A Non-Scaling FFAG Gantry Design for the PAMELA Project

A gantry is re­quired for the PAMELA pro­ject using non-scal­ing Fixed Field Al­ter­nat­ing Gra­di­ent (NS-FFAG) mag­nets. The NS-FFAG prin­ci­ple of­fers the pos­si­bil­i­ty of a gantry much small­er, lighter and cheap­er than con­ven­tion­al de­signs, with the added abil­i­ty to ac­cept a wide range of fast chang­ing en­er­gies. This paper will build on pre­vi­ous work to in­ves­ti­gate a de­sign which could be used for the PAMELA pro­ject

On the vanishing viscosity limit in a disk

We say that the solution u to the Navier-Stokes equations converges to a solution v to the Euler equations in the vanishing viscosity limit if u converges to v in the energy norm uniformly over a finite time interval. Working specifically in the unit disk, we show that a necessary and sufficient condition for the vanishing viscosity limit to hold is the vanishing with the viscosity of the time-space average of the energy of u in a boundary layer of width proportional to the viscosity due to modes (eigenfunctions of the Stokes operator) whose frequencies in the radial or the tangential direction lie between L and M. Here, L must be of order less than 1/(viscosity) and M must be of order greater than 1/(viscosity)

Use of shallow samples to estimate the total carbon storage in pastoral soils

Using data from pastoral soils sampled by horizon at 56 locations across New Zealand, we conducted a meta-analysis. On average, the total depth sampled was 0.93 ± 0.026 m (± SEM), and on a volumetric basis, the total C storage averaged 26.9 ± 1.8, 13.9 ± 0.6 and 9.2 ± 1.4 kg C m⁻² for allophanic (n=12), non-allophanic (n=40) and pumice soils (n=4), respectively. We estimated the total C storage, and quantified the uncertainty, using the data for samples taken from the uppermost A-horizon whose depth averaged 0.1 ± 0.003 m. For A-horizon samples of the allophanic soils, the mean C content was 108 ± 6 g C kg⁻¹ and the bulk density was 772 ± 29 kg m⁻³, for non-allophanic soils they were 51 ± 4 g C kg⁻¹ and 1055 ± 29 kg m⁻³, and for pumice soils they were 68 ± 9 g C kg⁻¹ and 715 ± 45 kg m⁻³. The C density —a product of the C content and bulk density —of the A-horizon samples was proportional to their air-dried water content, a proxy measure for the mineral surface area. By linear regression with C density of the A-horizon, the total C storage could be estimated with a standard error of 3.1 kg C m⁻², 19% of the overall mean

On the flow map for 2D Euler equations with unbounded vorticity

In Part I, we construct a class of examples of initial velocities for which the unique solution to the Euler equations in the plane has an associated flow map that lies in no Holder space of positive exponent for any positive time. In Part II, we explore inverse problems that arise in attempting to construct an example of an initial velocity producing an arbitrarily poor modulus of continuity of the flow map.Comment: http://iopscience.iop.org/0951-7715/24/9/013/ for published versio

An FFAG Transport Line for the PAMELA Project

The PAMELA project to design an accelerator for hadron therapy using non-scaling Fixed Field Alternating Gradient (NS-FFAG) magnets requires a transport line and gantry to take the beam to the patient. The NS-FFAG principle offers the possibility of a gantry much smaller, lighter and cheaper than conventional designs, with the added ability to accept a wide range of fast changing energies. This paper will build on previous work to investigate a transport line which could be used for the PAMELA project. The design is presented along with a study and optimisation of its acceptance

Chemical spray pyrolysis of Tl-Ba-Ca-Cu-O high-T(sub c) superconductors for high-field bitter magnets

The deposition of Tl-Ba-Ca-Cu-O thick films by spray pyrolyzing a Ba-Ca-Cu-O precursor film and diffusing thallium into the film to form the superconducting phase is examined. This approach was taken to reduce exposure to thallium and its health and safety hazards. The Tl-Ba-Ca-Cu-O system was selected because it has very attractive features which make it appealing to device and manufacturing engineering. Tl-Ba-Ca-Cu-O will accommodate a number of superconducting phases. This attribute makes it very forgiving to stoichiometric fluctuations in the bulk and film. It has excellent thermal and chemical stability, and appears to be relatively insensitive to chemical impurities. Oxygen is tightly bound into the systems, consequently there is no orthorhombic (conductor) to tetragonal (insulator) transition which would affect a component's lifetime. More significantly, the thallium based superconductors appear to have harder magnetic properties than the other high-Tc oxide ceramics. Estimates using magnetoresistance measurements indicate that at 77 K Tl2Ba2CaCu2O10 will have an upper critical field, H(sub c2) fo 26 Tesla for applied fields parallel to the c-axis and approximately 1000 Tesla for fields oriented in the a-b plane. Results to date have shown that superconducting films can be reproducibly deposited on 100 oriented MgO substrates. One film had a zero resistance temperature of 111.5 K. Furthermore, x ray diffraction analysis of the films showed preferential c-axis orientation parallel to the plane of the substrate. These results have now made it possible to consider the manufacture of a superconducting tape wire which can be configured into a topology useful for high-field magnet designs. The research which leads to the preparation of these films and plans for further development are reviewed

