44 research outputs found
Unsteady Fluid-Structure-Jet Interaction Modeling Methods for Agile High-Speed Vehicles
- Publication venue
- 'American Institute of Aeronautics and Astronautics (AIAA)'
- Publication date
- 01/01/2017
- Field of study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143063/1/6.2017-4356.pd
Unsteady Fluid-Structure-Jet Interactions of Agile High-Speed Vehicles
- Publication venue
- 'American Institute of Aeronautics and Astronautics (AIAA)'
- Publication date
- 01/01/2017
- Field of study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143059/1/6.2017-3549.pd
Views and experiences of people with intellectual disabilities regarding intimate relationships: a qualitative metasynthesis
- Author
- A Craft
- A Grieve
- A Lafferty
- A Liberati
- AA Szollos
- American Psychiatric Association (APA)
- Anna Tickle
- B Heyman
- Brad English
- C Bates
- C Fitzgerald
- CA Estabrooks
- CJ Drew
- D Evans
- D Kitson
- D Ryan
- Department of Health
- Department of Health
- DG Blanchflower
- DJ Bernert
- E Emerson
- E Healy
- E Rushbrooke
- E Rushbrooke
- E White
- E Zigler
- E Zigler
- F Sullivan
- F Williams
- G Bane
- G Kelly
- GH Murphy
- GW Noblit
- GW Turner
- H Brown
- H Koller
- I Brown
- J Lesseliers
- J Lesseliers
- J Mattinson
- J Robertson
- JR Thompson
- JS Newton
- K Hannes
- K Johnson
- L Festinger
- L Löfgren-Mårtenson
- LA Jensen
- M Bayley
- M Cuskelly
- M Dixon-Woods
- M Knox
- M McCarthy
- M Power
- M Sandelowski
- N Beail
- P Frawley
- R Forrester-Jones
- R McRuer
- R Morentin
- R Neuman
- RA Cummins
- RI Brown
- RL Schalock
- RL Shaw
- Roshan dasNair
- S Futcher
- TA Booth
- United Nations
- V Lloyd
- VJ Wilkinson
- W Wolfensberger
- W Wolfensberger
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2018
- Field of study
The aims of this review were to systematically identify, critically appraise and synthesize the results of existing qualitative literature exploring the views and experiences of intimate relationships amongst people with intellectual disabilities. Fourteen peer-reviewed articles were identified through a systematic search of eight databases, reference lists, citations, and relevant journals. The identified articles were appraised for quality, then synthesized using a metaethnography approach. No study met all quality criteria and references to ethical approval were often lacking. Interpretation of the findings suggested three key themes: the meaning of intimate relationships, external constraints and facilitators, and managing external constraints. Though many people with intellectual disabilities desire and benefit from intimate relationships, they experience restrictions that others do not, which can lead to isolation and loneliness. Intimate relationships are not always necessarily linked with sexual behavior; therefore, intimate relationships warrant their own focus in future research, as well as in education and training for people with intellectual disabilities and their caregivers. Within this, a commitment to transparency over research processes is needed, in particular with reference to how ethical approval was obtained, since this has been a shortcoming of research with this focus to date
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
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- Afilalo J.
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- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
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- AlBardis H.
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- Albesher N.
- Albrich W.
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- Aldridge J.
- Aleagha A. E.
