Combining to innovate: A collaborative interprofessional learning approach to delivering Tobacco Use Prevention and Cessation (TUPAC) education for undergraduate oral health students

This paper provides a description of a pilot project in Tobacco Use Prevention and Cessation (TUPAC) in response to a national and international trend to include TUPAC curriculum components in the clinical education of undergraduate oral health students. In order to deliver quality brief intervention strategies for smokers a need to adequately prepare oral health students was identified during student clinical placements. An interprofessional (IP) project team was established with membership from the University of Adelaide’s School of Dentistry, QuitSA, Cancer Council SA, the South Australian Dental Service (SADS) Somerton Park and TAFESA’s Faculty of Dental Studies to streamline the efficient use of resources and most importantly draw on a diverse range of interprofessional health care expertise. On the website for The UK Centre for the Advancement of Interprofessional Education (CAIPE) (2002) it states that “Interprofessional education occurs when two or more professions learn from and about each other to improve collaboration and the quality of care”. Through interprofessional learning (IPL) in classroom and clinical settings, second year Bachelor and Advanced Diploma oral health students were provided with the opportunity to develop an understanding of the respective roles of each health professional responsible for delivering positive health initiatives in the area of TUPAC. With limited national oral health curricula in the area of TUPAC, the project team forged links with the University of Manitoba’s Dental Hygiene Program, and the convenor of the TUPAC in Dental and Dental Hygiene Undergraduate Education European Workshops for curriculum benchmarking against evidence based criteria. Most importantly as the IP concept of health care considers the patient at the centre of the health care team, assessment was designed to encourage a patient centred approach through the review and analysis of a clinical case study. A formal evaluation of this project is currently in progress, however results were not yet available at the time of publication

Phi-values in protein folding kinetics have energetic and structural components

Phi-values are experimental measures of how the kinetics of protein folding is changed by single-site mutations. Phi-values measure energetic quantities, but are often interpreted in terms of the structures of the transition state ensemble. Here we describe a simple analytical model of the folding kinetics in terms of the formation of protein substructures. The model shows that Phi-values have both structural and energetic components. In addition, it provides a natural and general interpretation of "nonclassical" Phi-values (i.e., less than zero, or greater than one). The model reproduces the Phi-values for 20 single-residue mutations in the alpha-helix of the protein CI2, including several nonclassical Phi-values, in good agreement with experiments.Comment: 15 pages, 3 figures, 1 tabl

Blinded Outcome Assessment Was Infrequently Used and Poorly Reported in Open Trials

Objective Unblinded outcome assessment can lead to biased estimates of treatment effect in randomised trials. We reviewed published trials to assess how often blinded assessment is used, and whether its use varies according to the type of outcome or assessor. Design and setting A review of parallel group, individually randomised phase III trials published in four general medical journals (BMJ, Journal of the American Medical Association, The Lancet, and New England Journal of Medicine) in 2010. Main outcome measures Whether assessment of the primary outcome was blinded, and whether this differed according to outcome or assessor type. Results We identified 258 eligible trials. Of these, 106 (41%) were reported as double-blind, and 152 (59%) as partially or fully open-label (that is, they included some groups who were unblinded, such as patients, those delivering the intervention, or those in charge of medical care). Of the 152 open trials, 125 required outcome assessment. Of these 125 trials, only 26% stated that outcome assessment was blinded; 51% gave no information on whether assessment was blinded or not. Furthermore, 18% of trials did not state who performed the assessment. The choice of outcome type (e.g. instrument measured, rated, or naturally occurring event) did not appear to influence whether blinded assessment was performed (range 24-32% for the most common outcome types). However, the choice of outcome assessor did influence blinding; independent assessors were blinded much more frequently (71%) than participant (5%) or physician (24%) assessors. Despite this, open trials did not use independent assessors any more frequently than double-blind trials (17% vs. 18% respectively). Conclusions Blinding of outcome assessors is infrequently used and poorly reported. Increased use of independent assessors could increase the frequency of blinded assessment

