Radio Broadcasting Experience and Development Prospects (European Scientific Dialogue)

The paper presents an analysis of various opinions concerning radio-industry development issues, given new IT processes implemented in mass media. The authors study the technological evolution of radio broadcasting in terms of analyzing its main development stages. They provide an assessment of listeners’ high confidence in radio broadcasts as compared to other mass media sources. Focus is placed on promoting sonic brands in the sphere of media-communication. The researchers also pay special attention to podcasting as a new way to listen to audio-content. The advantages and possible consequences of podcasting influence on radio-industry are assessed. The research is based on the expert discussion on radio broadcasting issues which took place at “Radiodays Europe 2019”

Convergência organizacional como a tendência do desenvolvimento moderno de mídia de mass

Convergence is а key problem of modern mass media development. It mediates changes in content policy, media products distribution, and economic activity of media. Organizational convergence is one of the types of this phenomenon. It acts to make structural changes both in the media market and within a certain media. The purpose of such changes is to expand the influence of the media on the media market, to reduce the cost of its maintenance and development, and to expand social audience by transmedia distributing of the content. The article is devoted to the problems of understanding the phenomenon of organizational convergence as one of the types of convergence in the modern media environment. It also studies the main ways of building new forms of media organization.La convergencia es un problema clave del desarrollo moderno de los medios de comunicación. Medita los cambios en la política de contenido, la distribución de productos de medios y la actividad económica de los medios. La convergencia organizacional es uno de los tipos de este fenómeno. Actúa para realizar cambios estructurales tanto en el mercado de medios como dentro de ciertos medios. El objetivo de tales cambios es ampliar la influencia de los medios en el mercado de los medios, reducir el costo de su mantenimiento y desarrollo, y expandir la audiencia social mediante la distribución transmedia del contenido. El artículo está dedicado a los problemas de comprensión del fenómeno de la convergencia organizacional como uno de los tipos de convergencia en el entorno de los medios modernos. También estudia las principales maneras de construir nuevas formas de organización de los medios.A convergência é um problema fundamental no desenvolvimento moderno da mídia. Considere as mudanças na política de conteúdo, a distribuição de produtos de mídia e a atividade econômica da mídia. A convergência organizacional é um dos tipos desse fenômeno. Atua para fazer mudanças estruturais tanto no mercado de mídia quanto em certas mídias. O objetivo de tais mudanças é expandir a influência da mídia no mercado de mídia, reduzir o custo de manutenção e desenvolvimento e expandir o público social através da distribuição transmídia de conteúdo. O artigo é dedicado aos problemas de entender o fenômeno da convergência organizacional como um dos tipos de convergência no ambiente da mídia moderna. Também estuda as principais formas de construir novas formas de organização de mídia

Electrospun Produced 3D Matrices for Covering of Vascular Stents:Paclitaxel Release Depending on Fiber Structure and Composition of the External Environment

Paclitaxel is a natural, highly lipophilic anti proliferative drug widely used in medicine. We have studied the release of tritium-labeled paclitaxel (3H-PTX) from matrices destined for the coating of vascular stents and produced by the electrospinning method from the solutions of polycaprolactone (PCL) with paclitaxel (PTX) in hexafluoisopropanol (HFIP) and/or solutions of PCL with PTX and human serum albumin (HSA) in HFIP or HIFP-dimethyl sulphoxide (DMSO) blend. The release of PTX has been shown to depend on the composition of electrospinning solution, as well as the surrounding medium, particularly the concentration of free PTX and PTX-binding biomolecules present in human serum. It was shown that 3D matrices can completely release PTX without weight loss. Two-phase PTX release from optimized 3D matrices was obtained: ~27% of PTX was released in the first day, another 8% were released over the next 26 days. Wherein ~2.8%, ~2.3%, and ~0.25% of PTX was released on day 3, 9, and 27, respectively. Considering PTX toxicity, the rate of its diffusion through the arterial wall, and the data obtained the minimum cytostatic dose of the drug in the arterial wall will be maintained for at least three months. © 2018 by the authors

Сучасні тренди підготовки фахівців з управління проектами та програмами

У збірнику матеріалів конференції висвітлено роботи фіналістів Усеукраїнського конкурсу студентських наукових робіт 2018–2019 навчального року з «Управління проектами та програмами» й сучасні тренди підготовки фахівців з управління проектами та програмами, які були обговорені на науково-практичній конференції в м. Луцьку 5 квітня 2019 р. Збірник розрахований на широке коло фахівців з управління проектами та програмами, спеціалістів, що працюють у структурних підрозділах органів державної влади й управління, економістів, викладачів, аспірантів, здобувачів і студентів, а також усіх, хто цікавиться сучасними трендами підготовки фахівців з управління проектами та програмами

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

ACTUAL MENTAL STATE OF STUDENTS IN PROCESS OF PHYSICAL EDUCATION CLASSES

The transformation of the education system is taking place in modern Russia. There is a transition to a flexible learning system, adapted to the educational needs of every person with any age, cultural, linguistic affiliation. Practical training disciplines are becoming increasingly important. Academic disciplines that form universal competencies are transferred to online learning. Physical Education is such disciplines. All theoretical training is translated online, and the share of classes in the gym is minimized. The purpose of this pilot study is to identify the actual mental state of students in the gym in the conditions of using game and competitive methods. In addition, an important task is to compare the well-being, activity and mood of students studying physical education in the gym and online. An adapted version of the Dembo-Rubinstein technique was used to diagnose such indicators of the current mental state as well-being, activity and mood. The dynamics of these indicators in the conditions of employment in the gym using game and competitive methods was studied using a formative experiment. It was established that real classes in the gym have a positive effect on the actual mental state of students. Most students have improved health, mood, and increased activity. At the same time, classes using the game method, in contrast to classes using the competitive method, are much more effective for activating students and improving their mood. Comparison of indicators of the actual mental state of students in real classes in the gym and online showed that classes in the gym are able to more effectively influence the mood and activity of students.