AN AYURVEDIC REVIEW ON JANAPADODHWAMSA

Ayurveda the eternal life science from many centuries proved to be the most efficient tool in the health management system. It gives more weightage to the prevention than the cure. Janapadodhwamsa is one among the unique concept described in Ayurveda treatises which literally means demolition or annihilation of people or community. Acharya Charaka called it Janapadodhwamsa, Acharya Sushruta called it Maraka, and Acharya Bhela called it Janamaar. There are four factors that have been described which are common and essential for every living being, that is, Vayu (air), Jala (water), Desha (land), and Kaala (season). Among these four factors, Kaala is mainly main factor. Any abnormal alteration in these four factors can significantly influence individual or community or environment or all of them together. Vitiation of these four common factors is the cause for Janapadodhwamsa. Foremost reason for Janapadodhwamsa has been described as Adharma (immorality) and the root cause of Adharma is said to be Pragyaparadha (delinquency of wisdom). Considering the note worthiness of Janapadodhwamsa, a whole chapter has been depicted in CharakaSamhita illustrating its onset, causes, peculiar features, and management. Its causative agents, method of prevention has been clearly explained. To manage Janapadodhvamsa, it is advised to include the usage of Rasayana therapy, Panchkarama procedures, SadvritPaalan (code of right conducts), and Aachara Rasayana, that is, behavioral therapy

GEOMETRIC INEQUALITIES FOR DOUBLY WARPED PRODUCTS POINTWISE BI-SLANT SUBMANIFOLDS IN CONFORMAL SASAKIAN SPACE FORM

In this paper, we have established some geometric inequalities for the squared mean curvature in terms of warping functions of a doubly warped product pointwise bi-slant submanifold of a conformal Sasakian space form with a quarter symmetric metric connection. The equality cases havve also been considered. Moreover, some applications of obtained results are derived

Etiological profile in patients with heart failure

Background: The incidence and prevalence rates of heart failure (HF) are increasing worldwide. The prevalence of HF rises exponentially with increasing age and affects 4% to 8% of people older than 65. The leading causes of HF in India include coronary artery disease (CAD), diabetes, hypertension, rheumatic valvular heart diseases and primary cardiac muscle diseases. Rheumatic heart disease (RHD) is still a common cause of HF in India. Epidemiological studies have estimated that 1.5% to 2% population experience HF and it is the main reason for hospital admission of elderly patients. The objective of this study was to establish the etiological factors of heart failureMethods: A cross sectional study of 150 patients above the age of 18 years presented with heart failure diagnosed clinically on the basis of Framingham heart failure criteria and echocardiography, done over a period of one year in department of medicine in BRD medical college Gorakhpur Uttar Pradesh.Results: A total of 150 patients were include in this analysis the majority of patients were male (57.3%). Age of patients ranged from 18 - 70 years and 84% patients were above the age of 40 years.Conclusions: Heart failure was more prevalent in elderly male above 40 years of age. Myocardial infarction, DCMP, rheumatic heart disease and hypertensive heart failure are the common etiology leading to heart failure

ON KENMOTSU MANIFOLDS WITH SEMI-SYMMETRIC METRIC CONNECTION

The aim of the present paper is to study the properties of locally and globally $\phi$-concircularly symmetric Kenmotsu manifolds endowed with a semi-symmetric metric connection. First, we will prove that the locally $\phi$-symmetric and the globally $\phi$-concircularly symmetric Kenmotsu manifolds are equivalent. Next, we will study three dimensional locally $\phi$-symmetric, locally $\phi$-concircularly symmetric and locally $\phi$-concircularly recurrent Kenmotsu manifolds with respect to such connection and will obtain some geometrical results. In the end, we will construct a non-trivial example of Kenmotsu manifold admitting a semi-symmetric metric connection and validate our results. 

