Characterizing Transgender Health Issues in Twitter

Although there are millions of transgender people in the world, a lack of information exists about their health issues. This issue has consequences for the medical field, which only has a nascent understanding of how to identify and meet this population's health-related needs. Social media sites like Twitter provide new opportunities for transgender people to overcome these barriers by sharing their personal health experiences. Our research employs a computational framework to collect tweets from self-identified transgender users, detect those that are health-related, and identify their information needs. This framework is significant because it provides a macro-scale perspective on an issue that lacks investigation at national or demographic levels. Our findings identified 54 distinct health-related topics that we grouped into 7 broader categories. Further, we found both linguistic and topical differences in the health-related information shared by transgender men (TM) as com-pared to transgender women (TW). These findings can help inform medical and policy-based strategies for health interventions within transgender communities. Also, our proposed approach can inform the development of computational strategies to identify the health-related information needs of other marginalized populations

Модель выживаемости опухолевых клеток после фотодинамической терапии

Photodynamic therapy (PDT) is known as a routine treatment method in which cell survival index like viability plotted versus 1O2 concentration or light fluence in the form of a curve. In this paper, a mathematical model was proposed with ability of generating a mirrored-sigmoid curve which seems to be fitted to any experimental data relating to cell viability, survival probability or any cellular index representing living conditions through adjusting three parameters. It was validated by showing an excellent curve fitting relatively with data obtained from cancerous lung cells under ALA-PDT process in vitro. It was tried to define the relations between model’s parameters and biological/clinical factors with the curve regions of plateau (at low doses; non- sensitive part), steep (high-sensitive part), and steady state (at high doses; low-sensitive part). It seems this model could be excellently fitted to any data presenting the cell-living index versus the killer agent in «any cancer therapy technique (e.g. radiotherapy)». Although this claim showed to be correct for PDT, different relevant data of other researchers should also be used for this model and other usual models too, in order to compare their fitness rates.При проведении фотодинамической терапии (ФДТ) индекс выживаемости (жизнеспособность) клеток в зависимости от концентрации 1O2 или плотности мощности облучения на графике представляет собой кривую. В этой статье была предложена математическая модель с возможностью построения зеркально-сигмовидной кривой, которая, по мнению авторов, может быть использована для любых экспериментальных данных, касающихся жизнеспособности клеток или вероятности выживания, путем настройки трех параметров. Это было подтверждено демонстрацией совпадения кривой с данными, полученными в эксперименте in vitro для ФДТ с 5-аминолевулиновой кислотой клеток рака легкого.Была предпринята попытка определить взаимосвязь между параметрами биологической модели и формой участков кривой. При низких дозах наблюдали на кривой участок плато (нечувствительная часть), при средних дозах – участок крутого подъема (высокочувствительная часть) и при высоких дозах – стационарное состояние (низкочувствительная часть). Авторы считают, что предложенная ими модель может быть применена к описанию любых данных, представляющих собой показатель выживаемости клеток, в зависимости от дозы воздействия при любом методе лечения рака (например, при лучевой терапии). Хотя это утверждение оказалось верным для ФДТ, представляется перспективной оценка пригодности предложенной модели для других данных

The effect of 12 weeks regular physical activity and vitamin E in the treatment of non-alcoholic steatohepatitis: A pilot study

Background: Despite the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), there was no treatment has been proven to be effective in these common diseases. Although many studies have shown that lifestyle modifications such as increasing physical activities and exercise could be effective in the treatment of these common diseases, the optimal strategy was still not determined. According to the beneficial effects of antioxidant agents in the treatment of NASH, vitamin E has been used for this purpose by some clinicians. We designed this study for assessing beneficial effects of regular physical activity on the biochemical and imaging responses in patients with NASH and comparing this with vitamin E as an accepted treatment for NASH. Materials and Methods: This study was Randomized and single-blind clinical trials were carried out in Gonbad-e Kavus through which a total of 30 consecutive patients with the ultra sonographic diagnosis of non-alcoholic steatohepatitis (NASH)were enrolled and randomized to one of the three groups: Vitamin E 800 mg/day, regular physical activity, or both. Results: In all treatment groups improvement in liver transaminases level, serum lipids and ultrasonographic grading of fatty liver occurred after three months of treatment. When these decrement was compared between the treatment groups, there was no statistically significant difference in the value of improvement between the three groups (ANOVA: p>0.5). I.e. all three interventions improved the biochemical and ultrasonographic finding of fatty liver in the same way. Both groups with regular exercise had significant mean weight loss in comparison with the vitamin E group (a mean decrease of 3.0 kg in exercise group, 5.8 kg in subjects on regular exercise plus vitamin E and 0.2 kg in vitamin E group, ANOVA: p=0.04). Conclusion: There were no significant differences between exercise and vitamin E alone or in combination regarding the reduction in the level of liver enzymes and sonographic evidences of fatty liver although both resulted in significant improvements in biochemical endpoints. This implies that physical activity could be considered as effective as vitamin E in the improvement of biochemical and ultrasonographic presentations of NASH and the addition of Vitamin E does not offer any benefits. According to the findings of this pilot study a full-powered study with a control group should be designed. © 2015, Iranian Association of Gastroenterology and Hepatology. All rights reserved

The effect of 12 weeks regular physical activity and vitamin E in the treatment of non-alcoholic steatohepatitis: A pilot study

