8 research outputs found
Alternative therapy interaction with warfarin: what doctors should know
- Publication venue
- «SILICEA-POLIGRAF» LLC
- Publication date
- 01/06/2010
- Field of study
Warfarin effectiveness and safety is substantially affected by concurrent therapy. This paper reviews the main mechanisms of warfarin interactions with other agents, which underlie adverse effect development: platelet dysfunction, gastro-intestinal effects, suppressed intestinal synthesis of vitamin K, disturbed warfarin metabolism, or disrupted vitamin K cycle. The main medication groups, affecting warfarin effectiveness and safety, are presented. The effects of foods, supplements, and herbal medications on anticoagulant effect of warfarin are discussed
Model for calculating the risk of venous thrombosis
- Author
- Publication venue
- 'Silicea - Poligraf, LLC'
- Publication date
- 01/06/2019
- Field of study
Aim. To develop a model for calculating the risk of venous thrombosis, taking into account the presence of known risk factors, comorbidity and congenital thrombophilia.Material and methods. During the study (2015 to 2017), 79 patients with venous thrombosis were examined (36 men and 43 women, mean age â 56,76±15,570). The control group consisted of 83 patients and healthy volunteers without thrombosis at the moment and in history (35 men and 48 women, average age â 43,95±18,136). All individuals included in the study were analyzed for the presence of G1691A mutations in the factor V gene, G20210A in the prothrombin gene, C677T polymorphism in the 5,10-methylenetetrahydrofolate reductase gene, and polymorphism in the SERPINE1 gene of plasminogen activator inhibitor. Real-time polymerase chain reaction was used to identify mutations. To create a risk calculation model, a linear regression analysis was performed.Results. We have developed a model for calculating the risk of venous thrombosis. The resulting formula showed high prognostic accuracy (the area under the ROC curve is 95,9%). For patients who do not have data on the presence of these mutations, a short version of the risk calculation model was developed (the area under the ROC curve is 94,6%).Conclusion. We have developed a risk calculation model taking into account the presence of known risk factors, congenital thrombophilia and comorbidities. Thromboprophylaxis is necessary in >0,45 individual risk, which corresponds to a high risk of developing venous thrombosis. Patients who have not previously been diagnosed with thrombophilia and are in the middle risk group for venous thrombosis, according to a short version of the model, must be screened for congenital thrombophilia to clarify the risk
Edoxaban versus warfarin in patients with atrial fibrillation
- Author
- Abdullakutty J
- Abi-Mansour P
- Abril SB
- Accini J
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- Acikel M
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- Albert L. Waldo
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- Ćpinar J
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2013
- Field of study
Contains fulltext :
125374.pdf (publisher's version ) (Open Access)BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P<0.001 for noninferiority) and 1.61% with low-dose edoxaban (hazard ratio, 1.07; 97.5% CI, 0.87 to 1.31; P=0.005 for noninferiority). In the intention-to-treat analysis, there was a trend favoring high-dose edoxaban versus warfarin (hazard ratio, 0.87; 97.5% CI, 0.73 to 1.04; P=0.08) and an unfavorable trend with low-dose edoxaban versus warfarin (hazard ratio, 1.13; 97.5% CI, 0.96 to 1.34; P=0.10). The annualized rate of major bleeding was 3.43% with warfarin versus 2.75% with high-dose edoxaban (hazard ratio, 0.80; 95% CI, 0.71 to 0.91; P<0.001) and 1.61% with low-dose edoxaban (hazard ratio, 0.47; 95% CI, 0.41 to 0.55; P<0.001). The corresponding annualized rates of death from cardiovascular causes were 3.17% versus 2.74% (hazard ratio, 0.86; 95% CI, 0.77 to 0.97; P=0.01), and 2.71% (hazard ratio, 0.85; 95% CI, 0.76 to 0.96; P=0.008), and the corresponding rates of the key secondary end point (a composite of stroke, systemic embolism, or death from cardiovascular causes) were 4.43% versus 3.85% (hazard ratio, 0.87; 95% CI, 0.78 to 0.96; P=0.005), and 4.23% (hazard ratio, 0.95; 95% CI, 0.86 to 1.05; P=0.32). CONCLUSIONS: Both once-daily regimens of edoxaban were noninferior to warfarin with respect to the prevention of stroke or systemic embolism and were associated with significantly lower rates of bleeding and death from cardiovascular causes. (Funded by Daiichi Sankyo Pharma Development; ENGAGE AF-TIMI 48 ClinicalTrials.gov number, NCT00781391.)
Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains â„70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was 13.7 mg/dL or â€13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4â1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1â12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65â1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)âdefined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucoseâand risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring hospital admission. ODYSSEY OUTCOMES is registered with ClinicalTrials.gov, number NCT01663402. Findings: At study baseline, 5444 patients (28·8%) had diabetes, 8246 (43·6%) had prediabetes, and 5234 (27·7%) had normoglycaemia. There were no significant differences across glycaemic categories in median LDL cholesterol at baseline (2·20â2·28 mmol/L), after 4 months' treatment with alirocumab (0·80 mmol/L), or after 4 months' treatment with placebo (2·25â2·28 mmol/L). In the placebo group, the incidence of the primary endpoint over a median of 2·8 years was greater in patients with diabetes (16·4%) than in those with prediabetes (9·2%) or normoglycaemia (8·5%); hazard ratio (HR) for diabetes versus normoglycaemia 2·09 (95% CI 1·78â2·46, p<0·0001) and for diabetes versus prediabetes 1·90 (1·65â2·17, p<0·0001). Alirocumab resulted in similar relative reductions in the incidence of the primary endpoint in each glycaemic category, but a greater absolute reduction in the incidence of the primary endpoint in patients with diabetes (2·3%, 95% CI 0·4 to 4·2) than in those with prediabetes (1·2%, 0·0 to 2·4) or normoglycaemia (1·2%, â0·3 to 2·7; absolute risk reduction pinteraction=0·0019). Among patients without diabetes at baseline, 676 (10·1%) developed diabetes in the placebo group, compared with 648 (9·6%) in the alirocumab group; alirocumab did not increase the risk of new-onset diabetes (HR 1·00, 95% CI 0·89â1·11). HRs were 0·97 (95% CI 0·87â1·09) for patients with prediabetes and 1·30 (95% CI 0·93â1·81) for those with normoglycaemia (pinteraction=0·11). Interpretation: After a recent acute coronary syndrome, alirocumab treatment targeting an LDL cholesterol concentration of 0·65â1·30 mmol/L produced about twice the absolute reduction in cardiovascular events among patients with diabetes as in those without diabetes. Alirocumab treatment did not increase the risk of new-onset diabetes. Funding: Sanofi and Regeneron Pharmaceuticals
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- AndrĂĄssy PĂ©ter
- AngerÄs Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
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- Peroutka Zdenek
- Petrella Robert
- Petrov Ivan
- Petrov Ivo
- Petrov Ivo
- Petryka-Mazurkiewicz Joanna
- Pham Vinh
- Phillips Roland
- Piatti Piermarco
- Pichette Francis
- Pidlisna Viktoriya
- Piepiorka Marek
- Piesiewicz Wojciech
- PietilÀ Mikko
- Pilecki Piotr
- Pillai Perumal
- Pillay Soobramoney
- Pimentel Pedro
- Pincetti Christian
- Platt Bruce
- Plomp Jacobus
- Pluta Wladyslaw
- Podolec Piotr
- Popenda Grazyna
- Potthoff Sergio
- Pounds Kevin
- Pouzar Joe
- Prabhavathi
- Prado Aldo
- Prado Jose P
- Prager Rudolf
- Prasad Lakshman
- Prasada Sudhir
- Precoma Dalton
- Presser Dale
- Pressman Gregg
- Prieto Juan
- Prins Francisco
- Privalova Elena
- Prodafikas John
- Proietto Joseph
- Prokhorov Oleksandr
- Prokopczuk Janusz
- Puente Orlando
- Punt Zelda
- Puntus Ekaterina
- Purnell Peter
- Pursley Michael
- Pye Maurice
- PĂ©rez Ignacio P
- PĂŒski LĂĄszlĂł
- Quick Annette
- Quintana Ofsman
- Quintero Alvaro
- Quinteros Trinidad
- Racugno Paolo
- Raev Dimitar
- Raffo Carlos
- Ragonese Mauro
- Rahman Aref
- Raisinghani Ajit
- Rajan Raj
- Ramamurthee Kannaiyan
- Ramanathan Krishnan
- Ramos LĂłpez Gabriel A
- Randeva Harpal S.
