Origins of anomalous electronic structures of epitaxial graphene on silicon carbide

On the basis of first-principles calculations, we report that a novel interfacial atomic structure occurs between graphene and the surface of silicon carbide, destroying the Dirac point of graphene and opening a substantial energy gap there. In the calculated atomic structures, a quasi-periodic $6\times 6$ domain pattern emerges out of a larger commensurate $6\sqrt{3}\times6\sqrt{3}R30^\circ$ periodic interfacial reconstruction, resolving a long standing experimental controversy on the periodicity of the interfacial superstructures. Our theoretical energy spectrum shows a gap and midgap states at the Dirac point of graphene, which are in excellent agreement with the recently-observed anomalous angle-resolved photoemission spectra. Beyond solving unexplained issues of epitaxial graphene, our atomistic study may provide a way to engineer the energy gaps of graphene on substrates.Comment: Additional references added; published version; 4 pages, 4 figure

Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin

Influenza viruses continuously undergo antigenic changes with gradual accumulation of mutations in hemagglutinin (HA) that is a major determinant in subtype specificity. The identification of conserved epitopes within specific HA subtypes gives an important clue for developing new vaccines and diagnostics. We produced and characterized nine monoclonal antibodies that showed significant neutralizing activities against H1 subtype influenza viruses, and determined the complex structure of HA derived from a 2009 pandemic virus A/Korea/01/2009 (KR01) and the Fab fragment from H1-specific monoclonal antibody GC0587. The overall structure of the complex was essentially identical to the previously determined KR01 HA-Fab0757 complex structure. Both Fab0587 and Fab0757 recognize readily accessible head regions of HA, revealing broadly shared and conserved antigenic determinants among H1 subtypes. The beta-strands constituted by Ser110-Glu115 and Lys169-Lys170 form H1 epitopes with distinct conformations from those of H1 and H3 HA sites. In particular, Glu112, Glu115, Lys169, and Lys171 that are highly conserved among H1 subtype HAs have close contacts with HCDR3 and LCDR3. The differences between Fab0587 and Fab0757 complexes reside mainly in HCDR3 and LCDR3, providing distinct antigenic determinants specific for 1918 pdm influenza strain. Our results demonstrate a potential key neutralizing epitope important for H1 subtype specificity in influenza virus

The Influence of Atlantic Sea Surface Temperature Anomalies on the North Atlantic Oscillation

The influence of Atlantic sea surface temperature (SST) anomalies on the atmospheric circulation over the North Atlantic sector during winter is investigated by performing experiments with an atmospheric general circulation model. These consist of a 30-yr run with observed SST anomalies for the period 1961–90 confined geographically to the Atlantic Ocean, and of a control run with climatological SSTs prescribed globally. A third 30-yr integration with observed SSTs confined to the South Atlantic is made to confirm present findings. The simulated interannual variance of 500-hPa wintertime geopotential heights over the North Atlantic attains much more realistic values when observed Atlantic SSTs are prescribed. Circulation patterns that resemble the positive phase of the North Atlantic oscillation (NAO) become more pronounced in terms of the leading EOF of winter means, and a cluster analysis of daily fields. The variance of an interannual NAO index increases by fivefold over its control value. Atlantic SST variability is also found to produce an appreciable rectified response in the December–February time mean. Interannual fluctuations in the simulated NAO are found to be significantly correlated with SST anomalies over the tropical and subtropical South Atlantic. These SST anomalies are accompanied by displacements in the simulated summer monsoonal circulation over South America and the cross-equatorial regional Hadley circulation

Site-specific immobilization of microbes using carbon nanotubes and dielectrophoretic force for microfluidic applications

We developed a microbial immobilization method for successful applications in microfluidic devices. Single-walled nanotubes and Escherichia coli were aligned between two cantilever electrodes by a positive dielectrophoretic force resulting in a film of single-walled nanotubes with attached Escherichia coli. Because this film has a suspended and porous structure, it has a larger reaction area and higher reactant transfer efficiency than film attached to the substrate surface. The cell density of film was easily controlled by varying the cell concentration of the suspension and varying the electric field. The film showed excellent stability of enzyme activity, as demonstrated by measuring continuous reaction and long-term storage times using recombinant Escherichia coli that expressed organophosphorus hydrolase.X1133sciescopu

Observation of Scarred Modes in Asymmetrically Deformed Microcylinder Lasers

We report observation of lasing in the scarred modes in an asymmetrically deformed microcavity made of liquid jet. The observed scarred modes correspond to morphology-dependent resonance of radial mode order 3 with their Q values in the range of 10^6. Emission directionality is also observed, corresponding to a hexagonal unstable periodic orbit.Comment: 4 pages, 6 figure

Effect of Moisture on Engineering Properties of Soil Slopes from Melange in Sandakan Sabah, Malaysia

A total of five soil samples were collected from mélange weathered material in order to analysis the effect of moisture on engineering properties of the soils. The soil samples were collected along the main road in Sandakan, Sabah. The result of analysis shows that the soil moisture content was in the range of 15.26% to 22.10%. The average liquid limit of soil samples was from 45.1% to 59.8%, while the plasticity indexes were in the range of 23.25% to 33.91%. The plasticity chart plot of soil found that S1 and S5 were classified as low plasticity soil, while S2, S3 and S4 soil were classified as high plasticity. The result shows that the optimum moisture contents ranged from 13.0% to 28.9%, while the maximum dry density is within a range from 1.43Mg/m3 to 1.82Mg/m3. The unconfined compression strength indicated that S3 is classified as very soft soil, S1 and S4 soft soil, S2 moderate soft soil and s5 strong soil. Additional of moisture above optimum content in to the soil resulted in lower strength for all soil samples, whereas higher strength value range were observed when the moisture content is reduced below the optimum content. As conclusion, additional moisture contents influenced the engineering properties of soil samples due to its high adsorption of water in clayey soil as identified from the XRD and SEM analysis

Factors Associated with Mutations: Their Matching Rates to Cardiovascular and Neurological Diseases

Monogenic hypertension is rare and caused by genetic mutations, but whether factors associated with mutations are disease-specific remains uncertain. Given two factors associated with high mutation rates, we tested how many previously known genes match with (i) proximity to telomeres or (ii) high adenine and thymine content in cardiovascular diseases (CVDs) related to vascular stiffening. We extracted genomic information using a genome data viewer. In human chromosomes, 64 of 79 genetic loci involving \u3e25 rare mutations and single nucleotide polymorphisms satisfied (i) or (ii), resulting in an 81% matching rate. However, this high matching rate was no longer observed as we checked the two factors in genes associated with essential hypertension (EH), thoracic aortic aneurysm (TAA), and congenital heart disease (CHD), resulting in matching rates of 53%, 70%, and 75%, respectively. A matching of telomere proximity or high adenine and thymine content projects the list of loci involving rare mutations of monogenic hypertension better than those of other CVDs, likely due to adoption of rigorous criteria for true-positive signals. Our data suggest that the factor–disease matching rate is an accurate tool that can explain deleterious mutations of monogenic hypertension at a \u3e80% match—unlike the relatively lower matching rates found in human genes of EH, TAA, CHD, and familial Parkinson’s disease