33 research outputs found
Anthraquinones- A probe to enhance the photovoltaic properties of DSSCs
- Publication venue
- 'Institute of Advanced Engineering and Science'
- Publication date
- 01/06/2016
- Field of study
Natural dye sensitized solar cells are a promising class of photovoltaic cells with the capacity of generating green energy at low production cost since no expensive equipment is required in their fabrication. Photovoltaics are a precious technology in the hasty world where energy prices are goes on increasing within seconds. Researchers are focusing to facilitate for producing eco-friendly, low cost and more efficient dye sensitized solar cells. In the present work we discuss the comparative photovoltaic studies of Lawsone, a natural dye from henna plant and Alizarin, a natural dye from the root of madder for fabricating the Dye sensitized solar cells (DSSCs). The absorption spectrum of Lawsone and Alizarin is found to be shifted to the longer wavelength region after the complex formation. As a result there is a significant increase in short circuit current density and conversion efficiency. This result compares with the standard dye i.e. N719 dye
Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease
- Author
- Andreassen OA
- Bahrami S
- Blauwendraat C
- Ding J
- Ellinghaus D
- European Multiple System Atrophy Study Group
- Foubert-Samier A
- Franke A
- Frei O
- Gasser T
- Gibbs JR
- Gieger C
- Hammer M
- Hardy J
- Heras-Garvin A
- Hoffmann P
- Homuth G
- Houlden H
- Lieb W
- Makarious MB
- Meissner WG
- Mucha S
- MĂŒller-Nurasyid M
- Nöthen MM
- O'Connell KS
- Pavy-Le Traon A
- Rascol O
- Schmidt CO
- Schminke U
- Scholz SW
- Schreiber S
- Shadrin AA
- Sharma M
- Singleton A
- Sreelatha AAK
- Stefanova N
- Wenning G
- Publication venue
- Publication date
- 27/10/2020
- Field of study
BACKGROUND: Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by intracellular accumulations of α-synuclein and nerve cell loss in striatonigral and olivopontocerebellar structures. Epidemiological and clinical studies have reported potential involvement of autoimmune mechanisms in MSA pathogenesis. However, genetic etiology of this interaction remains unknown. We aimed to investigate genetic overlap between MSA and 7 autoimmune diseases and to identify shared genetic loci. METHODS: Genome-wide association study summary statistics of MSA and 7 autoimmune diseases were combined in cross-trait conjunctional false discovery rate analysis to explore overlapping genetic background. Expression of selected candidate genes was compared in transgenic MSA mice and wild-type mice. Genetic variability of candidate genes was