4 research outputs found
Liposomski sustavi za isporuku lijekova KliniÄka primjena
Liposomes have been widely investigated since 1970 as drug carriers for improving the delivery of therapeutic agents to specific sites in the body. As a result, numerous improvements have been made, thus making this technology potentially useful for the treatment of certain diseases in the clinics. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. The current pharmaceutical preparations of liposome-based therapeutic systems mainly result from our understanding of lipid-drug interactions and liposome disposition mechanisms. The insight gained from clinical use of liposome drug delivery systems can now be integrated to design liposomes that can be targeted on tissues, cells or intracellular compartments with or without expression of target recognition molecules on liposome membranes. This review is mainly focused on the diseases that have attracted most attention with respect to liposomal drug delivery and have therefore yielded most progress, namely cancer, antibacterial and antifungal disorders. In addition, increased gene transfer efficiencies could be obtained by appropriate selection of the gene transfer vector and mode of delivery.Od 1970. godine liposomi se intenzivno istražuju kao nosaÄi ljekovitih tvari za isporuku u odreÄene dijelova organizma. UnapreÄenje i razvoj liposoma omoguÄili su njihovu kliniÄku primjenu u terapiji odreÄenih bolesti. Na tržiÅ”tu je prisutan odreÄen broj ljekovitih oblika na bazi liposoma, a dio je joÅ” u kliniÄkim pokusima. Svi su oni rezultat boljeg razumjevanja raspodjele liposoma i interakcija izmeÄu lipida i ljekovite tvari. MoguÄe je pripremiti liposome koji se mogu usmjeriti u odreÄena tkiva, stanice ili meÄustaniÄne prostore, sa ili bez vezanih molekula za prepoznavanje na povrÅ”ini membrane. Ovaj revijalni Älanak uglavnom obuhvaÄa liposome za terapiju karcinoma, bakterijskih i gljiviÄnih infekcija jer je u tim podruÄjima primjena liposoma najviÅ”e opravdana i stoga najviÅ”e istraživana. Osim toga, pravilnim izborom vektora za prijenos gena i naÄina isporuke može se poveÄati i uÄinkovitost prijenosa gena