59 research outputs found
CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Recommended from our members
High molecular weight amyloid β1-42 oligomers induce neurotoxicity via plasma membrane damage.
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 01/08/2019
- Field of study
Amyloid β-protein (Aβ) molecules tend to aggregate and subsequently form low MW (LMW) oligomers, high MW (HMW) aggregates such as protofibrils, and ultimately fibrils. These Aβ species can generally form amyloid plaques implicated in the neurodegeneration of Alzheimer disease (AD), but therapies designed to reduce plaque load have not demonstrated clinical efficacy. Recent evidence implicates amyloid oligomers in AD neuropathology, but the precise mechanisms are uncertain. We examined the mechanisms of neuronal dysfunction from HMW-Aβ1-42 exposure by measuring membrane integrity, reactive oxygen species (ROS) generation, membrane lipid peroxidation, membrane fluidity, intracellular calcium regulation, passive membrane electrophysiological properties, and long-term potentiation (LTP). HMW-Aβ1-42 disturbed membrane integrity by inducing ROS generation and lipid peroxidation, resulting in decreased membrane fluidity, intracellular calcium dysregulation, depolarization, and impaired LTP. The damaging effects of HMW-Aβ1-42 were significantly greater than those of LMW-Aβ1-42. Therapeutic reduction of HMW-Aβ1-42 may prevent AD progression by ameliorating direct neuronal membrane damage.-Yasumoto, T., Takamura, Y., Tsuji, M., Watanabe-Nakayama, T., Imamura, K., Inoue, H., Nakamura, S., Inoue, T., Kimura, A., Yano, S., Nishijo, H., Kiuchi, Y., Teplow, D. B., Ono, K. High molecular weight amyloid β1-42 oligomers induce neurotoxicity via plasma membrane damage
Thrombophilia in East Asian countries: are there any genetic differences in these countries?
- Author
- B Dahlback
- Consortium TGP
- DG MacArthur
- F Banno
- Fumiaki Banno
- H Fujimura
- HJ Kim
- K Maruyama
- Keiko Maruyama
- L Tang
- L Tang
- L Tang
- M Ikejiri
- M Mitsuguro
- MA Rodger
- Q Ding
- R Kimura
- R Kimura
- R Neki
- R Neki
- Reiko Neki
- RM Bertina
- S Kinoshita
- T Hayashi
- T Kita
- T Miyata
- T Miyata
- T Miyata
- T Shigekiyo
- T Tsuda
- T Yamazaki
- T Yin
- Toshiyuki Miyata
- W Liu
- W Tsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
DOCK2 is involved in the host genetics and biology of severe COVID-19
- Author
- Abe Ryuzo
- Abe Shinji
- Adachi Tomohiro
- Adachi Yuichi
- Ai Masumi
- Amishima Masaru
- Amiya Saori
- Anan Ryusuke
- Ando Akira
- Anzai Tatsuhiko
- Aoki Ryousuke
- Arai Daisuke
- Arai Ryosuke
- Arai Sawako
- Arakawa Kenichi
- Arimura Ken
- Asai Satoshi
- Asakura Takanori
- Asano Koichiro
- Awano Nobuyasu
- Azekawa Shuhei
- Azuma Masanori
- Baba Hiroaki
- Baba Rie
- Baba Tomoya
- Beppu Satoru
- Chiba Shigeru
- Chihara Yusuke
- Chubachi Shotaro
- Edahiro Ryuya
- Egi Moritoki
- Eguchi Hirotaka
- Endo Akifumi
- Endo Mayu
- Enomoto Takatoshi
- Eriguchi Yoshihiro
- Fuchimoto Yasuko
- Fujii Kazuhiko
- Fujimoto Nobukazu
- Fujita Kazue
- Fujitani Shigeki
- Fujiwara Akiko
- Fuke Satoshi
- Fukui Takahiro
- Fukui Yasutaka
- Fukui Yoshinori
