Can social safety nets alleviate seasonal deprivation ? evidence from northwest Bangladesh

This paper examines the role of social safety-net programs in Bangladesh run by the government and nongovernmental organizations to mitigate seasonal deprivation in the country's highly vulnerable northwest region. Specifically, the paper explores whether social safety nets are limited to averting seasonal deprivation or can also address seasonality of income and employment more generally. Using a recent survey from the greater Rangpur (northwest) region, the paper finds that social safety nets have a positive effect on mitigating both seasonal and non-seasonal food deprivation. The results are robust, owing to the recent expanded coverage of social safety-net programs run by nongovernmental organizations active in the region. But given the annual recurrence of monga (seasonal food insecurity) in the northwest region owing to agricultural seasonality and an overwhelming dependence on agriculture for livelihoods, social safety nets are not a reliable tool for monga eradication. Programs are also needed to promote the income and productivity of the poor through diversification of income and employment.Safety Nets and Transfers,Rural Poverty Reduction,Food&Beverage Industry,Regional Economic Development,Housing&Human Habitats

Contactless Dielectric Process Monitoring (CDPM) of Polymer Composites Manufacturing

A feasibility study has been performed systematically to develop a real-time contactless measurement of the dielectric properties (DP) of composite surface by means of a high-frequency, free-space vector network analyser (VNA) associated with one steel conical horn antenna (mono- static method). Examinations of the dielectric spectra of thermoset epoxy systems over a frequency range of 1kHz to 10GHz have show

Enhancement of Growth and Grain Yield of Rice in Nutrient Deficient Soils by Rice Probiotic Bacteria

Plant associated bacteria are promising alternatives to chemical fertilizers for plant growth and yield improvement in an eco-friendly manner. In this study, rice associated bacteria were isolated and assessed for mineral phosphate solubilizationand indole-3-acetic acid (IAA) production activity in vitro. Six promising strains, which were tentatively identified as phylotaxon Pseudochrobactrum sp. (BRRh-1), Burkholderia sp. (BRRh-2), Burkholderia sp. (BRRh-3), Burkholderia sp. (BRRh-4), Pseudomonas aeruginosa (BRRh-5 and BRRh-6) based on their 16S rRNA gene phylogeny, exhibited significant phosphate solubilizing activity in National Botanical Research Institute phosphate growth medium, and BRRh-4 displayed the highest phosphate solubilizing activity, followed by BRRh-5. The pH of the culture broth declined, resulting in increase of growth rate of bacteria at pH 7, which might be due to organic acid secretion by the strains. In presence of L-tryptophan, five isolates synthesized IAA and the maximum IAA was produced by BRRh-2, followed by BRRh-1. Application of two most efficient phosphate solubilizing isolates BRRh-4 and BRRh-5 by root dipping (colonization) of seedling and spraying at the flowering stage significantly enhanced the growth and grain yield of rice variety BRRI dhan-29. Interestingly, application of both strains with 50% of recommended nitrogen, phosphorus and potassium fertilizers produced equivalent or higher grain yield of rice compared to the control grown with full recommended fertilizer doses, which suggests that these strains may have the potential to be used as bioinoculants for sustainable rice production

Recent progress in biohydrometallurgy and microbial characterisation

Since the discovery of microbiological metal dissolution, numerous biohydrometallurgical approaches have been developed to use microbially assisted aqueous extractive metallurgy for the recovery of metals from ores, concentrates, and recycled or residual materials. Biohydrometallurgy has helped to alleviate the challenges related to continually declining ore grades by transforming uneconomic ore resources to reserves. Engineering techniques used for biohydrometallurgy span from above ground reactor, vat, pond, heap and dump leaching to underground in situ leaching. Traditionally biohydrometallurgy has been applied to the bioleaching of base metals and uranium from sulfides and biooxidation of sulfidic refractory gold ores and concentrates before cyanidation. More recently the interest in using bioleaching for oxide ore and waste processing, as well as extracting other commodities such as rare earth elements has been growing. Bioprospecting, adaptation, engineering and storing of microorganisms has increased the availability of suitable biocatalysts for biohydrometallurgical applications. Moreover, the advancement of microbial characterisation methods has increased the understanding of microbial communities and their capabilities in the processes. This paper reviews recent progress in biohydrometallurgy and microbial characterisatio

Integration of bow-tie plasmonic nano-antennas on tapered fibers

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPIn this article, a new and flexible approach to control the electric field enhancement of bow-tie nano-antennas by integrating them on the lateral of a tapered optical fiber is proposed. The device is driven by a Q-switched laser and the performance of a fabricated nano-antenna in a quartz slide is tested by a Surface Enhanced Raman Scattering (SERS) experiment. A refractive index sensing experiment is also performed and a sensitivity of (240 +/- 30) nm/RIU is found in the 1.33-1.35 index range.25889868996FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP2014/50632-6The Asian Office of Aerospace Research and Development (AOARD US Air Force FA2386-15-1-4084); Australian Research Council (ARC LP160100253); and Sao Paulo Research Foundation (FAPESP) (#2014/50632-6)

Zeolite synthesis from low-cost materials and environmental applications: A review

