Plasma levels of apolipoprotein-E in residents of the European North of Russia

Background: Apolipoprotein-E (apoE) is one of the metabolically active apoproteins and plays an important role in lipid metabolism. However, there are no data on levels of apoE in residents of the North in spite of the fact that specific features of lipid metabolism in the northerners are described. The present work was designed to study plasma levels of apoE in residents of the European North of Russia. Methods: A total of 937 native residents of the European North of Russia (463 men and 474 women) aged 13–60 years were included in the study. ApoE concentrations in the blood plasma were measured by immunoturbidimetric method. Results: Plasma levels of apoE in residents of the European North of Russia were low. ApoE concentrations below the defined normal values were detected in 57.0% of the men and in 59.2% of the women. The mean plasma levels of apoE did not significantly differ in men and women (2.80 mg/dl vs 2.87 mg/dl). Plasma apoE concentrations in residents of the European North of Russia changed with age. Plasma levels of apoE decreased from 13 to 21 years in men and from 13 to 35 years in women and then increased in both sexes (p < 0.001). Conclusion: The limits of variation of plasma apoE levels in residents of the European North of Russia shift towards lower values. Plasma levels of apoE below normal values were observed in approximately half of investigation subjects

Preparation of nanocrystalline thin films of ZnO by sol-gel dip coating”,

Nanocrystalline ZnO thin films are deposited from sol-gel of zinc acetateand using dip coating onto two different substrates: glass and aluminium foil. (i) Films on glass substrates. Nanostructured ZnO thin films with different concentrations of Ni 2+ doping (0, 1, 5, 10 and 15 wt%) are prepared for the first time by the sol gel method. The film surface is with a ganglia-like structure as observed by Scanning Electron Microscopy (SEM). The films comprise of ZnO nanocrystallites with hexagonal crystal structure, as revealed by means of X-ray diffraction (XRD). (ii) Films on aluminium foil substrates. The ZnO films are annealed at different temperatures (100 °C, 300 °C and 500 °C) and characterized by means of SEM and XRD. The film surface is with the characteristic ganglia-like patterns. The crystalline structure is hexagonal with the crystallite sizes increasing with the annealing temperature

Range of values for lipid accumulation product (LAP) in healthy residents of the European north of Russia

BACKGROUND: Obesity is a major health problem in modern society and its prevalence throughout the world has reached the epidemic level. The unfavorable outcomes of obesity are associated with a high risk of numerous diseases due to metabolic disorders. Finding of diagnostic criteria for early detection of obesity is a priority in biomedical research. Therefore, of particular interest is the new visceral obesity marker &ndash; lipid accumulation product (LAP). Meanwhile, to date, the reference values for LAP are not defined, and data on sex- and age-related changes are contradictory. AIMS: The aim of this study was to determine the variation range, sex and age differences in LAP values in healthy subjects. MATERIALS AND METHODS: The study was conducted on apparently healthy subjects (455 men and 286 women) aged 20&ndash;59 years selected at routine examinations at the base of the central clinic in Arkhangelsk. Examination of subjects consisted of physical examination with measurement of anthropometric and clinical parameters, filling out a questionnaire, and evaluation of serum lipid levels. RESULTS: The LAP values in the subjects varied in a wide range (0.5&ndash;156.5 cm&times;mmol/l in men; 0.4 to 116.2 cm&times;mmol/l in women), but at the same they in 75% of the participants did not exceed 30 cm&times;mmol/l. Sex differences in LAP with the prevalence of values in men were observed in the age groups up to 40 years old, later they disappeared. LAP in men and women increased with age, but these changes were unequal. The LAP values increased to reach a plateau in men up to 30 years of age and in women up to 40 years of age. CONCLUSIONS: LAP is a combined index that simultaneously reflects distribution of adipose tissue and changes in blood lipids, and is considered a marker of obesity associated with the risk of metabolic disorders. This study was the first to determine the variation range, sex differences and age dynamics for LAP in the apparently healthy subjects