Design of CNN architecture for Hindi Characters

Handwritten character recognition is a challenging problem which received attention because of its potential benefits in real-life applications. It automates manual paper work, thus saving both time and money, but due to low recognition accuracy it is not yet practically possible. This work achieves higher recognition rates for handwritten isolated characters using Deep learning based Convolutional neural network (CNN). The architecture of these networks is complex and plays important role in success of character recognizer, thus this work experiments on different CNN architectures, investigates different optimization algorithms and trainable parameters. The experiments are conducted on two different types of grayscale datasets to make this work more generic and robust. One of the CNN architecture in combination with adadelta optimization achieved a recognition rate of 97.95%. The experimental results demonstrate that CNN based end-to-end learning achieves recognition rates much better than the traditional techniques

Application of nano-curcumin as a natural antimicrobial agent against Gram-positive pathogens

Gram-positive bacteria cause various diseases from the superficial skin to deep tissue infections. The capability of causing numerous diseases is due to the production of virulence factors which are tightly regulated by the virulence genes. Various Gram-positive pathogenic bacteria e.g. Staphylococcus, Mycobacterium, and Listeria are capable of causing lethal infections in humans and animals. Conventional antibiotics, targeted antibiotics, and combinatorial drugs are used as therapeutic agents against Gram-positive pathogens. Due to intricate virulence pathway bacteria readily adopt resistance to available drugs. Therefore, there is need to develop some alternative approaches to combat these infections. Various natural extracts are effective against pathogenic bacteria with or without the available drugs. Curcumin is a natural extract of Curcuma longas rhizome, known as turmeric. Curcumin shows various biological activities such as antimicrobial, antioxidant and anti-inflammatory. It also shows strong antibacterial activity against Gram-positive and few Gram-negative bacteria. Besides all these beneficial applications, major drawbacks of curcumin are poor aqueous solubility and less bioavailability. However, drug delivery approaches including nanoformulation are developed to increase its stability in vitro and in vivo settings. The present review article focused on the translation of potential applications of curcumin in various diseases specifically caused by Gram-positive pathogens. Various methods used for the formulations of curcumin nanoparticles, combinatorial strategies with curcumin nanoparticles and their application in the prevention of infections have been discussed. The present article also discusses the future aspects of curcumin-nanoparticles and its use as an alternative therapeutic approach against pathogens

Emissions from village cookstoves in Haryana, India, and their potential impacts on air quality

Air quality in rural India is impacted by residential cooking and heating with biomass fuels. In this study, emissions of CO, CO2, and 76 volatile organic compounds (VOCs) and fine particulate matter (PM2.5) were quantified to better understand the relationship between cook fire emissions and ambient ozone and secondary organic aerosol (SOA) formation. Cooking was carried out by a local cook, and traditional dishes were prepared on locally built chulha or angithi cookstoves using brushwood or dung fuels. Cook fire emissions were collected throughout the cooking event in a Kynar bag (VOCs) and on polytetrafluoroethylene (PTFE) filters (PM2.5). Gas samples were transferred from a Kynar bag to previously evacuated stainless-steel canisters and analyzed using gas chromatography coupled to flame ionization, electron capture, and mass spectrometry detectors. VOC emission factors were calculated from the measured mixing ratios using the carbon-balance method, which assumes that all carbon in the fuel is converted to CO2, CO, VOCs, and PM2.5 when the fuel is burned. Filter samples were weighed to calculate PM2.5 emission factors. Dung fuels and angithi cookstoves resulted in significantly higher emissions of most VOCs (p < 0.05). Utilizing dung-angithi cook fires resulted in twice as much of the measured VOCs compared to dung-chulha and 4 times as much as brushwood-chulha, with 84.0, 43.2, and 17.2g measured VOCkgg fuel carbon, respectively. This matches expectations, as the use of dung fuels and angithi cookstoves results in lower modified combustion efficiencies compared to brushwood fuels and chulha cookstoves. Alkynes and benzene were exceptions and had significantly higher emissions when cooking using a chulha as opposed to an angithi with dung fuel (for example, benzene emission factors were 3.18gkgg fuel carbon for dung-chulha and 2.38gkgg fuel carbon for dung-angithi). This study estimated that 3 times as much SOA and ozone in the maximum incremental reactivity (MIR) regime may be produced from dung-chulha as opposed to brushwood-chulha cook fires. Aromatic compounds dominated as SOA precursors from all types of cook fires, but benzene was responsible for the majority of SOA formation potential from all chulha cook fire VOCs, while substituted aromatics were more important for dung-angithi. Future studies should investigate benzene exposures from different stove and fuel combinations and model SOA formation from cook fire VOCs to verify public health and air quality impacts from cook fires