- Fukunaga Koichi
- Fukushima Munehisa
- Fukusumi Takahito
- Fukuta Tetsuya
- Fukuyama Satoru
- Funatsu Yohei
- Furukawa Yoichi
- Gon Yasuhiro
- Hagihara Masao
- Hagimoto Satoshi
- Hagiwara Eri
- Hagiwara Shigehiro
- Hamamoto Junko
- Hanada Satoko
- Hara Reina
- Harada Masahiro
- Harada Norihiro
- Harada Sonoko
- Harada Yuko
- Haruta Yuki
- Hase Isano
- Hasegawa Naoki
- Hasegawa Takanori
- Hasegawa Yoshinori
- Hashiguchi Mizuha
- Hashimoto Naozumi
- Hashimoto Satoru
- Hashino Takuya
- Hattori Takeshi
- Hayashi Hiroyuki
- Hayashi Kentaro
- Hayashi Reina
- Hayashi Shinichi
- Hida Naoya
- Higashiyama Masahiko
- Hiki Makoto
- Hirai Yoshihiro
- Hiramatsu Yuji
- Hirano Toshiyuki
- Hiranuma Hisato
- Hirata Haruhiko
- Hirouchi Takatomo
- Hizawa Nobuyuki
- Honda Takayuki
- Horinouchi Hirohisa
- Hoshino Kota
- Hosoda Chiaki
- Hyugaji Takayoshi
- Ichikado Kazuya
- Ichimura Naoya
- Igarashi Akira
- Ihara Shoichi
- Ikemura Shinnosuke
- Imai Takao
- Imamura Tomonori
- Imoto Seiya
- Inohara Hidenori
- Inomata Minoru
- Inoue Sumito
- Inoue Takashi
- Inoue Takuya
- Inoue Yoshiaki
- Ishiguro Takashi
- Ishihara Rino
- Ishihara Sayoko
- Ishihara Shoichiro
- Ishii Makoto
- Ishii Tomoo
- Ishikawa Motonao
- Ishikura Hiroyasu
- Ishioka Kota
- Isogai Susumu
- Isono Taisuke
- Ito Akihiro
- Ito Fumimaro
- Ito Kazuto
- Ito Satoshi
- Ito Yoko
- Iwagoe Hajime
- Iwamura Hiromu
- Izumi Namiki
- Izumo Takehiro
- Kabata Hiroki
- Kagaya Takashi
- Kagyo Junko
- Kai Hirayasu
- Kamata Hirofumi
- Kamatani Yoichiro
- Kamimaki Isamu
- Kamiya Akane
- Kan-o Keiko
- Kanai Masahiro
- Kanai Masayuki
- Kanai Takanori
- Kanaoka Kensuke
- Kanayama Syuji
- Kanda Hidenori
- Kanehiro Arihiko
- Kaneko Yutaro
- Kaneyama Yasunari
- Kasamatsu Yu
- Kashiwada Takeru
- Katayama Kazuhiko
- Katayama Kotoe
- Kato Kazuto
- Kato Yasuhiro
- Kawabata Shuhei
- Kawada Miki
- Kawamura Kodai
- Kawamura Yusuke
- Kawana Akihiko
- Kawana Masatoshi
- Kawashima Hidetoshi
- Kijima Noriyuki
- Kikuchi Ryota
- Kimizuka Yoshifumi
- Kimura Akinori
- Kimura Nozomu
- Kimura Tomoki
- Kimura Tomoyuki
- Kimura Yasuhiro
- Kishi Hiroto
- Kishikawa Toshihiro
- Kishima Haruhiko
- Kita Toshiyuki
- Kitagawa Yuichiro
- Kitagawa Yuko
- Kitamura Hideya
- Kobayashi Keigo
- Kobayashi Yoichi
- Kodaka Norio
- Kodama Nobuhiro
- Koh Hidefumi
- Kohashi Sumiko
- Koike Ryuji
- Koji Sakamoto
- Kojima Mitsuaki
- Kokuto Hiroyuki
- Komase Yuko
- Komuta Kiyoshi
- Konishi Shunichiro
- Kono Yuta
- Koretsune Yukihiro
- Koshida Kiyoshi
- Kozu Yutaka
- Kuge Tomoki
- Kumanogoh Atsushi
- Kuraki Takashige
- Kuramochi Mizuki
- Kurihara Yuko
- Kusaka Yu
- Kuse Naoyuki
- Kuwahara Naota
- Lee Ho
- Liu Yu-Chen
- Maeda Shunsuke
- Maeda Yuichi
- Maeno Toshitaka
- Makino Shohei
- Makino Yasushi
- Manabe Tadashi
- Maruyama Junichi
- Maruyama Shuhei
- Masaki Katsunori
- Mashimo Shuko
- Masuda Makoto
- Masumoto Akihide
- Masuzawa Keita
- Matsubara Yuta
- Matsuda Fumihiko
- Matsuda Koichi
- Matsui Yuma
- Matsumoto Kinnosuke
- Matsumoto Koichiro
- Matsumoto Shuichiro
- Matsumoto Takemasa
- Matsunaga Tomohiro
- Matsuo Hirotaka
- Matsuse Hiroto
- Matsushita Yasushi
- Mikami Yohei
- Minami Shiro
- Minemura Hiroyuki