further investigated using independent whole-exome genotyping data from large cohorts of MSA and autoimmune disease patients and healthy controls. RESULTS: We observed substantial polygenic overlap between MSA and inflammatory bowel disease and identified 3 shared genetic loci with leading variants upstream of the DENND1B and RSP04 genes, and in intron of the C7 gene. Further, the C7 gene showed significantly dysregulated expression in the degenerating midbrain of transgenic MSA mice compared with wild-type mice and had elevated burden of protein-coding variants in independent MSA and inflammatory bowel disease cohorts. CONCLUSION: Our study provides evidence of shared genetic etiology between MSA and inflammatory bowel disease with an important role of the C7 gene in both phenotypes, with the implication of immune and gut dysfunction in MSA pathophysiology. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC. on behalf of International Parkinson and Movement Disorder Society
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
- Abdallah J
- Abdul Ghani R
- Abdul Kadir K
- Abdullah R
- Abejuela Z
- Abouglila K
- Abraham O
- Abrahamsen I
- Abraira Munoz Ld
- Abramowitz M
- Abusnana S
- Accini Mendoza Jl
- Acosta I
- Agafyina A
- Agarwal R
- Agarwal Rajiv
- Aggarwal N
- Agra J
- Ahmed F
- Ahuad Guerrero Ra
- Aiello J
- Ainsworth P
- Aizenberg D
- Akiyama H
- Akright L
- Akyea-Djamson A
- Al-Karadsheh A
- Alamartine E
- Alappan R
- Albisu Jp
- Ali N
- Ali Z
- Alicic R
- Allison Dc
- Alvarez Garcia P
- Alvarisqueta A
- Alves da Costa Fa
- Amerena J
- Amigo A
- Amodeo C
- Andreeva V
- Andreotti Turatti La
- Angelescu Lm
- Angelova A
- Anghel V
- Antic S
- Aoki H
- Aquitania G
- Arauz-Pacheco C
- Arcos E
- Arfeen S
- Arif A
- Aronson R
- Arutchelvam V
- Arvind M
- Asano A
- Asmarats Mercadal L
- Atray N
- August P
- Avendano J
- Avram Ri
- Awad A
- Babikova J
- Badat A
- Bajaj H
- Baker J
- Bakris G
- Bakris George
- Barbarash O
- Barna O
- Barnard M
- Barnhill P
- Barranco E
- Barrera C
- Barrios C
- Bartaskova D
- Bartolacci I
- Barton P
- Barysheva O
- Beacom M
- Behara V
- Bellary S
- Belo D
- Belobradkova J
- Bentley-Lewis R
- Benusova O
- Berenguer R
- Berli Ma
- Bermudez L
- Bernardo M
- Bhushan Rs
- Bijata-Bronisz R
- Bilyk Sd
- Bin Shudim Ss
- Biscoveanu M
- Bompoint Severine
- Bonadonna R
- Bordonava A
- Borot S
- Botsyurko V
- Bowman-Stroud C
- Brandon D
- Breedt J
- Bregman R
- Brenner Barry M
- Brenner Bm
- Brusco O
- Buganova I
- Bull Scott
- Burst V
- Busch R
- Busegeanu Mm
- Calella P
- Camelo Sanches Fc
- Canaan Y
- Canani Lh
- Cannon Christopher P
- Cannon Cp
- Cantero Mc
- Capuano George
- Caringal C
