Chorioamnionitis: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data

Chorioamnionitis is a term encompassing a broad spectrum of disease during pregnancy that is characterized by inflammation and/or infection of intrauterine structures such as the placenta, the chorion and amnion. The clinical presentation of chorioamnionitis can vary based on clinical, microbiologic, and histologic factors which interact and overlap to varying degrees

High Levels of Group-Specific Component (Vitamin-D-Binding Protein) in the Cerebrospinal Fluid of Infants Aged < 2 Months

Because of the possible involvement of group-specific component (Gc) or vitamin-D-binding protein in the immunological functions of mononuclear cells and the increased risk of central nervous system infections in early infancy, we studied Gc levels in the cerebrospinal fluid (CSF) of children. CSFs were examined for the Gc concentration using ELISA and rocket immunoelectrophoresis, with purified Gc as standard. The results showed a significant inverse correlation (p 2 months (1.7 μg/ml, p 2 months of age a significant correlation was found between Gc levels and those of other CSF proteins (albumin, IgG and total protein, p < 0.002). However, no significant correlation between Gc levels and those of other CSF proteins was apparent in infants < 2 months of age, indicating the possibility that the concentration of Gc in the CSF may be selectively increased in this age group