ОПРЕДЕЛЕНИЕ ОСНОВНЫХ ПОРОДООБРАЗУЮЩИХ ЭЛЕМЕНТОВ, СТРОНЦИЯ И ЦИРКОНИЯ РЕНТГЕНОФЛУОРЕСЦЕНТНЫМ МЕТОДОМ ДЛЯ ГЕОХИМИЧЕСКОЙ ХАРАКТЕРИСТИКИ ДОННЫХ ОТЛОЖЕНИЙ

Quantitative X-ray fluorescence determination of major rock-forming oxides (Na2O, MgO, Al2O3, SiO2, P2O5, K2O, CaO, TiO2, MnO and Fe2O3) and some microelements (Sr and Zr) was performed in the samples of 143 cm-long sediment core of Lake Baunt (Buryat Republic) by the wavelength-dispersive X-ray fluorescence analysis on the S8 Tiger spectrometer. Calibration curves were obtained by measuring the certified reference materials of the sedimentary rocks. Both analyzed and reference samples were prepared as glass beads by fusion of 110 mg of sample with1.1 g of lithium metaborate. We have used 110 mg mass to ensure the formation of beads with appropriate 10 to 12 mm size across to be measured by the spectrometer with8 mm mask. Rh Kα Compton line was used as a background standard for Sr and Zr determination. The repeatability did not exceed the allowable standard deviation for a wide range of concentrations. Results of major rock-forming oxides determination were compared with the data of spectrophotometry and flame photometry techniques, results of Sr and Zr determination were compared with the data of synchrotron radiation excited X-ray fluorescence technique. All results of the X-ray fluorescence analysis were accepted as satisfactory. Quantitative analysis of each centimeter of Lake Baunt sediment core allowed building first reconstructions of the local environment during the last 7000 years with unique resolution of about 100 years.Keywords: wavelength-dispersive X-ray fluorescence analysis, synchrotron radiation induced X-ray fluorescence analysis, sediments, paleoclimate (Russian)DOI: http://dx.doi.org/10.15826/analitika.2017.21.1.003A.A. Amosova, V.M. Chubarov,E.V. Kaneva, Iu.N. MarkovaVinogradov Institute of Geochemistry, Siberian Branch of Russian Academy of Sciences, ul. Favorsky, 1A, Irkutsk, 664033, Russian FederationМетодика, разработанная для количественного рентгенофлуоресцентного анализа малых навесок изверженных горных пород, применена для осадочных горных пород, которые существенно отличаются по химическому и минеральному составу, в частности, могут содержать более 15 % органической составляющей. Градуировочные уравнения были построены с использованием стандартных образцов континентальных рыхлых отложений, речных и морских илов и глин. Были прокалены и сплавлены в форме стеклянных дисков с метаборатом лития 143 образца керна донных отложений континентального озера Баунт (республика Бурятия). Правильность определения основных породообразующих компонентов (Na2O, MgO, Al2O3, SiO2, P2O5, K2O, CaO, TiO2, MnO, Fe2O3) и некоторых микроэлементов (Sr, Zr) рентгенофлуоресцентным методом оценена сопоставлением полученных результатов с данными анализа методами спектрофотометрии, пламенной фотометрии и рентгенофлуоресцентного анализа с возбуждением синхротронным излучением. Полученные результаты соответствуют требованиям количественного химического анализа. Рентгенофлуоресцентный анализ каждого сантиметра керна донных отложений озера Баунт позволил выявить за последние 7000 лет значительные вариации содержаний элементов, их соотношений и геохимических индексов, важных при палеоклиматических реконструкциях изменений региональных условий окружающей среды.Ключевые слова: рентгенофлуоресцентный анализ с волновой дисперсией, рентгенофлуоресцентный анализ с возбуждением синхротронным излучением, донные отложения, палеоклиматDOI: http://dx.doi.org/10.15826/analitika.2017.21.1.00

Phenomenon of structural-technological proximity and knowledge spillovers between Russian regions