- Cariou B
- Cartasegna Lr
- Castellino P
- Cercos E
- Cereto Castro F
- Ceriello A
- Chacra Ar
- Chae Dw
- Chang Ct
- Chang T
- Chapin L
- Charytan David M
- Charytan Dm
- Che Yusof Md
- Cheifetz A
- Chen E
- Chen N
- Chen Q
- Cherney D 3rd
- Chertow G
- Cheung Nw
- Chilito A
- Chiovato L
- Chizhov D
- Cho Ym
- Chouinard G
- Christensen T
- Christiano C
- Christofides E
- Chu Pei-Ling
- Chuang Lm
- Chuateco C
- Cif A
- Cigarran Guldris S
- Coffee L
- Cohen K
- Cohen R
- Cohen S
- Cohen-Stein D
- Coloma Gc
- Colombo H
- Comia Rs
- Commendatore V
- Conway J
- Cook C
- Correa Rotter Jr
- Cosma D
- Cournoyer S
- Coyne D
- Crisan C
- Cruz Jb
- Csecsei G
- Csiky B
- Cuadrado J
- Culak J
- Cuneo Ca
- Cunha Borges Jl
- Cunha V\ueancio Sa
- Cusumano Am
- D'Avila D
- da Silva Franco Rj
- Daboul N
- Danos P
- Daroza G
- Darwish R
- Daswani A
- David C
- Davies E
- Davies M
- Davies S
- Dawson A
- De Brouwer K
- de Carvalho Contieri Fl
- De Cosmo S
- De Nicola L
- De Serres S
- de Souza Portes E
- de Souza P
- de Zeeuw D
- de Zeeuw Dick
- Deak L
- Deboni Lm
- Deck K
- Deepak D
- Delos Santos L
- Demian Ld
- Derosa G
- Desouza C
- Destree M
- Dev D
- Dhillon M
- Di Carlo A
- Di Cianni G
- Diaz Escalante T
- Diaz Ruiz Jea
- Dimitrov S
- Distiller L
- Distiller L
- Djordjevic M
- Dobronravov V
- Dohnalova L
- Dominquez Lopez M
- Douthat Wg
- Dran Rd
- Drasnar T
- Dreval A
- Droste C
- Dua S
- Dub\ue9 F
- Dudar I
- Dudas M
- Dussol B
- Dzupina A
- Dzuponova J
- Eder F
- Edwards Robert
- Edwin Fm
- Egido de Los Rios J
- El Kossi M
- El-Shahawy M
- Elosegui Am
- English P
- Enriquez Sosa Fe
- Ervin J
- Esquenazi A
- Evans J
- Faghih M
- Farias E
- Faulmann G
- Fauvel Jp
- Ferariu Ie
- Ferkl R
- Fern\ue1ndez Montenegro Ma
- Fernandez Fresnedo G
- Fernandez Mf
- Feuerstein J
- Filho Ff
- Finkelstein H
- Fishbane S
- Flores Lozano F
- Flota Cervera Lf
- Fragale G
- Frasc\ue0 G
- Fraser D
- Fraser I
- Frenk Baron P
- Fretes Jo
- Frias J
- Fuiano G
- Fulcher G
- Fulop P
- Fushtey I
- G\uf3rriz Jl
- Gaglia J
- Galan Serrano A
- Galindo-Ramos E
- Galphin C
- Gambaro G
- Gan Cl
- Gan S
- Garcia Ballesteros C
- Garcia Ortiz Lh
- Garcia I
- Garcia Nh
- Garibotto G
- Gastaldi A
- Gaupsiene E
- Gelersztein E
- Geloneze Neto B
- Genadieva V
- Genova-Hristova G
- George S
- Ghazi A
- Giorda C
- Glenny Ja
- Glinkina I
- Gnudi L
- Godlevska O
- Godoy Jorquera Jg
- Goldenberg R
- Golovchenko O
- Gomes M
- Gomez Rangel Jd
- Gomez O
- Gonzalez Colaso Pdc
- Gonzalez Martinez Fj
- Gonzalez Orellana Ra
- Gonzalez A
- Gonzalez E
- Gonzalez Jp
- Gopalakrishnan N
- Gorelick P
- Gorson D
- Gourdy P
- Govender R
- Govender V
- Gowda A
- Goycoa C
