The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.

Excessive demands on the protein-folding capacity of the endoplasmic reticulum (ER) cause irremediable ER stress and contribute to cell loss in a number of cell degenerative diseases, including type 2 diabetes and neurodegeneration. The signals communicating catastrophic ER damage to the mitochondrial apoptotic machinery remain poorly understood. We used a biochemical approach to purify a cytosolic activity induced by ER stress that causes release of cytochrome c from isolated mitochondria. We discovered that the principal component of the purified pro-apoptotic activity is the proto-oncoprotein CRK (CT10-regulated kinase), an adaptor protein with no known catalytic activity. Crk(-/-) cells are strongly resistant to ER-stress-induced apoptosis. Moreover, CRK is cleaved in response to ER stress to generate an amino-terminal M(r)~14K fragment with greatly enhanced cytotoxic potential. We identified a putative BH3 (BCL2 homology 3) domain within this N-terminal CRK fragment, which sensitizes isolated mitochondria to cytochrome c release and when mutated significantly reduces the apoptotic activity of CRK in vivo. Together these results identify CRK as a pro-apoptotic protein that signals irremediable ER stress to the mitochondrial execution machinery

Inhibitory Control Efficiency In Successful Weight Loss Participants

Eating unhealthy foods and eating past satiety are inappropriate behaviors that promote obesity. The ability to effectively inhibit an inappropriate behavior is a key component of cognitive restraint and its impairment has been previously linked to obesity. In this study, a Go/No-Go fMRI task was completed by a cohort of adult women that had experienced initial weight loss followed by various levels of weight regain or continued weight loss. Region of interest fMRI analysis revealed that greater total weight loss was significantly related to decreasing activation in the right inferior frontal gyrus and the right superior frontal gyrus. These results suggest that as weight loss increases fewer cognitive resources are needed in order to maintain levels of inhibitory control. This cognitive efficiency, though only partially supported by better task performance, is supported by greater exercise. An analysis of resting state patterns of correlation between task-activated regions revealed a significant correlation between the right inferior frontal gyrus and the left middle temporal gyrus. The strength of this relationship was significantly correlated with increasing total weight loss and continued weight loss over time. Cognitive restraint was also associated with this fronto-temporal correlation and provides support for cognitive efficiency. Right inferior frontal gyrus was also correlated with left inferior frontal gyrus and this relationship was positively correlated with initial weight loss suggesting that fewer neurocognitive resources were required by those who were able to achieve greater initial weight loss

Street Crime in London: Deterrence, Disruption and Displacement

In early 2002 the Government implemented the Street Crime Initiative (SCI) in response to a rapid rise in street crime and growing public and media concern. The report examines the nature of street crime in the capital during 2001/02 and the early stages of the government initiative designed to tackle it. The study takes an innovative approach combining offence statistics, information gathered from interviews with offenders and those involved in the Street Crime Initiative (SCI) and crime mapping techniques to assess the impact of the SCI. It pays particular attention to how these offences can displace into other forms of crime or shift across time or place. It was precisely these issues which led the Government Office for London ultimately to commission this study in order to understand the nature of street crime across the London region

Formative Evaluation of Open Goals: A UK Community-Based Multi-Sport Family Programme

