In Vitro Study of Retentive Properties of Different Overdenture Attachment Systems On Straight and Divergent Dental Implants

Objectives: To evaluate the retention of Locator R-TX (ZEST Anchors LLC, Escondido, CA USA), Locator (ZEST Anchors LLC, Escondido, CA USA) and GPS (Implant Direct Sybron International, LLC, California, USA) dental implant attachment systems on parallel and divergent implants after sixteen months of simulated cyclic wear.;Methods: 30 acrylic blocks representing mandibular arches were used. Two Locator R-TX, two Locator, or two GPS abutment analogs were placed parallel or with 10 degrees of divergence in each block. The associated housings were picked up in corresponding acrylic blocks with clear Orthodontic resin (Dentsply GAC, Islandia, NY USA). The black processing liners in each housing were replaced with either low retentive or 1.5lb retentive elements. An eyebolt was attached to each block so it could be attached to an INSTRON 5565 Universal Testing Machine (Instron, Northwood, MA USA). The acrylic blocks were repeatedly separated and reattached by hand for 2000 pulls. The retentive force needed for dislodgement was measured at pull 500, 1000, 1500 and 2000.;Results: The type of attachments (GPS, Locator, Locator R-TX) showed statistical significance. The number of pulls and the inter-implants angulation did not exhibit a statistical significance. The Locator attachment had 10.3 N more retention than the GPS and 3.6N more than the R-TX attachment.;Conclusions: After 2000 cycles of seating and unseating, the retention generated by Locator attachments was greater than other attachments and was not negatively affected by inter-implants angulation in the 0 to 10 degrees range

Identification and mapping of potential recharge in the Middle Seybouse sub-catchment of the Guelma region (North East of Algeria): contribution of remote sensing, multi-criteria analysis, ROC-Curve and GIS

Due to the rapid population increase in the Middle Seybouse sub-catchment area in North-East Algeria, the intense agricultural practices, and the industrial development, precious water resources proven to be significantly challenged in their sustainable exploitation both in terms of quantity and quality. The aim of this study is to identify the most suitable areas for groundwater recharge in the Middle Seybouse sub-catchment, over about 770.91 km², using remote sensing data and Geographical Information Systems (GIS). Six factors are recognized to positively affect groundwater recharge: rainfall, land cover, topography, drainage density, lineament density, and lithology. According to their level of involvement in the recharge process, these parameters have been reclassified and then evaluated using the multi-criteria analysis known as “Analytical Hierarchy Process” (AHP). A potential recharge map of the study area was produced showing that 60% of this area, located in the southern and central parts of the catchment, has a high to very high potential. ROC (receiver operating characteristic) curve is used to validate the resulting groundwater potential recharge map using the existing wells in the study area

Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1 alpha

Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC-BSA nanoparticles (NPs). These PIC-BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1α. Our results indicate that PIC-BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1α in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC-BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC-BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC-BSA NPs, enhances its therpautice potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possiable human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients

Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer

Correction: Aljabali, A.A.A.; et al. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer via down Regulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113

The authors wish to make the following corrections to this paper [...]

Primary solitary fibrous tumor of the retroperitoneum

Solitary fibrous tumor is an uncommon neoplasm affecting adults and typically located in the pleura and can also occur in a large number of other extra thoracic sites. We present the case of a solitary fibrous tumor (SFT) of the retroperitoneum and describe their histopathological and immunohistochemical features. The identification of SFT in the retroperitoneum is of importance because its clinico-pathological behaviour is still unclear. The pathologist plays a fundamental role in establishing both the positive and differential diagnosis

Clinical features, socioeconomic status, management, short and long-term outcomes of patients with acute myocardial infarction: Phase I results of PEACE MENA registry.

BackgroundThe Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa (PEACE MENA) is a prospective registry program in Arabian countries that involves in patients with acute myocardial infarction (AMI) or acute heart failure (AHF).MethodsThis prospective, multi-center, multi-country study is the first report of the baseline characteristics and outcomes of inpatients with AMI who were enrolled during the first 14-month recruitment phase. We report the clinical characteristics, socioeconomic, educational levels, and management, in-hospital, one month and one-year outcomes.ResultsBetween April 2019 and June 2020, 1377 patients with AMI were enrolled (79.1% males) from 16 Arabian countries. The mean age (± SD) was 58 ± 12 years. Almost half of the population had a net income ConclusionIn the MENA region, patients with AMI present at a young age and have a high burden of cardiac risk factors. Most of the patients in the registry have a low income and low educational status. There is heterogeneity among key performance indicators of AMI management among various Arabian countries

Total ischemic time for STEMI.

BackgroundThe Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa (PEACE MENA) is a prospective registry program in Arabian countries that involves in patients with acute myocardial infarction (AMI) or acute heart failure (AHF).MethodsThis prospective, multi-center, multi-country study is the first report of the baseline characteristics and outcomes of inpatients with AMI who were enrolled during the first 14-month recruitment phase. We report the clinical characteristics, socioeconomic, educational levels, and management, in-hospital, one month and one-year outcomes.ResultsBetween April 2019 and June 2020, 1377 patients with AMI were enrolled (79.1% males) from 16 Arabian countries. The mean age (± SD) was 58 ± 12 years. Almost half of the population had a net income ConclusionIn the MENA region, patients with AMI present at a young age and have a high burden of cardiac risk factors. Most of the patients in the registry have a low income and low educational status. There is heterogeneity among key performance indicators of AMI management among various Arabian countries.</div

Questionnaire-typeset39MIO.

BackgroundThe Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa (PEACE MENA) is a prospective registry program in Arabian countries that involves in patients with acute myocardial infarction (AMI) or acute heart failure (AHF).MethodsThis prospective, multi-center, multi-country study is the first report of the baseline characteristics and outcomes of inpatients with AMI who were enrolled during the first 14-month recruitment phase. We report the clinical characteristics, socioeconomic, educational levels, and management, in-hospital, one month and one-year outcomes.ResultsBetween April 2019 and June 2020, 1377 patients with AMI were enrolled (79.1% males) from 16 Arabian countries. The mean age (± SD) was 58 ± 12 years. Almost half of the population had a net income ConclusionIn the MENA region, patients with AMI present at a young age and have a high burden of cardiac risk factors. Most of the patients in the registry have a low income and low educational status. There is heterogeneity among key performance indicators of AMI management among various Arabian countries.</div