- Goykhman S
- Gracious N
- Greco B
- Greene T
- Greene Tom
- Greloni Gc
- Grineva E
- Grubb S
- Guinsburg A
- Gulati R
- Gunstone A
- Gupta A
- Gupta M
- Gyrina O
- Haase Fp
- Hadjadj S
- Halciakova K
- Hall T
- Haller H
- Halmagyi I
- Hammoud J
- Hancu N
- Handelsman S
- Hanif W
- Hansraj A
- Harcsa E
- Harris R
- Hartman I
- Hawley C
- Heerspink Hiddo J L
- Heerspink Hjl
- Henein S
- Hermida S
- Hernandez Triana E
- Herrera Jimenez Le
- Hershon K
- Hettiarachchi M
- Higuera Jd
- Hillis G
- Hiser D
- Holman R
- Home P
- Hon G
- Hotlos L
- Hristozov K
- Hsia Tl
- Hsieh Ch
- Hudson M
- Hufert K
- Hwang Sj
- Ignjatovic J
- Iitsuka T
- Ilavska A
- Irizar Santana Ss
- Ismail M
- Jackson A
- Jacob R
- Jaffer S
- Jaime M
- Jain D
- Jamal A
- Januszewicz A
- Januzzi J
- Jardine M
- Jardine Meg J
- Jardine Mj
- Jeong Ik
- Jerwan-Keim R
- Jha V
- Ji L
- Jimenez Florez F
- Jimeno C
- Jodar Gimeno Je
- Johnson A
- Johnson D
- Joseph F
- Joshi M
- Juncos Li
- Jurgens J
- Kaczmarek B
- Kajiyama S
- Kamenov Z
- Kaminska A
- Kashine S
- Kasner S
- Kaupke C
- Kawada T
- Kazmirchuk A
- Keightley G
- Keitel E
- Keltai K
- Kendereski A
- Keresztesi S
- Kern E
- Kerr Saraiva Jf
- Keshavamurthy Cb
- Khandwala H
- Khanna R
- Khirmanov V
- Khitan Z
- Khullar D
- Kim S
- Kim Sg
- Kim Yh
- Kiss K
- Kissela B
- Klein A
- Klokocnikova V
- Klyver Mi
- Kodera T
- Kohara Sk
- Koizumi M
- Kolansky D
- Kolesnyk I
- Kolesnyk M
- Kolmakova E
- Komisarenko I
- Kong Wy
- Kong Y
- Kono H
- Konyves L
- Koppolu D
- Kopyt N
- Koroleva T
- Korzh O
- Koundurdjiev A
- Kovar R
- Kovesdy C
- Koyama K
- Kozloviene D
- Kraft F
- Krane V
- Kravchun N
- Krishna G
- Krishnan S
- Kropp J
- Krynski F
- Kumar A
- Kumar J
- Kumar N
- Kumeda Y
- Kumwenda M
- Kurtz Lisboa Hr
- Kusnir J
- Kvitkova L
- Kwon Hs
- Kwon Mj
- Lalic K
- Lalic N
- Lam Sw
- Lanchiotti Pv
- Lane W
- Lastuvka J
- Latiff G
- Laviada Molina H
- Lawrence M
- Lazuka L
- Le Meur Y
- Lee Bw
- Lee J
- Lee Ly
- Lee Mk
- Legun O
- Lehrner L
- Leia C
- Leiter L
- Lentz J
- Leon de la Fuente Ra
- Levin A
- Levin Adeera
- Levinson D
- Lewis D
- Li D
- Li N
- Li W
- Li X
- Lim Sk
- Lim-Abrahan Ma
- Limos A
- Lin Cc
- Lin G
- Lin H
- Lin P
- Lindley R
- Liss K
- Liu J
- Loh Cl
- Lombard L
- Lozanov L
- Lu W
- Lu Yc
- Lukac M
- Luna Ceballos Ri
- Macdougall I
- Maddux A
- Madej A
- Madore F
- Mah Pm
- Mahaffey Kenneth W.
- Mahaffey Kw
- Maheshwari H
- Major L
- Malaver N
- Malberti F
- Malek Marin T
- Mandayam S
- Mandreoli M
- Manisha S
- Mankovskyy B
- Mannucci E
- Manocha Ab
- Mao H
- Marar I
- Marasaev V
- Marchetta N
- Margaritov V
- Martin Del Camp Blanco B
- Martinka E
- Martynyuk L
- Mascaro D
- Maxeiner S
