6,197 research outputs found
Three-dimensional micro-droplet collision simulation using the Lattice Boltzmann method
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.The modelling of binary droplet collisions has important applications in many engineering problems, including spray coating and fuel injection. The Lattice Boltzmann method (LBM) is a well established technique for modelling multiphase fluids, and does so without the difficulties of explicit interface tracking found in other CFD methods. However, simulating droplet collisions under realistic conditions remains a complex problem. Challenges include reproducing the different collision outcomes observed experimentally (Qian and Law, 1997), and maintaining a stable simulation at sufficiently high Reynolds and Weber numbers, and with a high density ratio between the liquid and gas phases. Although previous studies have achieved these goals individually, they have not been successfully combined to simulate droplet collisions with realistic physical parameters. A number of different methods for extending the LBM for multiphase flow exist, with the Shan-Chen interparticle potential method (Shan and Chen, 1993) being the basic model used here. Many extensions to improve the original Shan-Chen method have been proposed, to improve achievable Reynolds number and density ratio. Using combinations of these, both coalescence and separation of two-dimensional droplets were successfully simulated at density ratios of order 1000, and high Weber numbers (Lycett-Brown et al., 2011). In this study, the developed methodologies in Lycett-Brown et al. (2011) are extended to simulate three dimensional micro-droplet collisions by making use of the LBM’s excellent scalability on massively parallel computers. These high-resolution simulations are also compared with low-resolution three-dimensional simulations using a multiple-relaxation-time LBM approach (Monaco and Luo, 2008).This study is funded by the Engineering and Physical Sciences Research Council for Grant No. EP/I000801/1 and a HEC Studentship
Multiphase cascaded lattice Boltzmann method
To improve the stability of the lattice Boltzmann method (LBM) at high Reynolds number the cascaded LBM has recently been introduced. As in the multiple relaxation time (MRT) method the cascaded LBM introduces additional relaxation times into the collision operator, but does so in a co-moving reference frame. This has been shown to significantly increase stability at low viscosity in the single phase case. Here the cascaded LBM is further developed to include multiphase flow. For this the force term is calculated by the interaction potential method, and introduced into the collision operator via the exact difference method (EDM). Comparisons are made with the lattice Bhatnagar–Gross–Krook (LBGK) method, and an MRT implementation. Both the cascaded and MRT methods are shown to significantly reduce spurious velocities over the LBGK method. For the particular case of the Shan–Chen interparticle force term calculation with the EDM, the cascaded LBM is successfully combined with a multiphase method, and shown to perform as well as the more established MRT method. The cascaded LBM is found to be a considerably improved approach to the simulation of multiphase flow over the LBGK, significantly increasing the stability range of both density ratio and Reynolds number. Additionally the importance of including third order velocity terms in the equilibria of both the cascaded and MRT methods is discussed
Cascaded lattice Boltzmann method with improved forcing scheme for large-density-ratio multiphase flow at high Reynolds and Weber numbers
A recently developed forcing scheme has allowed the pseudopotential multiphase lattice Boltzmann method to correctly reproduce coexistence curves, while expanding its range to lower surface tensions and arbitrarily high density ratios [Lycett-Brown and Luo, Phys. Rev. E 91, 023305 (2015)]. Here, a third-order Chapman-Enskog analysis is used to extend this result from the single-relaxation-time collision operator, to a multiple-relaxation-time cascaded collision operator, whose additional relaxation rates allow a significant increase in stability. Numerical results confirm that the proposed scheme enables almost independent control of density ratio, surface tension, interface width, viscosity, and the additional relaxation rates of the cascaded collision operator. This allows simulation of large density ratio flows at simultaneously high Reynolds and Weber numbers, which is demonstrated through binary collisions of water droplets in air (with density ratio up to 1000, Reynolds number 6200 and Weber number 440). This model represents a significant improvement in multiphase flow simulation by the pseudopotential lattice Boltzmann method in which real-world parameters are finally achievable
An exploration of how specialist dementia nurses perceive and maintain the skills and competencies that frame their specialism: A qualitative survey.