Squaring the Circle Between Freedom of Expression and Platform Law

Among the greatest emerging challenges to global efforts to promote and protect human rights is the role of private sector entities in their actualization, since international human rights rules were designed to apply primarily, and in many cases solely, to the actions of governments. This paradigm is particularly evident in the expressive space, where private sector platforms play an enormously influential role in determining the boundaries of acceptable speech online, with none of the traditional guardrails governing how and when speech should be restricted. Many governments now view platform-imposed rules as a neat way of sidestepping legal limits on their own exercise of power, pressuring private sector entities to crack down on content which they would be constitutionally precluded from targeting directly. For their part, the platforms have grown increasingly uncomfortable with the level of responsibility they now wield, and in recent years have sought to modernize and improve their moderation frameworks in line with the growing global pressure they face. At the heart of these discussions are debates around how traditional human rights concepts like freedom of expression might be adapted to the context of “platform law.” This Article presents a preliminary framework for applying foundational freedom of expression standards to the context of private sector platforms, and models how the three-part test, which lies at the core of understandings of freedom of expression as a human right, could be applied to platforms’ moderation functions

The New Cybersquatters: The Evolution of Trademark Enforcement in the Domain Name Space

The domain name space has become a particularly contentious area of trademark enforcement as a result of the growth of online commerce, an intense competition for popular domain names, and new conceptual challenges stemming from the borderless and textual nature of the medium. In response, the Internet Corporation for Assigned Names and Numbers (“ICANN”), a global non-profit which oversees the domain-name space, has implemented a highly sophisticated set of rights-protection mechanisms. This Article examines the scope of trademark protections applied under ICANN’s rights protection mechanisms to demonstrate that they have evolved far beyond their traditional consumer protection function; indeed, they have morphed into offensive brand management tools, whose application in the global domain name space vastly exceeds the protections that are available under domestic legal frameworks. The Article begins by introducing ICANN and its main trademark protection instruments, namely the Uniform Dispute Resolution Policy, the Uniform Rapid Suspension, and the Trademark Clearinghouse, before demonstrating the divergence between protections under these systems and the protections under domestic legal frameworks. The result is that trademark owners turn to ICANN for rights and remedies that would not be available from ordinary sovereigns, embodying a major expansion of trademark protections. The Article concludes by outlining the contours of ongoing discussions re-examining these mechanisms, and the challenges in curbing this maximalist view of trademark law

Subverting Democracy to Save Democracy: Canada’s Extra-Constitutional Approaches to Battling “Fake News”

Nearly a decade after the first Twitter and Facebook revolutions, the early narratives pointing to social media as a great agent of democratization1 have given way to a more nuanced understanding of the impact of the Internet on our political discourse. While there is no question that Internet access provides tremendous expressive benefits, scholars are increasingly questioning whether this information diet is ultimately healthy for society. An analogy to sugars, fats and salts has emerged, where just as an appetite for rich foods served our species well when resources were scarce, but have become a liability in an age of plenty, our natural curiosity and hunger for new ideas has led to problems in an online world teeming with misinformation and extremism. The potential for mischief was illustrated in stark terms in 2016, when well documented campaigns of foreign interference, including social media manipulation, impacted both the Brexit referendum and the United States presidential race. In response to these, and other high profile cases of the Internet being used as a vector to distribute manipulative content, many countries around the world are re-examining their approach to regulating online speech, as well as their specific posture on electrion speech. However, while there is no question that the Internet has created a raft of new regulatory challenges, it is important not to lose sight of the foundational importance of freedom of expression to an effective democracy. Solutions which attempt to address the challenges posed by online speech, but which do this by undermining core freedom of expression principles, are ultimately destined to be counter-productive. Any victory against forces that threaten our democracy will be hollow if it comes at the cost of the human rights principles which undergird our democratic system

