Effect of minor loop on magnetic characteristics of permanent magnet type of MRI

A modeling technique of the minor loop using typical hysteresis loops is shown. The effect of the minor loop and eddy current in the pole piece of a permanent magnet type of MRI on the residual flux density of the probe coil is examined. It is illustrated that the change &#916;B of residual flux density occurs due to the minor loop of the pole piece. It is also pointed out that the choice of time interval &#916;t is important in a nonlinear analysis considering the minor loop</p

Effects of residual magnetism due to minor loop on magnetic property of permanent magnet type of MRI

Summary form only given. The flux distribution of a permanent magnet type of MRI shown in Fig.1 is affected by the hysteresis (minor loop) and eddy currents in the pole piece and yoke due to the pulse current (Fig.2) of the gradient coil. In this paper, the effects of the hysteresis and the eddy current in the yoke on the residual flux density of the probe coil are investigated. It can be assumed that the eddy current does not flow in the pole piece because it is divided into pieces. The eddy current flows in the yoke. Fig.3 shows the change of residual flux density /spl Delta/B/sub z/ at the point S(0,0) in Fig.1. /spl Delta/B/sub z/ is given by /spl Delta/B/sub z/=B/sub z1/-B/sub z0/ (1), where B/sub z0/ is the flux density at the instant t=0(I=0A). B/sub z1/ is the flux density at the instant t=i(I=0A). The instant of 1,2,3,... in Fig.2 corresponds to 1,2,3,... in Fig.3. Fig.3 shows that the hysteresis in the pole piece and yoke should be taken into account. The effect of eddy current in the yoke on the residual flux density /spl Delta/B/sub z/ is not negligible. These results suggests that the reduction of the amplitudes of minor loop and eddy current is important in order to improve the operating characteristics of the permanent magnet type of MRI.</p

Analysis of the magnetic property of a permanent-magnet-type MRI - Behavior of residual magnetization

The minor loops of B and H of steel due to pulse excitation and eddy currents induced in steel affect the magnetic characteristics of a permanent-magnet-type MRI. In this paper, the magnetic properties of a permanent magnet assembly is examined by using the finite-element method taking into account minor loop. The distribution of residual magnetization in the yoke is illustrated, and the effect of residual magnetization on the behavior of residual flux density is examined. It is shown that the behavior of B and H in minor loops is affected by the eddy currents in the yoke and pole piece.</p

In vitro import of peroxisome-targeting signal type 2 (PTS2) receptor Pex7p into peroxisomes

AbstractPex7p, the peroxisome-targeting signal type 2 (PTS2) receptor, transports PTS2 proteins to peroxisomes from the cytosol. We here established a cell-free Pex7p translocation system. In assays using post-nuclear supernatant fractions each from wild-type CHO-K1 and pex7 ZPG207 cells, 35S-labeled Pex7p was imported into peroxisomes. 35S-Pex7p import was also evident using rat liver peroxisomes. 35S-Pex7p was not imported into peroxisomal remnants from a pex5 ZPG231 defective in PTS2 import and pex2 Z65. When the import of 35S-Pex5pL was inhibited with an excess amount of recombinant Pex5pS, 35S-Pex7p import was concomitantly abrogated, suggesting that Pex5pL was a transporter for Pex7p, unlike a yeast cochaperone, Pex18p. 35S-Pex7p as well as 35S-Pex5p was imported in an ATP-independent manner, whilst the import of PTS1 and PTS2 cargo-proteins was ATP-dependent. Thereby, ATP-independent import of Pex7p implicated that Pex5p export requiring ATP hydrolysis is not a limiting step for its cargo recruitment to peroxisomes. PTS1 protein import was indeed insensitive to N-ethylmaleimide, whereas Pex5p export was N-ethylmaleimide-sensitive. Taken together, the cargo-protein translocation through peroxisomal membrane more likely involves another ATP-requiring step in addition to the Pex5p export. Moreover, upon concurrent import into peroxisomes, 35S-Pex5pL and 35S-Pex7p were detected at mutually distinct ratios in the immunoprecipitates each of the import machinery peroxins including Pex14p, Pex13p, and Pex2p, hence suggesting that Pex7p as well as Pex5p translocated from the initial docking complex to RING complex on peroxisomes

Investigation of simulated annealing method and its application to optimal design of die mold for orientation of magnetic powder

Factors affecting the convergence characteristics and results obtained by the optimal design method using the finite element method and simulated annealing are investigated systematically, and the optimal parameters for simulated annealing method are obtained. The optimal shape of the die mold for orientation of the magnetic powder (nonlinear magnetostatic problem) is obtained using finite elements and simulated annealing. The experimental verification is also carried out </p

Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain

<p>Abstract</p> <p>Background</p> <p>Chotosan (CTS, <it>Diaoteng San</it>), a Kampo medicine (<it>ie </it>Chinese medicine) formula, is reportedly effective in the treatment of patients with cerebral ischemic insults. This study aims to evaluate the therapeutic potential of CTS in cognitive deficits and investigates the effects and molecular mechanism(s) of CTS on learning and memory deficits and emotional abnormality in an animal aging model, namely 20-week-old senescence-accelerated prone mice (SAMP8), with and without a transient ischemic insult (T2VO).</p> <p>Methods</p> <p>Age-matched senescence-resistant inbred strain mice (SAMR1) were used as control. SAMP8 received T2VO (T2VO-SAMP8) or sham operation (sham-SAMP8) at day 0. These SAMP8 groups were administered CTS (750 mg/kg, p.o.) or water daily for three weeks from day 3.</p> <p>Results</p> <p>Compared with the control group, both sham-SAMP8 and T2VO-SAMP8 groups exhibited cognitive deficits in the object discrimination and water maze tests and emotional abnormality in the elevated plus maze test. T2VO significantly exacerbated spatial cognitive deficits of SAMP8 elucidated by the water maze test. CTS administration ameliorated the cognitive deficits and emotional abnormality of sham- and T2VO-SAMP8 groups. Western blotting and immunohistochemical studies revealed a marked decrease in the levels of phosphorylated forms of neuroplasticity-related proteins, N-methyl-D-aspartate receptor 1 (NMDAR1), Ca²⁺/calmodulin-dependent protein kinase II (CaMKII), cyclic AMP responsive element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the frontal cortices of sham-SAMP8 and T2VO-SAMP8. Moreover, these animal groups showed significantly reduced levels of vasculogenesis/angiogenesis factors, vascular endothelial growth factor (VEGF), VEGF receptor type 2 (VEGFR2), platelet-derived growth factor-A (PDGF-A) and PDGF receptor α (PDGFRα). CTS treatment reversed the expression levels of these factors down-regulated in the brains of sham- and T2VO-SAMP8.</p> <p>Conclusion</p> <p>Recovery of impaired neuroplasticity system and VEGF/PDGF systems may play a role in the ameliorative effects of CTS on cognitive dysfunction caused by aging and ischemic insult.</p

Convenient Syntheses of 3-Deoxy-D-manno-2-octulosonic Acid (KDO) and 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN) Derivatives from D-Mannose

Horner-Wittig reactions of 4-O-benzyl-2,3:5,6-di-O-isopropylidene-D-mannose and 2,3,4,5,6,7-hexa-O-benzyl-6-D-glycero-2,3,4,5-D-galacto-heptose with methyl 2-benzyloxycarbonylamino-2-(diethoxyphosphoryl)acetate gave the corresponding α-dehydroamino acid derivatives in good yields, respectively. They were converted to methyl 3-deoxy-4,5:7,8-di-O-isopropylidene-α-D-manno-2-octulopyranosonate and methyl (methyl 3-deoxy-D-glycero-β-D-galacto-2-nonulopyranosid)onate via methyl α-oxoalkanoate derivatives

Retrograde Jejuno-Jejunal Intussusception after Total Gastrectomy

An eighty-year-old female was transferred to the hospital after experiencing abdominal pain and nausea. She had had a history of total gastrectomy for gastric cancer 14 years previously. Abdominal X-ray revealed a localized expansion of the small bowel. Computed tomography revealed a mass with a lamellar structure in a concentric circle. With a tentative diagnosis of small bowel obstruction due to intussusception, she underwent emergency operation. Laparotomy revealed a retrograde jejuno-jejunal intussusception. Bowel resection was performed due to the severe ischemic damage. All reported intussusception cases after total gastrectomy displayed retrograde characteristics and could occur both during the early and late period after surgery. It is important to consider the possibility of intussusception for patients presenting with acute abdomen who have previously undergone gastric resection

Experimental anemia induced by excess iron excretion.

The effect of desferrioxamine on several hematological parameters was studied in growing rats. Animals given desferrioxamine intramuscularly (150 mg/kg daily) had increased urinary iron after one week, and decreased hemoglobin after 2 weeks. The difference in hemoglobin concentration between the treated and control groups was significant after 4 weeks of treatment with desferrioxamine, but the difference in the numbers of erythrocytes was not significant. The anemia was of hypochromic type. Desferrioxamine at this dosage did not retard growth. These findings support our previously reported concept of &#34;iron-losing anemia&#34;