Primary Sequences of Protein-Like Copolymers: Levy Flight Type Long Range Correlations

We consider the statistical properties of primary sequences of two-letter HP copolymers (H for hydrophobic and P for polar) designed to have water soluble globular conformations with H monomers shielded from water inside the shell of P monomers. We show, both by computer simulations and by exact analytical calculation, that for large globules and flexible polymers such sequences exhibit long-range correlations which can be described by Levy-flight statistics.Comment: 4 pages, including 2 figures; several references added, some formulations improve

Jet-Induced Explosions of Core Collapse Supernovae

We numerically studied the explosion of a supernova caused by supersonic jets present in its center. The jets are assumed to be generated by a magneto-rotational mechanism when a stellar core collapses into a neutron star. We simulated the process of the jet propagation through the star, jet breakthrough, and the ejection of the supernova envelope by the lateral shocks generated during jet propagation. The end result of the interaction is a highly nonspherical supernova explosion with two high-velocity jets of material moving in polar directions, and a slower moving, oblate, highly distorted ejecta containing most of the supernova material. The jet-induced explosion is entirely due to the action of the jets on the surrounding star and does not depend on neutrino transport or re-acceleration of a stalled shock. The jet mechanism can explain the observed high polarization of Type Ib,c and Type II supernovae, pulsar kicks, very high velocity material observed in supernova remnants, indications that radioactive material was carried to the hydrogen-rich layers in SN1987A, and some others observations that are very difficult or impossible to explain by the neutrino energy deposition mechanism. The breakout of the jet from a compact, hydrogen- deficient core may account for the gamma-ray bursts and radio outburst associated with SN1998bw/GRB980425.Comment: 14 pages, LaTeX, aaspp4.sty, epsf.sty, submitted to ApJ Let

Ethical aspects of using software with artificial intelligence technology

Today, artificial intelligence (AI) technologies can offer solutions to many social problems, including those used to diagnose and treat diseases. However, for this it is necessary to provide an appropriate legal basis. The article presents a brief history of the development of AI, explains the conceptual apparatus, describes the legal basis for its development and implementation in Russian healthcare, the methodology for conducting clinical trials of AI systems, and gives their classification. Particular attention is paid to the ethical principles of clinical trials of AI systems. The ethical examination of projects of clinical trials of AI systems by the Ethics Committee is considered in detail

Ethical aspects of the Internet of Bodies

This article outlines bioethical issues related to the application of the Internet of Body (IoB) technology in health care so-called medical IoB devices. Manufacturers of medical IoB devices promise to provide significant health benefits, improved treatment outcomes and other benefits, but such IoB also carry serious risks to health and life, including the risks of hacking (cyberhacking), malfunctioning, receiving false positive measurements, breaching privacy, deliberate invasion of privacy. In addition, medical IoB products can directly cause physical harm to the human body. As human flesh is intertwined with hardware, software, and algorithms, the IoB will test our social values and ethics. In particular, IoB will challenge notions of human autonomy and self-government as they threaten to undermine the fundamental precondition of human autonomy. Thus, the protection of human autonomy should become the main ethical principle of the use of medical IoB devices

Methodical approaches to bioassay of substances containing unstable functional groups

This article describes the method development approaches for bioassay of substances containing unstable functional groups and forming unstable metabolites using the example of mycophenolic acid, methyldopa and mebeverine metabolite

Search for f1(1285)→π+π−π0f_1(1285) \to \pi^+\pi^-\pi^0 decay with VES detector

The isospin violating decay $f_1(1285)\to\pi^+\pi^-\pi^0$ has been studied at VES facility. This study is based at the statistics acquired in $\pi^- Be$ interactions at 27, 36.6 and 41 GeV/c in diffractive reaction $\pi^- N \to (f_1 \pi^-) N$. The $f_1(1285) \to \pi^+\pi^-\pi^0$ decay is observed. The ratio of decay probabilities $BR(f_1(1285) \to \pi^+\pi^-\pi^0)$ to $BR(f_1(1285) \to \eta \pi^+\pi^-) \cdot BR(\eta \to \gamma\gamma)$ is $\sim\:1.4$.Comment: 10 pages, 8 figures, presented at XII Conference on Hadron Spectroscop