- Mazur S
- Mcguire Dk
- Mcmahon A
- Medina Fari\uf1a M
- Mehta B
- Meininger G
- Meininger Gary
- Mele P
- Middleton J
- Milagres R
- Mileder M
- Miyauchi S
- Mizuyama K
- Mkrtumyan A
- Mlodawska-Choluj D
- Molina de Salazar Di
- Molnar M
- Montenegro Junior R
- Mookadam M
- Morales Franco G
- Morales Portillo C
- Mordujovich J
- Moreda R
- Moreira de Brito C
- Moreira Diaz Jp
- Moreno Loza Ot
- Morren F
- Morugova T
- Mostovoy Y
- Moustafa M
- Mu\uf1oz Lopez Mendoza M
- Mu\uf1oz Torres M
- Mucsi J
- Muirhead N
- Mujica Trenche S
- Munar Vila Ma
- Munteanu M
- Mustieles Rocha C
- Nagibovich G
- Nagibovich O
- Nam Ms
- Narayanan M
- Narvarte J
- Nassar T
- Navickas A
- Nazario Sabbag \uc2r
- Nazzer Hissa M
- Neal B
- Neal Bruce
- Nedogoda S
- Negru D
- Newman G
- Ng Ks
- Ngcakani N
- Nichol B
- Nicholls K
- Nicol P
- Nicolai S
- Nieto Iglesias J
- Niiya T
- Nik Ahmad Nnf
- Nisnisan J
- Nixon P
- Nonchev B
- Noonan P
- Noronha I
- Nortje H
- Nossuli Ak
- Novoa Pa
- Nowicki M
- Nowicki M
- O'Hare J
- O'Shaughnessy A
- Obialo C
- Obrador Vera G
- Obrador G
- Ochodnicka Z
- Oh Kh
- Oishi H
- Olelewe S
- Oliver M
- Onaca Ag
- Oosthuizen H
- Orio Si
- Orlowska-Kowalik G
- Oroszlan T
- Orozco Castellanos R
- Orsi E
- Ory I
- Osipova I
- Ota S
- Otreras F
- Ounadjela S
- Oviedo A
- Packham D
- Padron J
- Panarotto D
- Pankhaniya R
- Pantoja Perez J
- Paragh G
- Parfrey P
- Park Cy
- Park Sh
- Parker R
- Paschen B
- Pashkovska N
- Patel D
- Patel G
- Patel N
- Pavon H
- Pecoits Filho R
- Pecoits-Filho R
- Pella D
- Penfornis A
- Peralta Calcaneo J
- Pereira Ma
- Pererva L
- Perez Vera M
- Perez A
- Perez C
- Peringat J
- Perkovic V
- Perkovic Vlado
- Perlman A
- Pertseva T
- Pesickova S
- Peterfai E
- Peterka K
- Petrica L
- Petro G
- Pettis K
- Pharr W
- Philip S
- Phillips A
- Piatti P
- Pichette V
- Pillay-Ramaya L
- Plassmann G
- Plaza Mv
- Pollock C
- Pollock Carol
- Popa Ar
- Popenda G
- Popovic-Radinovic V
- Portoles Perez Jm
- Prasad N
- Proietto J
- Prozesky H
- Pumprla J
- Purighalla R
- Quesada Sim\uf3n Ma
- Quesada-Suarez L
- Rabasa-Lhoret R
- Raduan Ra
- Raffaele P
- Railey M
- Ramirez Roca La
- Ramos Jc
- Ramtoola S
- Ranetti Ae
- Rangelov R
- Ranjan R
- Raskina T
- Rastogi S
- Ratnasingam V
- Reddy J
- Reddy J
- Ren Y
- Rendell M
- Resk Jh
- Revesz K
- Rewerska B
- Reyes Rosano Ma
- Rheeder P
- Rich L
- Rista L
- Roberts A
- Robinson M
- Rodriguez Papini N
- Rodriguez Pattzi H
- Rodriguez H
- Roger S
- Rosas Guzman J
- Rosas S
- Rose L
- Rosero R
- Rosivall L
- Roussel R
- Rucker Joerg Ie
- Rychl\uedk I
- Rychlik I
- S\ue1nchez Arenales Ja
- Saaveddra Sanchez Sb
- Saavedra Gajardo V
- Saba F
- Sakakibara T
