720 research outputs found
Spreading Width for Decay out of a Superdeformed Band
The attenuation factor F responsible for the decay out of a superdeformed
(SD) band is calculated with the help of a statistical model. This factor is
given by 1/F = (1 + Gamma(down) / Gamma(S)). Here, Gamma(S) is the width for
the collective E2 transition within the superdeformed band, and Gamma(down) is
the spreading width which describes the mixing between a state in the SD band
and the normally deformed (ND) states of equal spin. The attenuation factor F
is independent of the statistical E1 decay widths Gamma(N) of the ND states
provided that the Gamma(N) are much larger than both Gamma(down) and Gamma(S).
This condition is generically met. Previously measured values of F are used to
determine Gamma(down).Comment: Submitted to Physical Review Letter
Alternative Interpretation of Sharply Rising E0 Strengths in Transitional Regions
It is shown that strong 0+2 -> 0+1 E0 transitions provide a clear signature
of phase transitional behavior in finite nuclei. Calculations using the IBA
show that these transition strengths exhibit a dramatic and robust increase in
spherical-deformed shape transition regions, that this rise matches well the
existing data, that the predictions of these E0 transitions remain large in
deformed nuclei, and that these properties are intrinsic to the way that
collectivity and deformation develop through the phase transitional region in
the model, arising from the specific d-boson coherence in the wave functions,
and that they do not necessarily require the explicit mixing of normal and
intruder configurations from different IBA spaces.Comment: 6 pages, 3 figure
Characterization of the Ca2+-gated and voltage-dependent k+-channel slo-1 of nematodes and its interaction with emodepside
The cyclooctadepsipeptide emodepside and its parent compound PF1022A are broad-spectrum nematicidal drugs which are able to eliminate nematodes resistant to other anthelmintics. The mode of action of cyclooctadepsipeptides is only partially understood, but involves the latrophilin Lat-1 receptor and the voltage- and calcium-activated potassium channel Slo-1. Genetic evidence suggests that emodepside exerts its anthelmintic activity predominantly through Slo-1. Indeed, slo-1 deficient Caenorhabditis elegans strains are completely emodepside resistant. However, direct effects of emodepside on Slo-1 have not been reported and these channels have only been characterized for C. elegans and related Strongylida. Molecular and bioinformatic analyses identified full-length Slo-1 cDNAs of Ascaris suum, Parascaris equorum, Toxocara canis, Dirofilaria immitis, Brugia malayi, Onchocerca gutturosa and Strongyloides ratti. Two paralogs were identified in the trichocephalids Trichuris muris, Trichuris suis and Trichinella spiralis. Several splice variants encoding truncated channels were identified in Trichuris spp. Slo-1 channels of trichocephalids form a monophyletic group, showing that duplication occurred after the divergence of Enoplea and Chromadorea. To explore the function of a representative protein, C. elegans Slo-1a was expressed in Xenopus laevis oocytes and studied in electrophysiological (voltage-clamp) experiments. Incubation of oocytes with 1-10 µM emodepside caused significantly increased currents over a wide range of step potentials in the absence of experimentally increased intracellular Ca2+, suggesting that emodepside directly opens C. elegans Slo-1a. Emodepside wash-out did not reverse the effect and the Slo-1 inhibitor verruculogen was only effective when applied before, but not after, emodepside. The identification of several splice variants and paralogs in some parasitic nematodes suggests that there are substantial differences in channel properties among species. Most importantly, this study showed for the first time that emodepside directly opens a Slo-1 channel, significantly improving the understanding of the mode of action of this drug class
Augmented particle trapping and attenuated inflammation in the liver by protective vaccination against Plasmodium chabaudi malaria
Investigations on the occurrence of tapeworm infections in German horse populations with comparison of different antibody detection methods based on saliva and serum samples
Background
Effective and sustainable worm control in horses would benefit from detailed information about the current regional occurrence of tapeworms. Different diagnostic methods are currently available to detect Anoplocephala spp. infections in horses. However, the format as well as the sensitivity and specificity of the methods vary considerably.
Methods
A coprological, serological and questionnaire study was conducted to investigate the prevalence and risk factors of tapeworm infections on 48 horse farms in the region of Berlin and Brandenburg, Germany. In total, faecal samples of 484 horses were analysed using the double centrifugation/combined sedimentation-flotation and mini-FLOTAC. Serum (n = 481) and saliva (n = 365) samples were analysed by ELISAs to determine antibody levels against Anoplocephala spp. 12/13 kDa excretory/secretory (E/S) antigens.
Results
Cestode eggs were detected in 0.6% of faecal samples (farm prevalence 6.3%) without differences between the two methods. In contrast, antibodies against Anoplocephala spp. were detected in 16.2% (farm prevalence 52.1%) and in 29.5% (farm prevalence 75.7%) of the serum and saliva samples, respectively. Both ELISA based methods for detection of tapeworms reported a greater number of infected animals requiring treatment than were positively identified by coproscopy. Logistic regression analysis identified permanent pasture access, large pastures and regular pasture changes and high strongyle egg counts as risk factors for positive serum antibody responses to Anoplocephala spp. while last treatment with praziquantel was protective. Other protective factors were the presence of foals and high numbers of horses on the farm. Daily removal of faeces from the pasture and horse age did not have a significant effect.
Conclusions
The findings of the present serological investigation indicate that tapeworm prevalence in Berlin/Brandenburg horse farms is much higher than would be anticipated by using conventional/coproscopic analyses. Moreover, the majority of tapeworm-positive horses had not received a cestocidal drug at their last treatment. Considering the already known low sensitivity of the coproscopic detection, the equine veterinary diagnostics can be enhanced by the use of antibody detection methods such as the saliva-based ELISA
Production of 26Al in stellar hydrogen-burning environments: spectroscopic properties of states in 27Si
Model predictions of the amount of the radioisotope 26Al produced in
hydrogen-burning environments require reliable estimates of the thermonuclear
rates for the 26gAl(p,{\gamma})27Si and 26mAl(p,{\gamma})27Si reactions. These
rates depend upon the spectroscopic properties of states in 27Si within about 1
MeV of the 26gAl+p threshold (Sp = 7463 keV). We have studied the
28Si(3He,{\alpha})27Si reaction at 25 MeV using a high-resolution
quadrupole-dipole-dipole-dipole magnetic spectrograph. For the first time with
a transfer reaction, we have constrained J{\pi} values for states in 27Si over
Ex = 7.0 - 8.1 MeV through angular distribution measurements. Aside from a few
important cases, we generally confirm the energies and spin-parity assignments
reported in a recent {\gamma}-ray spectroscopy study. The magnitudes of neutron
spectroscopic factors determined from shell-model calculations are in
reasonable agreement with our experimental values extracted using this
reaction.Comment: accepted for publication in Phys. Rev.
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