- Mitamura Keiko
- Miyagawa Kazuya
- Miyake Takahito
- Miyano Satoru
- Miyawaki Masayoshi
- Miyawaki Satoru
- Miyazaki Masatoshi
- Miyazaki Yasunari
- Miyazaki Yoshimune
- Miyazawa Naoki
- Mochimaru Takao
- Mori Nobuaki
- Morikawa Daiki
- Morisaki Hiroshi
- Morisaki Takayuki
- Morita Atsuho
- Morita Takayoshi
- Motegi Mitsuru
- Motooka Daisuke
- Murakami Koji
- Murakami Teruaki
- Murakami Yoshinori
- Muranaka Hiroyuki
- Murayama Shigeo
- Murohashi Kota
- Muto Kaori
- Mutoh Yoshikazu
- Nagai Akiko
- Nagai Hideaki
- Nagao Genta
- Nagasaka Tomoki
- Nagasaki Tadao
- Nagasaki Yoji
- Nagata Kaoru
- Nagayama Satoshi
- Naito Tatsuhiko
- Naito Toshio
- Naito Yoko
- Nakachi Ichiro
- Nakada Taka-Aki
- Nakajima Jun
- Nakajima Yukiko
- Nakamori Yasushi
- Nakamura Ai
- Nakamura Kazunori
- Nakamura Morio
- Nakamura Yoshihiko
- Nakano Chihiro
- Nakano Yasushi
- Nakatsumi Hiroki
- Nakayama Akiyoshi
- Nakayama Sohei
- Namba Shinichi
- Namkoong Ho
- Nanki Kosaku
- Nannya Yasuhito
- Narita Atsuya
- Narumoto Osamu
- Nii Takuro
- Niitsu Takayuki
- Nikaido Takefumi
- Nishi Koichi
- Nishida Takashi
- Nishihara Hiroshi
- Nishikawa Masanori
- Nishimura Tomoyasu
- Nishio Kazumi
- Nishitsuji Masaru
- Nishiyama Kei
- Nishiyama Kenta
- Niwa Kazuki
- Noda Yoshimi
- Noguchi Yoichiro
- Nukaga Shigenari
- Obara Wataru
- Obata Daisuke
- Ochi Junichi
- Odani Toshio
- Odate Mitsuru
- Ogata Hideo
- Ogata Tomouki
- Ogawa Aki
- Ogawa Seishi
- Ogawa Shinichi
- Oguma Tsuyoshi
- Ogura Shinji
- Ogura Takashi
- Ogura Takayuki
- Ohba Takehiko
- Ohira Yoshiyuki
- Ohta Kazuhide
- Ohta Ken
- Ohta Shin
- Okabayashi Hiroko
- Okada Takenori
- Okada Yukinori
- Okamori Satoshi
- Okamoto Masaki
- Okudela Koji
- Okuzaki Daisuke
- Omae Yosuke
- Omote Norihito
- Ono Akihiro
- Ono Hiroshi
- Ono Yoshinao
- Onoi Keisuke
- Ooshima Nobuharu
- Osawa Takeshi
- Oshima Taku
- Oshio Takeshi
- Ota Sho
- Oyama Baku
- Oyamada Yoshitaka
- Ozaki Shinji
- Sado Reiko
- Sado Toshikatsu
- Sagara Hironori
- Sageshima Hisako
- Saiki Ryunosuke
- Saito Fukuki
- Saito Fumitake
- Saito Hiroshi
- Saito Ryuichi
- Saito Yoshinobu
- Sakagami Satoru
- Sakakibara Shuhei
- Sakurai Toshihiro
- Sano Hirohito
- Sano Tomoya
- Sasa Noah
- Sasaki Junichi
- Sasaki Kana
- Sasano Hajime
- Sasano Hitoshi
- Sassa Chihiro Tani
- Sato Masamichi
- Sato Ryuichi
- Sato Tomonori
- Sato Toshiro
- Sato Yoko
- Sato Yuki
- Satomi Ryosuke
- Seike Masahiro
- Sekikawa Yoshiyuki
- Shibata Shun
- Shibata Yoko
- Shibusawa Takayuki
- Shichinohe Yasuo
- Shimada Hisato
- Shimada Tadanaga
- Shimizu Eigo
- Shimizu Tetsuo
- Shimo Masatoshi
- Shimoda Masafumi
- Shinoki Masato
- Shinozuka Jun
- Shinozuka Keisuke
- Shiomi Tetsuya
- Shirai Yuya
- Shiroyama Takayuki
- Shoko Tomohisa
- Sinozaki Nobuaki
- Sonehara Kyuto
- Sonobe Kazunari
- Suematsu Ryohei
- Sueyoshi Atsushi
- Sugihara Fuminori
- Sugimoto Hideyasu
- Sugiura Hisatoshi
- Suzuki Junya
- Suzuki Ken
- Suzuki Motoyuki
- Suzuki Shoji
- Suzuki Takao
- Suzuki Yusuke
- Tachikawa Natsuo
- Tada Ai
- Tagaya Etsuko
- Takada Minoru
- Takagaki Masatoshi
- Takagi Haruhi
- Takahashi Hidenori
- Takahashi Hiroshi
- Takahashi Kazuhisa
- Takahashi Kenichiro
