A Comparative Study Of The Kayon In The Shadow Puppet Theatre Of Java, Bali And Kelantan: A Visual And Interpretive Understanding Of Its Symbols

The kayon of Java, known also as kakayonan in Bali, and referred to as the pohon beringin in Kelantan, is an ornate tree-or leaf-shaped puppet with which all shadow puppet theatre performances across these locations are formally opened and closed. A tree-shaped figure, with equivalent functions, does not appear in the shadow puppet theatre outside Indonesia and Malaysia. However, it appears in a disguised fashion in the Thai nang talung version of the shadow puppet theatre (the sage carries in his hand an object that resembles the kayon)

A 3D <i>in vitro</i> model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury.

Aim: This study aimed to develop a 3D culture model to test the extent to which transplanted stem cells modulate astrocyte reactivity, where exacerbated glial cell activation could be detrimental to CNS repair success. Materials & methods: The reactivity of rat astrocytes to bone marrow mesenchymal stem cells, neural crest stem cells (NCSCs) and differentiated adipose-derived stem cells was assessed after 5 days. Schwann cells were used as a positive control. Results: NCSCs and differentiated Schwann cell-like adipose-derived stem cells did not increase astrocyte reactivity. Highly reactive responses to bone marrow mesenchymal stem cells and Schwann cells were equivalent. Conclusion: This approach can screen therapeutic cells prior to in vivo testing, allowing cells likely to trigger a substantial astrocyte response to be identified at an early stage. NCSCs and differentiated Schwann cell-like adipose-derived stem cells may be useful in treating CNS damage without increasing astrogliosis

Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve.

Adipose-derived stem cells were isolated from rats and differentiated to a Schwann cell-like phenotype in vitro. The differentiated cells (dADSCs) underwent self-alignment in a tethered type-1 collagen gel, followed by stabilisation to generate engineered neural tissue (EngNT-dADSC). The pro-regenerative phenotype of dADSCs was enhanced by this process, and the columns of aligned dADSCs in the aligned collagen matrix supported and guided neurite extension in vitro. EngNT-dADSC sheets were rolled to form peripheral nerve repair constructs that were implanted within NeuraWrap conduits to bridge a 15 mm gap in rat sciatic nerve. After 8 weeks regeneration was assessed using immunofluorescence imaging and transmission electron microscopy and compared to empty conduit and nerve graft controls. The proportion of axons detected in the distal stump was 3.5 fold greater in constructs containing EngNT-dADSC than empty tube controls. Our novel combination of technologies that can organise autologous therapeutic cells within an artificial tissue construct provides a promising new cellular biomaterial for peripheral nerve repair

Increased Dust Deposition in New Zealand Related to Twentieth Century Australian Land Use

Mineral aerosols (dust) generated in the dryland regions of Australia have the potential to reach New Zealand through atmospheric transport. Although a large portion of dust in New Zealand originates in Australia, little is known about how dust deposition has varied over time in New Zealand or what may have caused this variation. We used geochemical dust proxies to examine the recent history of dust deposition to two alpine lakes in Kahurangi National Park, South Island, New Zealand. Geochemical indicators suggest that dust deposition began to increase around 1900, with the greatest deposition rates occurring from ~1920 to ~1990. In subsequent decades, dust deposition rates to New Zealand lakes appear to have declined. This rise and fall of dust deposition recorded in New Zealand lakes is consistent with dust records from the Antarctic Ice Sheet, Eastern Australia, and incidents of low visibility due to dust events recorded at Australian climate stations. The dust deposition rate over time also follows the temporal pattern of land use in south and central Australia over the time scale of the twentieth century suggesting a causal linkage. It is possible, and perhaps likely, that drought cycles also affected both emissions and transport pathways but over shorter time periods this was difficult to discern at the temporal resolution of these lake sediment cores. The increase in dust deposition to the high‐elevation regions of New Zealand likely has implications for the biogeochemistry of alpine lakes in the Tasman Mountains

Vlasov-Fokker-Planck simulations of fast-electron transport with hydrodynamic plasma response

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