BACKGROUND: UK policy for complex and long-term health conditions including dementia has recommended that specialist nursing intervention is offered across the trajectory of the condition, but there is a lack of agreement regarding the skills and competencies that specialist nurses are expected to possess. Admiral Nurses are the largest UK group of specialist dementia nurses. OBJECTIVE: To explore how Admiral Nurses met and were supported to meet competencies as defined in the Admiral Nurse Competency Framework, and to develop and maintain skills as dementia specialists. DESIGN: Cross-sectional, semi-structured survey. SETTING: Online national survey. PARTICIPANTS: Admiral (specialist dementia) Nurses. METHODS: We co-designed our survey with Admiral Nurses; then invited Admiral Nurses to complete it in 2022-23 Data were analysed thematically. RESULTS: 68 (20% of all Admiral Nurses) completed the survey; most were female (85.2%), from a white ethnic group (88.2%); they reported on average 24 years of nursing experience. We identified three themes in responses: 1.Having time and skills for meaningful support, explored how participants were resourced with time and skills to understand and address family carer client needs by active listening, tailoring person-centred support, and "walking alongside" families. 2.Partnering family carers, concerned how they co-designed interventions with family carers, learning from these collaborative partnerships where expertise was shared. 3.Practice and peer-based learning, explored how participants took responsibility for using available training, peer learning and self-reflection to develop their practice. CONCLUSIONS: Admiral Nurse roles enabled respondents to develop as autonomous practitioners and to access resources that supported them to build and sustain their dementia specialist practice. Learning was practice based, through partnerships with family carer clients, peer support and self-directed learning. Specialist nursing models may help address the global health workforce emergency, through enabling creative practice development and valued roles that support retention of experienced nurses
Resonance structure in the {\gamma}{\gamma} and systems in dC interactions
Along with and {\eta} mesons, a resonance structure in the invariant
mass spectrum of two photons at M{\gamma}{\gamma} = 360 \pm 7 \pm 9 MeV is
observed in the reaction d + C \rightarrow {\gamma} + {\gamma} + X at momentum
2.75 GeV/c per nucleon. Estimates of its width and production cross section are
{\Gamma} = 64 \pm 18 MeV and = 98 \pm 24 {\mu}b,
respectively. The collected statistics amount to 2339 \pm 340 events of 1.5
\cdot 10^6 triggered interactions of a total number ~ 10^12 of dC-interactions.
The results on observation of the resonance in the invariant mass spectra of
two mesons are presented: the data obtained in the d + C \rightarrow
{\gamma} + {\gamma} reaction is confirmed by the d + C \rightarrow +
reaction: = 359.2 \pm 1.9 MeV, {\Gamma} = 48.9 \pm 4.9
MeV; the ratio of Br(R\rightarrow{\gamma}{\gamma}) /
Br(R\rightarrow) = (1.8 {\div} 3.7)\cdot10^-3.Comment: 10 pages, 11 figure
Improved forcing scheme in pseudopotential lattice Boltzmann methods for multiphase flow at arbitrarily high density ratios
The pseudopotential lattice Boltzmann method has been widely used to simulate many multiphase flow applications. However, there still exist problems with reproducing realistic values of density ratio and surface tension. In this study, a higher-order analysis of a general forcing term is derived. A forcing scheme is then constructed for the pseudopotential method that is able to accurately reproduce the full range of coexistence curves. As a result, multiphase flow of arbitrarily high density ratios independent of the surface tension can be simulated. Furthermore, the interface width can be tuned to allow for grid refinement and systematic error reduction. Numerical results confirm that the proposed scheme enables independent control of density ratio, surface tension, and interface width simultaneously
On compression of Bruhat-Tits buildings
We obtain an analog of the compression of angles theorem in symmetric spaces
for Bruhat--Tits buildings of the type .
