167 research outputs found

    Suppression of Leukotriene B4 Generation by Ex-vivo Neutrophils Isolated from Asthma Patients on Dietary Supplementation with Gammalinolenic Acid-containing Borage Oil: Possible Implication in Asthma

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    Dietary gammalinolenic acid (GLA), a potent inhibitor of 5-lipoxygenase (5-LOX) and suppressor of leukotriene B(4) (LTB(4)), can attenuate the clinical course of rheumatoid arthritics, with negligible side effects. Since Zileuton, also an inhibitor of 5-LOX, attenuates asthma but with an undesirable side effect, we investigated whether dietary GLA would suppress biosynthesis of PMN-LTB(4) isolated from asthma patients and attenuate asthma. Twenty-four mild-moderate asthma patients (16–75 years) were randomized to receive either 2.0 g daily GLA (borage oil) or corn oil (placebo) for 12 months. Blood drawn at 3 months intervals was used to prepare sera for fatty acid analysis, PMNs for determining phospholipid fatty acids and for LTB4 generation. Patients were monitored by daily asthma scores, pulmonary function, and exhaled NO. Ingestion of daily GLA (i) increased DGLA (GLA metabolite) in PMN-phospholipids; (ii) increased generation of PMN-15-HETrE (5-LOX metabolite of DGLA). Increased PMN-DGLA/15-HETrE paralleled the decreased PMN generation of proinflammatory LTB(4). However, the suppression of PMN-LTB4 did not reveal statistically significant suppression of the asthma scores evaluated. Nonetheless, the study demonstrated dietary fatty acid modulation of endogenous inflammatory mediators without side effects and thus warrant further explorations into the roles of GLA at higher doses, leukotrienes and asthma

    Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

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    A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

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    Identifying and Addressing the Cultural Experiences/Challenges of Hmong Community and Their Interactions with Western Medicine: A Case Report and Review of Literature

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    Background: This literature review delves into the intricate relationship between Hmong culture and Western medicine. Originating from Southeast Asia, the Hmong people have a rich history of migration and have settled in various countries, including the United States, where their traditional practices, such as shamanism and herbal medicine, remain deeply rooted. The introduction of Western medicine has brought forth a clash of beliefs, leading to skepticism and resistance. Issues such as spiritual healing, medicinal usage, language barriers, and decision- making processes are explored, highlighting the importance of cultural competence for healthcare providers. Purpose: To identify the most common cultural experiences or challenges within the Hmong community as this group of people interacts and intertwines with Western Medicine Methods: A comprehensive literature review was conducted using google scholar, UpToDate, Lindell Library, and databases such as EBSCO. Studies from within the last five years were used in this research paper. Conclusions: The literature review and case study on Hmong immigrants highlight the importance of cultural sensitivity, effective communication, and collaboration between Western medicine and traditional beliefs. Culturally competent care can encourage trust with Hmong patients, improving treatment compliance and outcomes. Overcoming language barriers through interpreters is crucial. Integrating traditional and Western medicine offers more comprehensive treatment options, and empowering patient autonomy enhances satisfaction and compliance. Educating about Western medicine builds trust. Healthcare policy should consider cultural diversity for equitable services. Embracing cultural differences can lead to a more inclusive and patient-centered healthcare system
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