27 research outputs found
Translation correlations in anisotropically scattering media
Controlling light propagation across scattering media by wavefront shaping
holds great promise for a wide range of communications and imaging
applications. However, finding the right wavefront to shape is a challenge when
the mapping between input and output scattered wavefronts (i.e. the
transmission matrix) is not known. Correlations in transmission matrices,
especially the so-called memory-effect, have been exploited to address this
limitation. However, the traditional memory-effect applies to thin scattering
layers at a distance from the target, which precludes its use within thick
scattering media, such as fog and biological tissue. Here, we theoretically
predict and experimentally verify new transmission matrix correlations within
thick anisotropically scattering media, with important implications for
biomedical imaging and adaptive optics.Comment: main article (18 pages) and appendices (6 pages
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Phase-space measurement for depth-resolved memory-effect imaging
We use windowed Fourier transforms (spatial spectrograms) to image objects obscured by a thin scattering layer. Such phase-space methods can improve the resolution of the recovered object and allow for estimation of source depth
Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype
International audienceAdult T-cell leukemia/lymphoma (ATL) carries a poor prognosis even in indolent subtypes. We performed targeted deep sequencing combined with mapping of HTLV-1 proviral integration sites of 61 ATL patients of African and Caribbean origin. This revealed mutations mainly affecting TCR/NF-kB (74%), T-cell trafficking (46%), immune escape (29%), and cell cycle (26%) related pathways, consistent with the genomic landscape previously reported in a large Japanese cohort. To examine the evolution of mutational signatures upon disease progression while tracking the viral integration architecture of the malignant clone, we carried out a longitudinal study of patients who either relapsed or progressed from an indolent to an aggressive subtype. Serial analysis of relapsing patients identified several patterns of clonal evolution. In progressing patients, the longitudinal study revealed NF-kB/NFAT mutations at progression that were present at a subclonal level at diagnosis (allelic frequency < 5%). Moreover, the presence in indolent subtypes of mutations affecting the TCR/NF-kB pathway, whether clonal or subclonal, was associated with significantly shorter time to progression and overall survival. Our observations reveal the clonal dynamics of ATL mutational signatures at relapse and during progression. Our study defines a new subgroup of indolent ATLs characterized by a mutational signature at high risk of transformation