Understanding the Internet as a Human Right

Around the world, fundamental human rights have undergone a dramatic conceptual shift as a result of the spread of the Internet. The right to freedom of expression, once largely limited to printing, has exploded in a digital world that provides users with an unprecedented megaphone to broadcast their views. The right to political participation and the right to free assembly have similarly been reborn in an age of instant communication, allowing activists to mobilise hundreds of thousands of followers with a single email, text or tweet. Although these are the most notable examples, the Internet has also had a transformative impact on several other recognised human rights, including the right to education, to healthcare and to work. The Internet’s role in the enabling and delivery of human rights has led some to claim that access to the Internet itself should be considered a human right, an idea that has deep implications for both international law and domestic legal frameworks. If, indeed, access to the Internet is a human right, it adds an additional dimension to regulatory issues, since overly restrictive laws that compromise access or damage the vitality or utility of the Internet become more than just bad policy. In some cases, they may constitute violations of international human rights standards. This Paper discusses the Internet’s recognition as a human right and the implications that spring from this recognition in domestic and international law

Emergence of Minor Populations of Human Immunodeficiency Virus Type 1 Carrying the M184V and L90M Mutations in Subjects Undergoing Structured Treatment Interruptions

The use of structured treatment interruption (STI) in human immunodeficiency virus (HIV)-infected subjects is currently being studied as an alternative therapeutic strategy for HIV-1. The potential risk for selection of drug-resistant HIV-1 variants during STI is unknown and remains a concern. Therefore, the emergence of drug resistance in sequential plasma samples obtained from 28 subjects with chronic HIV infection was studied. They underwent 4 cycles of 2-week STI, followed by 8-week retreatment with highly active antiretroviral therapy identical to that used before STI, and they had never failed treatment before undergoing STI. At week 40, treatment was stopped for a longer period. Minor populations of drug-resistant variants were detected by quantitative real-time polymerase chain reaction, by use of allele-discriminating oligonucleotides for 2 key resistance mutations: L90M (protease) and M184V (reverse transcriptase). The approximate discriminative power was 0.1%. In 14 of 25 and in 3 of 25 subjects, the M184V and the L90M mutations, respectively, were detected as minor populations, at different times during STI. Overall, these results indicate that, in subjects undergoing multiple STIs, HIV-1 variants carrying drug-resistance mutations can emerge during periods of increased HIV-1 replicatio

Improving transparency and scientific rigor in academic publishing.

Progress in basic and clinical research is slowed when researchers fail to provide a complete and accurate report of how a study was designed, executed, and the results analyzed. Publishing rigorous scientific research involves a full description of the methods, materials, procedures, and outcomes. Investigators may fail to provide a complete description of how their study was designed and executed because they may not know how to accurately report the information or the mechanisms are not in place to facilitate transparent reporting. Here, we provide an overview of how authors can write manuscripts in a transparent and thorough manner. We introduce a set of reporting criteria that can be used for publishing, including recommendations on reporting the experimental design and statistical approaches. We also discuss how to accurately visualize the results and provide recommendations for peer reviewers to enhance rigor and transparency. Incorporating transparency practices into research manuscripts will significantly improve the reproducibility of the results by independent laboratories

Computational Design of Affinity and Specificity at Protein-Protein Interfaces

The computer-based design of protein-protein interactions is a rigorous test of our understanding of molecular recognition and an attractive approach for creating novel tools for cell and molecular research. Considerable attention has been placed on redesigning the affinity and specificity of naturally occurring interactions. Several studies have shown that reducing the desolvation costs for binding while preserving shape complimentarity and hydrogen bonding is an effective strategy for improving binding affinities. In favorable cases specificity has been designed by focusing only on interactions with the target protein, while in cases with closely related off-target proteins, it has been necessary to explicitly disfavor unwanted binding partners. The rational design of protein-protein interactions from scratch is still an unsolved problem, but recent developments in flexible backbone design and energy functions hold promise for the future