17 research outputs found
Considering, planning, and realizing migration in early adulthood: the influence of life-course events and perceived opportunities on leaving the city in Germany
Recent developments in planet migration theory
Planetary migration is the process by which a forming planet undergoes a
drift of its semi-major axis caused by the tidal interaction with its parent
protoplanetary disc. One of the key quantities to assess the migration of
embedded planets is the tidal torque between the disc and planet, which has two
components: the Lindblad torque and the corotation torque. We review the latest
results on both torque components for planets on circular orbits, with a
special emphasis on the various processes that give rise to additional, large
components of the corotation torque, and those contributing to the saturation
of this torque. These additional components of the corotation torque could help
address the shortcomings that have recently been exposed by models of planet
population syntheses. We also review recent results concerning the migration of
giant planets that carve gaps in the disc (type II migration) and the migration
of sub-giant planets that open partial gaps in massive discs (type III
migration).Comment: 52 pages, 18 figures. Review article to be published in "Tidal
effects in Astronomy and Astrophysics", Lecture Notes in Physic
Giant Planet Formation and Migration
© 2018, The Author(s). Planets form in circumstellar discs around young stars. Starting with sub-micron sized dust particles, giant planet formation is all about growing 14 orders of magnitude in size. It has become increasingly clear over the past decades that during all stages of giant planet formation, the building blocks are extremely mobile and can change their semimajor axis by substantial amounts. In this chapter, we aim to give a basic overview of the physical processes thought to govern giant planet formation and migration, and to highlight possible links to water delivery.S.-J. Paardekooper is supported by a Royal Society University Research Fellowship. A. Johansen is supported by the Knut and Alice Wallenberg Foundation, the Swedish Research Council (grant 2014-5775) and the European Research Council (ERC Starting Grant 278675-PEBBLE2PLANET)
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Beyond the clinical impact of aortic and pulmonary valve implantation: health-related quality of life, informal care and productivity
OBJECTIVES Our aim was to provide estimates of patient-reported health-related quality of life (HRQoL), use of informal care and productivity in patients after surgical aortic and pulmonary valve replacement and transcatheter aortic valve implantation.METHODS Consecutive cohorts of 1239 adult patients who had surgical aortic valve replacement or surgical pulmonary valve replacement and 433 patients who had transcatheter aortic valve implantation at 2 Dutch heart centres were cross-sectionally surveyed at a median time of 2.9 and 3.2years after the intervention, respectively. The survey included questions on HRQoL (EQ-5D-5L and SF-12-v2), use of informal care and productivity in paid and unpaid work. All outcomes were compared with age and sex-matched individuals from the general population.RESULTS The response rate was 56% (n=687) of patients who had surgical valve replacement and 59% (n=257) of those who had transcatheter aortic valve implantation. Compared with the general population, patients reported poorer HRQoL on physical health domains, whereas their scores were comparable for mental health domains. After a heart valve implantation, patients reported using informal care more frequently than the general population, but labour participation was comparable. Patients with late complications [antibiotic treatment for endocarditis (n=4), stroke (n=11), transient ischaemic attack (n=15)] reported lower HRQoL, greater use of informal care and greater productivity loss than patients without complications.CONCLUSIONS Patients who had aortic and pulmonary valve implantations experience relatively mild limitations in daily life compared to the general population. The consequences of a heart valve implantations beyond clinical outcomes should be considered to create realistic patient expectations of life after a heart valve implantation and unbiased resource allocation decisions at national levels.Cardiolog
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Long-range transport of ozone and related pollutants over the North Atlantic in spring and summer
This paper presents strong experimental evidence for a major perturbation in ozone
concentrations over large parts of the North Atlantic Ocean from the surface to 8 km associated with continental pollutants. The evidence was gathered in the course of 7
flights by the UK Meteorological Office C-130 aircraft based on the Azores, and 4 ferry flights between the UK to the Azores in spring and summer 1997 as a component of
the NERC-funded ACSOE project. The total latitude range covered was approximately
55°Nâ25°N, and the longitude range was approximately 0° to 40°W. Many profiles
were made between the sea surface and altitudes up to 9km to survey the composition of the marine atmosphere.
