Genetic analysis indicate superiority of perfomance of cape goosberry (Physalis peruviana L.) hybrids

The use of hybrids as a new type of cape gooseberry (Physalis peruviana L.) cultivars could improve yield in this crop, but little or no information is available on hybrid perfomance. We studied several vegetative characters, yield, fruit weight and fruit shape, soluble solids content (SSC), titratable acidity (TA) and ascorbic acid content (AAC) in three hybrids of cape gooseberry and their parents grown outdoors and in a glasshouse. The highest yields were obtained with hybrids, specially in a glasshouse. Interaction dominance environment for yield was very important; a higher dominance effect was detected in the glasshouse, than that observed outdoors. Quality characters were highly affected by the environment and showed variable results for the different families. For fruit composition traits, the additive and additive environment interactions were most important. Broad-sense heritability for all characters was high to medium (0.48-0.91), indicating that a high response to selection would be expected. Hybrids can improve cape gooseberry yield without impairing fruit quality.Leiva-Brondo, M.; Prohens Tomás, J.; Nuez Viñals, F. (2001). Genetic analysis indicate superiority of perfomance of cape goosberry (Physalis peruviana L.) hybrids. Journal of New Seeds. 3(3):71-84. doi:10.1300/J153v03n03_04718433Abak, K., Güler, H. Y., Sari, N., & Paksoy, M. (1994). EARLINESS AND YIELD OF PHYSALIS (P. IXOCARPA BROT. AND P. PERUVIANA L.) IN GREENHOUSE, LOW TUNNEL AND OPEN FIELD. Acta Horticulturae, (366), 301-306. doi:10.17660/actahortic.1994.366.37Kang, M. S. (1997). Using Genotype-by-Environment Interaction for Crop Cultivar Development. Advances in Agronomy Volume 62, 199-252. doi:10.1016/s0065-2113(08)60569-6Klinac, D. J. (1986). Cape gooseberry (Physalis peruviana) production systems. New Zealand Journal of Experimental Agriculture, 14(4), 425-430. doi:10.1080/03015521.1986.10423060Mather, K., & Jinks, J. L. (1977). Introduction to Biometrical Genetics. doi:10.1007/978-94-009-5787-9Mazer, S. J., & Schick, C. T. (1991). Constancy of population parameters for life history and floral traits in Raphanus sativus L. I. Norms of reaction and the nature of genotype by environment interactions. Heredity, 67(2), 143-156. doi:10.1038/hdy.1991.74Nyquist, W. E., & Baker, R. J. (1991). Estimation of heritability and prediction of selection response in plant populations. Critical Reviews in Plant Sciences, 10(3), 235-322. doi:10.1080/07352689109382313Pearcy, R. W. (1990). Sunflecks and Photosynthesis in Plant Canopies. Annual Review of Plant Physiology and Plant Molecular Biology, 41(1), 421-453. doi:10.1146/annurev.pp.41.060190.002225Péron, J. Y., Demaure, E., & Hannetel, C. (1989). POSSIBILITIES OF TROPICAL SOLANACEAE AND CUCURBITACEAE INTRODUCTION IN FRANCE. Acta Horticulturae, (242), 179-186. doi:10.17660/actahortic.1989.242.24Proctor, F. J. (1990). THE EUROPEAN COMMUNITY MARKET FOR TROPICAL FRUIT AND FACTORS LIMITING GROWTH. Acta Horticulturae, (269), 29-40. doi:10.17660/actahortic.1990.269.

Minimal residual disease in melanoma: circulating melanoma cells and predictive role of MCAM/MUC18/MelCAM/CD146

Circulating tumour cells (CTCs), identified in numerous cancers including melanoma, are unquestionably considered valuable and useful as diagnostic and prognostic markers. They can be detected at all melanoma stages and may persist long after treatment. A crucial step in metastatic processes is the intravascular invasion of neoplastic cells as circulating melanoma cells (CMCs). Only a small percentage of these released cells are efficient and capable of colonizing with a strong metastatic potential. CMCs' ability to survive in circulation express a variety of genes with continuous changes of signal pathways and proteins to escape immune surveillance. This makes it difficult to detect them; therefore, specific isolation, enrichment and characterization of CMC population could be useful to monitor disease status and patient clinical outcome. Overall and disease-free survival have been correlated with the presence of CMCs. Specific melanoma antigens, in particular MCAM (MUC18/MelCAM/CD146), could be a potentially useful tool to isolate CMCs as well as be a prognostic, predictive biomarker. These are the areas reviewed in the article

Detection of Minimal Residual Disease and Its Clinical Applications in Melanoma and Breast Cancer Patients.

Melanoma and breast cancer (BC) patients face a high risk of recurrence and disease progression after curative surgery and/or therapeutic treatment. Monitoring for minimal residual disease (MRD) during a disease-free follow-up period would greatly improve patient outcomes through earlier detection of relapse or treatment resistance. However, MRD monitoring in solid tumors such as melanoma and BC are not well established. Here, we discuss the clinical applications of MRD monitoring in melanoma and BC patients and highlight the current approaches for detecting MRD in these solid tumors