- Sala J
- Salazar Ma
- Samoylov O
- Samoylova Y
- Sanchez Mijangos Jh
- Sanchez Polo Jv
- Sankaram R
- Santoro D
- Santos F
- Santos Jc
- Saporito W
- Sarin R
- Sasso Fc
- Satyanarayana Rk
- Saudek F
- Saulnier Pj
- Saxena M
- Sazonova O
- Scharfstein D
- Schiavi Lb
- Schiller A
- Schmidt M
- Schreiman R
- Schuch T
- Scott D
- Scott R
- Scotton As
- Seeber M
- Sekkarie M
- Sennik D
- Sensenbrenner J
- Serafinceanu C
- Serrano Sanson P
- Serviddio G
- Sessa H
- Shahinfar S
- Shakeel M
- Shamkhalova M
- Shanik M
- Shaw S
- Sheth S
- Sheu Wh
- Shinkov A
- Shutemova E
- Shwartz Y
- Sim\uf5es de Almeida R
- Simo Canonge R
- Simon G
- Singh B
- Sinha Ad
- Slompo Ramos C
- Smatanova I
- Smirnov I
- Smith Casabella T
- Smith S
- Soares Fel\uedcio J
- Solomon R
- Song W
- Sood V
- Soto Gonzalez A
- Soto Mb
- Sowinski D
- Sprague A
- Spry L
- Sreedhar R
- Sreelatha M
- Starzec A
- Steele A
- Stella A
- Stephens J
- Strzelecka A
- Suchinda P
- Sudhakar B
- Sultan S
- Sun J
- Sun L
- Surampudi P
- Sussman S
- Svyshchenko Y
- Symonds R
- Takacs R
- Takai M
- Tamayo Y Orozco JA
- Tan A
- Tan G
- Tangri N
- Tellez Chavez E
- Temelkova M
- Terns Riera M
- Terrelonge A
- Terront Lozano Ma
- Tesar V
- Thervet E
- Thimmaiah R
- Thom\ue9 F
- Thompson M
- Tibes Hachmann Jc
- Tinahones Madueno Fj
- Toarba C
- Tolentino M
- Tomashkevych H
- Tomonaga O
- Topchii I
- Torshizi A
- Travis K
- Trespalacios F
- Trevisan R
- Trippe B
- Trueba P
- Tryshchuk N
- Tsang V
- Tseluyko V
- Tsujimoto M
- Tu P
- Turchin A
- Turcios Juarez E
- Turner W
- Twahirwa M
- Ulla Mr
- Updegrove J
- Urbanaviciene E
- Uriasyev O
- Valderrama Cometa L
- Valdes Depeda A
- Valdez M
- Valenzuela A
- Valis M
- Vallejos A
- Van Buren P
- Vangel S
- Vannorsdall M
- Vargas Alonso Rd
- Varghese F
- Vasas S
- Vazelov E
- Vejar M
- Velasquez-Mieyer P
- Velichkova E
- Venegas Carrillo L
- Vengadasalam P
- Ventrapragada S
- Veronelli Am
- Villagordoa Mesa J
- Villarino A
- Villegas I
- Visco Ve
- Vizir V
- Vlasenko M
- von Ingersleben G
- Vorobyev S
- Vukotic G
- Vyasam Rc
- Wada T
- Wadud K
- Wahba M
- Wakasugi M
- Wakeling J
- Wakida Y
- Walker R
- Wang G
- Wang H
- Warren M
- Wassermann A
- Watanabe T
- Watson E
- Watson H
- Watts R
- Weiner D
- Weiner P
- Welker J
- Welsh J
- Wheeler D
- Wheeler David C
- Wheeler Dc
- Williams M
- Williams S
- Winocour P
- Wong Ac
- Woo V
- Yakov A
- Yamada M
- Yamada S
- Yanagida K
- Yanase T
- Yang J
- Yao C
- Yap Ye
- Yavin Yshai
- Ygpuara Mdl
- Yin A
- Yoiti Hayashida C
- Yoon Kh
- Yost L
- Young S
- Yu X
- Yumita W
- Yupanqui H
- Zaidman Cj
- Zalunardo N
- Zamarripa Escobedo R
- Zanata Petry Tb
- Zanella Mt
- Zaniewski-Singh M.