The C-130 aircraft was comprehensively equipped to measure many chemical and
physical parameters along with standard meteorological instrumentation. Thus it was
able to measure ozone and speciated NOy, along with tracers including water vapour,
carbon monoxide and condensation nuclei, in near real time. The overall âpictureâ of the
troposphere over large parts of the North Atlantic is of layers of pollution from the continents of different ages interspersed with layers of air uplifted from the marine boundary layer. The lowest ozone concentrations were recorded in the marine boundary layer where there is evidence for extensive ozone destruction in summer.
Flights were made to penetrate the outflow of hurricane Erica, to determine the
southerly extent of polluted air in summer, to examine the impact of frontal systems
on the composition of remote marine air, and to trace long-range pollution from the
west coast of the USA interspersed with air with a stratospheric origin. In one of the
spring flights it is possible that a plume of polluted air with high ozone and NOy, and
with an origin in southeast Asia, was intercepted off the coast of Portugal. The concentrations of NOx in this plume were sufficient for ozone formation to be continuing along its track from west to east.
The instrument to measure NOy almost certainly was only measuring the sum of organic nitrates (mostly in the form of PAN) plus NOx. The high correlation between NOy and ozone under these conditions strongly suggests a non-stratospheric source for most of the ozone encountered over large parts of the atmosphere upwind of Europe.
There was a marked seasonal variation in the NOy with about twice as much present
in the spring flights than in the summer flights. The overall ozone levels in both spring and summer were somewhat similar although the highest ozone concentration encountered ~100 ppbv) was observed in summer in some polluted layers in mid Atlantic with an origin in the boundary layer over the southeastern USA.
The bulk of the pollutants, ozone, CO, and NOy, were in the free troposphere at altitudes between 3 and 8 km. The only instances of pollution at lower levels were in the form of ship plumes, which were encountered several times. The data therefore strongly support the need for more in-situ aircraft experiments to quantify and understand the phenomenon of long-range transport of pollution from continent to continent.
Observations at ground-based stations are inadequate for this purpose and satellite
data is incomplete both in terms of its altitude detail and in the extent of chemical speciation, particularly for ascertaining whether chemical production and destruction processes for ozone are occurring
Validation of an extractive, airborne, compact TDL spectrometer for atmospheric humidity sensing by blind intercomparison
The Delivery of Water During Terrestrial Planet Formation
The planetary building blocks that formed in the terrestrial planet region were likely very dry, yet water is comparatively abundant on Earth. We review the various mechanisms proposed for the origin of water on the terrestrial planets. Various in-situ mechanisms have been suggested, which allow for the incorporation of water into the local planetesimals in the terrestrial planet region or into the planets themselves from local sources, although all of those mechanisms have difficulties. Comets have also been proposed as a source, although there may be problems fitting isotopic constraints, and the delivery efficiency is very low, such that it may be difficult to deliver even a single Earth ocean of water this way. The most promising route for water delivery is the accretion of material from beyond the snow line, similar to carbonaceous chondrites, that is scattered into the terrestrial planet region as the planets are growing. Two main scenarios are discussed in detail. First is the classical scenario in which the giant planets begin roughly in their final locations and the disk of planetesimals and embryos in the terrestrial planet region extends all the way into the outer asteroid belt region. Second is the Grand Tack scenario, where early inward and outward migration of the giant planets implants material from beyond the snow line into the asteroid belt and terrestrial planet region, where it can be accreted by the growing planets. Sufficient water is delivered to the terrestrial planets in both scenarios. While the Grand Tack scenario provides a better fit to most constraints, namely the small mass of Mars, planets may form too fast in the nominal case discussed here. This discrepancy may be reduced as a wider range of initial conditions is explored. Finally, we discuss several more recent models that may have important implications for water delivery to the terrestrial planets