A roadmap towards a circular and sustainable bioeconomy through waste valorization

Municipal solid waste and food supply chain waste are globally generated in large quantities from various sectors including various stages of food supply chains, municipalities, open markets and catering services. A prevailing priority in the EU is to stimulate the transition towards a circular economy that fosters the promotion of sustainable and resource-efficient policies for long-term socio-economic and environmental benefits. Common practices for waste management include landfill disposal, anaerobic digestion, composting and wastewater treatment. Recently, new technologies have been introduced to produce value-added products from agricultural residues and food processing side streams. Integrated and holistic approaches for organic waste utilization as industrial feedstocks will boost the transition towards the bio-economy era. The establishment of circular economy would expand and diversify the market outlets of bio-based products. This review provides an overview of the current methods on waste and by-product streams bioconversion to develop biorefinery concepts

Novel Application of Cyclolipopeptide Amphisin: Feasibility Study as Additive to Remediate Polycyclic Aromatic Hydrocarbon (PAH) Contaminated Sediments

To decontaminate dredged harbor sediments by bioremediation or electromigration processes, adding biosurfactants could enhance the bioavailability or mobility of contaminants in an aqueous phase. Pure amphisin from Pseudomonas fluorescens DSS73 displays increased effectiveness in releasing polycyclic aromatic hydrocarbons (PAHs) strongly adsorbed to sediments when compared to a synthetic anionic surfactant. Amphisin production by the bacteria in the natural environment was also considered. DSS73’s growth is weakened by three model PAHs above saturation, but amphisin is still produced. Estuarine water feeding the dredged material disposal site of a Norman harbor (France) allows both P. fluorescens DSS73 growth and amphisin production

Efficacy of mobilization with movement (MWM) for shoulder conditions: a systematic review and meta-analysis

Objective: To assess the effects of mobilization with movement (MWM) on pain, range of motion (ROM), and disability in the management of shoulder musculoskeletal disorders. Methods: Six databases and Scopus, were searched for randomized control trials. The ROB 2.0 tool was used to determine risk-of-bias and GRADE used for quality of evidence. Meta-analyses were performed for the sub-category of frozen shoulder and shoulder pain with movement dysfunction to evaluate the effect of MWM in isolation or in addition to exercise therapy and/or electrotherapy when compared with other conservative interventions.Results: Out of 25 studies, 21 were included in eight separate meta-analyses for pain, ROM, and disability in the two sub-categories. For frozen shoulder, the addition of MWM significantly improved pain (SMD −1.23, 95% CI −1.96, −0.51)), flexion ROM (MD −11.73, 95% CI −17.83, −5.64), abduction ROM (mean difference −13.14, 95% CI −19.42, −6.87), and disability (SMD −1.50, 95% CI (−2.30, −0.7). For shoulder pain with movement dysfunction, the addition of MWM significantly improved pain (SMD −1.07, 95% CI −1.87, −0.26), flexion ROM (mean difference −18.48, 95% CI- 32.43, −4.54), abduction ROM (MD −32.46, 95% CI – 69.76, 4.84), and disability (SMD −0.88, 95% CI −2.18, 0.43). The majority of studies were found to have a high risk of bias. Discussion: MWM is associated with improved pain, mobility, and function in patients with a range of shoulder musculoskeletal disorders and the effects clinically meaningful. However, these findings need to be interpreted with caution due to the high levels of heterogeneity and risk of bias. Level of Evidence: Treatment, level 1a

INVESTIGATION OF MECHANICAL PROPERTY OF VARIOUS MIX DESIGN IN CONCRETE BY REPLACING FINE SAND WITH FOUNDRY SAND

Nowadays, concrete become most widely used material in construction. The demand of concrete increases day by day. Other way, Foundry sand is the byproduct of Ferrous and Non-Ferrous metal casting foundries where the river sand is used many times for the core and mould production with the binders. After a time these sand become unusual for the core production n called waste foundry sand. In this research paper, replacement of fine sand of concrete is done with the foundry sand, so the disposal problem related with the foundries have to be reduce so minor environmental issues create and the cost of concrete also reduced so with the increase in the strength of concrete by using foundry sand in it. Mix design of M30 and M25 were adopted for the replacement of fine sand. The fine sand has been replaced by foundry sand accordingly at replacement of 10%, 20% & 30% by weight for M-30 and M-25 Grade concrete. Concrete mixtures were produced, tested and compared in terms of different strength and different grade with the conventional concrete. Testing of these samples were carried out to calculate the Compressive strength for 7, 14 and 28 days. As a result, the compressive increased up to 20% addition of used foundry sand in M-30 grade and for M-25 the strength increment noticed at 1% replacement. This research work is anxious with experimental investigation on strength of concrete and optimum percentage of the partial replacement of foundry sand by replacing fine aggregate via 10%, 20%, and 30% with M30 and M-25 Grade. Keeping all this view, the aim of investigation is the behavior of concrete while adding of waste foundry sand with various proportions of various mix in concrete by replacing fine sand using tests on various strength

Development and Validation of Analytical Method for Simultaneous Estimation of Formoterol Fumarate Dihydrate and Fluticasone Propionate from Bulk and Dry Powder Inhaler Formulation

A method was developed and validated for analysis of Formoterol Fumarate and Fluticasone Propionate in dry powder inhaler formulations. Separation was achieved on a HiQ Sil C18HS, 250×4.6mm, 5µm column using a mobile phase consisting of Acetonitrile: 0.01 M Ammonium Dihydrogen Phosphate solution (80:20 %v/v) at a flow rate of 1ml/min PDA detection at 215.0 nm. This method is validated according to ICH guidelines, which include linearity, precision, accuracy, specificity, robustness. The result obtained were within the acceptance criteria as per ICH guidelines

The Rise and Fall of Hydroxychloroquine (HCQ) in COVID Era: A Therapeutic Journey and Synthetic Progress

With no proven therapy against COVID-19, the repurposing of existing drugs is an ongoing exercise. In this context, an antimalarial drug, hydroxychloroquine (HCQ) received immediate stardom when the US-FDA issued an Emergency Use Authorization (EUA) for HCQ against COVID-19 based on the limited clinical study. However, on 17 June 2020, WHO announced the stoppage of the HCQ trial for COVID-19 treatment based on data received from the Solidarity trial and UK\u27s Recovery trials indicating HCQ does not result in the reduction of mortality of hospitalized COVID-19 patients when compared with standard of care. In this context, the present review aims to provide a developmental journey of HCQ including medicinal chemistry highlighting the essential pharmacology and the current studies exploring its effectiveness against COVID-19, and its synthetic advancement

Assay Method Development and Validation for Simultaneous Estimation of Mometasone Furoate and Azelastine HCL for Nasal Spray by RP-HPLC

A simple, precise, accurate, method was developed and validated for analysis of Mometasone Furoate and Azelastine Hydrochloride in nasal spray formulations. For development, different chromatographic condition and stress conditions like acid, base, peroxide, thermal and humidity as per ICH guidelines were used. Method was developed on reversed-phase C18 column using a mobile phase consisting of potassium dihydrogen, phosphate buffer and acetonitrile. Other HPLC parameters were flow rare 1 ml/min, detection wavelength 239 nm, injection volume 20 µl and column temperature 30°C. The developed method was further validated with respect to linearity, precision, accuracy, specificity and robustness. The results obtained were within the acceptance criteria as per ICH guidelines