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- Wyllie D. H.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
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- C Ashbrook-Raby
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- C Beazley
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- C Clulow
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- C Demetriou
- C Dennis
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- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
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- C Murphy
- C Parmar
- C Pawley
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- C Pothecary
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- C Prendergast
- C Price
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- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
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- C Vigurs
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- C Whitton
- C Whyte
- C Wrey Brown
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- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
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- D Butcher
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- D Collier
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- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
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- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
- I Otahal
- I Otahal
- I Turner-Bone
- I Welters
- I White
- I Wynter
- Ilaria Meloni
- Immacolata Andolfo
- Isabella Zanella
- J Allan
- J Barker
- J Bewley
- J Biddle
- J Birch
- J Birch
- J Bradley-Potts
- J Brown
- J Bryant
- J Butler
- J Camsooksai
- J Carter
- J Caterson
- J Cebrian Suarez
- J Cockerill-Taylor
- J Cole
- J Colley
- J Cooper
- J Cupitt
- J Cuttler
- J Daglish
- J Dasgin
- J Dawson
- J Dearden
- J Deery
- J Donnachie
- J Dykes
- J Easton
- J Egan
- J Fernandez Roman
- J Finn
- J Fletcher
- J Frankham
- J Gaylard
- J Gill
- J Godden
- J Goodsell
- J Gregory
- J Greig
- J Gurasashvili
- J Hardy
- J Harris
- J Hatton
- J Hawes
- J Highgate
- J Hornsby
- J Hulme
- J Hunt
- J Hutter
- J Ingham
- J Jones
- J Jones
- J K Baillie
- J Kassam
- J Kenneth Baillie
- J Kenneth Baillie
- J Keshet-Price
- J Liew
- J Little
- J Mallinson
- J Martin
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- J Medhora
- J Melville
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- Janet T Scott
- Janie F Shelton
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- Jorge Esparza-Gordillo
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- Keating Sean
- Kenneth A Mclean
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- Knight Julian
- Kousathanas Athanasios
- L Abel
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- L Allen
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- L McMorrow
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- Lorenzo Salerni
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- Louise Cullum
- Louise Macgillivray
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- Luca Cantarini
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- Luca Masucci
- Luisa Tavecchia
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- Marco Sita
- Margherita Baldassarri
- Mari E K Niemi
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Eugenia Quiros-Roldan
- Maria Palmieri
- Maria Zambon
- Marie Connor
- Mario Capasso
- Mario U Mondelli
- Marta Corridi
- Maslove David
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Girardis
- Massimo Palmarini
- Massimo Vaghi
- Matteo Bassetti
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- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
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- Michelle Girvan
- Millar Jonathan
- Mirella Bruttini
- Miriana D'Alessandro
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- Murphy Lee
- Murray Wham
- N Ahmad
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- N Michalak-Glinska
- N Motherwell
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- Nichol Alistair
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- Openshaw Peter J M
- P Alexander
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- Pairo-Castineira Erola
- Pamela Raggi
- Paola Magro
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- Patrick Sulem
- Patrizia Zucchi
- Paul Finernan
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- Pietro Pinoli
- Ponting Chris P
- Porteous David J
- R Astin-Chamberlain
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- R Howle
- R Jacob
- R Jha
- R Johnson
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- Riinu Pius
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- Roberta Russo
- Ross Hendry
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- S MacFadyen
- S Manna
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- S Masuko
- S McIvor
- S McKechnie
- S Melling
- S Mellor
- S Mepham
- S Metherell
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- S Mohamed Ally
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- S Sousa Arias
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- S Srikaran
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- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
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- Serena Ludovisi
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- Seán Keating
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- Shih Barbara
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- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