- Range Gregoire
- Ranjith Naresh
- Rao Sunder
- Rasmussen Ole
- Rasputina Lesya
- Rassi Nelson
- Ray Kausik K
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- Reddy Jeevren
- Reddy M
- Refsgaard Jens
- Regalado Susana
- Reis Gilmar
- Repin Alexey
- Reshotko Dmytro
- Reszka Zygfryd
- Reuter Hannes
- Revtyak George
- Rewerska Barbara
- Reznik Elena
- Rha Seung W
- Richwine Randall
- RidderstrÄle Wilhelm
- RidderstrÄle Wilhelm
- Rieker Werner
- Rihacek Ivan
- Risberg Knut
- Rishko Mykola
- Rista Lucas
- Rodriguez Aldo
- Rodriguez Lilia
- Rodriguez Manuel
- Rodriguez Mara
- Rodriguez Victor
- Roguin Ariel
- Rohr Kathryn
- Roman Oscar
- Roman-Miranda Amaury
- Romanowski Leszek
- Romo AndrĂ©s Ă
- Ronner Eelko
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- Roseman Hal
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- Rozenman Yoseph
- Ruda Mikhail
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- Ruiz Jose
- Rummel Reinhard
- Runev Nikolai
- Rupka Dennis
- Rusev Nikolay
- Rusicka Teresa
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- Sabbah Eric
- Saini Satinder
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- Salinas Carlos A
- Samaan Rodney
- Sanchez Carlos G
- Sandoval Jorge
- Sansanayudh Nakarin
- Santos Queulla
- Santos Vladimir
- Saporito Wladmir
- Saraiva José
- Sasaki Kenichiro
- Sathe Prachee
- Sato Tomohiko
- Sauter Joachim
- Sawhney Jitendra S
- Saxena Manish
- Schenkenberger Isabelle
- Schernthaner Gerit-Holger
- Schiavi Beatriz
- Schmedtje John
- Schmidt Ekkehard
- Schnack Christoph
- Schock Joel
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- Sernia Virginia
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- Shammas Nicolas
- Shanes Jeffrey
- Sharma Susheel
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- Sharp Andrew
- Shealy Neal
- Sheu Huey-Herng
- Shibasaki Taro
- Shin Won-Yong
- Shukla Dinkar
- Shurmur Scott
- Shustov Sergey
- Shutemova Elena
- Shvarts Yuri
- Shyu Kou-Gi
- Sicer Maximiliano
- Siega Anthony D
- Silva Frederico
- Silver Marc
- Simon Tabassome
- Simon Tabassome
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- Simpson Patrick
- Singal Dinesh
- Singal Robert
- Singh Deovrat
- Singh Narendra
- Singh Pradeep
- Singh Sanjay
- Sinnaeve Peter
- Sinnaeve Peter R
- Siu Shing C
- Sivak Vladimir
- Sizova J M
- Skalicka Hana
- Skierkowska Joanna
- Skjelvan Gunnar
- Skura Marek
- Skwarna Bartosz
- Slaby Josef
- Sliwinska Teresa
- Smilov Lachezar
- Smith Ray
- Smith Simon
- Smith Stephen
- Smolenskaya Olga
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- Song Yang
- Song Zhifang
- Sonoda Masahiro
- Sookananchai Bancha
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- Sorokivskyy Mykhaylo
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- Spinale Francis
- Spinar Jindrich
- Spiridon Marilena
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- Stammen Francis
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- Stanciulescu Gabriela
- Stania Karol
- Staniloae Cezar
- Stanislavchuk Mykola
- Starczewski Pawel
- Stasinska Teresa
- Steg Philippe G
- Steg Philippe G
- Steg Philippe Gabriel
- Stolarczyk-Sowa Edyta
- Stone Jay
- Storey Robert
- Strand Jorma
- Strandberg Timo
- Strbova Jaroslava
- Striekwold Harry
- Strikwerda Sipke
- Strojek Krzysztof
- Stryuk Raisa
- Su Xi
- Such Slavomir
- Sudnik Wanda
- Sueyoshi Atsushi
- Sugino Hiroshi
- Sugiura Tatsushi
- Suh David
- Suneja Randeep
- Supryadkina Tatiana
- Suresh Damodhar
- Sussex Bruce
- Sutton Jennefer
- Suzuki Masahiro
- Svyshchenko Yevgeniya
- Swanson Neil
- Sychov Oleg
- Syed Faizullah
- Syed Mushtaq
- Sykulski Roman
- Szczasny Marcin
- Sztembis Rafal
- Szynal Slawomir
- SĂĄnchez Raul V
- SĂĄrszegi Zsolt
- SĂžrensen Torben
- Taggeselle Jens
- Taheri Hamid
- Tahk Seung-Jea
- Takagi Yuichiro
- Takase Shinichi
- Takenaka Takashi
- TakĂĄcs JĂĄnos
- Tan Edgar
- Tan Michinao
- Tanajura Luiz
- Tao Liang
- Tarasov Nikolay
- Taurio Jyrki
- Teefy Patrick
- Teliatnikova Zinaida
- Tenev Doncho
- Terrelonge Antonio
- Thadani Udho
- The Salem
- The Salem
- The Salem
- Theron Rust
- Thomas Dustin
- Tihchev Tihomir
- Timmermans Patrick
- Tisheva Snezhanka
- Tokmakova Maria
- Tomala Tadeusz
- Tomobuchi Yoshiaki
- Tonnessen Glen
- Torres Gustavo
- Toursarkissian Nicole
- Treasure Charles
- Trenk Dietmar
- Treshkur Tatiana
- Tresukosol Damras
- Tresukosol Damras
- Trevisan Roberto
- Trokis Julien
- Truong Binh
- Tsang Chiu C
- Tse Hung F
- Tseluyko Vira
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- Tsyba Larisa
- Turi Tibor
- Turner Traci
- Turturo Maurizio
- Ueda Osamu
- Uehara Hiroki
- Ueng Kwo-Chang
- Ueno Hideki
- Uguccioni Massimo
- Umpierrez Guillermo
- Urbach Dorothea
- Urban Miroslav
- Urbano Rafael H
- Urbinati Stefano
- Uretsky Barry
- Utsu Noriaki
- Uzunow Anna
- Vaca Carlos
- Vakaliuk Igor
- Valle Timo
- Vallejo Gregorio S
- van de Wal Ruud
- van den Heuvel Christian
- van der Zwaan Coen
- van Eck Martijn
- van Kesteren Henricus
- van Zyl Louis
- Varbella Ferdinando
- Varleta Paola
- Vasconcellos Eduardo
- Vasilyeva Larisa
- Vatova Ralitsa
- Vega Damaris
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- Viñas Jaime A
- Vlastaris Anthony
- von Engelhardt Charlotte
- von MĂŒnchhausen Candy
- Vora Kishor
- Voyce Steven
- Vrolix Mathias
- Vykoukalova Tatiana
- Wang Hao
- Wang Ji-Hung
- Wang Yi-Chih
- Weiderman Ann-Charlotte
- Weigmann Ingo
- Weirick Troy
- Weiss Melvin
- Welch Michelle
- Welter Ryan
- Werner Henri
- Westendorp Iris
- Whelan Alan
- WidimskĂœ Petr
- Wierucki Lukasz
- Wilderman Igor
- Wilke Andreas
- Willems Frank
- Willis John
- Wilson Vance
- Wilson William
- Wiseman Alan
- Witek Robert
- Wojcik Ronald
- Wojnowski Lukasz
- Wolzt Michael
- Wong Brian
- Wong Michelle
- Wongvipaporn Chaiyasith
- Woolf Kevin
- Worthley Matthew
- Wozakowska-Kaplon Beata
- Wu Chih-Cheng
- Wu Yen-Wen
- Wujkowski Marek
- Yagensky Andriy
- Yakushin Sergey
- Yalcin Ahmet
- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- ZĂłlyomi SzilĂĄrd
- Ădes IstvĂĄn
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11â154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8â3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74â0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78â1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75â1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48â2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36â3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74â1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75â0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
- Author
- Abbas Jalal
- Abbate Antonio
- Abdallah mouhamad
- Abdullakutty Jabir
- Abdullkutty Jabir
- Abhyanakar Atul D
- Aboyans Victor
- Abrantes José Antonio M
- Abu-Fadel Mazen
- Accini Mendoza Jose L
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Aggarwal Rahul
- Aggarwal Rajesh K
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A
- Aidar Ayoub José Carlos
- Airaksinen Juhani
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea YY
- Alan David
- Albert Seals
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M
- Alings Marco
- Alings Marco
- Alonso Martin Joaquin J
- Alonso Alvaro
- Alsweiler Caroline
- Alvarisqueta Andrés F
- Alves De Lima Alberto E
- Amarasekera Stanley
- Amarasena Naomali
- Amidon Thomas
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Anderson Jay
- Ando Kenji
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arambula Rafael Suarez
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroca Carlos Cotes
- Aroney Constantine
- Arstall Margaret A
- Asanin Milika R.
- Assi Nizar
- Aswegen Dina Van
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayaz Mohammad
- Aylward Philip E
- Aylward Philip E
- Aylward Philip E
- Aylward Philip E
- Azizad Masoud M
- BabiÄ Zdravko
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Ball Eric
- Bang Lia E
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L
- Barbato Emanuele
- Barna Olga M
- Barone-Rochette Gilles
- Barr Craig
- Barraud Pauline
- Barrera Silva Sandra I
- Barrucco Robert
- Bartels Gerard L
- Basart Dirk
- Bashir Riyaz
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Bejuit Raphael
- Bekkouche Mhamed
- Belhassane Abdelkader
- Beltran Pascale
- Benbernou Fadela
- Benedicto Amparo
- Bengrait Nafissa
- Bengston James
- Bengus Cristina M
- Benov Haralambi O
- Berdan Lisa
- Berger Rudolf
- Berglund Stefan
- Berk Martin
- Berland Jacques
- Berli Mario A
- Berlowitz Michael
- Berman Brett
- Bernan Alisa
- Berthou Christelle
- Berti Sergio
- Bezault Madeleine
- Bhagwat Ajit
- Bhagwat Ravi
- Bhansali Prasant
- Bhatt Deepak L.
- Bhatt Deepak L.
- Binde Ronald
- Birchem Jessica
- Bittner Vera A.
- Bittner Vera A.
- Blanquicett Marco
- Blicharski Tomasz
- Blok Thomas
- Blonder Ronald
- Blumberg Eduardo DS
- Boccara Franck
- Bodanese Luiz C
- Bojovski Stojko
- Bokarev Igor
- Bokern Marcel JJA
- Bonfanti Alberto J Cadena
- Bono Julio OE
- Bordonava Anselmo P
- Borger-Van Der Burg Alida
- Borse Rohidas
- Bortnick Anna
- Bos Robert J
- Botelho Ana
- Botelho Roberto V
- Bouancheau Cecile
- Bougon Nathalie
- Bourgeois Ronald
- Brabham David
- Braganza Denise
- Braun- Dullaeus RĂŒdiger
- Bravo Mannucci Jorge E
- Breedveld Robert W
- Brennan J. Matthew
- Brigui Imane
- Brocklehurst Maddy
- Brodison Adrian
- Bronzwaer Patrick NA
- Brueren Bart RG
- Brégeault Marie-France
- Budaj Andrzej
- Budaj Andrzej
- Bugan Viliam
- Busmane Arija
- Bustamante Labarta Miguel H
- Busz-Papiez Benita
- Butler Rob
- Butters Julie
- Bystryk Leszek
- Böcker Dirk
- BĂžttcher Morten
- Caccavo Alberto
- Caetano Francisca
- Caime Guillermo D
- CalabrĂČ Paolo
- Calderon Ticona Jorge R
- Calvillo Jorge Carrillo
- Camacho Cosavalente Luis A
- Cambier Patrick
- Campos Pedro Fajardo
- CamprubĂ Potau Mercedes
- Camsari Ahmet
- Car SiniĆĄa
- Caraco Yoseph
- Carey Charles
- Carlos Pablo
- Carlson Eric
- Carnero Gabriela S
- Carrion Chambilla Jesus M
- Carroll Patrick A
- Cartasegna Luis R
- Carter Luther
- Caruso Orlando C
- Cassimjee Soraya
- Castadot Marc
- Castillo Leon Reynaldo P
- Castillo Armando GarcĂa
- Cerqueira Maria José AG
- Cestari Horacio G
- Cevc Matija
- Cha James
- Chachalis Geargios
- Chae In-Ho
- Chaitman Bernard
- Chalavarya Gopal
- Chaleff Fred
- Chandna Harish
- Chane Majed
- Chang Mark
- Chaudhary Sanjeev
- Chavez Ayala Carlos A
- Cheema Muhammad
- Chen Dandan
- Chen Jiyan
- Chen Yundai
- Cheng Shi-Chi
- Cheng Xiaoshu
- Chengyue Zhu
- Chiang Chern-En
- Chiang Chern-En
- Chizhov Petr
- Chopda Manoj
- Chopra Vijay K
- Chotnoparatpat Paiboon
- Christenson Stuart
- Christopher Daniels
- Chu Alan
- Chua Terrance
- Chumakova Galina
- Chumburidze Vakhtang
- Chumburidze Vakhtang
- Cianciarulo Joseph
- Claeys Marc
- Claxton Edmund
- Clemmensen Peter
- Clerc JĂ©rĂŽme
- Cleveland David
- Clifford Piers
- Clifton Shaun
- Cobler Joanne
- Coching Raul Martin
- Codutti Oscar R
- Cohen Steven
- Colhoun Helen M.
- Collins Nicholas
- Colombo Hugo R
- Colquhoun David
- Coman Ioan
- Commerford Patrick J
- Conrad Gary
- Constantine Godwin
- Constantinescu Mircea CA
- Convens Carl
- Cools Frank
- Corbett Clive
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- Correa Flores Roger M
- Cortada Jordi Bruguera
- Costa Fernando
- Costamagna Osvaldo
- Coste Pierre
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- Cotruta Raluca
- Cottin Yves
- Coufal Zdenek
- Coulange Anthony
- Coverdale Steven GM
- Cristian Gabriel
- Cruz FernĂĄndez Jose M
- Cuccia Claudio
- Cui Lan
- Cyster Henry P
- Czerski Tomasz
- Daboul Nizar
- Dagher Georges
- Dahl Charles
- Dai Kazuoki
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- Dalby Anthony J
- Danchin Nicolas
- Danchin Nicolas
- Danchin Nicolas
- Danchin Nicolas
- Dandillaya Ramprasad
- Daniels Christopher
- Das Srihari
- Davidovic Goran
- Davidsen Flemming
- Davidson Laura
- Davies Richard
- Davis William
- De Berrazueta Fernåndez José R
- De Cesare Nicoletta B
- De La Tassa CĂ©sar MorĂs
- De Leon MarĂa Guerrero
- De Mora Martin Manuel
- De Salazar Dora I Molina
- de Santos Mayler ON
- de Silva H. Asita
- de Souza Juliana A
- de V Basson Matthys M
- Delarche Nicolas
- Delle-Karth Georg
- Deloatch Shalonda
- Demirtas Mustafa
- Dempsey Michael A.
- Denham Douglas
- Devarapalli Sai K
- Devaul Dawn
- DeVore Adam D.
- Diamantis Steve
- Diaz Ariel
- Diaz Rafael
- Diaz Rafael
- Diaz Rafael
- Dick Ronald
- Dickey Sheila
- Dilic Mirza
- Dilic Mirza
- Dimkovic Sinisa
- Dimov Bojidar I
- Dincic Dragan V.
- Ding Chunhua
- Dion Danielle
- Do Rose
- Dodds III George
- Dodic Slobodan
- Dohad Suhail
- Doi Yasuji
- Dombrowski Keith
- Domokos Szilvia
- Doncovska Snezana
- Dong Shaohong
- Dong Yugang
- Dorobantu Maria
- Dorobantu Maria
- Dorsel Thomas
- Dotani Imran
- Doty Daniel
- Dran Ricardo D
- Drexel Heinz
- Drexel Heinz
- Drouet Elodie
- Drzewiecka Anna
- du Toit Theron Hendrik
- Dubois-Gache Helene
- Ducas John
- Ducrocq Grégory
- Duda Norberto
- Dujardin Karl
- Dukat Andrej
- Dulak Elzbieta
- Dumitrescu Silviu
- Dupuis Robert
- Durak-Nalbantic Azra
- Durand Velasquez Julio R
- Duronto Ernesto A
- Dzupina Andrej
- Dzyak Georgiy
- DĂaz FernĂĄndez Jose Francisco
- DâUrso Michael
- Eagerton Donald
- Eapen Zubin
- East Cara
- Eaton Charles
- Ebrahim Iftikhar O
- Edelberg Jay M.
- Edward Kemala
- Egorova Liudmila
- Egydio Flavia
- Ehud Chorin
- Eisenberg Steven
- Ekanayaka Ruvan
- El Shahawy Mahfouz
- El- Ahdab Fadi
- Elias Mazen
- Elias Nizar
- Eliaschewitz Freddy G
- Elliott John
- Endsley Patricia
- Eppinger Arleen
- Erenrich Norman
- Erglis Andrejs
- Ersanli Murat
- Escudier Juan M
- Espinoza Andrey
- Etienne Alexis
- Fadlallah Hussein
- Faes Dirk
- Faggiano Pompilio
- Fairlamb James
- Faluközy József
- Fan Zhongcai
- Fang Chih-Yuan
- Fang Weiyi
- Farhat Naim
- Farrar Michael
- Faustino Douglas
- Fausto Ovando Sergio R
- Fazekas FrantiĆĄek
- Fazlibegovic Emir
- Feenema-Aardema Margriet
- Feenema-Aradema Margriet
- Feitosa Gilson S
- Fell David
- Feng Yi
- fenton Sarah
- Fernandez Ruiz Ricardo L
- Fernandez Mauricio
- Fernando Kaputella
- Fernando Nimali
- Ferrari Emile
- Ferratini Maurizio
- Ferrolino Arthur
- Filardi Pasquale Perrone
- Filho Pedro Pimentel
- Fillat Angel R. Cequier
- Fischer Stuart
- Fishberg Robert
- Fisher Daniel
- Fisher Nicholas
- Fisher Raewyn
- Florenzano Fernando
- Flores Enrique
- Fong Peter
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- Fras Zlatko
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- Frey Bernhard
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- Fu Guosheng
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- Fulop Peter
- Fulwani Mahesh C
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- Gabor Kiss Robert
- Gache Cecile
- Galski Thomas
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- Gamil Dawood
- Gapon Liudmila
- Garbelotto Raffaella
- Garcia Brasca Daniela F
- Garcia Duran Ruben O
- Garcia Lozada Henry J
- Garcia-Dorado David
- GarcĂa LledĂł JosĂ© Alberto
- Gardner Geraldine
- Garrahy Paul J
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- Giesler Gregory
- Gil-Extremera Blas
- Gilbert John M
- Gillespie Eve
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- Giordano Jorge A
- Giorgeto Flavio E
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- Giuliano Maria E
- Gniot Jacek
- Gobillot Caroline
- Goch Aleksander
- Goloborodko Borys
- Gomez Vilamajo Oscar A
- Gonsorcik Jozef
- Gonzalez-Juanatey Carlos
- Gonzalez-Juanatey Jose R
- GonzĂĄlez DĂaz Belinda
- GonzĂĄlez Salas Luis Gerardo
- Goodman Shaun G.