Background: Despite the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), there was no treatment has been proven to be effective in these common diseases. Although many studies have shown that lifestyle modifications such as increasing physical activities and exercise could be effective in the treatment of these common diseases, the optimal strategy was still not determined. According to the beneficial effects of antioxidant agents in the treatment of NASH, vitamin E has been used for this purpose by some clinicians. We designed this study for assessing beneficial effects of regular physical activity on the biochemical and imaging responses in patients with NASH and comparing this with vitamin E as an accepted treatment for NASH. Materials and Methods: This study was Randomized and single-blind clinical trials were carried out in Gonbad-e Kavus through which a total of 30 consecutive patients with the ultra sonographic diagnosis of non-alcoholic steatohepatitis (NASH)were enrolled and randomized to one of the three groups: Vitamin E 800 mg/day, regular physical activity, or both. Results: In all treatment groups improvement in liver transaminases level, serum lipids and ultrasonographic grading of fatty liver occurred after three months of treatment. When these decrement was compared between the treatment groups, there was no statistically significant difference in the value of improvement between the three groups (ANOVA: p>0.5). I.e. all three interventions improved the biochemical and ultrasonographic finding of fatty liver in the same way. Both groups with regular exercise had significant mean weight loss in comparison with the vitamin E group (a mean decrease of 3.0 kg in exercise group, 5.8 kg in subjects on regular exercise plus vitamin E and 0.2 kg in vitamin E group, ANOVA: p=0.04). Conclusion: There were no significant differences between exercise and vitamin E alone or in combination regarding the reduction in the level of liver enzymes and sonographic evidences of fatty liver although both resulted in significant improvements in biochemical endpoints. This implies that physical activity could be considered as effective as vitamin E in the improvement of biochemical and ultrasonographic presentations of NASH and the addition of Vitamin E does not offer any benefits. According to the findings of this pilot study a full-powered study with a control group should be designed. © 2015, Iranian Association of Gastroenterology and Hepatology. All rights reserved

Interacting viscous ghost tachyon, K-essence and dilaton scalar field models of dark energy

We study the correspondence between the interacting viscous ghost dark energy model with the tachyon, K-essence and dilaton scalar field models in the framework of Einstein gravity. We consider a spatially non-flat FRW universe filled with interacting viscous ghost dark energy and dark matter. We reconstruct both the dynamics and potential of these scalar field models according to the evolutionary behavior of the interacting viscous ghost dark energy model, which can describe the accelerated expansion of the universe. Our numerical results show that the interaction and viscosity have opposite effects on the evolutionary properties of the ghost scalar filed models.Comment: 16 pages, 17 figure

Interacting entropy-corrected new agegraphic dark energy in Brans-Dicke cosmology

Motivated by a recent work of one of us [1], we extend it by using quantum (or entropy) corrected new agegraphic dark energy in the Brans-Dicke cosmology. The correction terms are motivated from the loop quantum gravity which is one of the competitive theories of quantum gravity. Taking the non-flat background spacetime along with the conformal age of the universe as the length scale, we derive the dynamical equation of state of dark energy and the deceleration parameter. An important consequence of this study is the phantom divide scenario with entropy-corrected new agegraphic dark energy. Moreover, we assume a system of dark matter, radiation and dark energy, while the later interacts only with dark matter. We obtain some essential expressions related with dark energy dynamics. The cosmic coincidence problem is also resolved in our model.Comment: 16 pages, no figure, accepted for publication in Gen. Relativ. Gra

Growth factor in f(T) gravity

We derive the evolution equation of growth factor for the matter over-dense perturbation in $f(T)$ gravity. For instance, we investigate its behavior in power law model at small redshift and compare it to the prediction of $\Lambda$CDM and dark energy with the same equation of state in the framework of Einstein general relativity. We find that the perturbation in $f(T)$ gravity grows slower than that in Einstein general relativity if \p f/\p T>0 due to the effectively weakened gravity.Comment: 15 pages,1 figure; v2,typos corrected; v3, discussions added, accepted by JCA

Reconstruction of modified gravity with ghost dark energy models

In this work, we reconstruct the $f(R)$ modified gravity for different ghost and generalized ghost dark energy models in FRW flat universe, which describe the accelerated expansion of the universe. The equation of state of reconstructed $f(R)$ - gravity has been calculated. We show that the corresponding $f(R)$ gravity of ghost dark energy model can behave like phantom or quintessence. We also show that the equation of state of reconstructed $f(R)$ gravity for generalized ghost model can transit from quintessence regime to the phantom regime as indicated by recent observations.Comment: 13 pages, some references and one author are added. Accepted for publication by MPL

Reconstructing interacting new agegraphic polytropic gas model in non-flat FRW universe

We study the correspondence between the interacting new agegraphic dark energy and the polytropic gas model of dark energy in the non-flat FRW universe. This correspondence allows to reconstruct the potential and the dynamics for the scalar field of the polytropic model, which describe accelerated expansion of the universe.Comment: 9 page

Restoring New Agegraphic Dark Energy in RS II Braneworld

Motivated by recent works [1,2], we investigate new agegraphic model of dark energy in the framework of RS II braneworld. We also include the case of variable gravitational constant in our model. Furthermore, we establish correspondence between the new agegraphic dark energy with other dark energy candidates based on scalar fields.Comment: 13 pages, accepted for publication in IJT