Exclusion of BMP6 as a candidate gene for cleidocranial dysplasia

Cleidocranial dysplasia (CCD) is an autosomal dominant, generalized skeletal dysplasia in humans that has been mapped to the short arm of chromosome 6. We report linkage of a CCD mutation to 6p21 in a large family and exclude the bone morphogenetic protein 6 gene (BMP6) as a candidate for the disease by cytogenetic localization and genetic recombination. CCD was linked with a maximal two-point LOD score of 7.22 with marker D6S452 at θ = 0. One relative with a recombination between D6S451 and D6S459 and another individual with a recombination between D6S465 and CCD places the mutation within a 7 cM region between D6S451 and D6S465 at 6p21. A phage P1 genomic clone spanning most of the BMP6 gene hybridized to chromosome 6 in band region p23–p24 using FISH analysis, placing this gene cytogenetically more distal than the region of linkage for CCD. We derived a new polymorphic marker from this same P1 clone and found recombinations between the marker and CCD in this family. The results confirm the map position of CCD on 6p21, further refine the CCD genetic interval by identifying a recombination between D6S451 and D6S459, and exclude BMP6 as a candidate gene. Am. J. Med. Genet. 71:292–297, 1997. © 1997 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38269/1/9_ftp.pd

Moral Infringement and Repair in Antiquity : Supplement 1: Emotions and Hierarchies

Moral Infringement and Repair in Antiquity, is a series of publications related to a project on Dynamics of Moral Repair in Antiquity, run by Thomas Kazen and Rikard Roitto between 2017 and 2021, and funded by the Swedish Research Council, grant nr. 2016-02319. The volumes contain stand-alone articles and serve as supplements to the main outcome of the project, the volume Interpersonal Infringement and Moral Repair: Revenge, Compensation and Forgiveness in the Ancient World, forthcoming on Mohr Siebeck in 2023. Supplement 1: Emotions and Hierarchies, contains four articles and chapters by Thomas Kazen. Three of them are republished in accordance with the publishers' general conditions for author reuse. The fourth has not been published before. 1. Emotional Ethics in Biblical Texts: Cultural Construction and Biological Bases of Morality 2. Viewing Oneself through Others' Eyes: Shame between Biology and Culture in Biblical Texts 3. Law and Emotion in Moral Repair: Circumscribing Infringement4. Retribution and Repair in Voluntary Associations: Comparing Rule Texts from Qumran, Collegia, and Christ GroupsDynamics of Moral Repair in Antiquity 2017-202

Vida vidder : Om religionens rottrådar, andlighetens utgångspunkter och människans moral

Om religionens framväxt, utvecklingen av gudsföreställningar och andlighetens rötter. En evolutionär och psykobiologisk skiss med hjälp av kognitiv religionsvetenskap