ZMI - Newsletter 1/2005

"think tank" der Ludwig Boltzmann Gesellschaft nimmt Arbeit auf - 3.500.- € für Virtuelles Praktikumsportal - Deutsche politische Bildung als Vorbild: Koreanisches Fernsehen besucht Gießen - "Forum Gießen": Online über Stadt und Universität in Dialog treten - Web-Portal zur Lehrerfortbildung - MENA | log: Weblog mit Kommentaren und Analysen zur Entwicklung im Nahen Osten

Deep brain stimulation in schizophrenia

Deep brain stimulation (DBS) has successfully advanced treatment options of putative therapy-resistant neuropsychiatric diseases. Building on this strong foundation more and more mental disorders in the stadium of therapy-resistance are considered as possible indications for DBS. Especially schizophrenia with its associated severe and difficult to treat symptoms is gaining attention. This attention demands critical questions regarding the assumed mechanisms of DBS and its possible influence on the supposed pathophysiology of schizophrenia. Here we synoptically compare current approaches and theories of DBS and discuss the feasibility of DBS in schizophrenia as well as the transferability from other psychiatric disorders successfully treated with DBS. For this we consider recent advances in animal models of schizophrenic symptoms, results regarding the influence of DBS on dopaminergic transmission as well as data concerning neural oscillation and synchronization. In conclusion the use of DBS for some symptoms of schizophrenia seems to be a promising approach, but the lack of a comprehensive theory of the mechanisms of DBS as well as its impact on schizophrenia might void the use of DBS in schizophrenia at this point

Help-seeking pathways in early psychosis

INTRODUCTION: Understanding the help-seeking pathways of patients with a putative risk of developing psychosis helps improving development of specialised care services. This study aimed at obtaining information about: type of health professionals contacted by patients at putative risk for psychosis on their help-seeking pathways; number of contacts; type of symptoms leading to contacts with health professionals; interval between initial contact and referral to a specialised outpatient service. METHOD: The help-seeking pathways were assessed as part of a prospective study in 104 patients with suspected at-risk states for psychosis. RESULTS: The mean number of contacts prior to referral was 2.38. Patients with psychotic symptoms more often contacted mental health professionals, whereas patients with insidious and more unspecific features more frequently contacted general practitioners (GPs). CONCLUSIONS: GPs have been found to under-identify the insidious features of emerging psychosis (Simon et al. (2005) Br J Psychiatry 187:274–281). The fact that they were most often contacted by patients with exactly these features calls for focussed and specialised help for primary care physicians. Thus, delays along the help-seeking pathways may be shortened. This may be of particular relevance for patients with the deficit syndrome of schizophrenia

Deep brain stimulation in schizophrenia

Deep brain stimulation (DBS) has successfully advanced treatment options of putative therapy-resistant neuropsychiatric diseases. Building on this strong foundation more and more mental disorders in the stadium of therapy-resistance are considered as possible indications for DBS. Especially schizophrenia with its associated severe and difficult to treat symptoms is gaining attention. This attention demands critical questions regarding the assumed mechanisms of DBS and its possible influence on the supposed pathophysiology of schizophrenia. Here we synoptically compare current approaches and theories of DBS and discuss the feasibility of DBS in schizophrenia as well as the transferability from other psychiatric disorders successfully treated with DBS. For this we consider recent advances in animal models of schizophrenic symptoms, results regarding the influence of DBS on dopaminergic transmission as well as data concerning neural oscillation and synchronization. In conclusion the use of DBS for some symptoms of schizophrenia seems to be a promising approach, but the lack of a comprehensive theory of the mechanisms of DBS as well as its impact on schizophrenia might void the use of DBS in schizophrenia at this point

Primary Metabolic Chemistry.

Thioesters and acyl phosphates are important metabolites throughout the biosphere. This may imply that they were involved in prebiotic chemistry. The study of the reactivity of thioesters and acyl phosphates may therefore provide some insights into the possible roles for these molecules in prebiotic chemistry. The work described in this thesis demonstrates that acetyl phosphate and inorganic phosphate react to form pyrophosphate in the presence of salts of some divalent metals. Divalent metal ions and nitrogen containing compounds act in synergy to promote pyrophosphate formation in some cases. Ferrous salts were much more efficient at promoting the formation of pyrophosphate than similar reactions containing magnesium ions, Addition of pyridine, or a variety of other nitrogen containing compounds, did not enhance the pyrophosphate yield. The promotion of pyrophosphate formation at near neutral pH by ubiquitous metal salts is considered to be a feasible route for prebiotic production of pyrophosphate. One chemoautotrophic origin of life theory concentrates on the oxidative formation of pyrite (FeS2) from ferrous sulfide and hydrogen as a possible source of prebiotic reductive power. N-Phenyl acetamide can be prepared from mercaptoacetic acid and aniline in water using FeS/H2S as a reagent system. We have established that one possible intermediate, N-phenyl mercaptoacetamide does react to give the product, and that this reaction is fast. Ferrous ions were observed to promote the formation of N-acetyl alanine from alanine and thioacetic acid. Zinc and cadmium ions on the other hand, promote the hydrolysis of thioacetic acid to acetic acid in preference to the N-acylation reaction. Both ferrous ions and ferro cyanide ions were observed to promote the peptide bond formation between protected amino acid derivatives. The results described in this thesis are consistent with the proposal that iron chemistry may have been important in prebiotic chemistry

An Engineering Geological Investigation of the Seismic Subsoil Classes in the Central Wellington Commercial Area.