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-kappaB Activation

BACKGROUND AND AIMS: Tumor necrosis factor (TNF) is a major pathogenic effector and a therapeutic target in inflammatory bowel disease (IBD), yet the basis for TNF-induced intestinal epithelial cell (IEC) death is unknown, because TNF does not kill normal IECs. Here, we investigated how chronic nuclear factor (NF)- kappaB activation, which occurs in human IBD, promotes TNF-dependent IEC death in mice. METHODS: Human IBD specimens were stained for p65 and cleaved caspase-3. C57BL/6 mice with constitutively active IKKbeta in IEC (Ikkbeta(EE)(IEC)), Ripk1(D138N/D138N) knockin mice, and Ripk3(-/-) mice were injected with TNF or lipopolysaccharide. Enteroids were also isolated from these mice and challenged with TNF with or without RIPK1 and RIPK3 inhibitors or butylated hydroxyanisole. Ripoptosome-mediated caspase-8 activation was assessed by immunoprecipitation. RESULTS: NF-kappaB activation in human IBD correlated with appearance of cleaved caspase-3. Congruently, unlike normal mouse IECs that are TNF-resistant, IECs in Ikkbeta(EE)(IEC) mice and enteroids were susceptible to TNF-dependent apoptosis, which depended on the protein kinase function of RIPK1. Constitutively active IKKbeta facilitated ripoptosome formation, a RIPK1 signaling complex that mediates caspase-8 activation by TNF. Butylated hydroxyanisole treatment and RIPK1 inhibitors attenuated TNF-induced and ripoptosome-mediated caspase-8 activation and IEC death in vitro and in vivo. CONCLUSIONS: Contrary to common expectations, chronic NF-kappaB activation induced intestinal crypt apoptosis after TNF stimulation, resulting in severe mucosal erosion. RIPK1 kinase inhibitors selectively inhibited TNF destructive properties while preserving its survival and proliferative properties, which do not require RIPK1 kinase activity. RIPK1 kinase inhibition could be a potential treatment for IBD

Wave energy transmission apparatus for high-temperature environments

A wave energy transmission apparatus has a conduit made from a refractory oxide. A transparent, refractory ceramic window is coupled to the conduit. Wave energy passing through the window enters the conduit

A comparison of spectroscopy and imaging techniques utilizing spectrally resolved diffusely reflected light for intraoperative margin assessment in breast-conserving surgery: a systematic review and meta-analysis

Up to 19% of patients require re-excision surgery due to positive margins in breast-conserving surgery (BCS). Intraoperative margin assessment tools (IMAs) that incorporate tissue optical measurements could help reduce re-excision rates. This review focuses on methods that use and assess spectrally resolved diffusely reflected light for breast cancer detection in the intraoperative setting. Following PROSPERO registration (CRD42022356216), an electronic search was performed. The modalities searched for were diffuse reflectance spectroscopy (DRS), multispectral imaging (MSI), hyperspectral imaging (HSI), and spatial frequency domain imaging (SFDI). The inclusion criteria encompassed studies of human in vivo or ex vivo breast tissues, which presented data on accuracy. The exclusion criteria were contrast use, frozen samples, and other imaging adjuncts. 19 studies were selected following PRISMA guidelines. Studies were divided into point-based (spectroscopy) or whole field-of-view (imaging) techniques. A fixed-or random-effects model analysis generated pooled sensitivity/specificity for the different modalities, following heterogeneity calculations using the Q statistic. Overall, imaging-based techniques had better pooled sensitivity/specificity (0.90 (CI 0.76-1.03)/0.92 (CI 0.78-1.06)) compared with probe-based techniques (0.84 (CI 0.78-0.89)/0.85 (CI 0.79-0.91)). The use of spectrally resolved diffusely reflected light is a rapid, non-contact technique that confers accuracy in discriminating between normal and malignant breast tissue, and it constitutes a potential IMA tool