Construction of an Instrumentation Kit for Identification and Control of DC Motors

This paper presents the development of an instrumentation kit of voltage and current measurement for identification of the dynamic model and control of direct current (DC) motors. In the methodology for the parameters identification is used the responses of input voltage and current, and angular velocity of the DC motor. The validation of the obtained dynamic model is done through the comparison of the simulated and experimental responses, and the application of a control system based on state feedback and complete eigenstructure assignment (tracking system). The responses are compared through the normalized root-mean-square error criterion

Control of a Modified Ball and Beam System Using Tracking System in Real Time with a DC Motor as an Actuator

This paper presents amodified ball and beam system, with the intention of realizing a test bed, to study new control techniques in real-time.The ball and beam system consists of a ball over a long beam where the control objective is to stabilizethe position of the ball on the beam by changing the angular position of the beam.In this paper, the ball of the conventional system is replaced by a cart with an embedded microcontroller, enabling the use of a linear encoder as position sensor and allowing to transmit the position via RF (Radio Frequency). The mathematical model of the ball and beam is obtained through the equations of Newton-Euler and the equations were linearized. The system is controlled using the hardware-in-the-loop technique with MATLAB/Simulink.It is applied a tracking control system with entire eigenstructure assignment to control the position of the cart. The actuator used is a DC motor, and a PID(proportional, integral and derivative) control is used to perform the angular position control of beam.The simulation results and the experimental results are compared to validate the mathematical model. The results obtained were satisfactory with adequate accuracy

Study of Intelligent Control Techniques Applied to a Stirring Tank with Heat Exchanger

This work presents a study and evaluation of intelligent control techniques applied to the problem of temperature control of a stirring tank with heat exchanger. This problem is represented by the example provided and documented by MathWorks in MATLAB/Simulink software, called Heatex. The intelligent techniques used are Fuzzy Logic Controller (FLC), Fuzzy Cognitive Maps (FCM), Artificial Neural Networks (ANN) and the combination of these. The proportional-integral (PI) controller provided in the Heatex example is considered as a reference basis during the evaluation of the intelligent control techniques in different test scenarios. The metrics Integral of Absolute Error (IAE) and Integral Time-weighted Absolute Error (ITAE), as well as the parameters overshoot percentage and settling time are the criteria used to evaluate the control techniques performance

Virtual Prototyping, Identification and Control of a Twin Rotor with 3DOF

This paper presents a methodology for identification of the physical characteristics, generation of the mathematical model through virtual prototyping and control of the didactic plant of a twin rotor. In the identification of the physical characteristics, the centers of mass and moments of inertia of the twin rotor parts were identified separately, by means of an easel designed for such task. Still in the identification of the physical characteristics, the equation that relates the applied voltage in the direct current motor with the thrust force produced by the propellers was obtained. The mathematical model of the twin rotor was obtained by means of the identification of the physical characteristics allied to the virtual prototyping with the aid of ADAMS and SolidWorks software. The implemented control system uses state feedback and complete eigenstructure assignment. The ease and usefulness of the proposed methodology was presented through the plant instrumentation, simulation and control in MATLAB/Simulink environment

Parameters Identification of a Direct Current Motor Using the Trust Region Algorithm

In this paper, the trust region algorithm was used to identify the parameters of the dynamic model of a permanent magnet direct current (PMDC) motor, using the MATLAB/Simulink Parameter Estimation tool. The objective was to estimate the parameters applying the square wave, pseudo-random binary sequence (PRBS) and random signals in the motor excitation. The obtained models were evaluated in open and closed loop, where a speed control project was applied using the entire eigenstructure assignment. The error between the simulated and real curves of velocity and current were evaluated by means of the normalized root mean squared error (NRMSE)

Hepatitis B virus: molecular genotypes and HBeAg serological status among HBV-infected patients in the southeast of Brazil

<p>Abstract</p> <p>Background</p> <p>Knowledge of HBV genotype is very important for clinical treatment. Studies have suggested possible pathogenic and therapeutic differences among HBV genotypes. The aim of this study was to determine HBV subtypes and genotypes in HBV-infected patients in our region (southeast Brazil) and to correlate results with clinical and histopathological data.</p> <p>Methods</p> <p>One hundred and thirty-nine HBsAg-positive patients were included in the study. All patients were anti-HCV and anti-HIV negative (64% male; mean age 42 ± 14.5 years; range 7-80 years; 84% Caucasian) and were followed up at the University Hospital. A method for genotyping and subtyping HBV by partial HBsAg gene sequencing with primers common to all known genotypes was used. The viral load was measured by Amplicor Monitor assay (Roche).</p> <p>Results</p> <p>HBV genotype A was the most prevalent (55%), while genotypes C, D and F were found in 3%, 38% and 4% of HBV-infected patients, respectively. Among the patients infected by genotype A, 18.3% (14/76) were African descendents and, among the patients infected by genotype D, 11.3% (6/53) were also African descendents. In the four patients infected with genotype C, 2 were Asian descendents and 2 were Caucasians. All (7) genotype F infected patients were Caucasians. Seventy percent of our HBsAg-positive patients were HBeAg negative (62% genotypes A; 26.2% D; 7.1% C and 4.7%F). The viral load of HBV-DNA was about 5 times higher in HBeAg-positive than in HBeAg-negative patients. About 40% of these patients had alanine aminotransferase of up to 1.5 times the normal level. The mean stage of fibrosis in genotype A patients (2.8) was significantly higher than the mean stage of fibrosis in genotype D patients (2.0) (P = 0.0179).</p> <p>Conclusion</p> <p>The genotypes encountered in our HBV-infected patients were apparently a consequence of the types of immigration that occurred in our region, where European and African descendents predominate. The HBeAg-negative status predominated, possibly due to the length of time of infection. The viral load in HBeAg-positive patients was higher than in HBeAg-negative individuals. The fibrosis grade in genotype A-infected patients was more advanced than genotype D-infected patients.</p

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Membrane properties of an unusual intrinsically oscillating, wide‐field teleost retinal amacrine cell

In the retina, amacrine cells modulate the transfer of information from bipolar to ganglion cells. The nature of the modulation depends on the synaptic input and the membrane properties of the cells. In the retina of white bass, we identified a class of bistratified, wide-field amacrine cell characterized by immunopositive labelling for GABA and calmodulin. In isolation, the cells presented resting membrane potentials averaging -69 mV although some cells settled at more depolarized values (-30 mV). Injection of depolarizing current pulses induced oscillatory membrane responses. When elicited from depolarized cells, the oscillations were short-lived (< 40 ms). For the most part, the oscillatory potentials of hyperpolarized cells remained unattenuated throughout the depolarizing pulse. The frequency of the oscillations increased logarithmically with mean membrane potential, ranging from 74 to 140 Hz. Cells exhibiting depolarized membrane potentials oscillated at twice that rate. When the membrane potential of these cells was hyperpolarized to -70 mV, the oscillations became unattenuated and slowed. We found the cells expressed voltage-gated sodium, potassium and calcium currents and calcium-dependent potassium currents. We demonstrate that the oscillatory potentials arose as a result of the interplay between calcium and potassium currents. The cells responded to local application of GABA and glycine, both of which modulate the oscillatory potentials. Glutamate and its analogues depolarized the cell and induced oscillatory potentials. Our results indicate that oscillatory responses of a type of wide-field amacrine cell are an intrinsic feature of the cell and not due to circuit properties