Development of a Compact Wide-Field Telescope to be Mounted on VERTECS

In recent years, CubeSat projects have initiated plans to conduct astronomical observations by deploying mission payloads. CubeSats present a promising solution for swiftly addressing critical challenges in astrophysics with flexibility. Within Cubeats, where both the bus system and mission payload occupy about half of the volume, there is a necessity to miniaturize mission equipment. The critical factor in astronomical observations, light-gathering ability, is determined not only by the aperture size but, more importantly for diffuse emission, by the optical throughput, i.e., the product of the aperture area and the observing solid angle. Consequently, even with a compact optical system, specializing in wide-field observations enables achieving light-gathering ability equivalent to that of a large-diameter telescope. Therefore, we propose equipping CubeSats with small, wide-field telescopes specialized for observing essential quantities in understanding the cosmic history of star formation, such as extragalactic background Light (EBL), and foreground components like zodiacal light and diffuse galactic light. Radiation from first-generation celestial bodies, which is challenging to detect due to their darkness in the distant universe, is included in the EBL in the visible to near-infrared wavelengths. Hence, wide-field survey observations in the visible and near-infrared play a crucial role in unraveling when, where, and how the first-generation stars were born in the early universe. However, current technology has not enabled the development of CubeSats with mechanisms capable of cooling infrared detectors to temperatures below a few tens of Kelvin. Therefore, we have designed an optical system focusing on the visible EBL. In the astronomical W6U CubeSat mission VERTECS (Visible Extragalactic background RadiaTion Exploration by CubeSat), we are developing a 3U mission payload, comprised of 1U-sized lens optics, camera modules, and baffles each. The lens optical system achieves a high throughput ( \u3e 10-6 m2 sr) by covering the entire field of view with 6 degrees by 6 degrees and each pixel with a field of view of 11 arcseconds by 11 arcseconds. The camera module uses a CMOS sensor with high quantum efficiency in visible light, featuring sufficiently low dark current noise (approximately 0.01 electrons per second at 269 K) and readout noise (approximately 2.6 electrons at 24 dB analog gain), compared to the photocurrent generated by the EBL and foreground photon noise. The baffle is designed to attenuate stray light from the Sun and Earth to negligible levels compared to the EBL signal. Additionally, a set of color filters divides the wavelength range of 400 to 800 nm into four bands. In our observation strategy, we capture 60-second exposure images by shifting the field of view by 3 degrees and perform photometry on the stacked images in the four bands. VERTECS project was selected in JAXA-Small Satellite Rush Program in 2022 and is currently advancing in satellite development, with a scheduled launch in FY2025. Thus far, a significant portion of the mission payload design meets the required specifications, and progress is underway towards the fabrication of the engineering model. In this presentation, we will report on the progress of our optical telescope development, our strategy for visible EBL observations, and our future plans

VERTECS: 6U CubeSat Mission to Study Star-Formation History by Observation of Visible Extragalactic Background Light

We describe an astronomical 6U CubeSat mission VERTECS (Visible Extragalactic background RadiaTion Exploration by CubeSat). The scientific purpose of VERTECS is to reveal star-formation history of the universe by observation of the extragalactic background light (EBL) in visible wavelengths. Earlier observations by sounding rockets and infrared astronomical satellites have shown that the near-infrared EBL is several times brighter than the integrated light of known galaxies. As candidates for the excess light, first-generation stars in the early universe or low-redshift intra-halo light have been proposed, but it has not been concluded. Since these objects are expected to show different emission spectra in visible wavelengths, precise visible observation is important to reveal the origin of excess light. Since detection sensitivity of the EBL is determined by the product of telescope aperture and field of view, a small wide-field telescope system enables the EBL observation with high sensitivity. In VERTECS mission, we develop a 6U CubeSat equipped with a 3U size telescope optimized for observation of visible EBL. The telescope is composed of lens optics and a CMOS sensor of 3k times 3k array format, which is designed to observe the sky in four photometric bands in 400-800nm. The satellite bus is composed of on-board computer (OBC), electric power system (EPS), communication (COM), attitude determination and control system (ACDS), and thermal structure. Design of OBC and EPS is based on heritage of CubeSats developed at Kyushu Institute of Technology, but deployable solar array wings is added to EPS to supply sufficient power to the VERTECS subsystems. In COM system, S-band is used for command uplink and X-band is used for high-speed downlink of large-size images captured by the telescope. Since the EBL measurement need discrimination of the background light from discrete foreground stars, VERTECS requires 10 arcseconds pointing stability (1 sigma) over 1 minute exposure. In 2022, VERTECS was selected for JAXA-Small Satellite Rush Program (JAXA-SMASH Program), a new program that encourages universities, private companies and JAXA to collaborate to realize small satellite missions utilizing commercial small launch opportunities, and to diversify transportation services in Japan. We have been working on functionality and interface teast using Bread Board Model (BBM), and enviroonmental tests by using the satellite structure thermal model. Launch of the satellite is planned in FY2025. We aim at developing the satellite and obtaining scientific results much more quickly than recent large astronomical-satellite missions

Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

Cancer-associated fibroblasts (CAFs) play a significant role in tumor progression within the tumor microenvironment. Previously, we used near-infrared photoimmunotherapy (NIR-PIT), a next-generation cancer cell-targeted phototherapy, to establish CAF-targeted NIR-PIT. In this study, we investigated whether dual-targeted NIR-PIT, targeting cancer cells and CAFs, could be a therapeutic strategy. A total of 132 cases of esophageal cancer were analyzed for epidermal growth factor receptor (EGFR), human epidermal growth factor 2 (HER2), and fibroblast activation protein (FAP) expression using immunohistochemistry. Human esophageal cancer cells and CAFs were co-cultured and treated with single- or dual-targeted NIR-PIT in vitro. These cells were co-inoculated into BALB/c-nu/nu mice and the tumors were treated with single-targeted NIR-PIT or dual-targeted NIR-PIT in vivo. Survival analysis showed FAP- or EGFR-high patients had worse survival than patients with low expression of FAP or EGFR (log-rank, P < 0.001 and P = 0.074, respectively), while no difference was observed in HER2 status. In vitro, dual (EGFR/FAP)-targeted NIR-PIT induced specific therapeutic effects in cancer cells and CAFs along with suppressing tumor growth in vivo, whereas single-targeted NIR-PIT did not show any significance. Moreover, these experiments demonstrated that dual-targeted NIR-PIT could treat cancer cells and CAFs simultaneously with a single NIR light irradiation. We demonstrated the relationship between EGFR/FAP expression and prognosis of patients with esophageal cancer and the stronger therapeutic effect of dual-targeted NIR-PIT than single-targeted NIR-PIT in experimental models. Thus, dual-targeted NIR-PIT might be a promising therapeutic strategy for cancer treatment