Rationale and Design of a Prospective, Multicentre, Stop Tyrosine Kinase Inhibitor Trial of Paediatric Patients with Chronic Myeloid Leukaemia with Sustained Complete Molecular Response (STKI-14)

Chronic myeloid leukaemia (CML) is a relatively rare disease in children, accounting for 2–3% of all paediatric leukaemia cases. Generally, children with CML can avoid hematopoietic stem cell transplantation and achieve molecular responses with tyrosine kinase inhibitors (TKI). However, CML stem cells are thought to survive in many patients, even after TKI treatment. Many aspects of the toxic effects of prolonged exposure to TKIs during childhood remain unclear, particularly those regarding growth impairment. This lack of clarity underscores the importance of the present clinical trial, which aims to clarify the feasibility of treatment-free remission (TFR) in children following TKI treatment. We aim to examine the long-term out-comes and complications of TKIs before and after cessation to better understand the unknown complications that could arise in adulthood. This trial targets patients who were diagnosed with CML at an age younger than 20 years, were in the chronic or accelerated phase at initial diagnosis and remained in complete molecular remission for at least 2 years after TKI administration. We will examine the utility of TKI cessation and assess the treatment results of patients who resumed TKI therapy after losing a major molecular response. We will also investigate factors related to the feasibility of a TFR after TKI cessation

Posttraumatic growth (PTG) and posttraumatic depreciation (PTD) across ten countries: Global validation of the PTG-PTD theoretical model

info:eu-repo/semantics/publishedVersio

A comparison of personality maturity among Japanese youth and Finnish young adult students : a cross-sectional study using Erikson psychosocial stage inventory and sense of coherence scale

Objective: This study aimed to clarify the child rearing improvement approach in Japan by evaluating the ‘Personality Maturity’ of Japanese youth and Finnish young adult students. Methods: The cross-sectional survey was carried out on the Internet with youth aged 18–25 using the Erikson Psychosocial Stage Inventory (EPSI) and Sense of Coherence (SOC) scales. In total, 865 Japanese youth were recruited from GMO-Research Monitors and 898 Finnish young adult students were recruited from Tampere University; 762 Japanese youth and 896 Finnish young adult students responded to all 13 SOC and 42 EPSI questions. Results: Mean total and subscale scores of Japanese youth were lower than those of Finnish young adult students for both EPSI and SOC. We found a strong, negative correlation (r = −.685) in Japan and a strong, positive correlation in Finland (r = .831) between total EPSI and SOC scores. Conclusions: Japanese youth showed stronger development of either EPSI or SOC

A comparison of personality maturity among Japanese youth and Finnish young adult students: a cross-sectional study using Erikson psychosocial stage inventory and sense of coherence scale

Objective : This study aimed to clarify the child-rearing improvement approach in Japan by evaluating the ‘Personality Maturity’ of Japanese youth and Finnish young adult students. Methods : The cross-sectional survey was carried out on the Internet with youth aged 18–25 using the Erikson Psychosocial Stage Inventory (EPSI) and Sense of Coherence (SOC) scales. In total, 865 Japanese youth were recruited from GMO-Research Monitors and 898 Finnish young adult students were recruited from Tampere University; 762 Japanese youth and 896 Finnish young adult students responded to all 13 SOC and 42 EPSI questions. Results : Mean total and subscale scores of Japanese youth were lower than those of Finnish young adult students for both EPSI and SOC. We found a strong, negative correlation (r = −.685) in Japan and a strong, positive correlation in Finland (r = .831) between total EPSI and SOC scores. Conclusions : Japanese youth showed stronger development of either EPSI or SOC

The Efficacy of a Resilience-Enhancement Program for Mothers Based on Emotion Regulation: A Randomized Controlled Trial in Japan

This study evaluated the efficacy of a brief (four 2-h sessions) group-based resilience-enhancement program focused on emotion regulation in Japan. Mothers (n = 123) of children aged 3–6 years were recruited in two prefectures and allocated with stratified randomization by the prefecture to either a bi-weekly intervention or treatment as usual. Mothers self-reported online at pre/post-intervention and at 2-month follow-up. Analysis of covariance was used to compare groups. At post-intervention and 2-month follow-up, the intervention group mothers showed significant improvements compared to the control group in resilience (p < 0.001/p = 0.001), self-esteem (p = 0.008/p = 0.001), anger control toward the child (p < 0.001/p = 0.012), and positive attribution toward the child’s misbehavior (p < 0.001/p = 0.003). The partners of mothers in both groups answered the same questionnaire at the same timepoints without participating in either program; no differences between groups were found. This study was the first randomized controlled trial investigating how a resilience-enhancement program improves maternal resilience, emotion regulation, and cognition toward children and themselves. This preliminary study provides evidence that improving resilience may reduce the risk of child maltreatment. Further research regarding implementing this intervention in the community is warranted