652 research outputs found
Light-induced instabilities in photo-oriented liquid crystal cells
In a planar liquid crystal sample sandwiched between a photosensitive and a
reference plate instabilities occurred, when the cell was illuminated from the
reference side. The instabilities were induced both by polarized white light
source and monochromatic laser beams. Static and dynamic regimes were found;
for laser irradiation dynamic instability was found only in a range of
polarization directions. A model, developed for monochromatic excitation,
predicts that at certain thicknesses dynamic instability is forbidden.
Experiments on a wedge-like cell confirmed this conclusion.Comment: to appear in Mol. Cryst. Liq. Crys
Temporal response to harmonic driving in electroconvection
The temporal evolution of the spatially periodic electroconvection (EC)
patterns has been studied within the period of the driving ac voltage by
monitoring the light intensity diffracted from the pattern. Measurements have
been carried out on a variety of nematic systems, including those with negative
dielectric and positive conductivity anisotropy, exhibiting "standard EC"
(s-EC), those with both anisotropies negative exhibiting "non-standard EC"
(ns-EC), as well as those with the two anisotropies positive. Theoretical
predictions have been confirmed for stationary s-EC and ns-EC patterns.
Transitions with Hopf bifurcation have also been studied. While traveling had
no effect on the temporal evolution of dielectric s-EC, traveling conductive
s-EC and ns-EC patterns exhibited a substantially altered temporal behavior
with a dependence on the Hopf frequency. It has also been shown that in
nematics with both anisotropies positive, the pattern develops and decays
within an interval much shorter than the period, even at relatively large
driving frequencies.Comment: 19 pages, 5 figure
A molecular basis of analgesic tolerance to cannabinoids
Clinical usage of cannabinoids in chronic pain states is limited by their central side effects and the pharmacodynamic tolerance that sets in after repeated dosage. Analgesic tolerance to cannabinoids in vivo could be caused by agonist-induced downregulation and intracellular trafficking of cannabinoid receptors, but little is known about the molecular mechanisms involved. We show here that the type 1 cannabinoid receptor (CB1) interacts physically with G-protein-associated sorting protein 1 (GASP1), a protein that sorts receptors in lysosomal compartments destined for degradation. CB1 - GASP1 interaction was observed to be required for agonist-induced downregulation of CB1 in spinal neurons ex vivo as well as in vivo. Importantly, uncoupling CB1 from GASP1 in mice in vivo abrogated tolerance toward cannabinoid-induced analgesia. These results suggest that GASP1 is a key regulator of the fate of CB1 after agonist exposure in the nervous system and critically determines analgesic tolerance to cannabinoids
The Current-Temperature Phase Diagram of Layered Superconductors
The behavior of clean layered superconductors in the presence of a finite
electric current and in zero-magnetic field behavior is addressed. The
structure of the current temperature phase diagram and the properties of each
of the four regions will be explained. We will discuss the expected current
voltage and resistance characteristics of each region as well as the effects of
finite size and weak disorder on the phase diagram. In addition, the reason for
which a weakly non-ohmic region exists above the transition temperature will be
explained.Comment: 8 pages (RevTeX), 4 encapsulated postscript figure
Persistent global power fluctuations near a dynamic transition in electroconvection
This is a study of the global fluctuations in power dissipation and light
transmission through a liquid crystal just above the onset of
electroconvection.
The source of the fluctuations is found to be the creation and annihilation
of defects. They are spatially uncorrelated and yet temporally correlated. The
temporal correlation is seen to persist for extremely long times. There seems
to be an especially close relation between defect creation/annihilat ion in
electroconvection and thermal plumes in Rayleigh-B\'enard convection
Association of chronic obstructive pulmonary disease with morbidity and mortality in patients with peripheral artery disease: insights from the EUCLID trial
Background: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of developing lower extremity peripheral artery disease (PAD) and suffering PAD-related morbidity and mortality. However, the effect and burden of COPD on patients with PAD is less well defined. This post hoc analysis from EUCLID aimed to analyze the risk of major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with PAD and concomitant COPD compared with those without COPD, and to describe the adverse events specific to patients with COPD. Methods: EUCLID randomized 13,885 patients with symptomatic PAD to monotherapy with either ticagrelor or clopidogrel for the prevention of MACE. In this analysis, MACE, MALE, mortality, and adverse events were compared between groups with and without COPD using unadjusted and adjusted Cox proportional hazards model. Results: Of the 13,883 patients with COPD status available at baseline, 11% (n=1538) had COPD. Patients with COPD had a higher risk of MACE (6.02 vs 4.29 events/100 patient-years; p< 0.001) due to a significantly higher risk of myocardial infarction (MI) (3.55 vs 1.85 events/100 patient-years; p< 0.001) when compared with patients without COPD. These risks persisted after adjustment (MACE: adjusted hazard ratio (aHR) 1.30, 95% confidence interval [CI] 1.11– 1.52; p< 0.001; MI: aHR 1.45, 95% CI 1.18– 1.77; p< 0.001). However, patients with COPD did not have an increased risk of MALE or major bleeding. Patients with COPD were more frequently hospitalized for dyspnea and pneumonia (2.66 vs 0.9 events/100 patient-years; aHR 2.77, 95% CI 2.12– 3.63; p< 0.001) and more frequently discontinued study drug prematurely (19.36 vs 12.54 events/100 patient-years; p< 0.001; aHR 1.34, 95% CI 1.22– 1.47; p< 0.001). Conclusion: In patients with comorbid PAD and COPD, the risks of MACE, respiratory-related adverse events, and premature study drug discontinuation were higher when compared with patients without COPD. Registration: ClinicalTrials.gov: NCT01732822
World psychiatric association section of old age psychiatry consensus statement on ethics and capacity in older people with mental disorders
The World Psychiatric Association (WPA) Section of Old Age Psychiatry, since 1997, has developed Consensus Statements relevant to the practice of Old Age Psychiatry. Since 2006 the Section has worked to develop a Consensus Statement on Ethics and Capacity in older people with mental disorders, which was completed in Prague, September 2008, prior to the World Congress in Psychiatry. This Consensus meets one of the goals of the WPA Action Plan 2008–2011, ”to promote the highest ethical standards in psychiatric practice and advocate the rights of persons with mental disorders in all regions of the world“. This Consensus Statement offers to mental health clinicians caring for older people with mental disorders, caregivers, other health professionals and the general public the setting out of and discourse in ethical principles which can often be complex and challenging, supported by practical guidance in meeting such ethical needs and standards, and to encouraged good clinical practice. Copyright © 2009 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64443/1/2279_ftp.pd
Communications Biophysics
Contains research objectives and reports on two research projects.National Institutes of Health (Grant 2 PO1 GM-14941-01)Joint Services Electronics Programs (U. S. Army, U.S. Navy, and U.S. Air Force) under Contract DA 28-043-AMC-02536(E)National Aeronautics and Space Administration (Grant NsG-496)National Institutes of Health (Grant 2 RO1 NB-05462-04)National Institutes of Health (Grant 1 TO1 GM-01555-01
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