- Goodman Shaun G.
- Goodman Shaun G.
- Goodman Shaun G.
- Goraya Tauqir
- Gordeev Ivan
- Gordienko Alexander
- Gorny Jerzy
- Goronja Boris
- Gospodinov Maryana
- Gosselin Gilbert
- Gosselink Antonius TM
- Gotcheva Nina N
- Gotcheva Nina N
- Gouet Valerie
- Govinda Ravishankar A
- Goyal Naresh K
- Gremmler Uwe
- Grewal Jasprakash Singh
- Griffith Liddy
- Griffiths Huw
- Gring Christian
- Groenemeijer Bjorn E
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- Guardigli Gabriele
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- Gullestad Lars
- Guneri Sema
- Guneri Sema
- Guo Ying
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- Guy Douglas
- Guzman Pablo N
- GĂ€mperli Oliver
- Haddad Tariq
- Hagström Emil
- Hagström Emil
- Hagström Emil
- Hagström Emil
- Hahalis Georgios
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- Harding Scott
- Harkut Pankaj
- Harrington Robert A.
- Harrington Robert A.
- Harris Barry
- Harris Bill
- Harrison Robert W.
- Hart Hamish
- Hasan Mian
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- Henry John
- Hepditch Anita
- Herath Jagath I
- Hermans Kurt
- Hermans Walter RM
- Hernandez Zuniga Jose D
- Herrman Johannes PR
- Hersbach Ferry MRJ
- Herzog William
- Hess Connie Ng
- Hidalgo Urbano Rafael Jesus
- Higashikata Toshinori
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- Hirayama Atsushi
- Hirooka Keiji
- Hlatky Mark A.
- Hoag Gordon
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- Horvath IvĂĄn
- Horwitz Phillip
- Hove Jens D
- Hrabar Adrian D
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- Hsiang Lin Wei
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- Ilya Masterov
- Ince Carlos
- Iqbal Syed MR
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- Islam Othman
- Islam Shahidul
- Istratoaie Octavian
- Ito Kashima
- Ivanov Igor G
- Ivanova Raya
- Ivanovic Nikola
- Iyengar Shamanna S
- Iñiguez Andres
- Jacoby Douglas
- Jafar Zubair
- Jaffrani Naseem
- Jain Diwakar
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- Johansen Peter
- Johansen Peter Betton
- Jonas Michael
- Jones William Schuyler
- Jong Geert T
- Jordan Joseph Dedrick
- Jortveit Jarle
- Joshi Abhijeet B
- Joshi Parag
- Jovin Ion
- Jujjuru Srimannarayana
- Jukema J. Wouter
- Jukema J. Wouter
- Jukema Johan
- Jure Horacio O
- Jurgaitiene Ruta
- Jurgenson Tiina
- Kadr Honer
- Kaewsuwanna Pinij
- Kahali Dhiman
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- Kalil Renato
- Kamensky Gabriel
- Kamiya Haruo
- Kandasamy Balachandran
- Kanorsky Sergey
- Kapin Tibor
- Kaplan Refik
- Kapp Ilse E
- Karadzic Ana
- Karakas Mahir
- Karalis Ioannis
- Karlsberg Ronald
- Karpenko Oleksandr
- Karpenko Yuriy
- Karpov Yuri
- Karpov Yuri
- Karpov Yuriy
- Kartalis Athanasios
- Kasim Sazzli
- Kathryn Rohr
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- Katsuda Yousuke
- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
- Kawakami Anelise
- Kawasaki Tomohiro
- Ke Yuannan
- Keating Friederike
- Kedev Sasko
- Kedev Sasko
- Keen William
- Kehasukcharoen Wirash
- Kelsey Sheryl F.
- Kerkar Prafulla
- Khabeishvili George
- Khaira Ajit S
- Khaisheva Larisa
- Khan Abul
- Khan Aziz
- Khasanov Niiaz
- Khera Amit
- Khintibidze Irakli
- Khlevchuk Tatiana
- Khurana Sandeep
- Kibarskis Aleksandras
- Kichukov Kostadin N
- Killat Holger
- Kim Chongjin
- Kim Hack-Lyoung
- Kim Hae Young
- Kim Hyo Soo
- Kim Hyo-Soo
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- Kim Sang-Hyun
- Kim Sang-Hyun
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- Kimmelstiel Carey
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- Kimura Takeshi
- Kimura Takeshi
- King Marilyn
- Kinzfogl III George
- Kirma Cevat
- Kishi Koichi
- Kiss Robert Gabor
- Kjovkaroski Aleksandar
- Klancke Kim
- Klantsa Andriy
- Klausen Ib C
- Kline Geoffrey
- Klutstein Marc
- Knickelbine Thomas
- Knowles Joshua W.
- Knutson Thomas
- Koba Shinji
- Kobalava Zhanna
- Kobayashi John
- Koike Akihiro
- Koldas Lale
- Kolls Bradley J.
- Kondo Nicholas I
- Kong David F.
- Kopytsya Mykola
- Koren Michael
- Kormann Adrian
- Kornder Jan
- Kornowski Ran
- Korol Marek
- Kosinski Edward
- Kosmachova Elena
- Kostarska-Srokosz Edyta
- Kostis John
- Kotha Purushotham
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- Kovalskyi Ihor
- Kozuma Ken
- Kralova Katarina
- Krasowski Wlodzimierz
- Krawczyk Justine
- Krichmar Perry
- Kristensen Kjeld S
- Kristjan Arved
- Kubilius Raimondas
- Kuchar Jiri
- Kuhlman Peter
- KuliÄ Mehmed
- Kultursay Hakan
- Kumar Yerra Shiv
- Kumar Anil
- Kumar Priya
- Kumar Vinay
- Kumbla Mukund
- Kumkumian Greg
- Kuo Jen-Yuan
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- Kushnir Mykola
- Kutniy Oles
- Kuvin Jeffrey
- Kyiak Yulian
- Labeirie Julien
- Labroo Ajay
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- Landmesser Ulf
- Landmesser Ulf
- Landzberg Joel
- Larry John
- Larsen John
- Laucevicius Aleksandras
- Laufs Ulrich
- Laxson David
- Lazov Petar V
- Leaes Paulo E
- Leclercq Florence
- Lecorps Guillaume
- Lecorps Guillaume
- Lee Kaeng
- Lee Kwan
- LefĂšvre Thierry
- Leggewie Stefan
- Lehman Sam J
- Leimbach Wayne
- Lekakis John
- Leo Alessandro De
- Leonard Parilak
- Leonardi Sergio
- Leone Attilio
- Lepage Serge
- Lepor Norman
- Leshchuk Oleh
- Lester F. Martin
- Leung Raymond
- Levite Howard
- Levy Terry
- Li Huanming
- Li Jianping
- Li Tianchang
- Li Xiang
- Li Xiaodong
- Li Ying
- Lianopoulos Emmanouil
- Liberman Alberto
- Liberopoulos Evangelos
- Liberopoulos Evangelos
- Liberopoulos Evangelos
- Libov Igor
- Licciardello Giovanni
- Lieber Ira
- Liem Anho AH
- Liew Houng B
- Lillis Linda
- Lin Jinxiu
- Lin Wenhua
- Lin Xuefeng
- Lindsey Jason
- Linhart Ales
- Link Chad
- Lip Gregory YH
- Lipko Jan Andrzej
- Lishner Michael
- Liu Ming-En
- Liu Shaowen
- Liu Xuebo
- Llamas EsperĂłn Guillermo Antonio
- Llerena Navarro Nassip C
- Llois Susana
- Loizeau Virginie
- Lomakin Nikita V
- Lomholdt Jens D
- Lominadze Zaza
- Lopes Renato D.
- Lopes Renato D.
- Lopes Renato D.
- Lopes Renato D.
- Lopez Rodrigo Botero
- Lorenzato Christelle
- Lorenzatti Alberto J
- Lotan Chaim
- Lottering Hanlie
- Lotun Kapildeo
- Loussararian Arthur
- Love Michael
- LovriÄ BenÄiÄ Martina
- Lozance Nensi
- Lu Qinghua
- Lubinski Andrzej
- Luca Giuseppe De
- Luciardi Hector L
- Lui Henry
- Lukenda Josip
- Luna Botia Diana C
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- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo A
- Lutchmedial Sohrab
- Luyten Anne
- Lyamina Nadezhda
- Lysek Roman
- LĂłpez-Jaramillo Patricio
- MacDonald Paul
- Macdonell Alexander
- Mach Francois
- Machado Leandro
- Machecourt Jacques
- Machova Vilma
- Mackinnon Ignacio J
- Madrigal Jaime Carranza
- Mahaffey Kenneth W.