More precisely, consider a -adic linear space and the set of
all lattices in . The complex distance in is a complete system of
invariants of a pair of points of under the action of the complete
linear group. An element of a Nazarov semigroup is a lattice in the duplicated
linear space . We investigate behavior of the complex distance under
the action of the Nazarov semigroup on the set .Comment: 6 page
Simulating Dynamical Features of Escape Panic
One of the most disastrous forms of collective human behaviour is the kind of
crowd stampede induced by panic, often leading to fatalities as people are
crushed or trampled. Sometimes this behaviour is triggered in life-threatening
situations such as fires in crowded buildings; at other times, stampedes can
arise from the rush for seats or seemingly without causes. Tragic examples
within recent months include the panics in Harare, Zimbabwe, and at the
Roskilde rock concert in Denmark. Although engineers are finding ways to
alleviate the scale of such disasters, their frequency seems to be increasing
with the number and size of mass events. Yet, systematic studies of panic
behaviour, and quantitative theories capable of predicting such crowd dynamics,
are rare. Here we show that simulations based on a model of pedestrian
behaviour can provide valuable insights into the mechanisms of and
preconditions for panic and jamming by incoordination. Our results suggest
practical ways of minimising the harmful consequences of such events and the
existence of an optimal escape strategy, corresponding to a suitable mixture of
individualistic and collective behaviour.Comment: For related information see http://angel.elte.hu/~panic,
http://www.helbing.org, http://angel.elte.hu/~fij, and
http://angel.elte.hu/~vicse
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans
This is the final version. Available from Nature Research via the DOI in this record.RNA-sequencing data sets are available at ArrayExpress (www.ebi.ac.uk) under accession code E-MTAB-4075. ChIP-seq data sets are available at the NCBI SRA database (http://www.ncbi.nlm.nih.gov) under accession code SRP071687. The authors declare that all other data supporting the findings of this study are available within the article and its supplementary information files, or from the corresponding author upon request.Fever is a universal response to infection, and opportunistic pathogens such as Candida albicans have evolved complex circuitry to sense and respond to heat. Here we harness RNA-seq and ChIP-seq to discover that the heat shock transcription factor, Hsf1, binds distinct motifs in nucleosome-depleted promoter regions to regulate heat shock genes and genes involved in virulence in C. albicans. Consequently, heat shock increases C. albicans host cell adhesion, damage and virulence. Hsf1 activation depends upon the molecular chaperone Hsp90 under basal and heat shock conditions, but the effects are opposite and in part controlled at the level of Hsf1 expression and DNA binding. Finally, we demonstrate that Hsp90 regulates global transcription programs by modulating nucleosome levels at promoters of stress-responsive genes. Thus, we describe a mechanism by which C. albicans responds to temperature via Hsf1 and Hsp90 to orchestrate gene expression and chromatin architecture, thereby enabling thermal adaptation and virulence.Wellcome TrustCanadian Institutes of Health ResearchCanadian Institutes of Health ResearchBiotechnology and Biological Sciences Research Council (BBSRC)European Research Council (ERC)Science and Technology Development Fund of Macau S.A.R (FDCT)Research and Development Administrative Office of the University of MacauNational Institutes of Health (NIH
Coevolved mutations reveal distinct architectures for two core proteins in the bacterial flagellar motor
Switching of bacterial flagellar rotation is caused by large domain movements of the FliG protein triggered by binding of the signal protein CheY to FliM. FliG and FliM form adjacent multi-subunit arrays within the basal body C-ring. The movements alter the interaction of the FliG C-terminal (FliGC) "torque" helix with the stator complexes. Atomic models based on the Salmonella entrovar C-ring electron microscopy reconstruction have implications for switching, but lack consensus on the relative locations of the FliG armadillo (ARM) domains (amino-terminal (FliGN), middle (FliGM) and FliGC) as well as changes during chemotaxis. The generality of the Salmonella model is challenged by the variation in motor morphology and response between species. We studied coevolved residue mutations to determine the unifying elements of switch architecture. Residue interactions, measured by their coevolution, were formalized as a network, guided by structural data. Our measurements reveal a common design with dedicated switch and motor modules. The FliM middle domain (FliMM) has extensive connectivity most simply explained by conserved intra and inter-subunit contacts. In contrast, FliG has patchy, complex architecture. Conserved structural motifs form interacting nodes in the coevolution network that wire FliMM to the FliGC C-terminal, four-helix motor module (C3-6). FliG C3-6 coevolution is organized around the torque helix, differently from other ARM domains. The nodes form separated, surface-proximal patches that are targeted by deleterious mutations as in other allosteric systems. The dominant node is formed by the EHPQ motif at the FliMMFliGM contact interface and adjacent helix residues at a central location within FliGM. The node interacts with nodes in the N-terminal FliGc α-helix triad (ARM-C) and FliGN. ARM-C, separated from C3-6 by the MFVF motif, has poor intra-network connectivity consistent with its variable orientation revealed by structural data. ARM-C could be the convertor element that provides mechanistic and species diversity.JK was supported by Medical Research Council grant U117581331. SK was supported by seed funds from Lahore University of Managment Sciences (LUMS) and the Molecular Biology Consortium
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