1,973 research outputs found
One Loop Renormalization of the Littlest Higgs Model
In Little Higgs models a collective symmetry prevents the Higgs from
acquiring a quadratically divergent mass at one loop. This collective symmetry
is broken by weakly gauged interactions. Terms, like Yukawa couplings, that
display collective symmetry in the bare Lagrangian are generically renormalized
into a sum of terms that do not respect the collective symmetry except possibly
at one renormalization point where the couplings are related so that the
symmetry is restored. We study here the one loop renormalization of a
prototypical example, the Littlest Higgs Model. Some features of the
renormalization of this model are novel, unfamiliar form similar chiral
Lagrangian studies.Comment: 23 pages, 17 eps figure
Transcriptomics of Tasmanian devil (Sarcophilus harrisii) ear tissue reveals homogeneous gene expression patterns across a heterogeneous landscape
In an era of unprecedented global change, exploring patterns of gene expression among wild populations across their geographic range is crucial for characterizing adaptive potential. RNA-sequencing studies have successfully characterized gene expression differences among populations experiencing divergent environmental conditions in a wide variety of taxa. However, few of these studies have identified transcriptomic signatures to multivariate, environmental stimuli among populations in their natural environments. Herein, we aim to identify environmental and sex-driven patterns of gene expression in the Tasmanian devil (Sarcophilus harrisii), a critically endangered species that occupies a heterogeneous environment. We performed RNA-sequencing on ear tissue biopsies from adult male and female devils from three populations at the extremes of their geographic range. There were no transcriptome-wide patterns of differential gene expression that would be suggestive of significant, environmentally-driven transcriptomic responses. The general lack of transcriptome-wide variation in gene expression levels across the devil’s geographic range is consistent with previous studies that documented low levels of genetic variation in the species. However, genes previously implicated in local adaptation to abiotic environment in devils were enriched for differentially expressed genes. Additionally, three modules of co-expressed genes were significantly associated with either population of origin or sex
A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are unknown. Here we report that a long NAT (Mm-antiNos1 RNA) complementary to mRNA encoding the neuronal isoform of nitric oxide synthase (Nos1) is expressed in the mouse brain and is transcribed from the non-template strand of the Nos1 locus. Nos1 produces nitric oxide (NO), a major signaling molecule in the CNS implicated in many important functions including neuronal differentiation and memory formation. We show that the newly discovered NAT negatively regulates Nos1 gene expression. Moreover, our quantitative studies of the temporal expression profiles of Mm-antiNos1 RNA in the mouse brain during embryonic development and postnatal life indicate that it may be involved in the regulation of NO-dependent neurogenesis
Hospitalists in Teaching Hospitals: Opportunities but Not Without Danger
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73210/1/j.1525-1497.2004.42002.x.pd
Pedestrian, Crowd, and Evacuation Dynamics
This contribution describes efforts to model the behavior of individual
pedestrians and their interactions in crowds, which generate certain kinds of
self-organized patterns of motion. Moreover, this article focusses on the
dynamics of crowds in panic or evacuation situations, methods to optimize
building designs for egress, and factors potentially causing the breakdown of
orderly motion.Comment: This is a review paper. For related work see http://www.soms.ethz.c
Requirement of Male-Specific Dosage Compensation in Drosophila Females—Implications of Early X Chromosome Gene Expression
Dosage compensation equates between the sexes the gene dose of sex chromosomes that carry substantially different gene content. In Drosophila, the single male X chromosome is hypertranscribed by approximately two-fold to effect this correction. The key genes are male lethal and appear not to be required in females, or affect their viability. Here, we show these male lethals do in fact have a role in females, and they participate in the very process which will eventually shut down their function—female determination. We find the male dosage compensation complex is required for upregulating transcription of the sex determination master switch, Sex-lethal, an X-linked gene which is specifically activated in females in response to their two X chromosomes. The levels of some X-linked genes are also affected, and some of these genes are used in the process of counting the number of X chromosomes early in development. Our data suggest that before the female state is set, the ground state is male and female X chromosome expression is elevated. Females thus utilize the male dosage compensation process to amplify the signal which determines their fate
A Formalism for the Systematic Treatment of Rapidity Logarithms in Quantum Field Theory
Many observables in QCD rely upon the resummation of perturbation theory to
retain predictive power. Resummation follows after one factorizes the cross
section into the rele- vant modes. The class of observables which are sensitive
to soft recoil effects are particularly challenging to factorize and resum
since they involve rapidity logarithms. In this paper we will present a
formalism which allows one to factorize and resum the perturbative series for
such observables in a systematic fashion through the notion of a "rapidity
renormalization group". That is, a Collin-Soper like equation is realized as a
renormalization group equation, but has a more universal applicability to
observables beyond the traditional transverse momentum dependent parton
distribution functions (TMDPDFs) and the Sudakov form factor. This formalism
has the feature that it allows one to track the (non-standard) scheme
dependence which is inherent in any scenario where one performs a resummation
of rapidity divergences. We present a pedagogical introduction to the formalism
by applying it to the well-known massive Sudakov form factor. The formalism is
then used to study observables of current interest. A factorization theorem for
the transverse momentum distribution of Higgs production is presented along
with the result for the resummed cross section at NLL. Our formalism allows one
to define gauge invariant TMDPDFs which are independent of both the hard
scattering amplitude and the soft function, i.e. they are uni- versal. We
present details of the factorization and resummation of the jet broadening
cross section including a renormalization in pT space. We furthermore show how
to regulate and renormalize exclusive processes which are plagued by endpoint
singularities in such a way as to allow for a consistent resummation.Comment: Typos in Appendix C corrected, as well as a typo in eq. 5.6
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