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- T McHugh
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- T O Jones
- T Pogreban
- T Rees
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- T Smith
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- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
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- Victoria Shaw
- Vitart Veronique
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- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
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- Y Thirlwall
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- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
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- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
The gap between policy and practice: a systematic review of patient-centred care interventions in chronic heart failure
- Author
- A Kitson
- A Liberati
- B Jani
- B Riegel
- B. A. Daveson
- B. McAdam
- BJ Wakefield
- C Delaney
- C Hudon
- C Ramsenthaler
- C Rathert
- C. Ellis-Smith
- C. Howley
- C. Raleigh
- C. Tracey
- CA Charles
- Committee on Quality of Health Care in America Institute of Medicine
- D Fitzsimons
- DE Forman
- E Uphoff
- EH Bradley
- ER Schwarz
- F. E. M. Murtagh
- G. O’Gara
- GC Fonarow
- GC Stewart
- HM Krumholz
- I Ekman
- I Ekman
- I. J. Higginson
- JE Epping-Jordan
- JH Hibbard
- JJV McMurray
- JN Dionne-Odom
- Julian P T Higgins
- JW Blom
- K Dudas
- K Dunderdale
- K Taylor
- K. Ryan
- KE Joyce
- KJ Boyd
- KT Kirchhoff
- L Olsson
- LA Allen
- LA Allen
- LA McCormack
- LS Evangelista
- LS Evangelista
- LS Evangelista
- M Brannstrom
- M Metra
- M Mirzaei
- M Rodgers
- M Shively
- M Stewart
- M Stewart
- M Stewart
- MC Farquhar
- MJ Shively
- MN Walsh
- MR Cowie
- N Mead
- N Mead
- N. G. Mahon
- P. M. Kane
- R Say
- R. McQuillan
- S Gastone
- S Michie
- S Schellinger
- S Stewart
- SH Downs
- SM Campbell
- SS McMillan
- T Jaarsma
- TR Fried
- TS Alharbi
- TSJ Alharbi
- Y Ismail
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Patient-centred care (PCC) is recommended in policy documents for chronic heart failure (CHF) service provision, yet it lacks an agreed definition. A systematic review was conducted to identify PCC interventions in CHF and to describe the PCC domains and outcomes. Medline, Embase, CINAHL, PsycINFO, ASSIA, the Cochrane database, clinicaltrials.gov, key journals and citations were searched for original studies on patients with CHF staged II–IV using the New York Heart Association (NYHA) classification. Included interventions actively supported patients to play informed, active roles in decision-making about their goals of care. Search terms included ‘patient-centred care’, ‘quality of life’ and ‘shared decision making’. Of 13,944 screened citations, 15 articles regarding 10 studies were included involving 2540 CHF patients. Three studies were randomised controlled trials, and seven were non-randomised studies. PCC interventions focused on collaborative goal setting between patients and healthcare professionals regarding immediate clinical choices and future care. Core domains included healthcare professional-patient collaboration, identification of patient preferences, patient-identified goals and patient motivation. While the strength of evidence is poor, PCC has been shown to reduce symptom burden, improve health-related quality of life, reduce readmission rates and enhance patient engagement for patients with CHF. There is a small but growing body of evidence, which demonstrates the benefits of a PCC approach to care for CHF patients. Research is needed to identify the key components of effective PCC interventions before being able to deliver on policy recommendations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10741-015-9508-5) contains supplementary material, which is available to authorized users
Understanding the conservation patterns and molecular phylogenetics of human death receptors family through computational biology
- Author
- A Algeciras-Schimnich
- A Ashkenazi
- A Marchler-Bauer
- A Nikolaev
- A Thorburn
- AM Chinnaiyan
- B Huang
- BS Hostager
- C Branden
- C Chakraborty
- C Chakraborty
- C Chakraborty
- D Aldous
- DL Vaux
- DS Huang
- EW Sayers
- F Glaser
- F Sandra
- FK Chan
- G Pan
- H Ashkenazy
- H Hsu
- H Hsu
- H Sandvik
- HB Shu
- HM Berman
- HZ Imtiyaz
- I Carpentier
- I Mayrose
- J Kitson
- JG Ryan
- JH Choi
- JT Bridgham
- K Schulze-Osthoff
- LJ Jensen
- LR Thomas
- M Los
- ME Munroe
- MO Hengartner
- MP Boldin
- N Harper
- N Itoh
- N Tanaka
- P Schneider
- PH Krammer
- PM Chaudhary
- R Chenna
- RC Edgar
- RG Latta
- RM Siegel
- S Cory
- S Kumar
- S Pype
- SF Altschul
- SG Hymowitz
- SW Fesik
- T Bouwmeester
- T Miyazaki
- TJ Sayers
- X Wang
- YS Jung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
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- Ã…svold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Aeroelastic Modeling and Simulation of High-Speed Flexible Vehicles
- Publication venue
- 'American Institute of Aeronautics and Astronautics (AIAA)'
- Publication date
- 01/01/2016
- Field of study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140579/1/6.2016-1324.pd
Modeling and Simulation of Flexible Jet Transport Aircraft with High-Aspect-Ratio Wings
- Publication venue
- 'American Institute of Aeronautics and Astronautics (AIAA)'
- Publication date
- 01/01/2016
- Field of study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140603/1/6.2016-2046.pd