Теоретические и эмпирические исследования в разных странах показали, что важной предпосылкой развития и экономического роста регионов является феномен пространственной и непространственной близости регионов, который порождает перетоки знаний. Цель исследования - разработка методического подхода к измерению и визуализации пространственной и структурнотехнологической близости, влияющей на переток знаний между регионами, апробация приемов картографической визуализации близости регионов России. В статье проанализированы зарубежные и отечественные подходы к исследованию пространственной и непространственной близости. Новыми результатами для отечественных исследований являются обоснование содержания этапов, составляющих методический инструментарий количественной оценки разных видов близости регионов, и способ построения типологии регионов на основе коэффициентов матрицы непространственной близости, рассчитанных по показателю «валовая добавленная стоимость» по 15 секторам общероссийского классификатора видов экономической деятельности (ОКВЭД) для регионов России. На примере Новосибирской области для 2005 и 2016 гг. выполнены методические приемы измерения и визуализации географической и структурно-технологической близости данного региона по отношению к другим регионам РФ. Показано, что для Новосибирской области, занимающей срединное географическое положение в стране и имеющей диверсифицированную структуру видов экономической деятельности и науки, возрастает возможность возникновения каналов перетока знаний со многими европейскими регионами России и некоторыми регионами Урала и Дальнего Востока. Матрицы близости могут использоваться в эконометрических исследованиях, проверяющих гипотезы о влиянии разных форм близости на экономический рост регионов. Рекомендации о необходимости активизации каналов перетока знаний совпадают с предложениями о поддержке территорий инновационного развития, выдвинутыми в Пространственной стратегии России до 2025 г.International theoretical and empirical studies have shown that regional development and economic growth largely depend on spatial and non-spatial proximity of regions, which generates knowledge spillovers. We developed a methodological approach to measuring and visualising spatial and structural-technological proximity affecting regional knowledge spillovers. Moreover, we tested the techniques of the cartographic visualisation of the proximity of Russian regions. Further, we analysed foreign and domestic approaches to studying spatial and non-spatial proximity and obtained new results. We described the stages constituting a methodology for the quantitative assessment of different types of regional proximity. Additionally, we proposed a method for constructing a typology of regions based on the coefficients of the non-spatial proximity matrix, calculated according to the indicator “gross value added” for 15 sectors of the Russian National Classifier of Economic Activities (OKVED) for Russian regions. Using the data for the Novosibirsk region in 2005 and 2016, we applied methodological techniques for measuring and visualising geographical and structural-technological proximity (STB) of a region in relation to other constituent entities of the Russian Federation. The Novosibirsk region is located in the middle of the country and has a diversified structure of economic activities and science. For this particular region, there has been an increase in the likelihood of the emergence of knowledge spillover channels with various European regions of Russia and some regions of the Urals and the Far East. Proximity matrices can be used in econometric studies to test hypotheses about the impact of different forms of proximity on regional economic growth. Recommendations to enhance knowledge spillover coincide with the proposals to support the areas of innovative development stated in The Strategy of Spatial Development of the Russian Federation for the period until 2025.Исследование выполнено в рамках базового проекта плана НИР Проект XI.174.1.1.(0.325–2019–0008) «Экономика Сибири и ее регионов в условиях внешних и внутренних вызовов и угроз: методология, тенденции, прогнозы».The article has been prepared in accordance with the research plan the Project XI.174.1.1. (0.325–2019–0008) “Economy of Siberia and its regions in the context of external and internal challenges and threats: methodology, trends, forecasts”

Determination of main rock-forming elements, strontium and zirconium by X-ray fl uorescence analysis for the geochemical characterization of bottom sediments