- Mahaffey Kenneth W.
- Mahajan Ajaykumar
- Mahal Sharan
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- Makoali Makotoko Ellen
- Malhotra Vinay
- Malis Mihaela
- Malozzi Christopher
- Malynovsky Yaroslav
- Manakshe Gajendra V
- Manenti Euler Roberto F Fernandes
- Mano Toshiaki
- Manolis Athanassios
- Mansourati Jacques
- Manvelian Garen
- Manzur Jatin Fernando G
- Marais H. John
- Marco Valgimigli
- Marcus Jill
- Markov Dimitar T
- Markov Valentin
- Marmor Alon
- Maron David J.
- MartĂnez SĂĄnchez Carlos Rodolfo
- Marusincova Ivana
- Marx Nikolaus
- Marx Nikolaus
- Marx Nikolaus
- Marx Roger
- MarĂn Francisco
- Maskon Oteh
- Massey Clara
- Masutani Motomaru
- Matei Adrian V
- Mathews Robin
- Mathur Rishabh
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- Matthews Alexander
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- Mayurathan Gnanamoorthy
- Mazur Juraj
- McClanahan Mark A.
- Mcclure Sam
- Mcgarvey Joseph
- McGinniss Jennifer
- Mcgough Martin
- Mclaurin Brent
- Medrano Allende Juan C
- Mehta Rajendra H.
- Mehta Shamir
- Mejic-Krstulovic Stanka
- Meloni Chiara
- Mendis Sepalika
- Mendonça Carlos
- Mentz Robert J.
- Merkely Bela
- Mesquita Bastos Jose
- Metra Marco
- Metwally Lamia
- Michalaros Yorghos L
- Michaud Nicolas
- Michishita Ichiro
- Micko Karol
- Midzic Zlatko
- Miklaszewicz Beata
- Mileta Dean
- Militaru Constantin
- MiliÄiÄ Davor
- Mincheva Valentina M
- Minescu Bogdan
- Mintale Iveta
- Misonis Nerijus
- Mittal Suneet
- Moccetti Tiziano
- Mody Freny
- Mohart Ann Elizabeth
- Molchanova Olga
- Mollov Mihail N
- Monier Myriam
- Monraats Pascalle
- Montalescot Gilles
- Montaña Oscar R
- Montecinos Humberto
- Monteiro Minguel R
- Monteiro Pedro
- Montenegro Valdovinos Pablo Carlos
- Moodley Rajendran
- Morais Joao
- Morais Joao
- Morales Dante D.
- Morales Ulises
- Moran Joseph
- Moreira Humberto Graner
- Morel Olivier
- Moriarty Andrew
- Moriarty Katie
- Moriarty Patrick M.
- Moriarty Patrick M.
- Morino Yoshihiro
- Morisset Anne
- Morrello Christine
- Moryusef AngĂšle
- Mosseri Morris
- Mostovoy Yuriy
- Motovska Zuzana
- Moura Jorge Jose C
- Mourgues Maxime
- Mourtzinis Georgios
- Mrabti Asmaa
- Mthombeni Bicky
- Mudawi Telal
- Muenzel Thomas
- Mulkay Angel
- Munk Peter S
- Munusamy Vengatesh
- Murillo Fernando Civeira
- Murin Jan
- Murin Jan
- Murphy Judith
- Murphy Sherrill
- Muslibegovic Adis
- Musumeci Giuseppe
- Muthusamy Rangasamy
- Mutlu Bulent
- Mynhardt Joseph H
- Myshanych Halyna
- MĂ€rtsin Kaja
- MĂŒller Christian
- MĂŒller Christian
- MĂŒller GĂĄbor
- MĂŒller-Wieland Dirk
- Nacoud Ackar Alfredo
- Nager Paul
- Nagy Lajos
- Nahhas Ahed
- Nahuelpan Leonardo
- Nakao Koichi
- Nani Sebastian
- Naplava Robert
- Natour Mohammed
- Negron Miguel Sandra A
- Nelson William
- Neto Jose A Marin
- Neuenschwander Fernando
- Neustel Mark
- Nicol Peter
- Nicolau Jose C
- Nielsen Peter Kaiser
- Nielsen Tonny
- Nieminen Markku S
- Nieminen Markku S
- Nigro Frank
- Nijmeijer Remco
- Nikolaev Konstantin
- Nikolov Fedya P
- Nikolsky Eugenia
- Ninio Daniel
- Nishibe Akira
- Nishibe Akira
- Nociar Jan
- Nogareda Gustavo
- Norkiene Sigute
- Normand Mickael
- Novaretto Leonardo P
- Novo Salvatore
- Novoa Federico
- Novotny Vojtech
- Nuding Sebastian
- NygÄrd Ottar
- NĂșñez Fragoso Juan Carlos
- Ofer Havakuk
- Offers Elmar
- Okan Betim
- Olexa Peter
- Olivares Claudia
- Olivari Zoran
- Oliveira Janaina
- Oliver Richard
- Olsson Anders G.
- Omran Heyder
- Ong Tiong Kiam
- Ono Yujiro
- Oomen Antonius
- Oomman Abraham
- Oqueli Flores Romulo E
- Orcajo Norberto Alonso
- Orlikova Olga
- Osokina Natalya
- Ossei-Gerning Nicholas
- Ostadal Petr
- Ostadal Petr
- Ourliac Anne
- OâDonnell Philip J.
- Paganelli Franck
- Pagava Zurab
- Palimkar Priya
- Palka Juraj
- Palmer Bruce
- Palvarini Michela
- Panchal Vipul
- Pancholy Samir
- Pandey Amritanshu
- Pandurangi Ulhas
- Parada Jeffrey Castellanos
- Parepa Irinel R
- Park Hyeun (Tom)
- Parkhomenko Alexander
- Parkhomenko Alexander
- Parthenakis Frangkiskos
- Pasquini John
- Patange Dr. Aparna
- Patel Chetan B.
- Paterlini Gustavo A
- Patil Chandrakant
- Patil Sachin N
- Patki Nitin
- Patocchi Cristian A
- Patsilinakos Sotiris
- Pawar Sudhir
- Pawlowicz Lidia
- Payeras Antonio Coca
- Pearce Stephen
- Pederson Robert
- Pella Daniel
- Pellan Valerie
- Pellegrin Annamaria De
- Peng Daoquan
- Penny William
- Pepine Carl
- Pereira Edward
- Pereira Helder H
- Pereira Sabrina Bernardez
- Perez Ignacio Plaza
- Perez Luis
- Pericas Laia Matas
- Peris Vicente BodĂ
- Perkins Lynn
- Perlmutter Neal
- Perthuis Aurelie
- PerĆĄiÄ Viktor
- Pesant Yves
- Petranov Stanislav L
- Petrulioniene Zaneta
- PeÄin Ivan
- Piatti Piermarco
- Picault Patrick
- Picone Mark
- Piepiorka Marek
- Pillay Thayabran
- Pincetti Cristian
- PintariÄ Hrvoje
- Piovaccari Giancarlo
- Pirenne Bruno
- Piyayotai Dilok
- Podoleanu Cristian GC
- Podpera Ivo
- Poh Kian-Keong
- Pojskic Belma
- Poklukar Janez
- Pollock Stewart
- Ponce George
- Ponnamperuma Chandrike
- Pontaga Natalija
- Pope Theodore
- Pordy Robert
- Pordy Robert
- Portales Javier Fernandez
- Porwal Sanjay
- Pothineni Ramesh B
- Potthoff Sergio
- Poulsen Steen H
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- Povolny Petr
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- Povzun Anton
- Precoma Dalton B
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- Probst Vincent
- Prokhorov Alexander
- PrvuloviÄ Äeiti
- Puccioni Enrico
- Puri Sanjeev
- Purow Joshua
- Puymirat Etienne
- PĂ©rez RĂos JesĂșs Antonio
- Qu Baiming
- Quintero Ossa Alvaro M.
- Quintero Kirby
- Racca Vittorio
- Raczak Grzegorz
- Radin Michael
- Radovanovic Slavica
- Raev Dimitar H
- Raffel Owen
- Raffo Carlos A
- Raghuraman Bagirath
- Rahma Gohar
- Rahman Aref
- Rahul Patil
- Raisinghani Ajit
- Rajapaksha Ajantha
- Ramin Ebrahimi
- Ramos LĂłpez Gabriel Arturo
- Ramos LĂłpez Gabriel Arturo
- Ramos Walter Mogrovejo
- Ranadive Nandkishore
- Ranasinghe Gotabhaya
- Ranjith Naresh
- Rao Sunder
- Rasmanis Gundars
- Rasoul Saman
- Ratky Caroline
- Rauch-Kröhnert Ursula
- Raungaard Bent
- Ray Kausik K.
