6 research outputs found
Task-Oriented Diffusion Model Compression
As recent advancements in large-scale Text-to-Image (T2I) diffusion models
have yielded remarkable high-quality image generation, diverse downstream
Image-to-Image (I2I) applications have emerged. Despite the impressive results
achieved by these I2I models, their practical utility is hampered by their
large model size and the computational burden of the iterative denoising
process. In this paper, we explore the compression potential of these I2I
models in a task-oriented manner and introduce a novel method for reducing both
model size and the number of timesteps. Through extensive experiments, we
observe key insights and use our empirical knowledge to develop practical
solutions that aim for near-optimal results with minimal exploration costs. We
validate the effectiveness of our method by applying it to InstructPix2Pix for
image editing and StableSR for image restoration. Our approach achieves
satisfactory output quality with 39.2% and 56.4% reduction in model footprint
and 81.4% and 68.7% decrease in latency to InstructPix2Pix and StableSR,
respectively
Anti-Inflammatory Effect of Cudrania tricuspidata Extract and Stewartia koreana Extract Mixture in a Collagen-Induced Arthritis Mouse Model
Cudrania tricuspidata extracts (CTE) and Stewartia koreana extracts (SKE) are viable drugs for managing inflammation. We investigated the nitric oxide levels of CTE and a mixture of CTE/SKE (CTE mix) against lipopolysaccharide-induced RAW264.7 cells. In addition, we administered the CTE and CTE mix to mice with collagen-induced arthritis to confirm an anti-inflammatory effect against rheumatoid arthritis. We analyzed arthritis symptoms by oral administration of CTE mix using a CIA-induced animal model and analyzed the inhibitory activity of NO production with in vitro experiments. Both the CTE and CTE mix decreased nitric oxide levels, and a 2:1 ratio of CTE mix was most effective in vivo among the varying ratios of CTE mix tested. The spleen size increased by about 2.1 times, and the lymph node size decreased by about 2.5 times relative compared to the vehicle group. In blood biochemical analyses, tumor necrosis factor–α levels decreased by about three times, interleukin-1β and interleukin-6 levels were reduced by about eight times and three times, and PRG4 expression levels were increased by about 2.5 times relative to the vehicle group. We suggest that the CTE mix was superior to CTE alone and has potential as an anti-inflammatory treatment for patients with rheumatoid arthritis