- Zanoli L
- Zaoui P
- Zateyshchikova A
- Zateyshshikov D
- Zaviriukha V
- Zemek S
- Zhang H
- Zhang Hong
- Zhao M
- Zheng H
- Zinman B
- Zinman Bernard
- Zlova T
- Zsom M
- Zub L
- Zykova T
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodiumâglucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with reninâangiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase
- Author
- Adisakwattana S
- Ahmed F
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Measurement of the Higgs boson production via vector boson fusion and its decay into bottom quarks in proton-proton collisions at sâ = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbott S
- Abbrescia M
- Abdalla H
- Abdullah Al-Mashad M
- Abdullin S
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/01/2024
- Field of study
A preprint version of the article is available at arXiv:2308.01253v2 [hep-ex], https://arxiv.org/abs/2308.01253v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/HIG-22-009 (CMS Public Pages). Report number: CMS-HIG-22-009, CERN-EP-2023-110.A measurement of the Higgs boson (H) production via vector boson fusion (VBF) and its decay into a bottom quark-antiquark pair (bbÂŻ) is presented using proton-proton collision data recorded by the CMS experiment at sâ = 13 TeV and corresponding to an integrated luminosity of 90.8 fbâ1. Treating the gluon-gluon fusion process as a background and constraining its rate to the value expected in the standard model (SM) within uncertainties, the signal strength of the VBF process, defined as the ratio of the observed signal rate to that predicted by the SM, is measured to be ÎŒqqHHbbÂŻ = 1.01 +0.55â0.46. The VBF signal is observed with a significance of 2.4 standard deviations relative to the background prediction, while the expected significance is 2.7 standard deviations. Considering inclusive Higgs boson production and decay into bottom quarks, the signal strength is measured to be ÎŒincl.HbbÂŻ = 0.99 +0.48â0.41, corresponding to an observed (expected) significance of 2.6 (2.9) standard deviations.SCOAP3, STFC; Marie-Curie program and the European Research Council and Horizon 2020 Gran
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Evidence for tWZ production in proton-proton collisions at âs=13 TeV in multilepton final states
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- Yuldashev BS
- Yusuff I
- Zabi A
- Zabolotny W
- Zacharopoulou A
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
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- Zaza A
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- Zehetner P
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- Zghiche A
- Zhang F
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- Zimermmane Castro Santos A
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- Zisopoulos I
- Zoi I
- Zolkapli Z
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- Zorbilmez C
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- Zotz A
- Zou R
- Zucchetta A
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- Zuolo D
- Zygala L
- Publication venue
- Elsevier BV
- Publication date
- 21/06/2024
- Field of study
Data availability - https://www.sciencedirect.com/science/article/pii/S0370269324003733?via%3Dihub#dav0001 [Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS data preservation, re-use and open access policy (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2)]The first evidence for the standard model production of a top quark in association with a W boson and a Z boson is reported. The measurement is performed in multilepton final states, where the Z boson is reconstructed via its decays to electron or muon pairs. At least one W boson, associated or from top quark decay, decays leptonically, too. The analysed data were recorded by the CMS experiment at the CERN LHC in 2016â2018 in proton-proton collisions at âs=13 TeV, and correspond to an integrated luminosity of 138 fbâ1. The measured cross section is 354±54(stat)±95(syst) fb, and corresponds to a statistical significance of 3.4 standard deviations.SCOAP
Recommended from our members
Search for dark matter particles in W+Wâ events with transverse momentum imbalance in proton-proton collisions at âs = 13 TeV
- Author
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- Aarup Petersen H
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 02/03/2024
- Field of study
A preprint version of the article is available at arXiv:2310.12229v2 [hep-ex], https://arxiv.org/abs/2310.12229v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-012 (CMS Public Pages).A search for dark matter particles is performed using events with a pair of W bosons and large missing transverse momentum. Candidate events are selected by requiring one or two leptons (â = electrons or muons). The analysis is based on proton-proton collision data collected at a center-of-mass energy of 13 TeV by the CMS experiment at the LHC and corresponding to an integrated luminosity of 138 fbâ1. No significant excess over the expected standard model background is observed in the âÎœqq and 2â2Îœ final states of the W+Wâ boson pair. Limits are set on dark matter production in the context of a simplified dark Higgs model, with a dark Higgs boson mass above the W+Wâ mass threshold. The dark matter phase space is probed in the mass range 100â300 GeV, extending the scope of previous searches. Current exclusion limits are improved in the range of dark Higgs masses from 160 to 250 GeV, for a dark matter mass of 200 GeV.SCOAP3