- Ray Michael
- Recena Javier Balaguer
- Rech Rafael
- Reddy Proddutur Naveen
- Regella Reddy
- Reiner Zeljko
- Reis Gilmar
- Reis Helder JL
- Rensing Bernard JWM
- Repincay JĂ©rĂŽme
- Reshetko Olga
- Reshotko Dmytro
- Reuter Helmuth
- Reynolds Timothy
- Rha Seungwoon
- Riaz Garda
- Richard Kerensky
- Rider James
- Rieker Werner
- Rincon Pablo Loma-Osorio
- Rishko Mykola
- Ristic Arsen D.
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- Roberts-Thomson Philip
- Robinson Simon
- Rodes-Cabau Josep
- Rodriguez Chavez VĂctor E
- Rodriguez De Leon Edgar R
- Rodriguez Javier Botas
- Roe Matthew T.
- Roe Matthew T.
- Roe Matthew T.
- Roe Matthew T.
- Rogelio Gregorio
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- Rokyta Richard
- Roldan Concha Yudy M
- Romeo Stefano
- Rondel Christelle
- Ronner Eelko
- Roosen John
- Rorick Tyrus
- Rosas Enrique LĂłpez
- Rose Gregory
- Rosenberg Michael
- Rosenschein Uri
- Rosenson Robert
- Rossi Joseph
- Rossi Paulo RF
- Rossi Peter
- Rosu Doina
- Rouleau Jean-Lucien
- Rozeman Phillip
- Rozenman Yoseph
- Rubenstein Howard
- Rudenko Anatolii
- Rudenko Leonid
- Saaiman Jan A
- Saathe Shireesh
- Saavedra Silvia S
- Sabatino Kenneth
- Sabbah Eric
- Sachin Patil
- Sader Mark
- Sakagami Satoru
- Sakalyte Gintare
- Salmón Guillermo FanghÀnel
- Salomone Oscar
- Salvioni Alessandro
- Saminski Krzysztof
- Sanabria Perez Enrique S
- Sandhu Manjinder
- Sansanayudh Nakarin
- Saporito Wladmir
- Sarkar David
- Sarvan Mahomed
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- Sassone Sonia A
- Sastravaha Krisada
- Sathe Shireesh
- Sato Katsuhiko
- Savard Daniel
- Sawhney Jitendra
- Scalise Filippo
- Scemama Michel
- Scemama Michel
- Schaeufele Tim
- Schellenberg Detlev
- Schiavi Lilia B
- Schiele Francois
- Schifferdecker Branislav
- Schmalfuss Carsten
- Schmedtje John F
- Schmidberg Jorge M
- Schmidt Ekkehard
- Schmitt Susanne
- Schuchard Timothy
- Schwartz Gregory G.
- Schwartz Gregory G.
- Schwartz Michael
- Schwartz Steven
- Scott Douglas
- Sebastian Peter J
- Seferovic Petar
- Seixo Filipe
- Selecky Juraj
- Senaratne Manohara
- Senaratne Vajira
- Senni Michelle
- Serrano Antolin Jose Maria
- Sethi Sumeet
- Shaburishvili Tamaz
- Shah Anil V
- Shah Bimal R.
- Shah Vipul
- Shalaev Sergey
- Sharma Mukesh
- Sharman David
- Shaw James
- Shaw Michelle
- Shchekotov Vladimir
- Shechter Michael
- Shehova-Yankova Nina S
- Sheldon William
- Sheller Jennifer
- Sherwood Matthew W.
- Shetty Sanjay
- Shi Xubo
- Shimatani Yuji
- Shimizu Masatoshi
- Shinde Rituparna
- Shinke Toshiro
- Shou Xiling
- Shoukfeh Mohammad
- Shustov Sergey
- Shvarts Yury
- Sijbrands Eric J.G.
- Sik Park Hun
- Silva Pedro
- Silva Ricardo P
- Silveira Jose A
- Silver Kevin
- Simaitis Audrius
- Sime Iveta
- Simic Dragan
- Simon Tabassome
- Simonis Gregor
- Simoons Maarten L.
- Singal Dinesh
- Singh Narendra
- Singsaas Erlend gyllensten
- Sinha Dhurjati
- Sinnaeve Peter
- Sinnaeve Peter
- Sinnaeve Peter
- Sionis Dimitrios
- Sirisena Thilak
- Siu David CW
- Skonieczny Grzegorz
- Skorski Marcin
- Skoumas Ioannis
- Slapikas Rimvydas
- Smik Rudolf
- Smith Lucile
- Smith Simon
- Soggia Ana Priscila
- Soonfuang Wasant
- SoopĂ”ld Ăllar
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- Sopena Sebastien
- Soran Handrean
- Soroka Eugene
- Sotnikova Tatiana
- Sotomayor Herazo Aristides
- Sotty Marc
- Sousa Luciano
- Souza Weimar KSB
- Soward Allan
- Sparby Jon Arne
- Speirs Shawn
- Spinar Jindrich
- Sporn Daniel
- Spriggs Douglas
- Spriging david
- Sritara Piyamitr
- Sritara Piyamitr
- Staneta Pawel
- Stanislavchuk Mykola
- Stankovic Aleksandar
- Stapleton Dwight
- Starcevic Boris
- Starmer Gregory
- Stasiewski Arkadiusz
- Steg P. Gabriel
- Steg Ph. Gabriel
- Steiner Stephan
- Stellbrink Christoph
- Stewart Ralph
- Stojic Stevo
- Stone James
- Storey Robert
- Strader James
- Strain Janet
- Stratmann Matthias
- Strbova Jaroslava
- Strelnieks Aldis
- Striekwold Harry
- Stringfellow Kenya
- Strozzi Maja
- Stryuk Raisa
- Su Guohai
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- Todorov Georgi V
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- Viigimaa Margus
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- Voevoda Mikhail I
- Vogel Robert
- Vohra Rakesh
- Vora Kishor
- Vora Kishor
- Voyce Stephen
- Vrolix Mathias CM
- Vulic Dusko
- Vuurmans Tycho
- Våzquez de Prada José Antonio
- VĂĄzquez Eduardo Salcido
- Vöhringer Hans Friedrich
- Völler Heinz
- Wada Atsuyuki
- Waider Winfried
- Waisman Gabriel D
- Waites Jonathon H
- Wali Andreas
- Walichiewicz Piotr Maria
- Waltenberger Johannes
- Waltman Jonathan
- Wan Mohamed Wan Mohd Izani
- Wang Jianzhong
- Wang JianâAn
- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weiss Robert
- WeiĂbrodt Matthias
- Welka Stephen
- Welker James
- Welker James
- Wells Terry
- Wells Terry
- Werner Christian
- Werner Nikos
- Westbrook Melissa
- Westerhausen Donald
- Whitaker Jack
- White Harvey D.
- White Harvey D.
- White Harvey D.
- White Harvey D.
- White Lindsey
- White Matthew
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- Wijeyasingam Santharaj
- Wilkins Gerard
- Wilkinson Peter
- Willems Frank F
- Wilson Matthew D.
- Wilson Samuel
- Winkelmann Bernhard
- Wiseman Alan
- Witt Nils
- Wlodarczak Adrian
- Wojewoda Pawel
- Wolf Luc De
- Wolfovitz Efrat
- Wollaert Bart
- Wong Yuk- Ki
- Wongpraparut Nattawut
- Worner Diz Fernando
- Wozniak Julianna
- Wright Scott
- Wu Chun
- Xavier Denis
- Xenakis Mark
- Xiang Meixiang
- Xu Biao
- Xu Dingli
- Xu Xiping
- Xu Yizhou
- Yagensky Andriy
- Yakushin Sergey
- Yan Bryan PY
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yañez Mario
- Yee Ong Hean
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Yusoff Khalid
- Zahger Doron
- Zahr Firas
- Zaidman Cesar J
- Zainea Mark
- Zaman Azfar
- Zamorano Jose Luis
- Zapata Gerardo
- Zea Nunez Carlos A
- Zeiher Andreas M.
- Zeiher Andreas M.
- Zhang Ruiyan
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Shuiping
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhong Yi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zukermann Robert
- Zurakowski Aleksander
- Zvi Vered
- Zwart Peter
- Zweiker Robert
- Ădes IstvĂĄn
- Ć ikiÄ Jozica
- Ć tambuk Kresimir
- Ć uligoj NataĆĄa ÄerniÄ
- Ćœuran Ivan
- Publication venue
- American Heart Association
- Publication date
- 30/08/2022
- Field of study
Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18â924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity scoreâmatched models. Results: Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9â3.6], 4.0 [95% CI, 3.6â4.5], and 5.5 [95% CI, 5.0â6.1] events per 100 patient-years in strata 35â<50, and â€35 mg/dL, respectively). Compared with propensity scoreâmatched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or nonâhigh-density lipoprotein cholesterol but not vice versa. Conclusions: In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or nonâhigh-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as â€35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01663402.gov; Unique identifier: NCT01663402.URL: https://www
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
- Author
- Abbas Jalal
- Abbate Antonio
- Abdallah Mouhamad
- Abdullakutty Jabir
- Abhyanakar Atul D
- Aboyans Victor
- Abrantes José Antonio M
- Abu-Fadel Mazen
- Accini Mendoza Jose L
- Acevedo Monica
- Adamkova Vera
- Adamo Antony
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Agergaard Jensen Steen
- Aggarwal Rahul
- Aggarwal Rajesh K
- Agnetti Veronique
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A.