Quantitative X-ray fluorescence determination of major rock-forming oxides (Na2O, MgO, Al2O3, SiO2, P2O5, K2O, CaO, TiO2, MnO and Fe2O3) and some microelements (Sr and Zr) was performed in the samples of 143 cm-long sediment core of Lake Baunt (Buryat Republic) by the wavelength-dispersive X-ray fluorescence analysis on the S8 Tiger spectrometer. Calibration curves were obtained by measuring the certified reference materials of the sedimentary rocks. Both analyzed and reference samples were prepared as glass beads by fusion of 110 mg of sample with 1.1 g of lithium metaborate. We have used 110 mg mass to ensure the formation of beads with appropriate 10 to 12 mm size across to be measured by the spectrometer with 8 mm mask. Rh Kα Compton line was used as a background standard for Sr and Zr determination. The repeatability did not exceed the allowable standard deviation for a wide range of concentrations. Results of maj photometry techniques, results of Sr and Zr determination were compared with the data of synchrotron radiation excited X-ray fluorescence technique. All results of the X-ray fluorescence analysis were accepted as satisfactory. Quantitative analysis of each centimeter of Lake Baunt sediment core allowed building first reconstructions of the local environment during the last 7000 years with unique resolution of about 100 years.Методика, разработанная для количественного рентгенофлуоресцентного анализа малых навесок изверженных горных пород, применена для осадочных горных пород, которые существенно отличаются по химическому и минеральному составу, в частности, могут содержать более 15 % органической составляющей. Градуировочные уравнения были построены с использованием стандартных образцов континентальных рыхлых отложений, речных и морских илов и глин. Были прокалены и сплавлены в форме стеклянных дисков с метаборатом лития 143 образца керна донных отложений континентального озера Баунт (республика Бурятия). Правильность определения основных породообразующих компонентов (Na2O, MgO, Al2O3, SiO2, P2O5, K2O, CaO, TiO2, MnO, Fe2O3) и некоторых микроэлементов (Sr, Zr) рентгенофлуоресцентным методом оценена сопоставлением полученных результатов с данными анализа методами спектрофотометрии, пламенной фотометрии и рентгенофлуоресцентного анализа с возбуждением синхротронным излучением. Полученные результаты соответствуют требованиям количественного химического анализа. Рентгенофлуоресцентный анализ каждого сантиметра керна донных отложений озера Баунт позволил выявить за последние 7000 лет значительные вариации содержаний элементов, их соотношений и геохимических индексов, важных при палеоклиматических реконструкциях изменений региональных условий окружающей среды

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate the association between genetic variation across this region and PrCa, we performed a fine-mapping analysis by genotyping 134 SNPs using a custom Illumina iSelect array or Sequenom MassArray iPlex, followed by imputation of 1094 SNPs in 22 301 PrCa cases and 22 320 controls in The PRACTICAL consortium. Multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of TERT that independently associated with PrCa risk. Gene expression analysis of normal prostate tissue showed evidence that SNPs within one of these regions also associated with TERT expression, providing a potential mechanism for predisposition to disease

ИССЛЕДОВАНИЕ ВОЗМОЖНОСТИ ПОЛУЧЕНИЯ ФЕРРИТА МАРКИ 2000НМ ПО КОРОТКОЙ ТЕХНОЛОГИЧЕСКОЙ СХЕМЕ

The possibility of obtaining Mn—Zn-ferrite 2000 NM on the short process flow, which differs from the usual lack of diffusion operations roasting and grinding. It is shown that the use of the basic composition in sintering processes develop secondary recrystallization and zonal isolation, leading to the formation of highly inhomogeneous microstructure obtained with low values of the magnetic permeability. A homogeneous microstructure characteristic recrystallization, managed by doping copper oxide and zinc. By doping CuO permeability far from the desired value, but its temperature coefficient is small. By doping ZnO reached the desired value of magnetic permeability, but dramatically increases its temperature coefficient.The optimum combination of the magnetic parameters obtained in complex copper oxides doped ferrite and zinc.Рассмотрена возможность получения Mn—Zn-феррита марки 2000 НМ по короткой технологической схеме, отличающейся от традиционной отсутствием операций диффузионного обжига и измельчения. Показано, что при использовании базового состава при спекании развиваются процессы вторичной рекристаллизации и зонального обособления, приводящие к формированию резко неоднородной микроструктуры. При этом получены низкие значения магнитной проницаемости. Однородную микроструктуру, характерную для собирательной рекристаллизации, наблюдали при легировании оксидами меди и цинка. Оптимальное сочетание магнитных параметров достигнуто при комплексном легировании феррита оксидами меди и цинка