Do the Efficacy and Safety of Treatment with Landiolol, an Ultra-short-acting β1-Selective Blocker, Differ in the Urgent Management of Rapid Atrial Fibrillation between Patients Complicated with Cardiac Versus Non-cardiac Disease ?

Article信州医学雑誌 68(1): 31-39(2020)journal articl

Prevalence of Takotsubo Syndrome among Patients Admitted to an Emergency Department

Article信州医学雑誌 70(1) : 39-46(2022)departmental bulletin pape

Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies

The definitive version is available at www.blackwell-synergy.comWe here report the efficacy and toxicity of a conditioning regimen with fractionated 8-Gy TBI, fludarabine, and cyclophosphamide in allogeneic HSCT for pediatric hematological malignancies. Among 22 children who received related or unrelated HSCT, nine were transplanted with refractory disease and/or from HLA two or more loci-mismatched family donors. None of the patients developed graft failure. The Seattle grading system revealed that 18 patients had no RRT, and the remaining patients had grade I gastrointestinal toxicity alone. The estimated overall survival and leukemia-free survival at two yr were 57.1% and 48.0%, respectively, in 10 patients with acute lymphoblastic leukemia; 91.7% and 71.3%, respectively, in 12 patients with myeloid leukemia. The incidence of TRM was 4.8% at two yr. The rates of RRT above grade II and TRM in an 8-Gy TBI-containing regimen were significantly lower than the data of historical control patients who underwent 12-Gy TBI and cyclophosphamide with or without etoposide. The intermediate-dose TBI-based conditioning regimen may confer successful engraftment combined with minimized RRT, although its efficacy should be further evaluated.ArticlePEDIATRIC TRANSPLANTATION. 13(6):737-745 (2009)journal articl

Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan

Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real-world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1–75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2–357). Adverse events occurred in 12.7%. Life-threatening complications occurred in 0.5%, but there were no treatment-related deaths. During a median follow-up period of 46.1 months (range 1–113), the 3-year overall survival rate, relapse-free survival rate, cause-specific survival rate, and larynx-preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment

A Method for EEG Fluctuation Processing -Application to Fertilizer Difference Analysis in Vegetable Ingestion

Summary The electroencephalogram (EEG) is frequently used for studying psychological influences, by transforming original voltage fluctuations with the Fast Fourier Transform (FFT) or deciphering the waveform directly. While internal behavior of the brain remains difficult to evaluate, using FFT, powers of α and β waves (μV) can be analyzed by various sub-methods to evaluate the relaxed or stressed state of the brain, since these waves exhibit specific characteristics related to brain state. In the present study, we measured and analyzed EEG fluctuations while examinees ate Komatsuna, also known as the Japanese Mustard Spinach. Komatsuna plants were grown in three different and fertilizers at two densities, chemical, organic, and organic + chemical (each ×1 and ×2 density). We first applied analysis of variance (ANOVA) and relational voltage graphs that use relational values from initial values, to the formatted data. The formatted data are generated from the EEG data, by our specialized program that is developed in the previous work. Subsequently, we applied a detailed analysis that makes precise graphs with "interactions" of ANOVA. Results indicate that α and β waves have significant differences when eating Komatsuna grown using different fertilizers. Furthermore, some interactions between defined factors, including the kinds of fertilizers, showed significant differences. Thus, the fertilizers used for growing Komatsuna could influence EEGs in our experimental conditions

Hemodialysis-Induced P-Wave Signal-Averaged Electrocardiogram Alterations Are Indicative of Vulnerability to Atrial Arrhythmias

信州大学博士（医学）・学位論文・平成24年1月30日授与（甲第923号）・嶋田健太郎Background: Atrial fibrillation (AF) is the most common supraventricular arrhythmia, often occurring during hemodialysis (HD). Prolongation of the total filtered P-wave duration (PWD) and reduction of the root mean square voltages for the last 20 ms of the P wave (RMS20) on a P-wave signal-averaged electrocardiogram (P-SAECG) are predictors of AF. We investigated whether HD induces alterations of P-SAECG, and determined the influential factors. Methods and Results: Thirty-three end-stage kidney disease patients (66.7 +/- 12.6 years, 23 males) undergoing maintenance HD were enrolled in this study. Digital ambulatory P-SAECG monitoring and laboratory examination of serum proteins and ions were carried out before, during, and after the HD sessions. Data were analyzed by multiple regression analysis. PWD was significantly prolonged, and RMS20 significantly reduced, during HD. These values recovered after completion of HD. Multiple regression analysis showed that prolongation of PWD significantly correlated with HD duration and the rate of removal of body fluid. On the other hand, RMS20 significantly correlated with HD duration and blood urea nitrogen variation. Conclusions: HD resulted in prolongation of PWD and reduction of RMS20, indicating the vulnerability of HD patients to AF. These P-SAECG changes correlated with HD duration and the rate of removal of the body fluid. These findings underline the importance of the control of dialysis variables in the prevention of atrial arrhythmias following HD. (Circ J 2012; 76: 612-617)ArticleCIRCULATION JOURNAL. 76(3):612-617 (2012)journal articl