Zeolites with the three-dimensional structures occur naturally or can be synthesized in the laboratory. Zeolites have versatile applications such as environmental remediation, catalytic activity, biotechnological application, gas sensing and medicinal applications. Although, naturally occurring zeolites are readily available, nowadays, more emphasis is given on the synthesis of the zeolites due to their easy synthesis in the pure form, better ion exchange capabilities and uniform in size. Recently, much attention has also been paid on how zeolite is being synthesized from low-cost material (e.g., rice husk), particularly, by resolving the major environmental issues. Hence, the main purpose of this review is to make an effective resolution of zeolite synthesis methods together with potential applications in environmental engineering. Among different synthesis methods, hydrothermal method is commonly found to be used widely in the synthesis of various zeolites from inexpensive raw materials such as fly ash, rice husk ash, blast furnace slag, municipal solid waste, paper sludge, lithium slag and kaolin. Besides, future expectation in the field of synthetic zeolites research is also included

Status of Groundnut Research and Production in South Asia

South Asia, comprising Bangladesh, Bhutan, India, Myanmar, Nepal, Pakistan, and Sri Lanka, accounts for about 43.4% of the world groundnut (Arachis hypogaea) area (8.6 million ha) and 35.7% of production (8.1 million t). The period coinciding with the Southwest monsoon is the main growing season in the region although the crop is grown in more than one season in India, Myanmar, and Sri Lanka. The low average yields of groundnut in the region result from: raising the crop mostly under rainfed conditions on marginal and submarginal lands with low levels of inputs, use of varieties with long maturity periods, susceptibility of the crop to a plethora of insect pests and diseases, and nonavailability of efficient farm machinery and quality seed. All countries in the region made sustained efforts in the development of improved technology, including development of high-yielding varieties, improved agronomic practices, new and efficient strains of Bradyrhizobium, and efficient and economical plant protection schedules for the control of major insect pests and diseases. When tested in the farmers' fields, the technology indicated much unrealized yield poten- tial. The future crop improvement research in the region aims to concentrate on the areas of crop duration. fresh seed dormancy, resistance/tolerance to major biotic stresses, seed quality and production. and design and development of efficient farm implements and machinery. To realizefull impact of research on groundnut production in the region, it is important to ensure adequate support price and market to the crop. The International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) has contributed substantially towards the development of improved cultivars as well as offering training facilities to accomplish better human resource development in the region

Protein Kinase A Binds and Activates Heat Shock Factor 1

BACKGROUND. Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli. We have studied such regulation of Heat Shock Factor 1 (HSF1), a key protein in control of the heat shock response, and a participant in carcinogenisis, neurological health and aging. As the mechanisms involved in the intracellular regulation of HSF1 in good health and its dysregulation in disease are still incomplete we are investigating the role of posttranslational modifications in such regulation. METHODOLOGY/PRINCIPAL FINDINGS. In a proteomic study of HSF1 binding partners, we have discovered its association with the pleiotropic protein kinase A (PKA). HSF1 binds avidly to the catalytic subunit of PKA, (PKAca) and becomes phosphorylated on a novel serine phosphorylation site within its central regulatory domain (serine 320 or S320), both in vitro and in vivo. Intracellular PKAca levels and phosphorylation of HSF1 at S320 were both required for HSF1 to be localized to the nucleus, bind to response elements in the promoter of an HSF1 target gene (hsp70.1) and activate hsp70.1 after stress. Reduction in PKAca levels by small hairpin RNA led to HSF1 exclusion from the nucleus, its exodus from the hsp70.1 promoter and decreased hsp70.1 transcription. Likewise, null mutation of HSF1 at S320 by alanine substitution for serine led to an HSF1 species excluded from the nucleus and deficient in hsp70.1 activation. CONCLUSIONS. These findings of PKA regulation of HSF1 through S320 phosphorylation add to our knowledge of the signaling networks converging on this factor and may contribute to elucidating its complex roles in the stress response and understanding HSF1 dysregulation in disease.National Institutes of Health (2RO1CA047407, RO1CA077465

Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo

<p>Abstract</p> <p>Background</p> <p>Epigallocatechin-3-gallate (EGCG), one of the major catechins in green tea, is a potential chemopreventive agent for various cancers. The aim of this study was to examine the effect of EGCG on the expression of heat shock proteins (HSPs) and tumor suppression.</p> <p>Methods</p> <p>Cell colony formation was evaluated by a soft agar assay. Transcriptional activity of HSP70 and HSP90 was determined by luciferase reporter assay. An EGCG-HSPs complex was prepared using EGCG attached to the cyanogen bromide (CNBr)-activated Sepharose 4B. <it>In vivo </it>effect of EGCG on tumor growth was examined in a xenograft model.</p> <p>Results</p> <p>Treatment with EGCG decreased cell proliferation and colony formation of MCF-7 human breast cancer cells. EGCG specifically inhibited the expression of HSP70 and HSP90 by inhibiting the promoter activity of HSP70 and HSP90. Pretreatment with EGCG increased the stress sensitivity of MCF-7 cells upon heat shock (44°C for 1 h) or oxidative stress (H₂O₂, 500 μM for 24 h). Moreover, treatment with EGCG (10 mg/kg) in a xenograft model resulted in delayed tumor incidence and reduced tumor size, as well as the inhibition of HSP70 and HSP90 expression.</p> <p>Conclusions</p> <p>Overall, these findings demonstrate that HSP70 and HSP90 are potent molecular targets of EGCG and suggest EGCG as a drug candidate for the treatment of human cancer.</p