- Takahashi Kunihiko
- Takahashi Mai
- Takahashi Meiko
- Takahashi Saeko
- Takahashi Takeshi
- Takahashi Yasuo
- Takaku Yotaro
- Takano Kenji
- Takano Tomomi
- Takaoka Hatsuyo
- Takata Tohru
- Takayanagi Noboru
- Takeda Yoshito
- Takei Reoto
- Takemoto Norihiko
- Takeuchi Mayumi
- Taki Reiko
- Takita Mumon
- Takoi Hiroyuki
- Takuwa Ayako
- Tanaka Akihiko
- Tanaka Hiromu
- Tanaka Toru
- Tanaka Yoshiaki
- Tani Mayuko
- Tanino Yoshinori
- Tateishi Tomoya
- Tateno Hiroki
- Terai Hideki
- Terashima Mariko
- Togashi Yuki
- Tohda Shuji
- Tokunaga Katsushi
- Tokunaga Yoshihisa
- Tominaga Yoshiteru
- Tomono Kazunori
- Tone Mari
- Tsuburai Takahiro
- Tsuchida Tomoya
- Uchida Sho
- Uchida Tomoyuki
- Uchimura Yuji
- Ueda Ken
- Ueda Soichiro
- Ueda Suguru
- Ueda Tetsuya
- Ueno Takafumi
- Ueno Yuya
- Umeda Akira
- Uno Shunsuke
- Utsugi Mitsuyoshi
- Uwamino Yoshifumi
- Wada Daiki
- Wada Sae
- Wakabayashi Aya
- Wakahara Keiko
- Wang Qingbo S.
- Watanabe Chie
- Watanabe Hiroki
- Watanabe Hiroko
- Watanabe Kazuyoshi
- Watanabe Masafumi
- Wing James B.
- Yagi Kazuma
- Yamada Mitsuhiro
- Yamada Shuhei
- Yamada Yuichiro
- Yamagata Kunihiro
- Yamaguchi Hiroki
- Yamaguchi Yuta
- Yamaji Ken
- Yamamoto Kenichi
- Yamamoto Makoto
- Yamamoto Masaomi
- Yamamoto Yuji
- Yamanashi Yuji
- Yamano Yasuhiko
- Yamasaki Masaki
- Yamashita Tatsuya
- Yanagita Emmy
- Yasui Yoshinori
- Yatomi Masakiyo
- Yokote Koutaro
- Yoneda Midori
- Yonekawa Akiko
- Yoshida Eriko
- Yoshida Kosuke
- Yoshida Shozo
- Yoshida Shuichi
- Yoshida Toru
- Yoshifuji Ayumi
- Yoshihara Tomoyuki
- Yoshimori Kozo
- Yoshimura Yukihiro
- Yoshiya Kazuhisa
- Yoshiyama Takashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
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- Guérin Claude
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- Zhao Jun
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- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
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- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
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- Antonarakis Stylianos E.
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- Courtney Laura P.
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- Cox Anthony
- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
- Craig Matthew
- Crane Tom
- Crawford Amanda L.
- Crawley Matt
- Cree Andrew
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- Crew Victor
- Critchlow Terrance
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- Culley Karl
- Cummings Auli
- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
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- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
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- Davidson Stuart
- Davies Jonathon
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- Davis Cheryl
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- Dawson Elisabeth
- De Anda Claudia
- De Latorre Andrea
- Deadman Rebecca
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- Dear Simon
- Dearden Frances
- DeArellano Kurt
- Deaven Larry I.
- Deaven Larry L.
