Additional Shared Decoder on Siamese Multi-view Encoders for Learning Acoustic Word Embeddings

Acoustic word embeddings --- fixed-dimensional vector representations of arbitrary-length words --- have attracted increasing interest in query-by-example spoken term detection. Recently, on the fact that the orthography of text labels partly reflects the phonetic similarity between the words' pronunciation, a multi-view approach has been introduced that jointly learns acoustic and text embeddings. It showed that it is possible to learn discriminative embeddings by designing the objective which takes text labels as well as word segments. In this paper, we propose a network architecture that expands the multi-view approach by combining the Siamese multi-view encoders with a shared decoder network to maximize the effect of the relationship between acoustic and text embeddings in embedding space. Discriminatively trained with multi-view triplet loss and decoding loss, our proposed approach achieves better performance on acoustic word discrimination task with the WSJ dataset, resulting in 11.1% relative improvement in average precision. We also present experimental results on cross-view word discrimination and word level speech recognition tasks.Comment: Accepted at 2019 IEEE Automatic Speech Recognition and Understanding Workshop (ASRU 2019

Voluntary wheel running augments aortic L-arginine transport and endothelial function in rats with chronic kidney disease

Reduced nitric oxide (NO) synthesis contributes to risk for cardiovascular disease in chronic kidney disease (CKD). Vascular uptake of the NO precursor L-arginine (ARG) is attenuated in rodents with CKD, resulting in reduced substrate availability for NO synthesis and impaired vascular function. We tested the effect of 4 wk of voluntary wheel running (RUN) and/or ARG supplementation on endothelium-dependent relaxation (EDR) in rats with CKD. Twelve-week-old male Sprague-Dawley rats underwent 5/6 ablation infarction surgery to induce CKD, or SHAM surgery as a control. Beginning 4 wk following surgery, CKD animals either remained sedentary (SED) or received one of the following interventions: supplemental ARG, RUN, or combined RUN + ARG. Animals were euthanized 8 wk after surgery, and EDR was assessed. EDR was significantly impaired in SED vs. SHAM animals after 8 wk, in response to ACh (10(-9)-10(-5) M) as indicated by a reduced area under the curve (AUC; 44.56 +/- 9.01 vs 100 +/- 4.58, P \u3c 0.05) and reduced maximal response (E-max; 59.9 +/- 9.67 vs. 94.31 +/- 1.27%, P \u3c 0.05). AUC was not improved by ARG treatment but was significantly improved above SED animals in both RUN and RUN + ARG-treated animals. Maximal relaxation was elevated above SED in RUN + ARG animals only. L-[H-3] arginine uptake was impaired in both SED and ARG animals and was improved in RUN and RUN + ARG animals. The results suggest that voluntary wheel running is an effective therapy to improve vascular function in CKD and may be more beneficial when combined with L-arginine

Impact of a delirium prevention project among older hospitalized patients who underwent orthopedic surgery: a retrospective cohort study

Background Postoperative delirium (POD) is a common clinical syndrome with significant negative outcomes. Thus, we aimed to evaluate the feasibility and effectiveness of a delirium screening tool and multidisciplinary delirium prevention project. Methods A retrospective cohort study was conducted at a single teaching center in Korea. A cohort of patients who underwent a delirium prevention program using a simple delirium screening tool from December 2018 to February 2019 (intervention group, N = 275) was compared with the cohort from the year before implementation of the delirium prevention program (December 2017 to February 2018) (control group, N = 274). Patients aged ≥65 years who were admitted to orthopedic wards and underwent surgery were included. The incidence rates of delirium before and after implementation of the delirium prevention program, effectiveness of the delirium screening tool, change in the knowledge score of nurses, and length of hospital stay were assessed. Results The sensitivity and specificity of the screening tool for the incidence of POD were 94.1 and 72.7%, respectively. The incidence rates of POD were 10.2% (control group) and 6.2% (intervention group). The odds ratio for the risk reduction effect of the project related to the incidence of POD was 0.316 (95% confidence interval: 0.125–0.800, p = 0.015) after adjustment for possible confounders. The delirium knowledge test score increased from 40.52 to 43.24 out of 49 total points (p < 0.001). The median length of hospital stay in the intervention and control groups was 6.0 (interquartile range, 4–9) and 7.0 (interquartile range, 4–10) days, respectively (p = 0.062). Conclusion The screening tool successfully identified patients at a high risk of POD at admission. The POD prevention project was feasible to implement, effective in preventing delirium, and improved knowledge regarding delirium among the medical staff. Trial registration None.This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors

Efficient mutation screening for cervical cancers from circulating tumor DNA in blood

Background Early diagnosis and continuous monitoring are necessary for an efficient management of cervical cancers (CC). Liquid biopsy, such as detecting circulating tumor DNA (ctDNA) from blood, is a simple, non-invasive method for testing and monitoring cancer markers. However, tumor-specific alterations in ctDNA have not been extensively investigated or compared to other circulating biomarkers in the diagnosis and monitoring of the CC. Therfore, Next-generation sequencing (NGS) analysis with blood samples can be a new approach for highly accurate diagnosis and monitoring of the CC. Method Using a bioinformatics approach, we designed a panel of 24 genes associated with CC to detect and characterize patterns of somatic single-nucleotide variations, indels, and copy number variations. Our NGS CC panel covers most of the genes in The Cancer Genome Atlas (TCGA) as well as additional cancer driver and tumor suppressor genes. We profiled the variants in ctDNA from 24 CC patients who were being treated with systemic chemotherapy and local radiotherapy at the Jeonbuk National University Hospital, Korea. Result Eighteen out of 24 genes in our NGS CC panel had mutations across the 24 CC patients, including somatic alterations of mutated genes (ZFHX3-83%,KMT2C-79%, KMT2D-79%, NSD1-67%,ATM-38% andRNF213-27%). We demonstrated that theRNF213mutation could be used potentially used as a monitoring marker for response to chemo- and radiotherapy. Conclusion We developed our NGS CC panel and demostrated that our NGS panel can be useful for the diagnosis and monitoring of the CC, since the panel detected the common somatic variations in CC patients and we observed how these genetic variations change according to the treatment pattern of the patient

New Iconography in Court-Sponsored Buddhist Prints of the Early Joseon Dynasty&mdash;Focusing on Record of the Manifestation of Avalokitesvara

Many recent studies show that during the early Joseon dynasty, even kings who externally appeared strongly anti-Buddhist defended or condoned royal relatives who sponsored Buddhist works. Extant sutras produced under court sponsorship attest to this fact. An analysis of the production of court Buddhist prints, focusing on the King Sejo era when a particularly large number of Buddhist projects were completed, yields diverse information such as changes in the style of Buddhist prints and their causes, as well as the intentions of the sponsors. This article examines the creation of new iconography and other aspects of Buddhist prints sponsored by the royal family during the early Joseon period, focusing on the print in the Record of the Manifestation of Avalokitesvara, published during the reign of King Sejo. This new iconography was created at a time that, according to the intentions of the sponsor, clearly attests that the independent creation of iconography did occur in Joseon Buddhist prints, which were mostly considered to be reproductions made by copying the woodblocks of existing prints. Moreover, the projection of the ruler onto Buddhist images as a way to strengthen power shows that Joseon shared perceptions with other countries that sought to use Buddhism as a means of rule

Korean Single-Sheet Buddhist Woodblock Illustrated Prints Produced for Protection and Worship

This paper examines the characteristics and production background of major examples of single-sheet Buddhist woodblock illustrated prints. In the form a single sheet of paper, the original first prints were not easily handed down, and in most cases the date and place of production are not clearly known. These factors made systematic research difficult, but the release of various related materials has recently enabled comprehensive study of the subject. As materials substantiating Buddhism&rsquo;s religious role in society and the propagation activities of temples, single-sheet Buddhist prints hold great value. Research showed that two major types of single-sheet Buddhist prints were made: dharani-type prints used as talismans and prints used for worship or spiritual practice. The former type was likely made for self-protection or Buddhist enshrinement in statues for their protection and to seek blessings for this meritorious deed or to protect the dharma. The latter type was used as a visual aid in worship and chanting. They can be divided into prints featuring universally loved icons and prints featuring icons reflecting the trends of certain periods. They were analyzed in relation to popular beliefs and methods of spiritual practice in the Buddhist circle as well as trends in faith among the ordinary people