On the optimum representation of a signal with a limited spectrum truncated by the Kotelnikov series

Optimum representation of signal with limited spectrum truncated by Kotelnikov serie

Animal models of cerebral ischemia

Cerebral ischemia remains one of the most frequent causes of death and disability worldwide. Animal models are necessary to understand complex molecular mechanisms of brain damage as well as for the development of new therapies for stroke. This review considers a certain range of animal models of cerebral ischemia, including several types of focal and global ischemia. Since animal models vary in specificity for the human disease which they reproduce, the complexity of surgery, infarct size, reliability of reproduction for statistical analysis, and adequate models need to be chosen according to the aim of a study. The reproduction of a particular animal model needs to be evaluated using appropriate tools, including the behavioral assessment of injury and non-invasive and post-mortem control of brain damage. These problems also have been summarized in the review

Высокомощный лазер на кристалле Yb3+:YAlO3, работающий в режиме синхронизации мод на основе полупроводниковых зеркал с насыщающимся поглотителем

Yttrium aluminium perovskite YAlO3 (YAP) crystal, doped with rare-earth ions, has been extensively studied as a diode-pumped laser host material. The wide interest to rare-earth ions doped YAP crystals is explained by its good thermal and mechanical properties, high natural birefringence, widely used Czochralski growth method. The aim of this work was to study the Yb3+:YAlO3 crystal as an active medium for high power mode-locked laser. Yb3+-doped perovskite-like aluminate crystals have unique spectroscopic and thermooptical properties that allowed using these crystals as an active medium of high power continuous wave (CW) and modelocked (ML) bulk lasers with diode pumping. In our work spectroscopic properties of Yb:YAP crystal and laser characteristics in CW and ML regimes are investigated. Maximum output power of 4 W with optical-to-optical efficiency of 16.3 % and 140 fs pulse duration have been obtained for Yb:YAP E //c-polarization with 10 % output coupler transmittance. Tunability range as wide as 67 nm confirms high promise of using Yb:YAP crystal for lasers working in wide spectral range

Регенеративный усилитель чирпированных импульсов на кристалле Yb3+:LuAlO3 с усилением отдельных спектральных компонент для применений в терагерцовой области спектра

Compact diode-pumped chirped pulse regenerative amplifier systems with pulse repetition rate of hundreds kilohertz based on Yb3+-doped crystals are of practical importance for wide range of applications such as materials processing, medicine, scientific research, etc. The aim of this work was to study the Yb3+:LuAlO3 crystal based dual wavelength chirped pulse regenerative amplifier. Perovskite-like aluminate crystals have unique spectroscopic properties that allowed to use amplifier active element gain spectrum as an amplitude filter for amplified pulse spectrum and even obtained dual wavelength amplification without any additional components. In our work a simple way to obtain dual-wavelength operation of chirped pulse regenerative amplifier by using the active medium gain spectrum as an amplitude filter for the formation of the amplified pulses spectrum demonstrated for the first time to our knowledge. Maximum output power of 5.4 W of chirped pulses (3.8 W after compression) and optical-to-optical efficiency of 22.5 % have been obtained for Yb:LuAP E//b-polarization at 200 kHz repetition rate. Compressed amplified pulse duration was about 708 fs while separate spectral components durations were 643 fs and 536 fs at 1018.3 nm and 1041.1 nm central wavelengths, respectively. Performed investigations show high potential of Yb3+:LuAP crystals as active elements of compact diode pumped chirped pulse regenerative amplifiers

Macromolecular proton fraction as a myelin biomarker: principles, validation, and applications

Macromolecular proton fraction (MPF) is a quantitative MRI parameter describing the magnetization transfer (MT) effect and defined as a relative amount of protons bound to biological macromolecules with restricted molecular motion, which participate in magnetic cross-relaxation with water protons. MPF attracted significant interest during past decade as a biomarker of myelin. The purpose of this mini review is to provide a brief but comprehensive summary of MPF mapping methods, histological validation studies, and MPF applications in neuroscience. Technically, MPF maps can be obtained using a variety of quantitative MT methods. Some of them enable clinically reasonable scan time and resolution. Recent studies demonstrated the feasibility of MPF mapping using standard clinical MRI pulse sequences, thus substantially enhancing the method availability. A number of studies in animal models demonstrated strong correlations between MPF and histological markers of myelin with a minor influence of potential confounders. Histological studies validated the capability of MPF to monitor both demyelination and re-myelination. Clinical applications of MPF have been mainly focused on multiple sclerosis where this method provided new insights into both white and gray matter pathology. Besides, several studies used MPF to investigate myelin role in other neurological and psychiatric conditions. Another promising area of MPF applications is the brain development studies. MPF demonstrated the capabilities to quantitatively characterize the earliest stage of myelination during prenatal brain maturation and protracted myelin development in adolescence. In summary, MPF mapping provides a technically mature and comprehensively validated myelin imaging technology for various preclinical and clinical neuroscience applications