IN VITRO ANTI-INFLAMMATORY, ANTIOXIDANT AND NEPHROPROTECTIVE STUDIES ON LEAVES OF AEGLE MARMELOS AND OCIMUM SANCTUM

Objective: To study the in vitro anti-inflammatory, antioxidant and nephroprotective studies on leaves of Aegle marmelos and Ocimum sanctum.Methods: In vitro nephroprotective screening of aqueous extract of leaves were performed employing cytoprotective assay using epiflourescence dual staining assay was performed against normal kidney cell treated with gentamicin. In vitro anti-inflammatory studies were also performed for the extracts using protease inhibition activity, membrane stabilization and protein denaturation inhibition assays. In vitro nephroprotective activity was conducted using gentamicin induced normal rat kidney cells. In silico modelling and docking studies were also performed and in vitro cytoprotective assay was performed to evaluate cell cytotoxic efficacy. Results: Leaf extracts clearly revealed the dose dependent increase in nephroprotection. Similarly in vitro antioxidant and anti-inflammatory activities proved scientifically the ethnomedicinal claim of these selected plant drugs. Aegelin, marmin and marmesin identified from Aegle marmelos extract showed good binding affinity towards the active site of MCP1 and NGAL protein. In silico modelling and docking studies were also performed to suggest the probable mechanism of action of these plant extracts. In vitro cytoprotective assay showed its potent cell cytotoxic efficacy.Conclusion: The present study showed in vitro antioxidant and anti-inflammatory activities along with nephroprotective property which scientifically prove the ethnomedicinal claim of these selected plant drugs.Keywords: Aegle marmelos, Ocimum sanctum, antioxidant, anti-inflammatory, cytoprotective, nephroprotective, in silico, ethnomedicinal

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Not AvailableIn human clinical trials and biological experiments, randomization has been extensively used as a method of experimental control. It insures against the accidental bias and helps in preventing the selection bias. In treatment assignments, it eliminates the source of bias and produces the comparable groups, thereby expressing the likelihood of chance as a source for the difference of end outcome by permitting the use of probability theory. This study covers different methods of randomization and the use of online statistical computing web programming www.randomization. com for generating the randomization schedule. Issues related to randomization are also discussed in this studyNot Availabl

Rectangular cone b-metric spaces over Banach algebra and contraction principle

Abstract Rectangular cone b-metric spaces over a Banach algebra are introduced as a generalization of metric space and many of its generalizations. Some fixed point theorems are proved in this space and proper examples are provided to establish the validity and superiority of our results. An application to solution of linear equations is given which illustrates the proper application of the results in spaces over Banach algebra

Assessment of sesame (Sesamum indicum L.) cake as a source of high-added value substances: from waste to health

The risk of exhaustion of natural resources and raw materials have given rise to emerging trends such as recycling of food waste. From the economical and ecological points of view, conversion of biowaste to high added value compounds has been getting great attention among the science and commercial entities. Due to their high-added value phytochemicals, agricultural and food residues have been a great significant to the researchers around the world. This study focuses on the valorisation of cake derived from sesame oil processing. If the very valuable non-nutrient phytochemicals in sesame cake are not evaluated properly, they would be consumed as just animal feed or fertilizers. They might be employed as antiaging (in pharmaceutical products), or free radical scavenger (in dietary supplements), or preservative additive against lipid oxidation (in fat containing food products). This review article aims to present pharmacological and therapeutic effects of sesame cake extract by pointing out its application in pharmaceutical, cosmetic and food industries

Valorization of a biomass: phytochemicals in oilseed by-products

A huge amount of residue is released every year in agricultural and food industries. If this waste is valorised properly, it would be very beneficial from both economic and environmental aspects. Recently, seeds of oil crops have been getting great interest due to their waste rich in a great variety of lipophilic and hydrophilic phytochemicals. On the other hand, oilseed processing by-products comprise approximately 35 millions of tons seed for oil in European Union. Therefore, this remarkable amount of residue should be considered as a resource from waste to health. The purpose of the present research is to introduce the types of oilseed by-product and their high added value phytochemicals by summarizing the recent studies on the valorization of different wastes of several oilseed crops. This research also supplies an overview of the oilseed sources with their botanical names, production regions and target phytochemical ingredients. Moreover, further remarks with some certain concerns are discussed

Proceedings of the 2nd International Conference on Modern Trends in Engineering Technology and Management

This proceeding contains articles on the various ideas of the academic community presented at The 2nd International Conference on Modern Trends in Engineering Technology and Management (ICMEM 2023) organized by the Sree Narayana Institute of Technology Adoor-691554, Kerala, India on 4th-6th May 2023.  ICMEM 2023 aimed to provide a forum for the exchange of ideas, issues, challenges, discoveries, opportunities, and applications of Modern Trends in Engineering Technology and Management. The ever-changing scope and rapid development of science and technology generate new problems, questions, and curiosity, necessitating the exchange of brilliant ideas and raising awareness of this vital research field in a variety of directions.  Conference Title: 2nd International Conference on Modern Trends in Engineering Technology and ManagementConference Acronyms: ICMEM 2023Conference Date: 4th-6th May 2023Conference Location: Hybrid ModeConference Organizer: SNIT Adoor, Kerala, Indi