3,966 research outputs found

    Optimal read/write memory system components

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    Two holographic data storage and display systems, voltage gradient ionization system, and linear strain manipulation system are discussed in terms of creating fast, high bit density, storage device. Components described include: novel mounting fixture for photoplastic arrays; corona discharge device; and block data composer

    Sound ranking algorithms for XML search

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    Ranking algorithms for XML should reflect the actual combined content and structure constraints of queries, while at the same time producing equal rankings for queries that are semantically equal. Ranking algorithms that produce different rankings for queries that are semantically equal are easily detected by tests on large databases: We call such algorithms not sound. We report the behavior of different approaches to ranking content-and-structure queries on pairs of queries for which we expect equal ranking results from the query semantics. We show that most of these approaches are not sound. Of the remaining approaches, only 3 adhere to the W3C XQuery Full-Text standard

    Tunable biohybrid hydrogels from coacervation of hyaluronic acid and PEO‐based block copolymers

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    Accurately tuning the macroscopic properties of biopolymer‐based hydrogels remains challenging due to the ill‐defined molecular architecture of the natural building blocks. Here, we report a biohybrid coacervate hydrogel, combining the biocompatibility and biodegradability of naturally occurring hyaluronic acid (HA) with the tunability of a synthetic polyethylene oxide (PEO) ‐based ABA‐triblock copolymer. Coacervation of the cationic ammonium or guanidinium‐functionalized copolymer A‐blocks with the anionic HA leads to hydrogel formation. Both mechanical properties and water content of the self‐healing hydrogels can be controlled independently by altering the copolymer structure. By controlling the strength of the interaction between the polymer network and small‐molecule cargo, both release rate and maximum release are controlled. Finally, we show that coacervation of HA and the triblock copolymer leads to increased biostability upon exposure to hyaluronidase. We envision that noncovalent crosslinking of HA hydrogels through coacervation is an attractive strategy for the facile synthesis of tunable hydrogels for biomedical applications

    Error modeling of precision orientation sensors in a fixed base simulation

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    Models of noise and dynamic characteristics of gyro and autocollimator for very small signal levels are presented. Measurements were evaluated using spectral techniques for identifying noise from base motion. The experiment was constructed to measure the precession, due to relativistic effects, of an extremely precise earth-orbiting gyroscope. The design goal for nonrelativistic gyro drift is 0.001 arcsec per year. An analogous fixed base simulator was used in developing methods of instrument error modeling and performance evaluation applicable to the relativity experiment sensors and other precision pointing instruments. Analysis of autocollimator spectra uncovered the presence of a platform gimbal resonance. The source of resonance was isolated to gimbal bearing elastic restraint properties most apparent at very small levels of motion. A model of these properties which include both elastic and coulomb friction characteristics is discussed, and a describing function developed

    Magnetic field--induced modification of selection rules for Rb D2_2 line monitored by selective reflection from a vapor nanocell

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    Magnetic field-induced giant modification of the probabilities of five transitions of 5S1/2,Fg=25P3/2,Fe=45S_{1/2}, F_g=2 \rightarrow 5P_{3/2}, F_e=4 of 85^{85}Rb and three transitions of 5S1/2,Fg=15P3/2,Fe=35S_{1/2}, F_g=1 \rightarrow 5P_{3/2}, F_e=3 of 87^{87}Rb forbidden by selection rules for zero magnetic field has been observed experimentally and described theoretically for the first time. For the case of excitation with circularly-polarized (σ+\sigma^+) laser radiation, the probability of Fg=2, mF=2Fe=4, mF=1F_g=2, ~m_F=-2 \rightarrow F_e=4, ~m_F=-1 transition becomes the largest among the seventeen transitions of 85^{85}Rb Fg=2Fe=1,2,3,4F_g=2 \rightarrow F_e=1,2,3,4 group, and the probability of Fg=1, mF=1Fe=3, mF=0F_g=1,~m_F=-1 \rightarrow F_e=3,~m_F=0 transition becomes the largest among the nine transitions of 87^{87}Rb Fg=1Fe=0,1,2,3F_g=1 \rightarrow F_e=0,1,2,3 group, in a wide range of magnetic field 200 -- 1000 G. Complete frequency separation of individual Zeeman components was obtained by implementation of derivative selective reflection technique with a 300 nm-thick nanocell filled with Rb, allowing formation of narrow optical resonances. Possible applications are addressed. The theoretical model is perfectly consistent with the experimental results.Comment: 6 pages, 5 figure

    Light-sensitive polymeric nanoparticles based on light-cleavable chromophores

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    Effect of culture in simulated microgravity on the development of mouse embryonic testes

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    BACKGROUND All known organisms develop and evolve in the presence of gravitational force, and it is evident that gravity has a significant influence on organism physiology and development. Microgravity is known to affect gene expression, enzyme activity, cytoskeleton organization, mitotic proliferation and intracellular signaling. OBJECTIVES: The aim of the present study was to study some aspects of the development in vitro of mouse embryonic testes in simulated microgravity. MATERIAL AND METHODS: Testes from mouse embryos (12.5-16.5 days post coitum, d.p.c.) were cultured in simulated microgravity and standard static culture conditions. The microgravity condition was provided by a Rotary Cell Culture System (RWV) bioreactor, an apparatus designated for 3D tissue and small organ cultures. After 48 h of the culture in the RWV, testis morphology and size was evaluated. RESULTS: The first observation was that the culture in the RWV bioreactor had a beneficial effect on the testis growth and on the survival of germ cells in comparison to static 2D culture methods. Moreover, we found, that RWV culture caused disorganization the gonadal tissues, namely of the testis cords. CONCLUSIONS: The results suggest that the maintenance of testis cord could be sensitive to microgravity. We hypothesize that while the effect on testis growth is due to a better nutrient and oxygen supply, the testis cord's disorganization might depend on the microgravity conditions simulated by the bioreactor. Considering the complexity of the processes involved in the formation of the testis cords and their dynamic changes during the embryo fetal period, further studies are needed to identify the causes of such effect

    Modifications of comet materials by the sublimation process: Results from simulation experiments

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    An active comet like comet Halley loses by sublimation a surface layer of the order of 1 m thickness per perihelion passage. In situ measurements show that water ice is the main constituent which contributes to the gas emission although even more volatile species (CO, NH3, CH4, CO2 etc.) have been identified. Dust particles which were embedded in the ices are carried by the sublimating gases. Measurements of the chemical composition of cometary grains indicate that they are composed of silicates of approximate chondritic composition and refractory carbonaceous material. Comet simulation experiments show that significant modifications of cometary materials occur due to sublimation process in near surface layers which have to be taken into account in order to derive the original state of the material
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