norway and b) determine how the choice of metrics for climate change affects the results. System boundaries were from cradle to farm gate and the temporal boundary was 2017 with future scenarios for 2040. The actual production and consumption in Norway in 2017 was used as a baseline (BL), and the sustainability of future Norwegian domestic production of milk and beef was assessed through three scenarios for 2040: 1) a trend yield scenario (TrendY) based on an expected increase in milk yield following the present trend, 2) a high yield scenario (HighY) with higher increase in the milk yield per cow per year than the trend, and 3) a low yield scenario (LowY) where the milk yield per cow per year was adjusted for covering the domestic demand for beef solely from dual-purpose production and no domestic specialized beef production. The beef production per dual-purpose cow was kept constant and the remaining domestic demand in scenario 1 and 2 were covered by specialized beef production. Climate change was assessed using both a GWP100 and a GWP* approach. The HighY scenario had the lowest impact on climate change using GWP100, but when taking the different behaviors of short- and long-term climate pollutants into account (GWP*), the ranking of the future scenarios changed and favored LowY. The potential biodiversity loss was lower for the LowY scenario because the proportion of concentrates in the dairy cow ration was decreased due to lower milk yield. Similarly, the feed-food competition was lower (land use ratio < 1) for the LowY. The results of our study suggest that the choice of metric for GWP and time frame highly affects the results and conclusions and strategies for climate smart and sustainable livestock production should therefore be made with caution.publishedVersio

Book Reviews

Book Reviews: Donna Haraway: Manifestly Haraway. (Reviewed by&nbsp;Lis Højgaard) &nbsp; Ayo Wahlberg &amp; Tine Gammeltoft (eds.): Selective Reproduction in the 21st Century. (Reviewed by Lisbeth B. Knudsen) &nbsp; Clarke, Adele, Friese, Carrie and Washburn, Rachel S. (2018). Situational Analysis. Grounded Theory after the Interpretive Turn, 2nd Edition. (Reviewed by Stine Willum Adrian) &nbsp; Cordelia Fine: Testosterone Rex – Unmaking the myths of our gendered minds. (Reviewed by Lea Skewes) &nbsp; PhD notice: Michala Hvidt Breengaard: HOW TO MOTHER? Practices of infant feeding and the formation of maternal subjectivity among middle-class mothers in Beijing &nbsp

Trauma facilities in Denmark - a nationwide cross-sectional benchmark study of facilities and trauma care organisation

Background Trauma is a leading cause of death among adults aged < 44 years, and optimal care is a challenge. Evidence supports the centralization of trauma facilities and the use multidisciplinary trauma teams. Because knowledge is sparse on the existing distribution of trauma facilities and the organisation of trauma care in Denmark, the aim of this study was to identify all Danish facilities that care for traumatized patients and to investigate the diversity in organization of trauma management. Methods We conducted a systematic observational cross-sectional study. First, all hospitals in Denmark were identified via online services and clarifying phone calls to each facility. Second, all trauma care manuals on all facilities that receive traumatized patients were gathered. Third, anesthesiologists and orthopedic surgeons on call at all trauma facilities were contacted via telephone for structured interviews. Results A total of 22 facilities in Denmark were found to receive traumatized patients. All facilities used a trauma care manual and all had a multidisciplinary trauma team. The study found three different trauma team activation criteria and nine different compositions of teams who participate in trauma care. Training was heterogeneous and, beyond the major trauma centers, databases were only maintained in a few facilities. Conclusion The study established an inventory of the existing Danish facilities that receive traumatized patients. The trauma team activation criteria and the trauma teams were heterogeneous in both size and composition. A national database for traumatized patients, research on nationwide trauma team activation criteria, and team composition guidelines are all called for

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines

Background: Studies in taxane and/or anthracycline refractory metastatic breast cancer (mBC) patients have shown approximately 30% response rates to irinotecan. Hence, a significant number of patients will experience irinotecan-induced side effects without obtaining any benefit. The aim of this study was to lay the groundwork for development of predictive biomarkers for irinotecan treatment in BC. Methods: We established BC cell lines with acquired or de novo resistance to SN-38, by exposing the human BC cell lines MCF-7 and MDA-MB-231 to either stepwise increasing concentrations over 6months or an initial high dose of SN-38 (the active metabolite of irinotecan), respectively. The resistant cell lines were analyzed for cross-resistance to other anti-cancer drugs, global gene expression, growth rates, TOP1 and TOP2A gene copy numbers and protein expression, and inhibition of the breast cancer resistance protein (ABCG2/BCRP) drug efflux pump. Results: We found that the resistant cell lines showed 7-100 fold increased resistance to SN-38 but remained sensitive to docetaxel and the non-camptothecin Top1 inhibitor LMP400. The resistant cell lines were characterized by Top1 down-regulation, changed isoelectric points of Top1 and reduced growth rates. The gene and protein expression of ABCG2/BCRP was up-regulated in the resistant sub-lines and functional assays revealed BCRP as a key mediator of SN-38 resistance. Conclusions: Based on our preclinical results, we suggest analyzing the predictive value of the BCRP in breast cancer patients scheduled for irinotecan treatment. Moreover, LMP400 should be tested in a clinical setting in breast cancer patients with resistance to irinotecan