- Airaksinen Juhani
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea YY
- Alan David
- Albert Seals
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M
- Alexopoulos Dimitrios
- Alings Marco
- Alonso Martin Joaquin J
- Alonso Orcajo Norberto
- Alonso Alvaro
- Alsweiler Caroline
- Alvarisqueta Andrés F.
- Alves De Lima Alberto E.
- Amarasekera Stanley
- Amarasena Naomali
- Amidon Thomas
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Anchante Hernandez Henry A
- Andersen Dorthe
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Ando Kenji
- Andrzej Lipko Jan
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Aroney Constantine
- Arstall Margaret A
- Asanin Milika R.
- Assi Nizar
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayaz Mohammad
- Aylward Philip E.
- Ayoub José Carlos Aidar
- Azizad Masoud M
- BabiÄ Zdravko
- Baccara-Dinet Marie
- Badreddine Emmy
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Balaguer Recena Javier
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Ball Eric
- Bang Lia E
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L
- Barbato Emanuele
- Barna Olga M
- Barone-Rochette Gilles
- Barr Craig
- Barraud Pauline
- Barrera Silva Sandra I
- Barrucco Robert
- Bartels Gerard L
- Basart Dirk
- Bashir Riyaz
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Bejuit Raphael
- Bekkouche Mhamed
- Belhassane Abdelkader
- Beltran Pascale
- Benbernou Fadela
- Benedicto Amparo
- Bengrait Nafissa
- Bengston James
- Bengus Cristina M
- Benov Haralambi O
- BenÄiÄ Martina LovriÄ
- Berdan Lisa
- Berger Rudolf
- Berglund Stefan
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- Bernan Alisa
- Bernardez-Pereira Sabrina
- Berthou Christelle
- Berti Sergio
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- Bhatt Deepak L.
- Binde Ronald
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- Ding Chunhua
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- Dodds III George
- Dodic Slobodan
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- Jaramillo Nicolas
- Javierre Carine
- Jaworska Krystyna
- Jayawardena Jayanthimala
- Jeong Myung Ho
- Jeppesen JĂžrgen
- JeriÄ Melita
- Jeserich Michael
- Jiang Weihong
- Jintapakorn Woravut
- Johansen Peter
- Jonas Michael
- Jong Geert T
- Jordan Joseph Dedrick
- Jortveit Jarle
- Joshi Abhijeet B
- Joshi Parag
- Jovin Ion
- Jujjuru Srimannarayana
- Jukema J Wouter
- Jukema J. Wouter
- Jukema Johan
- Jure Horacio O.
- Jurgaitiene Ruta
- Jurgenson Tiina
- Kadr Honer
- Kaewsuwanna Pinij
- Kahali Dhiman
- Kaiser Sergio
- Kalashetti Suhas
- Kalil Renato
- Kamensky Gabriel
- Kamiya Haruo
- Kandasamy Balachandran
- Kanorsky Sergey
- Kapin Tibor
- Kaplan Refik
- Kapp Ilse E
- Karadzic Ana
- Karakas Mahir
- Karalis Ioannis
- Karlsberg Ronald
- Karna Sunil
- Karpenko Oleksandr
- Karpenko Yuriy
- Karpov Yuri
- Karpov Yuriy
- Kartalis Athanasios
- Kasim Sazzli
- Kathryn Rohr
- Katona AndrĂĄs
- Katsuda Yousuke
- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
- Kawakami Anelise
- Kawasaki Tomohiro
- Ke Yuannan
- Keating Friederike
- Kedev Sasko
- Keen William
- Kehasukcharoen Wirash
- Kelsey Sheryl F.
- Kerkar Prafulla
- Khabeishvili George
- Khaira Ajit S
- Khaisheva Larisa
- Khan Abul
- Khan Aziz
- Khan Misal
- Khasanov Niiaz
- Khera Amit
- Khintibidze Irakli
- Khlevchuk Tatiana
- Khurana Sandeep
- Kibarskis Aleksandras
- Kichukov Kostadin N
- Killat Holger
- Kim Chongjin
- Kim Hack-Lyoung
- Kim Hae Young
- Kim Hyo Soo
- Kim Hyo-Soo
- Kim Moo Hyun
- Kim Sang-Hyun
- Kim Youngkwon
- Kimmelstiel Carey
- Kimura Kazuo
- Kimura Takeshi
- Kimura Takeshi
- King Marilyn
- Kinzfogl III George
- Kirma Cevat
- Kishi Koichi
- Kiss Robert Gabor
- Kjovkaroski Aleksandar
- Klancke Kim
- Klantsa Andriy
- Klausen Ib C
- Kline Geoffrey
- Klutstein Marc
- Knickelbine Thomas
- Knowles Joshua W.
- Knutson Thomas
- Koba Shinji
- Kobalava Zhanna
- Kobayashi John
- Koike Akihiro
- Koldas Lale
- Kolls Bradley J.
- Kondo Nicholas I
- Kong David F.
- Kopytsya Mykola
- Koren Michael
- Kormann Adrian
- Kornder Jan
- Kornowski Ran
- Korol Marek
- Kosinski Edward
- Kosmachova Elena
- Kostarska-Srokosz Edyta
- Kostis John
- Kotha Purushotham
- Kouz Simon
- Kovalskyi Ihor
- Kozuma Ken
- Kralova Katarina
- Krasowski Wlodzimierz
- Krawczyk Justine
- Krichmar Perry
- Kristensen Kjeld S
- Kristjan Arved
- Kubica Jacek
- Kubilius Raimondas
- Kuchar Jiri
- Kuhlman Peter
- KuliÄ Mehmed
- Kultursay Hakan
- Kumar Anil
- Kumar Priya
- Kumar Vinay
- Kumbla Mukund
- Kumkumian Greg
- Kuo Jen-Yuan
- Kurian John
- Kushnir Mykola
- Kutniy Oles
- Kuvin Jeffrey
- Kyiak Yulian
- Labeirie Julien
- Labroo Ajay
- Lai Christopher
- Lai Wen-Ter
- Lambert Charles
- Lamoureux Maud
- Landmesser Ulf
- Landzberg Joel
- Larry John
- Larsen John
- Laucevicius Aleksandras
- Laufs Ulrich
- Laxson David
- Lazov Petar V
- Leaes Paulo E
- Leclercq Florence
- Lecorps Guillaume
- Lecorps Guillaume
- Lee Kaeng
- Lee Kwan
- LefĂšvre Thierry
- Leggewie Stefan
- Lehman Sam J
- Leimbach Wayne
- Lekakis John
- Leonard Parilak
- Leonardi Sergio
- Leone Attilio
- Lepage Serge
- Lepor Norman
- Leshchuk Oleh
- Lester F. Martin
- Leung Raymond
- Levite Howard
- Levy Terry
- Li Huanming
- Li Jianping
- Li Tianchang
- Li Xiang
- Li Xiaodong
- Li Ying
- Lianopoulos Emmanouil
- Liberman Alberto
- Liberopoulos Evangelos
- Libov Igor
- Licciardello Giovanni
- Lieber Ira
- Liem Anho AH
- Liew Houng B
- Lillis Linda
- Lin Jinxiu
- Lin Wei Hsiang
- Lin Wenhua
- Lin Xuefeng
- Lindsey Jason
- Linhart Ales
- Link Chad
- Lionarons Raymond
- Lip Gregory YH
- Lishner Michael
- Liu Ming-En
- Liu Shaowen
- Liu Xuebo
- Llamas EsperĂłn Guillermo Antonio
- Llerena Navarro Nassip C
- Llois Susana
- Loizeau Virginie
- Loizeau Virginie
- Loma-Osorio Rincon Pablo
- Lomakin Nikita V
- Lomholdt Jens D
- Lominadze Zaza
- Lopes Renato
- Lopes Renato D
- Lopes Renato D.
- Lorenzato Christelle
- Lorenzatti Alberto J.
- Lotan Chaim
- Lottering Hanlie
- Lotun Kapildeo
- Loussararian Arthur
- Love Michael
- Lozance Nensi
- Lu Qinghua
- Lubinski Andrzej
- Luciardi Hector L
- Lui Henry
- Lukenda Josip
- Luna Botia Diana C
- Luo Zhurong
- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo A
- Lutchmedial Sohrab
- Luyten Anne
- Lyamina Nadezhda
- LĂłpez Rosas Enrique
- LĂłpez-Jaramillo Patricio
- Macdonald Paul
- Macdonell Alexander
- Mach Francois
- Machado Leandro
- Machecourt Jacques
- Machova Vilma
- Mackinnon Ignacio J.
- Mahaffey Kenneth W.
- Mahajan Ajaykumar
- Mahal Sharan
- MajercĂĄk Ivan
- Makotoko Ellen Makoali
- Malhotra Vinay
- Malik Amir
- Malis Mihaela
- Malozzi Christopher
- Malynovsky Yaroslav
- Manakshe Gajendra V
- Manenti Euler Roberto Fernandes
- Mano Toshiaki
- Manolis Athanassios
- Mansourati Jacques
- Manzur Jatin Fernando G
- Marais H. John
- Marco Valgimigli
- Marcus Jill
- Marin-Neto Jose A
- Markov Dimitar T
- Markov Valentin
- Marmor Alon
- Maron David J.
