Radio-induced low-grade glioma: report of two cases and review of the literature

With the increasing number of cancer survivors, we can observe a population that will present a higher risk of developing secondary long-term toxicities related to adjuvant chemo and radiotherapy regimens. Among these, children surviving from acute lymphoblastic leukemia (ALL) that were treated with prophylactic cranial irradiation represent a group of patients at a high risk of developing secondary brain tumors. Radiation-induced intracranial tumors have been documented since 1950, and today, more than one-hundred cases have been described. We report our experience with two young patients who were hospitalized for low grade gliomas and had a positive anamnesis for ALL and consequent radiotherapy

Metabolism of no-carrier-added 2-[18F]fluoro-L-tyrosine in rats

Background: Several fluorine-18 labelled fluoroamino acids have been evaluated as tracers for the quantitative assessment of cerebral protein synthesis in vivo by positron emission tomography (PET). Among these, 2-[18F]fluoro-L-tyrosine (2-[18F]Tyr) has been studied in mice at a low specific activity. Its incorporation into proteins is fast and metabolism via other pathways is limited. The present in vivo study was carried out in normal awake rats using no-carrier-added 2-[18F]Tyr. Under normal physiological conditions, we have studied the incorporation into proteins and the metabolism of the tracer in different brain areas. Methods: No-carrier-added 2-[18F]Tyr was administered to awake rats equipped with chronic arterial and venous catheters. The time course of the plasma activity was studied by arterial blood sampling. The biodistribution of the activity in the main organs was studied at the end of the experiment. The distribution of radioactive species in plasma and brain regions was studied by acidic precipitation of the proteins and HPLC analysis of the supernatant. Results: The absolute uptake of radioactivity in brain regions was homogenous. In awake rats, nocarrier-added 2-[18F]Tyr exhibits a fast and almost quantitative incorporation into the proteins fractions of cerebellum and cortex. In striatum, this incorporation into proteins and the unchanged fraction of the tracer detected by HPLC could be lower than in other brain regions. Conclusion: This study confirms the potential of 2-[18F]fluoro-L-tyrosine as a tracer for the assessment of the rate of protein synthesis by positron emission tomography. The observed metabolism suggests a need for a correction for the appearance of metabolites, at least in plasma

In vivo incorporation of labelled methionine into proteins in brain tumors

Capítulo en: B.M. Mazoyer; W.D: Heiss; D. Comar (eds.). PET Studies on Amino Acid Metabolism and Protein Synthesis : Proceedings of a Workshop held in Lyon, France, within the framework of the European Community Medical and Public Health Research. Dordrecht: Springer, 1993, p.265-268. (Developments in Nuclear Medicine ; 23). ISBN 978-94-010-4706-7. ISBN 978-94-011-1620-6. DOI 10.1007/978-94-011-1620-6_22The incorporation of L-(14C-methyl) methionine into proteins was studied in two subjects presenting brain glioma. Comparing to normal brain tissue, an increased methionine metabolic activity was found in the tumors, with most of the tissue radioactivity incorporated into proteinsPeer Reviewe

Combined functional neuroimaging (fMRI and MEG) for the guidance of epidural motor cortex stimulation in chronic refractory neuropathic pain: a pilot study.

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