Ki-67 proliferative index correlation to the immunohistochemistry profile in early female breast cancer: a review of 515 cases

Introduction: Many biological markers are used as prognostic and predictive indicators in invasive breastcancers management. Among them, tumour size, grade, patho-morphological subtype, hormone receptorsstatus and HER2 receptor expression in addition to Ki-67 proliferative index. Also, they play a key role inadjuvant treatment decision making. Our aim was to evaluate the association between Ki-67 proliferativeindex and breast cancer immunological subtype.Material and methods: A total of 515 early invasive patients were enrolled, tumour biological characteristicsas histopathological subtype, immune-histo-chemistry (ER,PR,HER2) status and Ki-67 proliferation indexvalues have been collected. The Ki-67 index level of 20%, was used as the cut-off point to differentiatebetween low and high Ki-67 expression levels. Statistical analysis has been performed using the Chisquare test online tool.Results: In this cohort, about 42%, 33%, 7%, and 18% of the cases were grouped as luminal A-like, luminalB-like, HER2 enriched subtype, and triple-negative, respectively. All luminal A-like patients had Ki-67 levelless than 20%. About 3% of the cohort, are luminal B-like tumours with Ki-67 level less than 20%, where30.3% of the patients were luminal B-like tumours with Ki-67 level ≥ 20%. In HER2 enriched subtype, Ki-67 of < 20% level seen in 1.9% of cases, and Ki-67 levels ≥ 20% was observed in 5.2% of the cases. Inthe triple-negative group, Ki-67 was 20% or higher in 16% of cases, and only 1.7% of patients had Ki-67level less than 20%.Conclusion: Luminal A-like tumours were the most frequently encountered subtype, they have low Ki-67levels and are known to be of a low histological grade tumour, and usually associated with a good prognosis.Also, data indicates that high Ki-67 levels are seen more often in Luminal B-Like breast cancers aswell as in triple-negative breast cancers and HER2 enriched tumours

Evaluation of the correlation between Ki-67 proliferative index and the histopathological grade of invasive neoplasms in early breast cancer aged < 70 years of age: a review of 300 cases

Background and objectives: according to the WHO 2018 reports, breast cancer is the fourth most common cause of cancer deaths worldwide. The breast cancer is recognized as the most common malignancy in the UK, it accounts for about 15% of all newly diagnosed malignancies, followed by prostate (13%), lung (13%), and bowel (11%). Ki-67 proliferative index became a key element in the diagnostic process of breast cancer, in addition to its role as a predictive tool and prognostic marker during the planning of adjuvant therapy as hormonal manipulation of systemic chemotherapy. The study aims to present the correlation analysis between Ki-67 and the different histological grade in breast cancer tumours. Material and methods: a cohort of 300 patients treated for early breast cancer was included in the study. The demographic data, histopathological subtype, hormonal and HER2 (Human epidermal growth factor receptor-2) receptor status and Ki-67 were analysed. The cut-off point was set at 20% to distinguish “high Ki-67” from “low Ki-67”. Results: about 35% (n = 106) of the cases were grade II with low Ki-67 , 26% (n = 79) grade III with high Ki-67, 19% (n = 56) grade II with high Ki-67, 11% (n = 34) grade I with low Ki-67. The high Ki-67 seen in 135 patients who belong to grade II and III groups (45%), where low Ki-67 in 42% of those cases, however, grade III alone contained more cases of high Ki-67 than any other histological grade group. Conclusions: a higher tumour histopathologic grade was correlated with higher Ki-67 values (OR = 7.12, 95% CI 16.75–3.03; p &lt; 0.0001)