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Search for direct production of GeV-scale resonances decaying to a pair of muons in proton-proton collisions at sâ = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 30/11/2023
- Field of study
A preprint version of the article is available at arXiv:2309.16003v2 [hep-ex], https://arxiv.org/abs/2309.16003v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables, including additional supplementary figures, can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-005 (CMS Public Pages). Report number: CMS-EXO-21-005, CERN-EP-2023-165.A search for direct production of low-mass dimuon resonances is performed using sâ = 13 TeV proton-proton collision data collected by the CMS experiment during the 2017-2018 operation of the CERN LHC with an integrated luminosity of 96.6 fbâ1. The search exploits a dedicated high-rate trigger stream that records events with two muons with transverse momenta as low as 3 GeV but does not include the full event information. The search is performed by looking for narrow peaks in the dimuon mass spectrum in the ranges of 1.1-2.6 GeV and 4.2-7.9 GeV. No significant excess of events above the expectation from the standard model background is observed. Model-independent limits on production rates of dimuon resonances within the experimental fiducial acceptance are set. Competitive or world's best limits are set at 90% confidence level for a minimal dark photon model and for a scenario with two Higgs doublets and an extra complex scalar singlet (2HDM+S). Values of the squared kinetic mixing coefficient Δ2 in the dark photon model above 10â6 are excluded over most of the mass range of the search. In the 2HDM+S, values of the mixing angle sin(ΞH) above 0.08 are excluded over most of the mass range of the search with a fixed ratio of the Higgs doublets vacuum expectation tanÎČ = 0.5.SCOAP3
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Search for WâČ bosons decaying to a top and a bottom quark in leptonic final states in proton-proton collisions at sâ = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
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- Publication venue
- Springer Nature
- Publication date
- 05/04/2024
- Field of study
A preprint version of the article is available at arXiv:2310.19893v1 [hep-ex], https://arxiv.org/abs/2310.19893v1 . Comments: Submitted to the Journal of High Energy Physics. All figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/B2G-20-012 (CMS Public Pages). Report number: CMS-B2G-20-012, CERN-EP-2023-213.A search for W' bosons decaying to a top and a bottom quark in final states including an electron or a muon is performed with the CMS detector at the LHC. The analyzed data correspond to an integrated luminosity of 138 fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 Tev. Good agreement with the standard model expectation is observed and no evidence for the existence of the W' boson is found over the mass range examined. The largest observed deviation from the standard model expectation is found for a W' boson mass (mWâČ) hypothesis of 3.8 TeV with a relative decay width of 1%, with a local (global) significance of 2.6 (2.0) standard deviations. Upper limits on the production cross sections of W' bosons decaying to a top and a bottom quark are set. Left- and right-handed W' bosons with mWâČ below 3.9 and 4.3 TeV, respectively, are excluded at the 95% confidence level, under the assumption that the new particle has a narrow decay width. Limits are also set for relative decay widths up to 30%. These are the most stringent limits to date on this W' boson decay channel.SCOAP3
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 16/10/2023
- Field of study
A preprint version of the article is available at arXiv:2307.15761v2 [hep-ex], https://arxiv.org/abs/2307.15761v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-22-006 (CMS Public Pages). Report number: CMS-TOP-22-006, CERN-EP-2023-124.A search for new physics in top quark production with additional final-state leptons is performed using data collected by the CMS experiment in proton-proton collisions at âs = 13 TeV at the LHC during 2016-2018. The data set corresponds to an integrated luminosity of 138 fbâ1. Using the framework of effective field theory (EFT), potential new physics effects are parametrized in terms of 26 dimension-six EFT operators. The impacts of EFT operators are incorporated through the event-level reweighting of Monte Carlo simulations, which allows for detector-level predictions. The events are divided into several categories based on lepton multiplicity, total lepton charge, jet multiplicity, and b-tagged jet multiplicity. Kinematic variables corresponding to the transverse momentum (pT) of the leading pair of leptons and/or jets as well as the pT of on-shell Z bosons are used to extract the 95% confidence intervals of the 26 Wilson coefficients corresponding to these EFT operators. No significant deviation with respect to the standard model prediction is found.SCOAP3