- Martins Dinis
- MartĂnez SĂĄnchez Carlos Rodolfo
- Marusincova Ivana
- Marx Nikolaus
- Marx Nikolaus
- Marx Roger
- MarĂn Francisco
- Maskon Oteh
- Massey Clara
- Masutani Motomaru
- Matas Pericas Laia
- Matei Adrian V
- Mathews Robin
- Mathur Anthony
- Mathur Rishabh
- Matiga Generoso
- Matthews Alexander
- Matuska Jiri
- May Ole
- May Wade
- Mayurathan Gnanamoorthy
- Mazur Juraj
- Mcclanahan Mark A
- Mcclure Sam
- Mcgarvey Joseph
- Mcgough Martin
- Mclaurin Brent
- Medrano Allende Juan C.
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- Mejic-Krstulovic Stanka
- Meloni Chiara
- Mendis Sepalika
- Mendonça Carlos
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- Merkely Bela
- Mesquita Bastos Jose
- Metra Marco
- Metwally Lamia
- Michalaros Yorghos L
- Michaud Nicolas
- Michishita Ichiro
- Micko Karol
- Midzic Zlatko
- Miklaszewicz Beata
- Mileta Dean
- Militaru Constantin
- MiliÄiÄ Davor
- Mincheva Valentina M
- Minescu Bogdan
- Mintale Iveta
- Mirek-Bryniarska Ewa
- Misonis Nerijus
- Mittal Suneet
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- Molchanova Olga
- Molina De Salazar Dora I
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- Montaña Oscar R.
- Montecinos Humberto
- Monteiro Minguel R
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- Montenegro Valdovinos Pablo Carlos
- Moodley Rajendran
- Morais Joao
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- Moran Joseph
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- Moriarty Andrew
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- Morino Yoshihiro
- Morisset Anne
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- Myshanych Halyna
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- MĂŒller GĂĄbor
- MĂŒller-Wieland Dirk
- Nacoud Ackar Alfredo
- Nager Paul
- Nagy Lajos
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- Nahuelpan Leonardo
- Nakao Koichi
- Nani Sebastian
- Naplava Robert
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- Nelson William
- Neuenschwander Fernando
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- Nicol Peter
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- Nijmeijer Remco
- Nikolaev Konstantin
- Nikolov Fedya P
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- Nociar Jan
- Nogareda Gustavo
- Norkiene Sigute
- Normand Mickael
- Novaretto Leonardo P.
- Novo Salvatore
- Novoa Federico
- Novotny Vojtech
- Nowins Rosemary
- Nuding Sebastian
- NygÄrd Ottar
- NĂșñez Fragoso Juan Carlos
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- Okan Betim
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- Olivari Zoran
- Oliveira Janaina
- Oliver Richard
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- Ono Yujiro
- Oomen Antonius
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- Oqueli Flores Romulo E
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- Osokina Natalya
- Ossei-Gerning Nicholas
- Ostadal Petr
- Ourliac Anne
- Paganelli Franck
- Pagava Zurab
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- Palmer Bruce
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- Panchal Vipul
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- Pandey Amritanshu
- Pandurangi Ulhas
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- Peng Daoquan
- Penny William
- Pepine Carl
- Pereira Edward
- Pereira Helder H
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- Perthuis Aurelie
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- Piatti Piermarco
- Picault Patrick
- Picone Mark
- Piepiorka Marek
- Pillay Thayabran
- Pimentel Filho Pedro
- Pincetti Cristian
- PintariÄ Hrvoje
- Piovaccari Giancarlo
- Pirenne Bruno
- Piyayotai Dilok
- Plaza Perez Ignacio
- Podoleanu Cristian GC
- Podpera Ivo
- Poh Kian-Keong
- Pojskic Belma
- Poklukar Janez
- Pollock Stewart
- Ponce George
- Ponnamperuma Chandrike
- Pontaga Natalija
- Pope Theodore
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- PrvuloviÄ Äeiti
- Puccioni Enrico
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- Purow Joshua
- Putnikovic Tosic Biljana
- Puymirat Etienne
- PĂ©rez RĂos JesĂșs Antonio
- Qu Baiming
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- Radovanovic Slavica
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- Ranadive Nandkishore
- Ranasinghe Gotabhaya
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- Reshetko Olga
- Reshotko Dmytro
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- Riaz Garda
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- Rosu Doina
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- Saminski Krzysztof
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- Schaeufele Tim
- Schellenberg Detlev
- Schiavi Lilia B.
- Schiele Francois
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- Schmalfuss Carsten
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- Schmitt Susanne
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- Schuyler Jones William
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- Schwartz Michael
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- Selecky Juraj
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- Serrano Antolin Jose Maria
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- Shaburishvili Tamaz
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- Shetty Sanjay
- Shi Xubo
- Shimatani Yuji
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- Singh Narendra
- Singsaas Erlend gyllensten
- Sinha Dhurjati
- Sinnaeve Peter
- Sionis Dimitrios
- Sirisena Thilak
- Siu David CW
- Skonieczny Grzegorz
- Skorski Marcin
- Skoumas Ioannis
- Slapikas Rimvydas
- Smik Rudolf
- Smith Lucile
- Smith Simon
- Soggia Ana Priscila
- Soonfuang Wasant
- SoopĂ”ld Ăllar
- Soots Mai
- Sopena Sebastien
- Soran Handrean
- Soroka Eugene
- Sotnikova Tatiana
- Sotomayor Herazo Aristides
- Sotty Marc
- Sousa Luciano
- Souza Weimar KSB
- Soward Allan
- Sparby Jon Arne
- Speirs Shawn
- Spinar Jindrich
- Sporn Daniel
- Spriggs Douglas
- Sprigings David
- Sritara Piyamitr
- Stanescu-Cioranu Rodica
- Staneta Pawel
- Stanislavchuk Mykola
- Stankovic Aleksandar
- Stapleton Dwight
- Starcevic Boris
- Starmer Gregory
- Stasek Josef
- Stasiewski Arkadiusz
- Steg Ph. Gabriel
- Steg Philippe Gabriel
- Steiner Stephan
- Stellbrink Christoph
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- Stojic Stevo
- Stone James
- Storey Robert
- Strader James
- Strain Janet
- Stratmann Matthias
- Strbova Jaroslava
- Strelnieks Aldis
- Striekwold Harry
- Stringfellow Kenya
- Strozzi Maja
- Stryuk Raisa
- Su Guohai
- Su Xi
- Suarez Arambula Rafael
- Suarez Otero Rodrigo
- Subherwal Sumeet
- Subkovas Eduardas
- Sudnik Wanda
- Sugino Hiroshi
- Suh David
- Sujjavanich Darin
- Sukonthasarn Apichard
- Sulit Dennis Jose
- Sultan Ayyaz
- Sumner Andrew
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- Takahashi Toshiyuki
- Takata Theodore
- Takeda Yoshihiro
- Tamby Jean-François
- Tamura Ritsu
- Tan Edgar
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- Tashchuk Viktor
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- Tissera Nirmali
- Todic Branislava
- Todorov Georgi V
- Toledo Pablo
- Toma Mustafa
- Tomala Tadeusz
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- Vora Kishor
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- Vrolix Mathias CM
- Vulic Dusko
- Vuurmans Tycho
- Våzquez de Prada José Antonio
- Vöhringer Hans Friedrich
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- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weiss Robert
- WeiĂbrodt Matthias
- Welka Stephen
- Welker James
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- Wells Terry
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- Werner Christian
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- Whitaker Jack
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- Wlodarczak Adrian
- Wojewoda Pawel
- Wolfovitz Efrat
- Wollaert Bart
- Wong Yuk-Ki
- Wongpraparut Nattawut
- Worner Diz Fernando
- Wozniak Julianna
- Wright Scott
- Wu Chun
- Xavier Denis
- Xenakis Mark
- Xiang Meixiang
- Xu Biao
- Xu Dingli
- Xu Xiping
- Xu Yizhou
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- Yakushin Sergey
- Yan Andrew T.
- Yan Bryan PY
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yañez Mario
- Yerra Shiv Kumar
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Zahger Doron
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- Zea Nunez Carlos A
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- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Shuiping
- Zhao Xingsheng
- Zheleznyy Volodymyr
- Zheng Yang
- Zheng Zeqi
- Zhong Yi
- Zhou Yujie
- Zhu Hong
- Zhu Jianhua
- Zirlik Andreas
- Zizka Jiri
- Zobouyan Isabelle
- Zong Wenxia
- Zrazhevsky Konstantin
- Zukermann Robert
- Zurakowski Aleksander
- Zvi Vered
- Zwart Peter
- Zweiker Robert
- Ădes IstvĂĄn
- ÄerniÄ Ć uligoj NataĆĄa
- Ć ikiÄ Jozica
- Ć tambuk Kresimir
- Ćœuran Ivan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1.4-1.8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes