Quantifying Herbage Mass, Composition and Feed Value of Grass Land as Influenced by Altitude in Western Highlands of Ethiopia

Assement on the status of florisic composition, Biomass and Nutritive value of grass land was conducted in highland and mid altitude areas of Horro and Guduru districts with the objectives of assessing the present status of grazing lands interms of quality and quantity. The study was conducted during the last week of September to the first week October 2014 when much of herbs starts to flower. A total of 25 herbs were identified from grazing lands of the study area, of these 17 grass species (5 annuals and 12 perennial ), 3 legume species, 2 sedges and 4 weeds species were identified in both agro ecologies except one grass (Eleusine africana) which was only observed in mid altitude area. Most of grass species were prennials. The herbage yield of grass lands of highland was 2.52 ton per hectare while, that of mid highland was 2.73 t/ha and these were not significantly different (P>0.05). The compositions of grasses, legumes and weed and or sedges were 69.6, 28.7 and 2.18 percent respectively for highland while in mid highland it was 73.6, 25.6 and 0.8 percent respectively. The ash content of mid altitude composite herbs (16.9±0.02) was significantly higher (P<0.001) than that of highland samples (9.21±0.1).  There were no significant differences in crude protein (CP) content herbs harvested between the two agro ecologies.The neutral detergent fiber (NDF) content of mid altitude herb (61.7±.09) was significantly higher (P<0.001) than (54.8±0.07) percent reported for highland and  Adltitude. The in vitro dry matter digestibility (IVDMD) and metabolisable energy (ME) content of harvested highland herbs were significantly higher (P<0.01) than that of mid altitude while there were no significant difference in digestible crude protein (DCP) of herbs between the two agro ecologies.The dry matter digestibilities (DDM) of highland herbs were significantly higher than the mid altitude herbs. Similarily estimated dry matter intake (DMI) and relative feed value (RFV) of samples of herbs of highland were significantly higher (P<0.001) than that of mid altitude. The nutritive value of herbage harvested at flowering stage in the present study agro ecology generally indicate well in supplying basic nutritional requierement of livestock but, the low potential yield of the grass lands should be the area of intervention in both highland and mid altitude. Keywords: Annuals, Herbage yield, Nutrient composition, Prenial

Correlation studies and path coefficient analysis for seed yield and yield components in Ethiopian coriander accessions

Coriander (Coriandrum sativum L.) is an annual spice herb that belongs to the family Umbelliferae. Even though Ethiopia is a centre of primary diversity for the crop, the current knowledge about its biology, variety development and agronomy is neither complete nor conclusive under Ethiopian conditions. To contribute to filling some of the existing gaps, a field experiment was conducted during the main rainy season of 2007-2008 at Wondo Genet and Kokate, southern Ethiopia. Data for 15 agronomic and quality traits were measured and statistically tested. Moreof the traits were found having high correlation coefficients at genotypic level than the phenotypic level, demonstrating intrinsic associations among the traits. Seeds plant-1 and thousand seeds weight were associatedsignificantly and positively with seed yield plant-1 at phenotypic and genotypic levels. Essential oil and fatty oil contents were negatively associated with most of the trait studied. Path analysis revealed that days to end 50% flowering, longest basal leaf length, plant height, days to 50% maturity and seeds umbellet-1 exerted positive direct effect on seed yield plant-1, indicating that selection using these traits would be effective in improving seed yield in coriander.Key Words: Coriandrum sativum, essential oil, Ethiopia, fatty oi

Evaluating surgical skills from kinematic data using convolutional neural networks

The need for automatic surgical skills assessment is increasing, especially because manual feedback from senior surgeons observing junior surgeons is prone to subjectivity and time consuming. Thus, automating surgical skills evaluation is a very important step towards improving surgical practice. In this paper, we designed a Convolutional Neural Network (CNN) to evaluate surgeon skills by extracting patterns in the surgeon motions performed in robotic surgery. The proposed method is validated on the JIGSAWS dataset and achieved very competitive results with 100% accuracy on the suturing and needle passing tasks. While we leveraged from the CNNs efficiency, we also managed to mitigate its black-box effect using class activation map. This feature allows our method to automatically highlight which parts of the surgical task influenced the skill prediction and can be used to explain the classification and to provide personalized feedback to the trainee.Comment: Accepted at MICCAI 201

Towards interoperability of entity-based and event-based IoT platforms: The case of NGSI and EPCIS standards

With the advancement of IoT devices and thanks to the unprecedented visibility and transparency they provide, diverse IoT-based applications are being developed. With the proliferation of IoT, both the amount and type of data items captured have increased dramatically. The data generated by IoT devices reside in different organizations and systems, and a major barrier to utilizing the data is the lack of interoperability among the standards used to capture the data. To reduce this barrier, two major standards have emerged: the Global Standards One (GS1) Electronic Product Code Information Service (EPCIS) and the FIWARE Next Generation Services Interface (NGSI). However, the two standards differ not only in the data encoding but also in the underlying philosophy of representing IoT data; namely, EPCIS is event-based, and NGSI is entity-based. Interoperability between FIWARE and EPCIS is essential for system integration. This paper presents OLIOT Mediation Gateway, now one of the incubated generic enablers offered by the FIWARE Foundation, that realizes the required interoperability between NGSI and EPCIS systems. It also demonstrates the applicability and feasibility of the Gateway by applying it to a real-life case study of integrating transparency systems used in a meat supply chain

Study design and rationale for the Olpasiran trials of Cardiovascular Events And lipoproteiN(a) reduction-DOSE finding study (OCEAN(a)-DOSE).

BACKGROUND Data support lipoprotein(a) (Lp[Lp(a)]) being a risk factor for atherosclerotic cardiovascular disease (ASCVD). Olpasiran is a small interfering RNA molecule that markedly reduces Lp(a) production in hepatocytes. STUDY DESIGN The Olpasiran trials of Cardiovascular Events And lipoproteiN(a) reduction-DOSE finding study is a multicenter, randomized, double-blind, placebo-controlled dose-finding study in 281 subjects with established ASCVD and Lp(a) > 150 nmol/L. Patients were randomly allocated to one of 4 active subcutaneous doses of olpasiran (10 mg q12 weeks, 75 mg q12 weeks, 225 mg q 12 weeks, or 225 mg q24 weeks) or matched placebo. The primary objective is to evaluate the effects of olpasiran dosed every 12 weeks compared with placebo on the percent change in Lp(a) from baseline at 36 weeks. Enrollment is now complete and follow-up is ongoing. CONCLUSIONS OCEAN(a)-DOSE trial is assessing the Lp(a)-lowering efficacy and safety of olpasiran. These data will be used to determine optimal dosing and design for a cardiovascular outcomes trial

Integrated Modelling Frameworks for Environmental Assessment and Decision Support

As argued in Chapter 1, modern management of environmental resources defines problems from a holistic and integrated perspective, thereby imposing strong requirements on Environmental Decision Support Systems (EDSSs) and Integrated Assessment Tools (IATs). These systems and tools tend to be increasingly complex in terms of software architecture and computational power in order to cope with the type of problems they must solve. For instance, the discipline of Integrated Assessment (IA) needs tools that arc able to span a wide range of disciplines, from socio-economics to ecology to hydrology. Such tools must support a wide range of methodologies and techniques like agent-based modeling, Bayesian decision networks, optimization, multicriteria analyses and visualization tools, to name a few

Non-communicable diseases in Ethiopia: policy and strategy gaps in the reduction of behavioral risk factors

