Photodynamic Stromal Depletion in Pancreatic Ductal Adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid malignancies, with a five-year survival of less than 10%. The resistance of the disease and the associated lack of therapeutic response is attributed primarily to its dense, fibrotic stroma, which acts as a barrier to drug perfusion and permits tumour survival and invasion. As clinical trials of chemotherapy (CT), radiotherapy (RT), and targeted agents have not been successful, improving the survival rate in unresectable PDAC remains an urgent clinical need. Photodynamic stromal depletion (PSD) is a recent approach that uses visible or near-infrared light to destroy the desmoplastic tissue. Preclinical evidence suggests this can resensitise tumour cells to subsequent therapies whilst averting the tumorigenic effects of tumour–stromal cell interactions. So far, the pre-clinical studies have suggested that PDT can successfully mediate the destruction of various stromal elements without increasing the aggressiveness of the tumour. However, the complexity of this interplay, including the combined tumour promoting and suppressing effects, poses unknowns for the clinical application of photodynamic stromal depletion in PDAC

Performance investigation of organic Rankine-vapor compression refrigeration integrated system activated by renewable energy

In this article, the performance and working fluid selection for an organic Rankine cycle-vapor compression refrigeration (ORC–VCR) integrated system activated by renewable energy is investigated. The performance of the system is described by the system coefficient of performance (COPS), and the refrigerant mass flow rate per kilowatt refrigeration capacity ( m˙total m ˙ total ). Twenty-three pure substances are proposed as working fluids for the integrated system. The basic integrated system performance is assessed and compared using the proposed working fluids. The basic VCR cycle works between 35 and 0 °C, while the basic ORC works between 35 and 100 °C. The impacts of different operating parameters such as the evaporator, the boiler, and the condenser temperatures on the ORC–VCR system performance are also examined. The results show that the cyclopentane accomplished the highest system performance under all investigated operating conditions. Accordingly, among the examined 23 working fluids, cyclopentane is the most appropriate working fluid for the integrated system from the viewpoints of environmental concerns and system performance. Nevertheless, due to its high flammability, further restrictions should be taken. The basic integrated system COPS, refrigeration effect, and the corresponding m˙total m ˙ total utilizing cyclopentane are 0.654, 361.3 kW, and 0.596 × 10−2 kg/(s kW), respectively