Effects of a Novel Dental Gel on Plaque and Gingivitis: A Comparative Study.

ObjectivesThe goal of this prospective, randomized, controlled, double-blinded study was to evaluate the effects of a novel dental gel on plaque and gingival health. The dental gel was designed to (1) break up and prevent re-accumulation of microbial biofilm, and (2) inhibit metal mediated inflammation.Materials and methodsTwenty-five subjects with moderate gingival inflammation (Löe and Silness Gingival Index ≥2) and pocket depths <4 were randomly assigned to brush twice daily for 21 days with the test or the control dental gel. On Days 0, 7, 14 and 21, plaque levels (Quigley-Hein, Turesky Modification Plaque Index), gingival inflammation (Löe and Silness Gingival Index) and gingival bleeding (modified Sulcus Bleeding Index) were determined by one blinded, investigator using a pressure sensitive probe.ResultsAfter 3 weeks, all 3 clinical indices were significantly improved in both groups (P<0.05) and significantly lower in the test group (P<0.05).ConclusionThe novel dental gel formulation was provided effective plaque control and reduced gingival inflammation.Clinical relevanceA novel dentifrice formulation may be an effective tool for plaque removal and maintaining gingival health

Toward osteogenic differentiation of marrow stromal cells and in vitro production of mineralized extracellular matrix onto natural scaffolds

Uncorrected proofTissue engineering has emerged as a new interdisciplinary field for the repair of various tissues, restoring their functions by using scaffolds, cells, and/or bioactive factors. A temporary scaffold acts as an extracellular matrix analog to culture cells and guide the development of new tissue. In this chapter, we discuss the preparation of naturally derived scaffolds of polysaccharide origin, the osteogenic differentiation of mesenchymal stem cells cultured on biomimetic calcium phosphate coatings, and the delivery of biomolecules associated with extracellular matrix mineralization

American Academy of Periodontology best evidence consensus statement on the efficacy of laser therapy used alone or as an adjunct to nonâ surgical and surgical treatment of periodontitis and periâ implant diseases

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145589/1/jper10138_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/145589/2/jper10138.pd