Global Carbon-and-Conservation Models, Global Eco-States? Ecuador’s Yasuní-ITT Initiative and Governance Implications

The “global carbon age” marks a structural change far beyond the economic realms of implementing carbon trade, affecting the fabric of global environmental governance and its actors. Carbon trade and conservation in the Global South have taken on various forms, and climate change mitigation efforts in light of continued rainforest deforestation are scrambling to establish effective approaches. Ecuador’s Yasuní-ITT Initiative proposes a new global carbon-and-conservation model in the Ecuadorian Amazon that leaves oil reserves of the Yasuní Ishpingo Tambococha Tiputini (ITT) oil fields underground, in exchange for international compensation payments that would be based on voluntary contributions of governments and nongovernmental actors in an international conservation partnership and trust fund under the auspices of the United Nations Development Programme. This model suggests far-reaching consequences, as it introduces new global scales for the sharing and management of environmental costs within a framework of neoliberal cost internalization. The analysis in this paper uses the concept of the “ecological state” (Duit, 2008) as a theoretical point of departure to examine the trans-scalar implications of such a carbon-and-conservation model on global governance structures toward a “global ecological state” (or global eco-state)

The technical mitigation potential of demand-side measures in the agri-food sector: a preliminary assessment of available measures

A number of studies have suggested that addressing greenhouse gas (GHG) emissions from agricultural production, or ‘supply-side emissions’, will be insufficient to reduce agri-food sector GHG emissions to limit the increase of global temperatures to well below 2o C. Recent studies have also suggested that ‘demandside measures’ related to food consumption, food value chains, and food loss and waste, will be necessary to reduce emissions and may have a larger technical mitigation potential than supply-side measures. This report assesses the availability of demand-side policies and measures, and looks at evidence of these measures’ impacts on behavior that directly results in emissions from the agri-food sector. Often discussed demand-side measures include ‘soft’ measures (e.g. health promotion initiatives, product labeling) and ‘hard’ measures (e.g. consumption taxes or subsidies). We review here the effectiveness of these measures for dietary change and reductions in food loss and waste, with a focus on developing countries, where agrifood emissions are projected to grow most rapidly and where the gaps in knowledge are largest. This report is linked to CCAFS Info Note "Shifting food consumption to mitigate climate change is critical to fulfilling the Paris Agreement, but how?" https://cgspace.cgiar.org/bitstream/handle/10568/77145/Info%20note%20Demand%20side%20mitigation%20Aug%2022%202016.pd

Shifting food consumption to mitigate climate change is critical to fulfilling the Paris Agreement, but how?

Reducing emissions by changing consumption of foods with large greenhouse gas emissions could have a major impact on climate change. Yet past efforts to change diets through public policy have had mixed results, suggesting that recent estimates of technical mitigation potential likely exceed feasible reductions in emissions. Shifting consumption away from livestock products is a major opportunity for reducing emissions driven by consumption demand. In some contexts, this could also provide health, food security and other environmental benefits. Packages of policy mechanisms and interventions involving health, nutrition, efficiency and sustainability in supply chains will be more effective in achieving dietary change than any one measure. Focusing on reducing food loss and waste in high potential areas and involving key value chain actors can increase returns on efforts to mitigate climate change and improve food security. Private sector investment in reducing food loss and waste requires an enabling environment, support for development of commercially viable investments, and increased awareness among financial institutions of investment opportunities. This Info Note is related to the report on "The technical mitigation potential of demand-side measures in the agri-food sector: a preliminary assessment of available measures" https://cgspace.cgiar.org/bitstream/handle/10568/77142/CCAFS%20Report%2015%20for%20web.pd

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

Global Carbon-and-Conservation Models, Global Eco-States? Ecuador’s Yasuní-ITT Initiative and Governance Implications

The “global carbon age” marks a structural change far beyond the economic realms of implementing carbon trade, affecting the fabric of global environmental governance and its actors. Carbon trade and conservation in the Global South have taken on various forms, and climate change mitigation efforts in light of continued rainforest deforestation are scrambling to establish effective approaches. Ecuador’s Yasuní-ITT Initiative proposes a new global carbon-and-conservation model in the Ecuadorian Amazon that leaves oil reserves of the Yasuní Ishpingo Tambococha Tiputini (ITT) oil fields underground, in exchange for international compensation payments that would be based on voluntary contributions of governments and nongovernmental actors in an international conservation partnership and trust fund under the auspices of the United Nations Development Programme. This model suggests far-reaching consequences, as it introduces new global scales for the sharing and management of environmental costs within a framework of neoliberal cost internalization. The analysis in this paper uses the concept of the “ecological state” (Duit, 2008) as a theoretical point of departure to examine the trans-scalar implications of such a carbon-and-conservation model on global governance structures toward a “global ecological state” (or global eco-state)