- Deere Kerry
- DeGray Stewart
- Degusta David
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- Devlin Laurie
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- Doddington Daniel
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- Doggett Norman
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- Dong Hui
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- Donlin Jeremy E.
- Dooley Kathy
- Dooling David
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- Earthrowl Mark
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- Emelianenko Natalia
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- Endrizzi Matthew
- Engh Ger van den
- Engle David
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- Evans Gareth
- Evans John
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- Eveleth Gerald
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- Footman Simon
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- Fujiyama Asao
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- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
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- Garnes Jeffrey A.
- Garnett Jane
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- Geng Jianing
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- Goodstadt Leo
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- Gordon Catherine
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- Griffith Jeffrey K.
- Griffiths Coline
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- Hamilton Matt
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- Hancock Julie
- Harbes Brandy A.
- Harding Adam
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- Hawkins Natalie
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- Hillier LaDeana
- Hillyard Guy
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- Hinkins Russell
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- Hitchens Matthew Edward
- Ho Issac
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- Hodgson David
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- Idlebird Devincent G.
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- Imbro Paula
- Imo Kelvin C.
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- Ishizaki Hinako
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
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- Ludeman Thom
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- McMurray Kimberly
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- Meidi Patrick
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- Mercado Iracema C.
- Mercer Simon
- Merritt Christina E.
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- Metzker Michael Lee
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- Mu Feng
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- Mungall Andy
- Munidasa Mala
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- Murayama Yuji
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- Nagaraja R.
- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
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- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Association between blood glucose variability and coronary plaque instability in patients with acute coronary syndromes
- Author
- A Ceriello
- AC St-Pierre
- B-J Choi
- DECODE Study Group
- DJ Yang
- Eiichi Akiyama
- ES Kang
- G Sartore
- GS Mintz
- I Teraguchi
- IM Stratton
- K Piotrowski
- K Sano
- K Torimoto
- Kazuo Kimura
- Keiko Takano
- Kengo Tsukahara
- Kenichiro Saka
- Kiyoshi Hibi
- KK Griendling
- KK Griendling
- Kozo Okada
- L Monnier
- L Monnier
- M Asakura
- M Burgmaier
- M Hanefeld
- M Kawasaki
- M Kuroda
- Masami Kosuge
- Masaomi Gohbara
- Mitsuaki Endo
- MR Rizzo
- N Nakayama
- Nobuhiko Maejima
- Noriaki Iwahashi
- Peter J. Fitzgerald
- PG Steg
- R Salvayre
- RM Bergenstal
- S Inaba
- S Kojima
- Satoshi Umemura
- Shunsuke Kataoka
- T Amano
- T Hirano
- T Mitsuhashi
- T Nakamura
- T Sano
- Toshiaki Ebina
- TS Tylee
- V Fuster
- Y Fukushima
- Y Miyamoto
- Yasuhiro Honda
- Yasushi Matsuzawa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome
- Author
- Ackerman Kate G
- Babbitt Christopher J.
- Bembea Melania M
- Bhoojhawon Guru
- Bowens Cindy
- Bradford Tamara T
- Carcillo Joseph
- Carroll Christopher L.
- Carroll Ryan W
- Cengiz Pelin
- Chen Sabrina R
- Cholette Jill M
- Clouser Katharine N.
- Coates Bria M
- Crandall Hillary
- Cullimore Melissa L
- Cvijanovich Natalie Z.
- Dapul Heda
- Doymaz Sule
- Feldstein Leora R.
- Fernandes Neil D
- Fink Ericka
- Fitzgerald Julie C.
- Flori Heidi R.
- Gaspers Mary G
- Gertz Shira J.
- Gillen Jennifer K
- Giuliano John S.
- Graciano Ana Lia
- Halasa Natasha B.
- Hall Mark W.
- Harvey Helen
- Harwayne-Gidansky Ilana
- Havlin Kevin M
- Heidemann Sabrina M
- Hobbs Charlotte V.
- Horwitz Steven M
- Hume Janet R.
- Hymes Saul R
- Irby Katherine
- Keenaghan Michael A.
- Kimura Dai
- Kleinman Lawrence C.
- Koncicki Monica L
- Kong Michele
- Kucukak Suden
- Lansell Amanda N
- LaRovere Kerri L.
- Levy Emily R.
- Li Simon
- Lipton Susan V
- Loftis Laura L.
- Maamari Mia
- Mack Elizabeth H.
- Maddux Aline B.
- Marohn Kimberly L
- McCulloh Russell J
- McGuire John K.
- McLaughlin Gwenn E.