The city of Wellington has a high population concentration and lies within a geologically active landscape at the southern end of the North Island, New Zealand. Wellington has a high seismic risk due to its close proximity to several major fault systems, with the active Wellington Fault located in the north-western central city. Varying soil depth and properties in combination with the close proximity of active faults mean that in a large earthquake rupture event, ground shaking amplification is expected to occur in Thorndon, Te Aro and around the waterfront. This thesis focuses on the area bounded by Thorndon Overbridge in the north, Wellington Hospital in the south, Kelburn in the west, and Oriental Bay in the east. It includes many of the major buildings and infrastructural elements located within the central Wellington commercial area. The main objectives were to create an electronic database which allows for convenient access to all available data within the study area, to create a 3D geological model based upon this data, and to define areas of different seismic subsoil class and depth to rock within the study area at a scale that is useful for preliminary geotechnical analysis (1:5,000. Borelogs from 1025 holes with accompanying geological and geotechnical data obtained from GNS Science and Tonkin & Taylor were compiled into a database, together with the results from SPAC microtremor testing at 12 sites undertaken specifically for this study. This thesis discusses relevant background work and defines the local Wellington geology. A 3D geological model of the central Wellington commercial area, along with ten ArcGIS maps including surficial, depth to bedrock, site period, Vs30, ground shaking amplification hazard and site class (NZS 1170.5:2004) maps were created. These outputs show that a significant ground shaking amplification risk is posed on the city, with the waterfront, Te Aro and Thorndon areas most at risk

Web technologies and trends of SCADA-systems development in the field of APCS

This article discusses the use of Internet technologies for modern automated process control systems. As a result of the analysis, the author defines Scada systems and the Industrial Internet of Things. The main advantage of using Internet technologies in APCS is the ability to control and monitor from anywhere using a computer or mobile phone

Are lay people good at recognising the symptoms of schizophrenia?

©2013 Erritty, Wydell. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Aim: The aim of this study was to explore the general public’s perception of schizophrenia symptoms and the need to seekhelp for symptoms. The recognition (or ‘labelling’) of schizophrenia symptoms, help-seeking behaviours and public awareness of schizophrenia have been suggested as potentially important factors relating to untreated psychosis. Method: Participants were asked to rate to what extent they believe vignettes describing classic symptoms (positive and negative) of schizophrenia indicate mental illness. They were also asked if the individuals depicted in the vignettes required help or treatment and asked to suggest what kind of help or treatment. Results: Only three positive symptoms (i.e., Hallucinatory behaviour, Unusual thought content and Suspiciousness) of schizophrenia were reasonably well perceived (above 70%) as indicating mental illness more than the other positive or negative symptoms. Even when the participants recognised that the symptoms indicated mental illness, not everyone recommended professional help. Conclusion: There may be a need to improve public awareness of schizophrenia and psychosis symptoms, particularly regarding an awareness of the importance of early intervention for psychosis

CSF Metabolic and Proteomic Profiles in Patients Prodromal for Psychosis

BACKGROUND: The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the metabolic/proteomic profiles of cerebrospinal fluid (CSF) of first-onset drug naïve paranoid schizophrenia patients (n = 54) and individuals presenting with initial prodromal symptoms (n = 24), alongside healthy volunteers (n = 70) using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% of IPS patients displayed proteomic/metabolic profiles characteristic of first-onset, drug naïve schizophrenia, i.e., changes in levels of glucose and lactate as well as changes in a VGF-derived peptide (VGF23-62) and transthyretin protein concentrations. However, only 29% (n = 7) of the investigated IPS patients (who to date have been followed up for up to three years) have so far received a diagnosis of schizophrenia. The presence of biochemical alterations in the IPS group did not correlate with the risk to develop schizophrenia. CONCLUSIONS/SIGNIFICANCE: Our results imply that schizophrenia-related biochemical disease processes can be traced in CSF of prodromal patients. However, the biochemical disturbances identified in IPS patients, at least when measured at a single time point, may not be sufficient to predict clinical outcome

Evaluating Depressive Symptoms in Schizophrenia: A Psychometric Comparison of the Calgary Depression Scale for Schizophrenia and the Hamilton Depression Rating Scale

Background: The aim of this study was to compare two measures of depression in patients with schizophrenia and schizophrenia spectrum disorder, including patients with delusional and schizoaffective disorder, to conclude implications for their application. Sampling and Methods: A total of 278 patients were assessed using the Calgary Depression Scale for Schizophrenia (CDSS) and the Hamilton Depression Rating Scale (HAMD-17). The Positive and Negative Syndrome Scale (PANSS) was also applied. At admission and discharge, a principal component analysis was performed with each depression scale. The two depression rating scales were furthermore compared using correlation and regression analyses. Results: Three factors were revealed for the CDSS and HAMD-17 factor component analysis. A very similar item loading was found for the CDSS at admission and discharge, whereas results of the loadings of the HAMD-17 items were less stable. The first two factors of the CDSS revealed correlations with positive, negative and general psychopathology. In contrast, multiple significant correlations were found for the HAMD-17 factors and the PANSS sub-scores. Multiple regression analyses demonstrated that the HAMD-17 accounted more for the positive and negative symptom domains than the CDSS. Conclusions:The present results suggest that compared to the HAMD-17, the CDSS is a more specific instrument to measure depressive symptoms in schizophrenia and schizophrenia spectrum disorder, especially in acutely ill patients. Copyright (c) 2012 S. Karger AG, Base