Open Access/Open Research/Open Government: The Full Cycle of Access to Government Information

Stephanie Braunstein, Head Government Documents Librarian at Louisiana State University, and Maggie Kauffman, Senior Librarian and Housing Resource Coordinator at the California Department of Housing and Community Development, will describe the who, what, why, and how of current initiatives that promote the sharing of government-funded research--at both the federal and state levels. Emphasis will be placed on recent legislative efforts (such as the Fair Access to Science and Technology Research Act [FASTR]) and on the recommendations of various professional library organizations that support academic research (such as the Association of Research Libraries [ARL]). While much of the current discussion surrounding this issue takes place at the federal level, open access to information at the state level is vital in order to insure an educated and informed local population. After the informational portion of the presentation, the presenters will open up the floor for discussion with the intention of sharing a variety of perspectives on the government\u27s funding of research and how best to provide fair and equitable access to it

Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)

The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia

Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations