Torus links T2s,2tT_{2s,2t} and (s,t)(s,t)-log VOA

We reveal an intimate connection between the torus link $T_{2s,2t}$ and the logarithmic $(s,t)$ VOA. We show that the singlet character of $(s,t)$-log VOA at the root of unity coincides with the Kashaev invariant and that it has a property of the quantum modularity. Also shown is that the tail of the $N$-colored Jones polynomial gives the character. Furthermore we propose a geometric method to compute the character.Comment: 15 pages, 7 figure

Development of an accurate kinetic model for the central carbon metabolism of Escherichia coli

Additional file 2. Comparison of our kinetic model with other existing models

気管支喘息の臨床分類とその細胞性および液性因子の特徴

Characteristics of each asthma type classified by clinical symptoms and　findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several　patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types.気管支喘息72例を対象に,その臨床病態の特徴を,気道炎症性の細胞および化学伝達物質の観察により検討した｡1.気道反応の特徴を換気機能の面から検討すると,II細気管支閉塞型において,MMF,V(50)やV(25)などの小ないし細気管支領域の換気障害を示すパラメーターの値は,Ia型,Ib型に比べ 有意の低下を示した｡2.気道細胞反応では,II型において,他の臨床病型に比べ,BAL液中好中球の出現頻度の有意の増加が観察された(Ia, p<0.001 ; Ib, p<0.01)｡好酸球の出現頻度は,Ib過分泌型において著しい増加傾向を示す症例が見られたが,その平均出現頻度には3病型間に有意の差は見られなかった｡3.好中球からのメジェー夕ー遊離では,ヒスタミン遊離は,Ia単純性気管支撃縮型において最も高い値が示されたが,推計学的には3病型間に有意の差は見られなかった｡ロイコトリエンC(4)では,Ia型においてII型に比べ有意に高い遊離が観察された(p<0.05)｡ロイコトリエンB(4)遊離には,3病型間に差は見られなかった

気管支喘息における気道の反応性および炎症反応におよぼす加齢の影響について

Ventilatory function, cellular composition in bronchoalveolar lavage (BAL) fluid and release of chemical mediators from leucocytes were examined in 25 older asthmatics (mean age 66.7 years) and 25 younger asthmatics (mean age 45.1 years) in relation to clinical asthma types. 1. Ventilatory function tests showed that the values of ventilatory parameters such as % MMF, % V(50) and % V(25) were lower in older subjects than in younger subjects, and a significant difference was found in the % V(50) value between the two age groups. Regarding clinical asthma types, the values of % MMF, % V(50), and V(25) were significantly lower in both younger and older subjects with type II. 2. In analysis of cellular composition in BAL fluid, the proportion of BAL lymphocytes was significantly lower in type II older subjects than in younger subjects with the same type. A significantly increased proportion of BAL neutrophils was observed in both younger and older subjects with type II. 3. The release of leukotriene C(4) (LTC(4)) from leucocytes was significantly lower in type II older subjects than in younger subjects with the same type, and LTC(4) release in patients with type II was also significantly lower than that in those with other asthma types in both younger and older subjects. The release of histamine and leukotriene B(4) (LTB(4)) from leucocytes was not significantly different between the two age groups. These results demonstrate that ventilatory function, cellular composition in BAL fluid, and the release of chemical mediators from leucocytes are affected by aging and clinical asthma types.25例の老年者気管支喘息と25例の若壮年者喘息症例を対象に,換気機能,気道内細胞成分の頻度,白血球からの化学伝達物質遊離などの気道反応と関連した要素について,喘息の臨床病型との関連のもとに検討を加えた｡ 1. % MMF, % V(50), % V(25)などの換気パラメーターは老年症例において全般的に低く, % V(50)では若壮年症例に比べ有意の低値を示した｡臨床病型別では,II型喘息において,両年齢群とも他の病型に比べ% MMF, % V(50)及び% V(25)値は有意に低い傾向が見られた｡ 2. 気管支肺胞洗浄(BAL)液中のリンパ球頻度は,II型の老年症例において若壮年症例に比べ有意に低い値を示した｡BAL液中好中球頻度は,いずれの年齢群においても,他の病型に比べ有意に高い値を示した｡ 3. 白血球からのLTC(4)遊離は,II型の老年症例において若壮年症例に比べ,また他の臨床病型に比べ有意に低い値を示した｡ヒスタミンおよびLTB(4)遊離には両年歯群間に有意の差は見られなかった｡これらの結果は,換気機能,気道内細胞成分の頻度,白血球からの化学伝達物質遊離などが,加齢や臨床病態により影響を受けることをある程度示しているものと考えられた

Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

Synthesis of IL-1β and TNFα by human monocytesmacrophages was significantly inhibited by eleven bisbenzylisoquinolines and one half-molecule (benzylisoquinoline), with IC50 values in the μM range. The results indicate that these compounds may have value in the therapy of human diseases where these inflammatory cytokines have a central role in pathogenesis

Nanoscale electronic structure of the layered nitride superconductors α-KxTiNCl and β-HfNCly observed by scanning tunneling microscopy and spectroscopy

Scanning tunneling microscopy and spectroscopy (STM-STS) measurements have been carried out on the α (FeOCl)–type KxTiNCl (x∼0.5, Tc=16 K) and β (SmSI)–type HfNCly (y∼0.7, Tc=24 K) layered nitride superconductors. The STM images at 5 K showed clear atomic arrangements for both the compounds, namely, the rectangular lattice on α-KxTiNCl and the triangular lattice on β-HfNCly. The tunneling spectra in the superconducting states at low temperatures demonstrate qualitatively different features between these superconductors. For α-KxTiNCl, the spatial distributions of the density of states and the superconducting gap structures are very inhomogeneous, while those on β-HfNCly are found to be almost homogeneous. The nanoscale electronic features between these compounds correlate with the different lattice structures of the M (=Ti or Hf) N conducting layers, which are caused by the lattice symmetry difference itself or induced by the difference in the local doping distributions in these chemically reactive compounds. The averaged gap magnitudes in the superconducting states, Δ̅ ≃10.2 meV and 7.5 meV for α-KxTiNCl and β-HfNCly, corresponding to the gap ratios 2Δ̅ /kBTc≃ 15 and 7.2, respectively, indicate the unusually strong coupling effects of the superconductivity

老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴

Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects.70才以上の老年者気管支喘息11例(平均年齢71.4才)を対象に,重症度と気道細胞反応との関連について検討を加えた｡なお,対照として50才以下の喘息症例11例(平均年齢33.5才)を選んだ｡1.老年者の軽症型喘息における気管支肺胞洗浄(BAL)液中の出現細胞の頻度は,マクロファージが86.2%,リンパ球が11.0%,好中球が1.9%,好酸球が0.9%,好塩基性細胞が0.08%であった｡BAL液中の好中球,好酸球の頻度は若青年症例でやや高い傾向が見られたが,両群間に有意の差は見られなかった｡重症例では,老年症例,若青年症例とも,軽症例に比べリンパ球,好中球,好酸球などのBAL細胞の出現頻度が増加しており,特に好酸球では若青年症例の重症例で軽症例に比べ有意に高い頻度が観察された｡これらの結果は, リンパ球,好中球,好酸球などのBAL細胞は,軽症例に比べ重症例で増加してくること,そして,その増加は老年症例では好中球,若青年症例では好酸球の増加が特徴的であることを示唆しているものと考えられた