- Michelson Kelly N.
- Montgomery Vicki L
- Mourani Peter M
- Munoz Alvaro Coronado
- Newburger Jane W
- Newhams Margaret M.
- Nofziger Ryan A.
- Overby Philip J
- Overcoming COVID-19 Investigators
- Patel Manish M.
- Poussaint Tina Y.
- Randolph Adrienne G.
- Ratner Adam J
- Riggs Becky J.
- Rowan Courtney M.
- Sanders Ronald C
- Schuster Jennifer E.
- Schwartz Stephanie P
- Schwarz Adam J
- Shein Steven L.
- Singh Aalok R.
- Smith Lincoln S
- Soma Vijaya L
- Son Mary Beth F.
- Spinella Philip C.
- Staat Mary A.
- Sullivan Janice E
- Tarquinio Keiko M.
- Tenforde Mark W.
- Thomas Neal J.
- Typpo Katri V
- Walker Tracie C.
- Walsh Rowan F
- Wellnitz Kari
- Yager Phoebe H
- Young Cameron C.
- Zackai Sheemon P
- Zinter Matt S
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/03/2021
- Field of study
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Importance Coronavirus disease 2019 (COVID-19) affects the nervous system in adult patients. The spectrum of neurologic involvement in children and adolescents is unclear.
Objective To understand the range and severity of neurologic involvement among children and adolescents associated with COVID-19.
Setting, Design, and Participants Case series of patients (age <21 years) hospitalized between March 15, 2020, and December 15, 2020, with positive severe acute respiratory syndrome coronavirus 2 test result (reverse transcriptase-polymerase chain reaction and/or antibody) at 61 US hospitals in the Overcoming COVID-19 public health registry, including 616 (36%) meeting criteria for multisystem inflammatory syndrome in children. Patients with neurologic involvement had acute neurologic signs, symptoms, or diseases on presentation or during hospitalization. Life-threatening involvement was adjudicated by experts based on clinical and/or neuroradiologic features.
Exposures Severe acute respiratory syndrome coronavirus 2.
Main Outcomes and Measures Type and severity of neurologic involvement, laboratory and imaging data, and outcomes (death or survival with new neurologic deficits) at hospital discharge.
Results Of 1695 patients (909 [54%] male; median [interquartile range] age, 9.1 [2.4-15.3] years), 365 (22%) from 52 sites had documented neurologic involvement. Patients with neurologic involvement were more likely to have underlying neurologic disorders (81 of 365 [22%]) compared with those without (113 of 1330 [8%]), but a similar number were previously healthy (195 [53%] vs 723 [54%]) and met criteria for multisystem inflammatory syndrome in children (126 [35%] vs 490 [37%]). Among those with neurologic involvement, 322 (88%) had transient symptoms and survived, and 43 (12%) developed life-threatening conditions clinically adjudicated to be associated with COVID-19, including severe encephalopathy (n = 15; 5 with splenial lesions), stroke (n = 12), central nervous system infection/demyelination (n = 8), Guillain-Barré syndrome/variants (n = 4), and acute fulminant cerebral edema (n = 4). Compared with those without life-threatening conditions (n = 322), those with life-threatening neurologic conditions had higher neutrophil-to-lymphocyte ratios (median, 12.2 vs 4.4) and higher reported frequency of D-dimer greater than 3 μg/mL fibrinogen equivalent units (21 [49%] vs 72 [22%]). Of 43 patients who developed COVID-19–related life-threatening neurologic involvement, 17 survivors (40%) had new neurologic deficits at hospital discharge, and 11 patients (26%) died.
Conclusions and Relevance In this study, many children and adolescents hospitalized for COVID-19 or multisystem inflammatory syndrome in children had neurologic involvement, mostly transient symptoms. A range of life-threatening and fatal neurologic conditions associated with COVID-19 infrequently occurred. Effects on long-term neurodevelopmental outcomes are unknown
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
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- Yoo Jooheon
- Yoshioka T.
- Yu Hang
- Yu Haocun
- Yuzurihara H.
- Zadrożny A.
- Zahoor Jan Aasim
- Zanolin M.
- Zeidler Simon
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- Zendri J. -P.
- Zevin Michael
- Zhan M.
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- Zhang Rui
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- Zhao G.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barber J.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Bell Angus
- Benedetto V.
- Beniwal D.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
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- LEE SUNGHO.
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- LIETO ALBERTO. DI.
- LIGO Collaboration
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- MASCIOLI ADRIANO. FRATTALE.
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- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
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