Роль полиморфизма С677Т гена MTHFR в развитии осложненного течения ИБС и гипертонической болезни у пациентов с дислипидемиями

The present study was designed to determine the possibility of the application the genotyping of the patients with dislipidaemia as an additional factor for the prediction of the cardiovascular complications. The distribution of the polymorphism C677T of the gene MTHFR among the 62 patients with dislipidaemia was studied. Allele-specific PCR was applied for detection the C677T mutation/ These results provide the genetic evidence that 677T allele of the gene MTHFR correlates with the development of the complications of the coronary heart disease for the patients with dislipidaemia (p = 0,01). It was demonstrated that more complex and durable antihypertension and cardiotropic therapy must be applicated for the carries of the 677T allele among the dislipidaemia patients. These data indicate the appreciable role C677T polymorphism of MTHFR for the decreasing of the cardiovascular complications among the patients with dislipidaemia and for detection the complexity and longevity of the medical treatments.Работа проводилась с целью оценки прогностической значимости полиморфизма С677Т гена метилентетрагидрофолатредуктазы (MTHFR) в развитии осложненного течения ИБС и гипертонической болезни у пациентов с дислипидемиями. Для выявления мутации С677Т использовали аллель-специфические ПЦР. Была выявлена корреляционная зависимость между носительством мутантного аллеля 677Т и частой развития ИБС в исследуемой группе больных (р = 0,01). Для пациентов с дислипидемиями не выявлено значимой корреляции между носительством мутантного аллеля 677Т гена MTHFR и частотой возникновения и интенсивностью развития гипертонической болезни (р = 0,8). Полученные результаты имеют существенное значение для снижения риска осложненного и нестабильного течения сердечно-сосудистых заболеваний у пациентов с дислипидемиями, а также для выбора объема и продолжительности проводимой терапии и целесообразности применения гиполипидемических средств

Arterial hypertension and coronary heart diseases development in patients with dyslipoproteinemia against polymorphisms of gp iiia genes and prothrombin gene

The cause of a genetic predisposition to a variety of diseases, including coronary atherosclerosis and coronary heart disease is the presence of defective integrin receptors on the cell surfaces, as well as thrombophilia associated also with prothrombin gene mutations. This paper deals with the study of frequency of alleles of one of the integrins, GPIIIa glycoprotein (β- type III subunit), and prothrombin gene in patients with dyslipidemia. We have established that the presence of allele PLA2 of GPIIIa gene and allele G20210A of prothrombin gene in the genotype of a patient is a genetic risk factor for intensive development of coronary heart disease and hypertension in patients with dyslipidemia, which is associated with a higher incidence of complications and the need for carrying out more comprehensive antihypertensive therapy to stabilize blood pressure

Arterial hypertension and coronary heart diseases development in patients with dyslipoproteinemia against polymorphisms of gp iiia genes and prothrombin gene

The cause of a genetic predisposition to a variety of diseases, including coronary atherosclerosis and coronary heart disease is the presence of defective integrin receptors on the cell surfaces, as well as thrombophilia associated also with prothrombin gene mutations. This paper deals with the study of frequency of alleles of one of the integrins, GPIIIa glycoprotein (β- type III subunit), and prothrombin gene in patients with dyslipidemia. We have established that the presence of allele PLA2 of GPIIIa gene and allele G20210A of prothrombin gene in the genotype of a patient is a genetic risk factor for intensive development of coronary heart disease and hypertension in patients with dyslipidemia, which is associated with a higher incidence of complications and the need for carrying out more comprehensive antihypertensive therapy to stabilize blood pressure