Molecular composition of particulate matter emissions from dung and brushwood burning household cookstoves in Haryana, India

Emissions of airborne particles from biomass burning are a significant source of black carbon (BC) and brown carbon (BrC) in rural areas of developing countries where biomass is the predominant energy source for cooking and heating. This study explores the molecular composition of organic aerosols from household cooking emissions with a focus on identifying fuel-specific compounds and BrC chromophores. Traditional meals were prepared by a local cook with dung and brushwood-fueled cookstoves in a village in Palwal district, Haryana, India. Cooking was done in a village kitchen while controlling for variables including stove type, fuel moisture, and meal. Fine particulate matter (PM2.5) emissions were collected on filters, and then analyzed via nanospray desorption electrospray ionization-high-resolution mass spectrometry (nano-DESI-HRMS) and high-performance liquid chromatography-photodiode array-high-resolution mass spectrometry (HPLC-PDA-HRMS) techniques. The nano-DESI-HRMS analysis provided an inventory of numerous compounds present in the particle phase. Although several compounds observed in this study have been previously characterized using gas chromatography methods a majority of the species in the nano-DESI spectra were newly observed biomass burning compounds. Both the stove (chulha or angithi) and the fuel (brushwood or dung) affected the composition of organic aerosols. The geometric mean of the PM2.5 emission factor and the observed molecular complexity increased in the following order: brushwood-chulha (7.3±1.8 g kg-1 dry fuel, 93 compounds), dung-chulha (21.1±4.2 g kg-1 dry fuel, 212 compounds), and dung-angithi (29.8±11.5 g kg-1 dry fuel, 262 compounds). The mass-normalized absorption coefficient (MACbulk) for the organic-solvent extractable material for brushwood PM2.5 was 3.7±1.5 and 1.9±0.8m2 g-1 at 360 and 405 nm, respectively, which was approximately a factor of two higher than that for dung PM2.5. The HPLC-PDA-HRMS analysis showed that, regardless of fuel type, the main chromophores were CxHyOz lignin fragments. The main chromophores accounting for the higher MACbulk values of brushwood PM2.5 were C8H10O3 (tentatively assigned to syringol), nitrophenols C8H9NO4, and C10H10O3 (tentatively assigned to methoxycinnamic acid)

A REVIEW UPDATED ON CHEMOTHERAPEUTICS

Antineoplastic therapy aims at completely eliminating all neoplastic cells, by either surgical, radio therapeutic or pharmacological (administration of drugs) intervention. If this is not possible or feasible, the aim of therapy becomes palliative, that is, its purpose is to reduce the number of neoplastic cells, to improve the symptoms and, if possible, to prolong survival while maintaining an adequate quality of life. Neoplastic cells constitute a heterogeneous cellular population, with biochemical, morphological and immunological differences. Consequently, they evidence a widely varying sensitivity to antineoplastic drugs. Furthermore, not all the cells present in a given tumor are in the same phase in the cell cycle (generally, in the proliferative or in the rest phase). When a neoplasm is diagnosed, most of its cells have usually attained a phase of decelerated growth, because of vascularisation problems, of nutrient competitively problems, of lack of physical space, or of problems of other types. Many of the chemotherapeutic drugs are most effective on cells that are in their division process, and this means that, in principle, a large proportion of the neoplastic cells will be resistant to the effects of a given drug. The small-molecule drugs are the ones whose molecular weight is less than 1000 Daltons. The fastest growing cells in the body are present in skin, hair follicles and lining of the gastrointestinal tract and hence they are affected the most during chemotherapy. In this present review summarized knowledge of chemotherapy by different way