Introduction: Non-communicable diseases (NCDs) are the leading cause of death worldwide. Over 80% of NCD deaths occur in developing countries. Four modifiable behaviors, namely tobacco use, consumption of unhealthy diet, physical inactivity, and the harmful use of alcohol, contribute to 80% of the NCD burden. Studies show that the vast majority of NCDs can be prevented through behavioral risk-reduction interventions. Properly executed, the interventions could lead to a decrease in the burden of NCDs, ranging from a 30% drop in the prevalence of cancer to a 75% reduction in cardiovascular diseases. This study examined the policy and strategy gaps in the reduction of the modifiable NCD behavioral risk factors in Ethiopia to inform and guide policy-makers and other stakeholders. Methodology: This study used a data triangulation methodology with a sequential, explanatory, mixed-method design conducted in two stages. The authors carried out quantitative analysis on the prevalence and distribution of behavioral risk factors from the Ethiopia NCD STEPwise approach to surveillance (STEPS) survey. Qualitative data on national policies and strategies complemented the analysis of the progress made so far and the existing gaps. Results and Discussion: Ethiopia has made substantial progress in responding to the NCD epidemic by developing a health sector NCD strategic action plan, generating evidence, and setting time-bound national targets on NCD behavioral risk factors. Activities mainly aimed at reducing tobacco use, such as implementation of the ratified WHO Framework Convention on Tobacco Control (FCTC), using evidence of the Global Adult Tobacco Survey (GATS), and the articulation of legislative measures are ongoing. On this paper our analysis reveals policy and strategy gaps, status in law enforcement, social mobilization, and awareness creation to reduce the major behavioral risk factors. Conclusions: NCDs share common risk factors and risk reduction strategies creates an opportunity for an effective response. However, the national response still needs more effort to have a sufficient impact on the prevention of NCDs in Ethiopia. Thus, there is an urgent need for the country to develop and implement targeted strategies for each behavioral risk factor and design functional, multisectoral coordination. There is also a need for establishing sustainable financial mechanisms, such as increasing program budgets and levying ‘sin taxes,’ to support the NCD prevention and control program. Ethiop. J. Health Dev. 2019; 33(4):259-268] Key words: NCDs, behavioral risk factors, policy, strategy, multisectoral coordination, Ethiopi

Raltegravir Cerebrospinal Fluid Concentrations in HIV-1 Infection

Raltegravir is an HIV-1 integrase inhibitor currently used in treatment-experienced HIV-1-infected patients resistant to other drug classes. In order to assess its central nervous system penetration, we measured raltegravir concentrations in cerebrospinal fluid (CSF) and plasma in subjects receiving antiretroviral treatment regimens containing this drug.Raltegravir concentrations were determined by liquid chromatography tandem mass spectrometry in 25 paired CSF and plasma samples from 16 HIV-1-infected individuals. The lower limit of quantitation was 2.0 ng/ml for CSF and 10 ng/ml for plasma.Twenty-four of the 25 CSF samples had detectable raltegravir concentrations with a median raltegravir concentration of 18.4 ng/ml (range, <2.0-126.0). The median plasma raltegravir concentration was 448 ng/ml (range, 37-5180). CSF raltegravir concentrations correlated with CSF:plasma albumin ratios and CSF albumin concentrations.Approximately 50% of the CSF specimens exceeded the IC(95) levels reported to inhibit HIV-1 strains without resistance to integrase inhibitors. In addition to contributing to control of systemic HIV-1 infection, raltegravir achieves local inhibitory concentrations in CSF in most, but not all, patients. Blood-brain and blood-CSF barriers likely restrict drug entry, while enhanced permeability of these barriers enhances drug entry

Floods and health in Gambella region, Ethiopia: a qualitative assessment of the strengths and weaknesses of coping mechanisms

BACKGROUND: Floods are the most frequent and devastating type of natural disaster worldwide, causing unprecedented deaths, diseases, and destruction of property and crops. Flooding has a greater impact in developing countries due to lack of sufficient disaster management structures and a lack of economic resources. OBJECTIVE: This study was conducted with the aim of contributing to the knowledge base of development strategies that reduce flood-related health risks in developing countries. The study focused particularly on assessing the flood risks and health-related issues in the Gambella region of Ethiopia; with the intent of producing relevant information to assist with the improvements in the efficacy of the current flood coping strategies in the region. METHODS: Data were gathered through interviews with 14 officers from different government and non-governmental organizations and a questionnaire survey given to 35 flood victims in Itang woreda. A qualitative approach was applied and the data were analyzed using content analysis. RESULTS: It was found that flooding is a common problem in Gambella region. The findings also indicate that the flood frequency and magnitude has increased rapidly during the last decade. The increase in floods was driven mainly by climate change and changes in land use, specifically deforestation. The reported main impacts of flooding on human health in Gambella region were deaths, injuries, and diseases such as malaria and diarrhea. Another notable consequence of flooding was crop destruction and subsequent malnutrition. CONCLUSIONS: Three weaknesses that were identified in the current coping strategies for flood-related health impacts in Gambella region were a lack of flood-specific policy, absence of risk assessment, and weak institutional capacity. This study recommends new policy approaches that will increase the effectiveness of the current flood coping strategies to sustainably address the impact of flooding on human health