Community parks provide opportunities for physical activity (PA) and facilitate social interactions. This formative evaluation assesses the implementation of 'Open Goals' (OG), a novel multi-sport programme aiming to increase family PA and community cohesion, delivered weekly by Liverpool Football Club's charitable foundation to local parks in Liverpool, North West England. Three Open Goals parks were chosen for the evaluation settings. Formative evaluation measures included: System for Observing Play and Recreation in Communities (SOPARC) observations (n = 10), direct session observations (n = 8), semi-structured interviews with Open Goals coaching staff (n = 3), and informal feedback from families (n = 5) about their experiences of Open Goals. Descriptive statistics and thematic analysis were applied to quantitative and qualitative data, respectively. Within the three evaluation parks, Open Goals reached 107 participants from May-July 2019, through 423 session attendances. Fidelity of the programme was high (M = 69% of session content delivered as intended). Overall park use when OG was offered compared to when it was not offered was not statistically significant (p = 0.051), however, target area use was significantly increased (p = 0.001). Overall physical activity levels in parks were significantly (p = 0.002) higher when Open Goals was being offered, compared to when it was not. Coaches reported that engagement in OG positively affected family co-participation and children's behavioural development. Contextual issues included environmental and social barriers to programme engagement, including the co-participation element of the programme and criticism of the marketing of OG. It is evident that community-based multi-sport PA programmes endorsed by professional football clubs are well positioned to connect with local communities in deprived areas and to encourage PA and community engagement. This study suggests that such programmes may have the ability to improve park usage in specific areas, along with improving physical activity levels among families, although further research is required. Effective marketing strategies are needed for promotional purposes. Upskilling of coaches in the encouragement of family co-participation may support regular family engagement in PA in local parks

Street crime in London: deterrence, disruption and displacement

In early 2002 the Government implemented the Street Crime Initiative (SCI) in response to a rapid rise in street crime and growing public and media concern. The report examines the nature of street crime in the capital during 2001/02 and the early stages of the government initiative designed to tackle it. The study takes an innovative approach combining offence statistics, information gathered from interviews with offenders and those involved in the Street Crime Initiative (SCI) and crime mapping techniques to assess the impact of the SCI. It pays particular attention to how these offences can displace into other forms of crime or shift across time or place. It was precisely these issues which led the Government Office for London ultimately to commission this study in order to understand the nature of street crime across the London region

An international conversation on disabled children's childhoods: Theory, ethics and methods

This article brings together members of the International Advisory Committee for the Inclusive Early Childhood Service System (IECSS) project, a longitudinal study of interactions with institutional processes when families have a young child with disabilities. The article introduces international discourses on early childhood development (both individual and community) and raises questions about the ethics of these discourses in the context of historical and current global inequalities. We consider the exporting of professional discourses from the global north to the global south through directives from global institutions, and the imposition of medical thinking onto the lives of disabled children. We discuss theoretical positions and research methods that we believe may open up possibilities for change

Effectiveness of a community football programme on improving physiological markers of health in a hard-to-reach male population: the role of exercise intensity

© 2015 Taylor & Francis. The present study evaluated the effectiveness of participation in recreational football during a community health programme, on physiological markers of health within a hard to reach population. Nine men (Age: 33 ± 9 years, Mass: 75.4 ± 13.7 kg, Height: 1.74 ± 0.07 m and Body Fat: 19 ± 2%) were recruited to participate in the study in collaboration with an English Premier League Football Club. Participants completed the 12-week football-based programme which included two coached football sessions each week. Physiological tests for blood pressure, resting heart rate, cholesterol and an anthropometrical test for body composition were completed at three time points during the study (Weeks – 1, 6 and 12) in an attempt to evaluate the impact of the intervention on health. During each training session, measurements of intensity (%HRmax, identified from the yoyo intermittent level 1 test), duration and rating of perceived exertion were made. The 12-week programme (mean HRmax throughout programme = 75 ± 4% beats min−1; mean RPE throughout programme = 6 ± 1) elicited few changes in physiological markers of health with the only significant change been a decrease in resting heart rate from weeks 6 to 12 (87 ± 22 beats min−1 at week-6, to 72 ± 17 beats min−1; p < 0.05). These data would suggest that the current community football-related health project was not effective in improving physiological markers of health, but was able to maintain their level of health. A lack of improvement may be due to the low intensity of sessions and a lack of coach education for the promotion of sessions that aim to improve health

Perspectives from those involved in healthy stadia

Healthy stadia is a growing agenda across industry and in turn academia. In this era of growth, much of the research literature is primarily sourced from academics with little contribution from applied and industry stakeholders. As such, the editors have sought to offer practitioners a platform to share novel projects, perspectives and preliminary intervention evaluation findings. This applied article intends to share evaluation and insight from applied practice, to encourage closer debate between the academic community and applied industry